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1最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL 2014神经病学与神经康复学杂志2014,11,3:31
2查看详情显示文摘Ga(e)tan A Miroshnychenko Y Wilk T Chotia A Viteau M Comparat D Pillet P Browaeys A Grangier P 0,,:1
3Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD 2005Tuberculosis (Edinb)2005,85,12:1
4Comparison of the skin-prick test and Phadia Immuno CAP as tools to diagnose house-dust mite allergy显示文摘YONG G J HYUN J C GA Y P 2010Am J Rhinol Allergy2010,24,:1
5Comparative analysis of bat genomes provides insight into the evolution of flight and immunity 显示文摘Zhang G Cowled C Shi Z Huang Z Bishop-Lilly KA Fang X Wynne JW Xiong Z Baker ML Zhao W Tachedjian M Zhu Y Zhou P Jiang X Ng J Yang L Wu L Xiao J Feng Y Chen Y Sun X Zhang Y Marsh GA Crameri G Broder CC Frey KG Wang LF Wang J 2013Science2013,339,6118:1
6Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139:specificity and relevance to immunity显示文摘LOSONSKY GA LIM Y MOTAMEDI P 1997Clin Diagn Lab Immunol1997,4,3:1
7Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel 显示文摘 Lee IY Silverman GL Harrison PM Strome R Heinrich C Karunaratne A Pasternak SH Chishti MA Liang Y Mastrangelo P Wang K Smit AF Katamine S Carlson GA Cohen FE Prusiner SB Melton DW Tremblay P Hood LE Westaway D 1999J Mol Biol1999,292,4:1
8Enhanced photoprotection at the early stages of leaf expansion in field-grown soybean plants显示文摘Jiang C D Li P M Ga H Y 2005Plant Science2005,168,:1
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