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| 1 | Deep seismic reflection profile across the juncture zone between the Tarim Basin and the West Kunlun Mountains显示文摘Fine structures of the crust and upper mantle of the basin-and-range juncture on the northwestern margin of the Qinghai-Tibetan Plateau are first delineated by the deep seismic reflection profile across the juncture zone between the Tarim Basin and the West Kunlun Mountains. Evidence is found for the northward subduction of the northwest marginal lithosphere of the Qinghai-Tibetan Plateau and its collision with Tarim lithosphere beneath the West Kunlun Mountains. The lithosphere image of the face-to-face subduction and collision determines the coupling relationship between the Tarim Basin and the West Kunlun Mountains at the lithosphere scale and reflects the process of continent- continent collision. | GAO Rui HUANG Dongding LU Deyuan QIAN Guihua LI Yingkang KUANG Chaoyang Li Qiusheng LI Pengwu Feng Rujin Guan Ye | 2000 | Chinese Science Bulletin2000，45，24： | 30 |
| 2 | Transcriptional landscape of rice roots at the single-cell resolution显示文摘There are two main types of root systems in flowering plants,namely taproot systems of dicots and fibrous root systems found in monocots.Despite this fundamental split,our current knowledge of cellular and molecular mechanism driving root development is mainly based on studies of the dicot model Arabidopsis.However,the world major crops are monocots and little is known about the transcriptional programs underlying cell-type specification in this clade.Here,we report the transcriptomes of more than 20000 single cells derived from root tips of two agronomically important rice cultivars.Using combined computational and experimental analyses we were able to robustly identify most of the major cell types and define novel cell-type-specific marker genes for both cultivars.Importantly,we found divergent cell types associated with specific regulatory programs,including phytohormone biosynthesis,signaling,and response,which were well conserved between the two rice cultivars.In addition,we detected substantial differences between the cell-type transcript profiles of Arabidopsis and rice.These species-specific features emphasize the importance of analyzing tissues across diverse model species,including rice.Taken together,our study provides insight into the transcriptomic landscape of major cell types of rice root tip at single-cell resolution and opens new avenues to study cell-type specification,function,and evolution in plants. | Qing Liu Zhe Liang Dan Feng Sanjie Jiang Yifan Wang Zhuoying Du Ruoxi Li Guihua Hu Pingxian Zhang Yanfei Ma Jan ULohmann Xiaofeng Gu | 2021 | Molecular Plant2021，14，3： | 9 |
| 3 | Hierarchically porous carbon foams for electric double layer capacitors显示文摘对便携式的电子设备的成长要求意味着力量采购的那个无足轻重的人逐渐地被寻求在以后。电的双层电容器(EDLC ) 正在答应候选人因为使用尽最大努力由于他们的高力量密度和突出的控告 / 解除骑车稳定性采购原料。三维(3D ) 自食其力基于碳的材料广泛地在小 EDLC 为使用被学习了。然而,为 3D 碳电极的主要挑战是在他们的内部空格的有限离子散开率。探讨这限制,为内部离子散开提供另外的隧道的层次地多孔的 3D 结构被建议了。此处,我们为 ultralight 的合成报导一个新化学方法(9.92 mg/cm 3) 3D 面对钾碳酸盐包含连接 glutaraldehydecross 的 chitosan aerogel 的碳化的多孔的碳泡沫(PCF ) 。电子显微镜学图象表明碳泡沫是包含一致地驱散的 macropores 的碳表的一个互连的网络。另外, Brunauer-Emmett-Teller 大小证实层次地多孔的结构。PCF 电极能完成的电气化学的数据表演当当前的密度从 0.5 ~ 100 A/g 被增加时,在 0.5 A/g 的当前的密度的 246.5 F/g 的一个突出的 gravimetric 电容,和 67.5% 的显著电容保留被观察。伪固态的对称的 supercapacitor 经由二的汇编被制作新 PCF 并且被发现交付一超离频在 2.8 Wh/kg 的精力密度的 25 kW/kg 的力量密度。这研究与高电容的性能表明 ultralight 和层次地多孔的碳泡沫的合成。 | Feng Zhan Tianyu Liu Guihua Hou Tianyi Kou Lu Yue Rongfeng Guan Yat Li | 2016 | Nano Research2016，9，10： | 5 |
| 4 | Sorghum Insect Problems and Management显示文摘Sorghum (Sorghum bicolor) has high levels of starch,sugar,and fiber and is one of the most important energy crops in the world.Insect damage is one of the challenges that impacts sorghum biomass production.There are at least 150 insect species that can infest sorghum varieties worldwide.These insects can complete several generations within a growing season,they target various parts of sorghum plants at developmental stages,and they cause significant biomass losses.Genetic research has revealed the existence of resistant genetics in sorghum and insect tolerant sorghum varieties have been identified.Various control methods have been developed,yet more effective management is needed for increasing sorghum biomass production.Although there are no transgenic sorghum products on the market yet,biotechnology has been recognized as an important tool for controlling insect pests and increasing sorghum production. | Chunshan Guo Wei Cui Xue Feng Jianzhou Zhao Guihua Lu | 2011 | Journal of Integrative Plant Biology2011，53，3： | 3 |
| 5 | EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer显示文摘 | Qiuju Wu Zekun Chen Guihua Zhang Wenhui Zhou You Peng Rong Liu Ceshi Chen Jing Feng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 2 |
| 6 | Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays显示文摘Parkinson’s disease(PD)is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons.The precise mechanisms are still unknown.Since the neuronal communications are inherently electrical and chemical in nature,dual-mode detection of PD-related neuroelectrical and neurochemical information is essential for PD research.Subthalamic nucleus(STN)highfrequency stimulation(HFS)can improve most symptoms of PD patients and decrease the dosage of antiparkinsonian drugs.The mechanism of STN-HFS for PD still remains elusive.In this study,a silicon-based dual-mode microelectrode array(MEA)probe was designed and fabricated,and systematic dual-mode detection methods were established.The recording sites were modified using Pt nanoparticles and Nafion to improve the signal-to-noise(SNR)ratio.To evaluate its applicability to PD research,in vivo electrophysiological and electrochemical detection was performed in normal and hemiparkinsonian models,respectively.Through comparison of the dual-mode signals,we demonstrated the following in a PD monkey:(1)the maximum dopamine concentration in the striatum decreased by 90%;(2)the spike firing frequency increased significantly,especially in the region of the cortex;(3)the spectrogram analysis showed that much power existed in the 0–10 Hz frequency band;and(4)following repeated subthalamic nucleus high-frequency stimulation trials,the level of DA in the striatum increased by 16.5μM,which led to a better elucidation of the mechanism of HFS.The dual-mode MEA probe was demonstrated to be an effective tool for the study of neurological disorders. | Song Zhang Yilin Song Mixia Wang Guihua Xiao Fei Gao Ziyue Li Guoxian Tao Ping Zhuang Feng Yue Piu Chan Xinxia Cai | 2018 | Microsystems & Nanoengineering2018，4，1： | 2 |
| 7 | Numerical simulation on flow, combustion and heat transfer of ethylene cracking furnaces显示文摘 | Hu Guihua Wang Honggang Qian Feng | 2010 | Chemical Engineering Science2010，，8： | 2 |
| 8 | Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics显示文摘The nanoplatforms based on upconversion nanoparticles(UCNPs)have shown great promise in amplified photodynamic therapy(PDT)triggered by near-infrared(NIR)light.However,their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence(UCL)by photosensitizers.To solve these defects,core-satellite metal-organic framework@UCNP superstructures,composed of a single metal-organic framework(MOF)NP as the core and Nd3+-sensitized UCNPs as the satellites,are designed and synthesized via a facile electrostatic self-assembly strategy.The superstructures realize a high co-loading capacity of chlorin e6(Ce6)and rose bengal(RB)benefitted from the highly porous nature of MOF NPs,showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs.The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal(magnetic resonance(MR)/UCL/fluorescence(FL))imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation,avoiding the laser irradiation-induced overheating issue.This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics. | Zhike Li Xi Qiao Guihua He Xin Sun Danhua Feng Liefeng Hu Hua Xu Hai-Bing Xu Shengqian Ma Jian Tian | 2020 | Nano Research2020，13，12： | 2 |
| 9 | Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability显示文摘Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme temperatures.Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully understood.The histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or cofactors.In this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and purified.Crystal structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable mechanism.However,it shows that the crystal structure is conserved and no clue can be obtained from this single structure.Furthermore,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of HPr.Thus,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic bacteria.Using site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the HPrs.Understanding the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature. | FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN JingHua GAO George Fu | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 10 | One-pot synthesis of 2,5-bis(hydroxymethyl)furan from biomass derived 5-(chloromethyl)furfural in high yield显示文摘5-(Chloromethyl)furfural(CMF),as a new platform molecular,has become a hot topic in the field of biorefinery.Herein,the one-pot conversion of CMF to 2,5-bis(hydroxymethyl)furan(BHMF)in the water phase was demonstrated for the first time.A 91%BHMF yield was obtained over Ru/Cu Oxcatalyst,and BHMF was mainly produced by the consecutive hydrolysis and hydrogenation of CMF with 5-hydroxymethylfurfural(HMF)as an intermediate.Kinetic studies revealed that the conversion of HMF to BHMF was the rate-determining step.Remarkably,the characterizations and density functional theory(DFT)calculations further revealed the lower electron density of Ru NPs in Ru/Cu Oxcatalyst,resulting in a larger adsorption energy and a smaller free energy difference for the formation of alcohols.The present findings offered a new pathway for biomass-derived diol production through CMF as a potential source. | Binglin Chen Yunchao Feng Sen Ma Weizhen Xie Guihua Yan Zheng Li Jonathan Sperry Shuliang Yang Xing Tang Yong Sun Lu Lin Xianhai Zeng | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 11 | Analysis 24-hour ambulatory blood pressure monitoring in patients with diabetic nephropathy:a hospital-based study显示文摘 | Junhui Li Feng Wang Guihua Jian | 2013 | Clinical Nephrology2013，79，3： | 1 |
| 12 | Numerical simulation on flow, combustion and heat transfer of eth- ylene cracking furnaces 显示文摘 | Hu Guihua Wang Honggang Qian Feng | 2011 | Chemical Engineering Sci- ence2011，66，： | 1 |
| 13 | Burdock fruc- tooligosaccharide induces resistance to tobacco mosaic virus in tobacco seedlings显示文摘 | Fengde Wang Guihua Feng Kaoshan Chen | 2009 | Physiological and Molecular Plant Patholo- gy2009，，74： | 1 |
| 14 | Numerical simulation on flow,combustion and heat transfer of ethylene cracking furnaces显示文摘 | Hu Guihua Wang Honggang Qian Feng | | 0，，08： | 1 |
| 15 | Inhibition of P-glycoprotein and Glutathione S-transferase-pi mediated resistance by Fluoxetine in MCF-7/ADM cells显示文摘 | Ye Zhang Ting Zhou Jingjing Duan Zhijun Xiao Guihua Li Feng Xu | 2013 | Biomedicine & Pharmacotherapy2013，，： | 1 |
| 16 | Preparation and Photoactivity of a Novel Water-Soluble,Polymeriz-able Zinc Phthalocyanine显示文摘 | XIAOYUAN SHEN WANGYANG LU GUIHUA FENG | 2009 | Journal of Molecular Catalysis A:Chemical2009，298，： | 1 |
| 17 | p55PIK-PI3K stimulates angiogenesis in colorectal cancer cell by activating NF-κB pathway显示文摘 | Guihua Wang Cheng Chen Rui Yang Xiaonian Cao Senyan Lai Xuelai Luo Yongdong Feng Xianmin Xia Jianping Gong Junbo Hu | 2013 | Angiogenesis2013，，3： | 1 |
| 18 | c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α显示文摘 | Cheng Chen Shaoxin Cai Guihua Wang Xiaonian Cao Xi Yang Xuelai Luo Yongdong Feng Junbo Hu | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 19 | Seeded region growing: an extensive and comparative study显示文摘 | Feng J Zeng Guihua | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 20 | Selective killing effect of oxytetracycline,propafenone and metamizole on A549 or Hela cells显示文摘Objective:To determine the selective killing effect of oxytetracycline,propafenone and metamizole on A549 or Hela cells.Methods:Proliferation assay,lactate dehydrogenase(LDH)assay,apoptosis detecting,flow cytometry and western blot were performed.Results:It was found that treatment with propafenone at the concentration of 0.014 g/L or higher for 48 h could induce apoptosis in Hela cells greatly,while it was not observed in oxytetracycline and metamizole at the concentration of 0.20 g/L for 48 h.Oxytetracycline,propafenone and metamizole all displayed evident inhibitory effects on the proliferation of A549 cells.The results of LDH assay demonstrated that the drugs at the test range of concentration did not cause necrosis in the cells.Propafenone could elevate the protein level of P53 effectively(P<0.01).Conclusions:Oxytetracycline,propafenone and metamizol(dipyrone)all displayed evident inhibitory effects on the proliferation of A549 cells.Propafenone also displayed evident inhibitory effects on the proliferation of Hela cells. | Jinhui Shao Guihua Feng | 2013 | Chinese Journal of Cancer Research2013，25，6： | 0 |
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