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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 3 | Abrupt Climate Changes of Holocene显示文摘This paper is a review of studies of abrupt climate changes(ACCs) during the Holocene published during the past ten years.North Atlantic cold events are indicators of ACCs.As indicated by North Atlantic ice-rafted debris(IRD),there were nine confirmed cold events during the Holocene,occurring at 11.1 kyr,10.3 kyr,9.4 kyr,8.1 kyr,5.9 kyr,4.2 kyr,2.8 kyr,1.4 kyr,and 0.4 kyr respectively according to most representative results from Bond et al.(1997).However,the identification of chronology has been made with some uncertainties.Considerable climatic proxy data have shown that,during the cold events,substantial climate abnormalities have occurred widely across the globe,particularly in the areas surrounding the North Atlantic.These abnormalities were in the form of high-latitude cold in the both hemispheres,expansion of the Westerlies to low latitudes,drought in the monsoon regions,recession of summer monsoons,and intensification of the winter monsoons.Studies have indicated that the four ACCs occurring in the early Holocene may be related to freshwater pulses from ice melting in the northern part of the North Atlantic,and the other five ACCs that occurred during the middle and late Holocene may be related to the decreased solar activity. | WANG Shaowu GE Quansheng WANG Fang WEN Xinyu HUANG Jianbin | 2013 | Chinese Geographical Science2013，23，1： | 6 |
| 4 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 5 | Physicochemical properties,antimicrobial activity and oil release of fish gelatin films incorporated with cinnamon essential oil显示文摘Fish skin gelatin films incorporated with various concentrations of cinnamon essential oil(CEO)were prepared and characterized.The results showed that tensile strength(TS),elongation at break(EAB),and water content(WC)of the gelatin based film decreased with the increasing concentrations of CEO,but water vapor permeability(WVP)increased.Addition of CEO improved light barrier property of the film.The Scanning electron microscope(SEM)showed that the heterogeneous surface and porous formation appeared in gelatin-CEO films.Fourier transform infrared spectroscopy analyses(FTIR-ATR)spectra indicated the interactions existed between gelatin and CEO.The gelatin-CEO films exhibited good inhibitory effects against the tested microorganisms(Escherichia coli,Staphylococcus aureus,Aspergillus niger,Rhizopus oryzae,and Paecilomyces varioti)and their antifungal activity seemed to be more effective than the resistance to bacterial growth.In vitro release studies showed an initial burst effect of CEO release and that subsequently slowed down at 40℃,but the initial burst release was not obvious at 4℃.The obtained results suggested that incorporation of CEO as a natural antimicrobial agent into gelatin film has potential for developing as active food packaging. | Jiulin Wu Xinyu Sun Xiaoban Guo Shangying Ge Qiqing Zhang | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 6 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 7 | A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis显示文摘Under stress,the endomembrane system undergoes reorganization to support autophagosome biogenesis,which is a central step in autophagy.How the endomembrane system remodels has been poorly understood.Here we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment(ERGIC)and the ER-exit site(ERES)in the ER-Golgi system,which is essential for promoting autophagosome biogenesis induced by different stress stimuli.The ERGIC-ERES contact is established by the interaction between TMED9 and SEC12 which generates a short distance opposition(as close as 2-5 nm)between the two compartments.The tight membrane contact allows the ERES-located SEC12 to transactivate COPII assembly on the ERGIC.In addition,a portion of SEC12 also relocates to the ERGIC.Through both mechanisms,the ERGIC-ERES contact promotes formation of the ERGIC-derived COPII vesicle,a membrane precursor of the autophagosome.The ERGIC-ERES contact is physically and functionally different from the TFG-mediated ERGIC-ERES adjunction involved in secretory protein transport,and therefore defines a unique endomembrane structure generated upon stress conditions for autophagic membrane formation. | Shulin Li Rui Yan Jialu Xu Shiqun Zhao Xinyu Ma Qiming Sun Min Zhang Ying Li Jun-Jie Gogo Liu Liangyi Chen Sai Li Ke Xu Liang Ge | 2022 | Cell Research2022，32，2： | 3 |
| 8 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 9 | Possibility of women treated with fertility-sparing surgery fornon-epithelial ovarian tumors to safely and successfully becomepregnant--a Chinese retrospective cohort study among 148cases显示文摘This study was performed to evaluate the oncological and reproductive outcomes of childbearing-agewomen treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred andforty eight non-epithelial ovarian tumor women treated with FSS between January I, 2000 and August 31, 2015from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overallsurvival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P = 0.023),whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associatedwith PFS and OS (P 〈 0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), nonedeveloped amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestationsincluding 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis afterFSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followedby ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase thePFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility. | Bin Yang Yan Yu Jing Chen Yan Zhang Ye Yin Nan Yu Ge Chen Shifei Zhu Haiyan Huang Yongqun Yuan Jihui Ai Xinyu Wang Kezhen Li | 2018 | Frontiers of Medicine2018，12，5： | 3 |
| 10 | 一种采用内部线栅偏振片的半透半反射式液晶显示器显示文摘为了同时获得具有高透射率和反射率的液晶显示器,提出了一种采用内部线栅式偏振片(wiregridpolarizer,WGP)的单倍盒间距的半透半反式液晶显示器方法。在反射模式中,液晶盒内嵌的WGP作为依赖于偏振的外界光的反射器;在透射模式中,不需要消色差的四分之一波片。基于液晶盒的初始取向,该器件可用于正常显黑模式(垂直取向)和正常显白模式(扭曲向列相取向)。本文研究了这两种器件结构详细的电光特性,如电压依赖光效率特性和视角特性。 | Zhibing Ge Xinyu Zhu Shin-Tson Wu 王文根(译) | 2006 | 现代显示2006，，10： | 3 |
| 11 | Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1显示文摘Human cytosolic sulfotransferase 2 A1(SULT2A1) is an important phase II metabolic enzyme. The detection of SULT2A1 is helpful for the functional characterization of SULT2A1 and diagnosis of its related diseases. However, due to the overlapping substrate specificity among members of the sulfotransferase family, it is difficult to develop a probe substrate for selective detection of SULT2A1. In the present study, through characterization of the sulfation of series of bufadienolides, arenobufagin(AB) was proved as a potential probe substrate for SULT2A1 with high sensitivity and specificity. Subsequently, the sulfation of AB was characterized by experimental and molecular docking studies. The sulfate-conjugated metabolite was identified as AB-3-sulfate.The sulfation of AB displayed a high selectivity for SULT2A1 which was confirmed by in vitro reaction phenotyping assays. The sulfation of AB by human liver cytosols and recombinant SULT2A1 both obeyed Michaelis-Menten kinetics, with similar kinetic parameters. Molecular docking was performed to understand the interaction between AB and SULT2A1, in which the lack of interaction with Met-137 and Tyr-238 of SULT2A1 made it possible to eliminate substrate inhibition of AB sulfation. Finally, the probe was successfully used to determine the activity of SULT2A1 and its isoenzymes in tissue preparations of human and laboratory animals. | Xiangge Tian Chao Wang Peipei Dong Yue An Xinyu Zhao Weiru Jiang Gang Wang Jie Hou Lei Feng Yan Wang Guangbo Ge Xiaokui Huo Jing Ning Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 12 | 高透过率共面转换液晶显示器显示文摘我们开发了一种在同一个基板上使用特殊电极设计的高透过率共面转换(HT-IPS)液晶显示器。这种特殊的电极构造在电极组之间产生实际的水平电场,在电极组区域内的边缘电场具有较高水平场成份。上半部分类似于IPS模式,而下半部分类似于边缘场转换(FFS)模式。HT-IPS模式显示出了很高的透过率[大于扭曲向列相(TN)模式的90%],同时,无论使用正性或负性各向异性的液晶材料,液晶盒都具有宽视角。此外,我们对比了相同条件下HT-IPS与IPS、FFS盒的光电特性。 | Zhibing Ge Xinyu Zhu Thomas X. Wu Shin-Tson Wu 彭增辉(译) | 2006 | 现代显示2006，，10： | 2 |
| 13 | Thermodynamics of Molten Pool Predicted by Computational Fluid Dynamics in Selective Laser Melting of Ti6Al4V:Surface Morphology Evolution and Densification Behavior显示文摘The three-dimensional physical model of the randomly packed powder material irradiated by the laser beam was established,taking into account the transformation of the material phase,the melt spreading and the interaction of the free surface of the molten pool and the recoiling pressure caused by the material evaporation during the selective laser melting.Influence of the processing parameters on the thermal behavior,the material evaporation,the surface morphology and the densification behavior in the connection region of the molten pool and the substrate was studied.It was shown that the powder material underwent the transformation from the partial melting state to the complete melting state and finally to the overheating state with the applied laser energy density increasing from 167 J/mm^(3) to 417 J/mm^(3).Therefore,the solidified track ranged from the discontinuous tracks with the rough surface to the continuous tracks with residual porosities,then to the continuous and dense tracks and terminally to the fluctuated tracks with the increase in the laser energy density.Meanwhile,the laser energy effect depth was maintained the positive relationship with the laser energy density.The vortex velocity obtained in the free surface of the molten pool towards to the rear region in the opposite laser scan direction promoted the melt convection to the edge region of the molten pool as the laser energy density was higher than 277 J/mm^(3),demonstrating the efficient energy dissipation from the center of the irradiation region to the whole part of the molten pool and the attendant production of the sufficient melt volume.Therefore,the efficient spreading of the molten pool and the metallurgical bonding ability of the melt with the substrate was obtained at the optimized laser energy density of 277 J/mm^(3).However,the severe material evaporation would take place as the melt was overheated,resulting in the formation of the residual pores and poor surface quality. | Donghua Dai Dongdong Gu Qing Ge Chenglong Ma Xinyu Shi Han Zhang | 2020 | Computer Modeling in Engineering & Sciences2020，，9： | 1 |
| 14 | Anti-inflammatory properties of Fu brick tea water extract contribute to the improvement of diarrhea in mice显示文摘Fu brick tea,a special kind of dark tea fermented dominantly by Eurotium cristatum,is traditionally used for diarrhea therapy in China.However,limited reports are available on the anti-diarrhea of Fu brick tea water extract(FTE)and its potential mechanisms.In the present study,the treatment effects of FTE on the senna-induced diarrhea in mice were investigated.We found that FTE effectively improved diarrhea index and inhibited gut peristalsis.Additionally,histopathological examination revealed that FTE protected the integrity and reduced inflammatory infiltration of the ileum mucosal barrier.Furthermore,FTE significantly decreased the levels of the pro-inflammatory factor 5-hydroxytryptamine(5-HT)and increased the expression of sodium–hydrogen exchanger 3(NHE-3).The association among both intestinal damage and electrolyte balance and inflammation has been reported by many studies.Collectively,our study showed that FTE had anti-diarrhea activity,which may be associated with anti-inflammatory properties. | Xinyue Dai Binggang Ge Mingzhi Zhu Huiwen Wang Tingyu Zeng Zhonghua Liu Donghe Fu | 2022 | Beverage Plant Research2022，2，1： | 1 |
| 15 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 16 | Hybrid Hydrogels Toughened by Chemical Covalent Bonding and Physical Electrostatic Interactions显示文摘 | LIU Li PAN Ge WANG Licheng PEN Xiuyan ZHANG Xinyue WU Guangfeng | 2018 | Chemical Research in Chinese Universities2018，34，3： | 1 |
| 17 | Metformin Rescues the MG63 Osteoblasts against the Effect of High Glucose on Proliferation显示文摘 | Xinyu Shao Xiaojun Cao Ge Song Yuan Zhao Bimin Shi Wang Chen | 2014 | Journal of Diabetes Research2014，，： | 1 |
| 18 | Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen a显示文摘 | Xinyue Zhang Meng Wu Wei Zhuo JinkeGu Sensen Zhang Jingpeng Ge Maojun Yang | 2015 | Protein & Cell2015，6，10： | 1 |
| 19 | In-vitro experimental study on the fluid-structure interaction in an image-based flexible model with a lateral cerebral aneurysm显示文摘Aiming to experimentally investigate the effect of aspect ratio(AR)of image-based aneurysm on wall deformation oscillation under different pulsatile flow conditions with considering the fluid-structure interaction.In this study,three silicon aneurysm models with different AR(0.8,1.0,and 1.2)were constructed.It was found that the detected wall deformation oscillation of patient-specific aneurysm increased with pulsatile inflow frequency increases,which was greater and more obvious oscillation than that in the ideal lateral aneurysm.In addition,the maximum amplitude of wall deformations oscillation of the aneurysm at the dome during the systolic phase decrease and the oscillation of wall deformation become obvious as AR increases.These results could provide more knowledge about the effect of AR and pulsatile flow on the wall deformation of aneurysm and will be helpful for understanding the aneurysm rupture risk. | Qingzhuo Chi Xinyu Li Sheng Chang Lizhong Mu Ying He Ge Gao | 2019 | Medicine in Novel Technology and Devices2019，，3： | 0 |
| 20 | Sedimentology,provenance and geochronology of the Miocene Qiuwu Formation:Implication for the uplift history of Southern Tibet显示文摘Located on the south of the Gangdese,the Qiuwu Formation has traditionally been considered as Eocene coal-bearing clastic sediments consisting of sandstone,mudstone and conglomerate,unconformably on top of Gangdese batholith.However,its precise age and depositional environment remain ambiguous.Here,we present a newly measured stratigraphic section near the Ngamring County,western Xigaze.Detrital zircon U-Pb ages were also applied to trace the provenance of sediments and to constrain the maximum depositional age of the Qiuwu Formation.Sedimentary facies analyses indicate subaqueous fan and alluvial fan depositional environments.Clast composition of the conglomerate is dominated by magmatic rocks at the lower part,while chert and mafic detritus occur in the upper part,suggesting a southern source.Sandstone modal analyses indicate that the compositions of quartz,feldspar and lithic grains changed from transitional arc to dissected arc,implying the unroofing of the Gangdese arc.Detrital zircon U-Pb ages of the Qiuwu Formation are compared with those from Gangdese magmatic rocks and Yarlung-Zangbo ophiolites,suggesting that the Gangdese arc is a main source of the Qiuwu detritus and that the southern source played a role during the later stage.The major peak of detrital zircon ages is at 45-55 Ma,which corresponds to Linzizong volcanic rocks in southern Gangdese arc.The weighted mean age of the five youngest zircons from the lower part of the section is 21.0 ± 2.2 Ma,suggesting that the Qiuwu Formation was deposited in early Miocene,coeval with other conglomerates exposed along the southern margin of Gangdese.Combining new observations with previously published data,we propose that the provenance of the Qiuwu Formation had shifted from a single northern source to double sources from both the north and the south.Activities of Great Counter Thrust were primarily responsible for the shift by making the south area a high elevation to provide sediments for the Qiuwu Formation. | Jiawei Zhang Jingen Dai Xinyu Qian Yukui Ge Chengshan Wang | 2017 | Geoscience Frontiers2017，8，4： | 0 |
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