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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Role of mast cell tryptase in renal interstitial fibrosis 显示文摘 | Kondo S Kagami S Kido H Strutz F Muller GA Kuroda Y | 2001 | J Am Soc Nephrol2001，12，8： | 1 |
| 3 | A Comparison of the Korean-Ages and Stages Questionnaires and Denver Developmental Delay Screening Test显示文摘 | Ga H Y Kwon J Y | 2011 | Annals of Rehabilitation Medicine2011，35，3： | 1 |
| 4 | successful liver transplantation from aliving donor to her son显示文摘 | Lynch SV Ong TH Matsunami H Koido Y Balderson GA | 1990 | N Engl J Med1990，333，： | 1 |
| 5 | Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks 显示文摘 | DONG Y ZHU H SAGNELLA GA | 1999 | Hypertension1999，34，6： | 1 |
| 6 | Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘 | Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD | 2005 | Tuberculosis (Edinb)2005，85，12： | 1 |
| 7 | Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons显示文摘 | Barsoum MJ Yuan H Gerencser AA Liot G Kushnareva Y Grber S Kovacs I Lee WD Waggoner J Cui J White AD Bossy B Martinou JC Youle RJ Lipton SA Ellisman MH Perkins GA Bossy-Wetzel E | 2006 | EMBO J2006，25，16： | 1 |
| 8 | Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites 显示文摘 | Zhu H Sagnella GA Dong Y | 2003 | J Hypertens2003，21，1： | 1 |
| 9 | The IANA Task Force on frailty assessment of older people in clinical practice 显示文摘 | Van Kan GA Rolland Y Bergman H | 2008 | J Nutr Health Aging2008，12，1： | 1 |
| 10 | Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension显示文摘 | Zhu H Sagnella GA Dong Y | 2004 | J Hypertens2004，22，7： | 1 |
| 11 | daptively robust filtering for kinematic geodetic positioning显示文摘 | Yang Y He H Xu GA | 2001 | J Geod2001，75，： | 1 |
| 12 | Optimum (Cs,O)/GaAs interface of negative-electron-affinity GaAs photocathodes显示文摘 | Lu Q B Pan Y X Ga H R | 1990 | Journal of Applied Physics1990，68，2： | 1 |
| 13 | Extraction, purification and properties of aequorin, a biolumines- cent protein from the luminous hydromedusan, Ae- quorea显示文摘 | Shimomura O Johnson F H Sa|ga Y | 1962 | Journal of Cellular Physiology1962，59，3： | 1 |
| 14 | Research of correlation between the amount of leukocyte in EPS and NIH-CPSI:result from 1242 men in Fangchenggang Area in Guangxi Province 显示文摘 | Mi H Ga~ Y Yan Y | 2012 | Urology2012，79，2： | 1 |
| 15 | A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity 显示文摘 | Frayling TM Timpson N J Weedon MN Zeggini E Freathy RM Lindgren CM Perry JR Elliott KS Lango H Rayner NW Shields B Harries LW Barrett JC Ellard S Groves C J Knight B Patch AM Ness AR Ebrahim S Lawlor DA Ring SM Ben-Shlomo Y Jarvelin MR Sovio U Bennett A J Melzer D Ferrucci L Loos RJ Barroso I Wareham N J Karpe F Owen KR Cardon LR Walker M Hitman GA Palmer CN Doney AS Morris AD Smith GD Hattersley AT McCarthy MI 2007 | 2007 | Science2007，316，： | 1 |
| 16 | Full-scalefield tests of concrete slabs subjected to blast lo ad s显示文摘 | SC H E N K E R A A N TEB Y I GA L E | 2008 | International Journal of Im pact Engineering2008，35，3： | 1 |
| 17 | Alginate-based com-posite sponge containing silver nanoparticles synthesizedin situ 显示文摘 | Song Y S Ga H L Se G L | 2012 | Carbohydrate Polymers2012，90，1： | 1 |
| 18 | Enhanced photoprotection at the early stages of leaf expansion in field-grown soybean plants显示文摘 | Jiang C D Li P M Ga H Y | 2005 | Plant Science2005，168，： | 1 |
| 19 | Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites显示文摘 | Zhu H Sagnella GA Dong Y | 2003 | J Hypertens2003，，21： | 1 |
| 20 | Association between the C825T polymorphism of the G protein beta3-subunit gene and hypertension in blacks 显示文摘 | Dong Y Zhu H Sagnella GA | 1999 | Hypertension1999，34，6： | 1 |
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