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| 1 | Grain-size features of a Miocene loess-soil sequence at Qinan: Implications on its origin显示文摘In this study, grain-size of 507 bulk samples from the QA-I Miocene loess-soil sequence at Qinan were analyzed, and the grain-size features are compared with those of typical Quaternary loess and soil samples, representative lacustrine and fluvial samples. The results indicate that the grain-size distribution pattern of the Miocene loess is essentially similar to that of Quaternary loess, but greatly differs from the lacustrine and fluvial sediments. Loess layers are regularly coarser than soil layers, indicating cyclical climate changes. Median grain-size along the 253.1 m sequence varies from 6 to 13 μm and the >63 μm fraction represents only 5.3% in maximum, 0.9% in average. Long-term grain-size variations are consistent with the loess accumulation rate at Qinan and with the eolian mass accumulation rate in the North Pacific. These features firmly indicate an eolian origin of the studied sequence, and also reveal a coeval changes between the long-term changes of eolian grain-size and continental aridity in the dust source regions. | QIAO Yansong1,3, GUO Zhengtang2,1, HAO Qingzhen1, YIN Qiuzhen1, YUAN Baoyin1 & LIU Tungsheng1 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 3. Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China | 2006 | Science China Earth Sciences2006，49，7： | 33 |
| 2 | Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products显示文摘最近的婴儿的公式奶粉污染事件证明了在牛奶质量控制的经典标记或标准在识别鈥渕a nipulated 鈥 ? 是不够的差质量的牛奶。在现在的学习,我们第一次证明奶牛牛奶包含大量 microRNAs ( miRNAs )并且牛奶特定的 miRNAs 的唯一的表示侧面能为未加工的牛奶和牛奶相关的商业产品的质量控制用作新奇指示物和可能的新标准,例如液体牛奶和粉状的公式牛奶。用定序的 Solexa,首先,我们系统地在未加工的牛奶屏蔽了 miRNA 表示并且在未加工的牛奶识别了 245 miRNAs 的一个总数。不同于层次在哺乳的不同时期是其表达式将近相同的另外的经典 biomarkers,单个 miRNAs 能显著地在哺乳过程期间被改变,含有那 miRNAs 可以是更精确的指示物反映牛奶的优秀改变。第二,使用 TaqMan 基于探查的 miRNA 量的 RT-PCR ,我们进一步识别了七 miRNAs 重要地在整个哺乳过程,和更多有相对一致的表情,这七牛奶特定的 miRNAs 的表示侧面能为区别用作理想的 biomarker 差质量或从纯未加工的牛奶的 鈥渕a nipulated 鈥?牛奶,象为商业乳制品的质量控制一样,例如液体,牛奶和粉状的公式挤。一起,我们的调查结果为为决定未加工的牛奶或牛奶相关的商业产品的质量理解牛奶 miRNAs 和一个新潜在的标准的生理的角色提供一个基础。 | Xi Chen Chao Gao Haijin Li Lei Huang Qi Sun Yanye Dong Chunliang Tian Shengpu Gao Hailin Dong Danping Guan Xiaoyun Hu Shujian Zhao Liang Li Lin Zhu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Cell Research2010，20，10： | 29 |
| 3 | Therapeutic effect of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients:a clinical two-center randomized controlled trial显示文摘OBJECTIVE:To evaluate the therapeutic effects of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients.METHODS:One hundred and twenty hemiplegia patients with stage I shoulder-hand syndrome were randomly divided into a group treated with standardized electric acupuncture and massage,and a group treated with rehabilitation therapy for 6 weeks.The primary indices evaluated were pain on passive movement of the shoulder using the numeric pain rating scale(NPRS),and the number of patients with shoulder-hand syndrome at Steinbrocker stage II or III after treatment.The secondary indices were Fugl-Meyer evaluation of functional movement of the upper limb and hand using the modified rankin scale(MRS).RESULTS:At post-treatment evaluation and a 12-week follow-up visit,NPRS score,number of patients with stage II or III shoulder-hand syndrome,and MRS score were all improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).On Fugl-Meyer evaluation,functional movement of the upper limb was also improved in the acupuncture-massage group compared with the rehabilitation group(P<0.05).CONCLUSION:Standardized acupuncture-massage therapy may have curative effects on shoulder-hand syndrome in hemiplegia patients. | Ning Li Fengwei Tian Chengwei Wang Pengming Yu Xi Zhou Qian Wen Xiulan Qiao Lu Huang | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 25 |
| 4 | Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression显示文摘长期的 periodontitis (CP ) 是最普通的口头的疾病之一,它在成年人引起牙槽的骨头吸收和牙齿损失。在我们试图调查 plumbagin (PL ) 的潜力的这研究,广泛地调查的活跃混合物在对待 CP 从繁体中文植物石墨 zeylanica L 提取了。人的牙齿周围的系带干细胞(PDLSC ) 在 vitro 被用于研究,而 CP 的一个动物模型被 ligation+Porphyromonas gingivalis (Pg ) 在 SD 老鼠建立刺激。老鼠与 PL 被注射(2, 4,和 6 mgs。在这研究,我们建立了 biomarkers 的焦点模式描绘 Gegen Qinlian 煎(GQD ) 的剂量效果关系,为对待类型 2 糖尿病 mellitus (2-DM ) 的一个 TCM 公式。2-DM 的一个老鼠模型通过喂的饮食与低剂量的 STZ 注射相结合的高脂肪被建立。有 2-DM 的老鼠是管理高度,中间或低剂量(6.785, 4.071, 1.357 mgl/L ) 在 vitro 引起了 glomerular podocyte apoptosis,它被无毒的 chrysin (1-20 mol/L ) dose-dependently 通过 DNA 的减小稀释破碎。Chrysin 处理 dose-dependently 恢复了增加的 Bax/Bcl-2 比率,并且在高暴露葡萄糖的肾的 podocytes 压制了 Apaf-1 正式就职和提高的细胞色素 c 版本。在糖尿病的 db/db 老鼠, chrysin 的口头的管理(10 mgf 1.84 ??? ?? | Xin-yi ZHENG Chuan-yuan MAO Han QIAO Xi ZHANG Li YU Ting-yu WANG Er-yi LU | 2017 | Acta Pharmacologica Sinica2017，38，8： | 22 |
| 5 | Initial Exploration of Wind Farm Cluster Hierarchical Coordinated Dispatch Based on Virtual Power Generator Concept显示文摘China has made many strides in large-scale development and centralized integration of wind power in recent years.The wind power penetration of some regions has reached a high level,which brings significant challenges for power system dispatch due to the inherent variability and uncertainty of wind resources.To increase the dispatch capabilities of wind power generation,the spatial smoothing effect among adjacent wind farms needs to be fully utilized.This paper presents the concept of hierarchical coordinated dispatch for wind power based on a new concept of a virtual power generator.The spatial smoothing effect of wind power is analyzed first.Next,the virtual power generator method of a wind farm cluster is defined and established.Then,the hierarchical coordinated dispatch mode is compared with an existing wind power dispatch mode for individual wind farms.Finally,the proposed concept is implemented on a simulation case to demonstrate applicability and effectiveness. | Zongxiang Lu Xi Ye Ying Qiao Yong Min | 2015 | CSEE Journal of Power and Energy Systems2015，1，2： | 22 |
| 6 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 7 | Expression and identification of recombinant soluble single-chain variable fragment of monoclonal antibody MC3显示文摘AIM: To generate soluble single chain variable fragments (ScFv) of monoclonal antibody MC3 recognizing colorectal and gastric carcinomas.METHODS: mRNA was isolated from the hybridoma cell lineproducing MC3 and the DNAs encoding variable domains ofheavy and light chains(VH and VL) oftthe antibody wereamplified separately byRT-PCR and assembled into ScFvDNA with a linker DNAThe ScFv DNA was iigated into thephagemid vector pCANTAB5E and the ligated sample wastransformed into E. coil TG1. The transformed cells wereinfected with M13KO7 helper phage to yield recombinantphages. After two rounds of panning with gastric carcinomacell line AGS highly expressing MC3-binding antigen, thephage clones displaying ScFv fragments of the antibodywere selected by ELISA. 4 phage clones showing strongsignal in ELISA were used to infect E. coil HB2151 toexpress soluble ScFvs. The soluble ScFve were identified byDot blot and Western blot, and their antigen-binding activitywas assayed by ELISA. The VH and VL DNAs of the ScFvDNA derived from phage clone 19 were sequenced.RESULTS: The VH, VL and ScFv DNAs were about 340 bp,320 bp and 750 bp respectively. After two rounds of panningto the recombinant phages, 18 antigen-positive phageclones were selected from 30 preselected phage clones byELISA. All the soluble ScFvs derived from the 4 out of the 18antigen-positive phage clones were about Mr 32 000 andconcentrated in periplasmatic space under the given culturecondition. The soluble ScFvs could bind the antigen, andthey shared the same binding site with MC3. The sequencesof the VH and VL DNAs of the MC3 ScFv showed that thevariable antibody genes belonged to the IgG1 subgroup,κ-type.CONCLUSION: The soluble ScFv of MC3 is successfullyproduced, which not only provides a possible novel targetingvehicle for in vivo and in vitro study on associated cancers,but also offers the anuibody a stable genetic source. | Feng-Tian He Rong-Fen Li Yun-Sheng Kang Yan Zhang,Department of Biochemistry & Molecular Biology,Third Military Medical University,Chongqing 400038,China Yong-Zhan Nie Bao-Jun Chen Tai-Dong Qiao Dai-Ming Fan,Institute of Digestive Disease,Xijing Hospital,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 13 |
| 8 | A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women显示文摘Objective: The automated breast ultrasound system(ABUS) is a potential method for breast cancer detection;however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound(HHUS) and mammography(MG).Methods: Eligible participants underwent HHUS and ABUS testing; women aged 40–69 years additionally underwent MG. Images were interpreted using the Breast Imaging Reporting and Data System(BI-RADS).Women in the BI-RADS categories 1–2 were considered negative. Women classified as BI-RADS 3 underwent magnetic resonance imaging to distinguish true-and false-negative results. Core aspiration or surgical biopsy was performed in women classified as BI-RADS 4–5, followed by a pathological diagnosis. Kappa values and agreement rates were calculated between ABUS, HHUS and MG.Results: A total of 1,973 women were included in the final analysis. Of these, 1,353(68.6%) and 620(31.4%)were classified as BI-RADS categories 1–3 and 4–5, respectively. In the older age group, the agreement rate and Kappa value between the ABUS and HHUS were 94.0% and 0.860(P<0.001), respectively; they were 89.2% and0.735(P<0.001) between the ABUS and MG, respectively. Regarding consistency between imaging and pathology results, 78.6% of women classified as BI-RADS 4–5 based on the ABUS were diagnosed with precancerous lesions or cancer; which was 7.2% higher than that of women based on HHUS. For BI-RADS 1–2, the false-negative rates of the ABUS and HHUS were almost identical and were much lower than those of MG.Conclusions: We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China. | Xi Zhang Xi Lin Yanjuan Tan Ying Zhu Hui Wang Ruimei Feng Guoxue Tang Xiang Zhou Anhua Li Youlin Qiao | 2018 | Chinese Journal of Cancer Research2018，30，2： | 13 |
| 9 | Outcomes of the national programme on prevention of mother-to-child transmission of hepatitis B virus in China,2016-2017显示文摘Background:In addition to providing free hepatitis B vaccine(HBvacc)series to all infants in China since 2005,the national programme on prevention of mother-to-child transmission(PMTCT)of hepatitis B virus(HBV)started providing free hepatitis B immunoglobulin for all new-borns born to hepatitis B surface-antigen(HBsAg)positive mothers in 2010.However,few studies have evaluated the effectiveness of the PMTCT programme.Therefore,we aimed to investigate the outcomes of the programme and identify associated factors.Method:Using a cross-sectional study design,we collected data on 4112 pairs of HBsAg-positive mothers and their children aged 7-22 months in four representative provinces through interviews and medical record review.We tested HBsAg and hepatitis B surface antibody(anti-HBs)of children by enzyme-linked immunosorbent assay at designated maternal and child hospital laboratories.We used logistic regression to analyse factors associated with child HBsAg and anti-HBs positivity.Results:Thirty-five children were HBsAg positive,indicating the mother-to-child transmission(MTCT)rate was 0.9%(0.6-1.1%).The anti-HBs positive rate was 96.8%(96.3-97.4%).Children receiving HBvacc between 12 and 24h of birth were 2.9 times more likely to be infected than those vaccinated in less than 12 h(adjusted odds ratio[aOR]=2.9,95%confidence interval[CI]:1.4-63,P=0.01).Maternal hepatitis B e-antigen(HBeAg)positivity was associated with higher MTCT rate(aOR=79.1,95%Cl:10.8-580.2,P<0.001)and lower anti-HBs positive rate(aOR=0.4,95%CI:03-0.6,P<0.001).Children with low birth weight(LBW)were 60%less likely to be anti-HBs positive than those with normal birth weight(aOR=0A,95%CI:02-0.8,P=0.01).Conclusions:The MTCT rate was lower than the 2030 WHO elimination goal,which implies the programme is on track to achieve this target.As earlier HBvacc birth dose(HBvcc-BD)was associated with lower MTCT rate,we suggest that the PMTCT programme work with the Expanded Programme on Immunization(EPI)to modify the current recommendation for early HBvcc-BD to a requirement Our finding that LBW was associated with lower anti-HBs positivity points to the need for further studies to understand factors associated with these risks and opportunities for program strengthening.The programme needs to ensure providing essential test to identify HBeAg-positive mothers and their infants and provide them with appropriate medical care and follow-up. | Ya-Ping Qiao Min Su Yao Song Xiao-Yan Wang Zhen Li Yan-Lin Li Li-Xia Dou Qian Wang Katrina Hann Guo-Min Zhang Xiao-Na Huang Yu-Ning Yang Xi Jin Ai-Ling Wang | 2019 | Infectious Diseases of Poverty2019，8，4： | 10 |
| 10 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 11 | Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss显示文摘Objective: To identify presence of inflammasome activated in mouse cochlea with sensorineural hearing loss(SNHL) caused by cytomegalovirus(CMV) infection.Method: MCMV was injected into the right cerebral hemisphere in neonatal BALB/c mice at 2000 pfu virus titers. Auditory brainstem responses(ABRs) were tested to evaluate hearing at 21 days. Histopathological studies were conducted to confirm localizations of MCMV infected cells in the inner ear. Expression of inflammasome related factors was assessed by immunofluorescence, Quantitative real-time PCR and Western blotting.Results: In the mouse model of CMV induced SNHL, inflammasome related kinase Caspase-1 and downstream inflammatory factor IL-1b and IL-18 were found increased and activated after CMV infection in the cochlea. These factors could further up-regulate expression of IL-6 and TNFa. These inflammatory factors are neurotoxicity and may contribute to hearing impairment. Furthermore, we also detected significantly increased AIM2 protein that accumulated in the SGN of cochleae with CMV infection.Significance: We have shown that inflammasome as a novel inherent immunity mechanism may contribute to hearing impairment.Conclusion: Our data indicate that imflammasome assemble in mouse inner ear in response to CMV infection. We have revealed a novel pathology event in CMV induced SNHL involving activation of inflammasome in mouse cochlea. Additionally, we have shown that inflammasome may be a novel target for prevention and treatment of CMV related SNHL. | Xi Shi Yanfen Dong Ya Li ZenLu Zhao Huan Li Shiwei Qiu Yaohan Li Weiwei Guo Yuehua Qiao | 2015 | Journal of Otology2015，10，4： | 9 |
| 12 | Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics显示文摘Traditionally, antibiotics are included in animal feed at subtherapeutic levels for growth promotion and disease prevention.However, recent links between in-feed antibiotics and a rise in antibiotic-resistant pathogens have led to a ban of all antibiotics in livestock production by the European Union in January 2006 and a removal of medically important antibiotics in animal feeds in the United States in January 2017.An urgent need arises for antibiotic alternatives capable of maintaining animal health and productivity without triggering antimicrobial resistance.Host defense peptides(HDP) are a critical component of the animal innate immune system with direct antimicrobial and immunomodulatory activities.While in-feed supplementation of recombinant or synthetic HDP appears to be effective in maintaining animal performance and alleviating clinical symptoms in the context of disease, dietary modulation of the synthesis of endogenous host defense peptides has emerged as a cost-effective,antibiotic-alternative approach to disease control and prevention.Several different classes of smallmolecule compounds have been found capable of promoting HDP synthesis.Among the most efficacious compounds are butyrate and vitamin D.Moreover, butyrate and vitamin D synergize with each other in enhancing HDP synthesis.This review will focus on the regulation of HDP synthesis by butyrate and vitamin D in humans, chickens, pigs, and cattle and argue for potential application of HDP-inducing compounds in antibiotic-free livestock production. | Kelsy Robinson Xi Ma Yulan Liu Shiyan Qiao Yongqing Hou Guolong Zhang | 2018 | Animal Nutrition2018，，2： | 9 |
| 13 | Underwater image quality enhancement of sea cucumbers based on improved histogram equalization and wavelet transform显示文摘Sea cucumbers usually live in an environment where lighting and visibility are generally not controllable,which cause the underwater image of sea cucumbers to be distorted,blurred,and severely attenuated.Therefore,the valuable information from such an image cannot be fully extracted for further processing.To solve the problems mentioned above and improve the quality of the underwater images of sea cucumbers,pre-processing of a sea cucumber image is attracting increasing interest.This paper presents a newmethod based on contrast limited adaptive histogram equalization and wavelet transform(CLAHE-WT)to enhance the sea cucumber image quality.CLAHE was used to process the underwater image for increasing contrast based on the Rayleigh distribution,and WTwas used for de-noising based on a soft threshold.Qualitative analysis indicated that the proposed method exhibited better performance in enhancing the quality and retaining the image details.For quantitative analysis,the test with 120 underwater images showed that for the proposed method,the mean square error(MSE),peak signal to noise ratio(PSNR),and entropy were 49.2098,13.3909,and 6.6815,respectively.The proposed method outperformed three established methods in enhancing the visual quality of sea cucumber underwater gray image. | Xi Qiao Jianhua Bao Hang Zhang Lihua Zeng Daoliang Li | 2017 | Information Processing in Agriculture2017，4，3： | 9 |
| 14 | Effect of proteolytic starter culture isolated from Chinese Dong fermented pork(Nanx Wudl)on microbiological,biochemical and organoleptic attributes in dry fermented sausages显示文摘The effect of a proteolytic starter culture isolated from Nanx Wudl,on microbiological,biochemical and organoleptic attributes of dry fermented sausages was investigated during processing.Based on preliminary screening,the combination of Staphylococcus xylosus SX16 and Lactobacillus plantarum CMRC6,showing excellent proteolytic activity in vitro,was selected as the multi-strain starter(starter LS).For comparison,the single-strain starter culture of L.plantarum CMRC6(starter LB)and non-inoculated control were also tested.During fermentation,lactic acid bacteria and staphylococci dominated the microbiota and suppressed the Enterobacteriaceae growth in LS-inoculated sausages.The addition of LS starter accelerated acidification and proteolysis during ripening,improving the contents of total free amino acids and several essential free amino acids(Phe,Ile and Leu).Volatile compounds analysis revealed that LS-fermented sausage showed the highest abundance of 3-methyl-1-butanol,probably due to the inoculated S.xylosus.The inoculation of LS starter improved the sensory properties of sausages,especially the flavor attribute.Therefore,S.xylosus SX16 and L.plantarum CMRC6 are promising candidates for inclusion as multi-strain starters in the manufacture of gourmet fermented dry sausage. | Xi Chen Ruifang Mi Biao Qi Suyue Xiong Jiapeng Li Chao Qu Xiaoling Qiao Wenhua Chen Shouwei Wang | 2021 | Food Science and Human Wellness2021，10，1： | 9 |
| 15 | Computer vision technology in agricultural automation--A review显示文摘Computer vision is a field that involves making a machine “see”.This technology uses a camera and computer instead of the human eye to identify,track and measure targets for further image processing.With the development of computer vision,such technology has been widely used in the field of agricultural automation and plays a key role in its development.This review systematically summarizes and analyzes the technologies and challenges over the past three years and explores future opportunities and prospects to form the latest reference for researchers.Through the analyses,it is found that the existing technology can help the development of agricultural automation for small field farming to achieve the advantages of low cost,high efficiency and high precision.However,there are still major challenges.First,the technology will continue to expand into new application areas in the future,and there will be more technological issues that need to be overcome.It is essential to build large-scale data sets.Second,with the rapid development of agricultural automation,the demand for professionals will continue to grow.Finally,the robust performance of related technologies in various complex environments will also face challenges.Through analysis and discussion,we believe that in the future,computer vision technology will be combined with intelligent technology such as deep learning technology,be applied to every aspect of agricultural production management based on large-scale datasets,be more widely used to solve the current agricultural problems,and better improve the economic,general and robust performance of agricultural automation systems,thus promoting the development of agricultural automation equipment and systems in a more intelligent direction. | Hongkun Tian Tianhai Wang Yadong Liu Xi Qiao Yanzhou Li | 2020 | Information Processing in Agriculture2020，7，1： | 8 |
| 16 | Conditional probability Markov chain simulation based reliability analysis method for nonnormal variables显示文摘Based on fast Markov chain simulation for generating the samples distributed in failure region and saddlepoint approximation(SA) technique,an efficient reliability analysis method is presented to evaluate the small failure probability of non-linear limit state function(LSF) with non-normal variables.In the presented method,the failure probability of the non-linear LSF is transformed into a product of the failure probability of the introduced linear LSF and a feature ratio factor.The introduced linear LSF which approximately has the same maximum likelihood points as the non-linear LSF is constructed and its failure probability can be calculated by SA technique.The feature ratio factor,which can be evaluated on the basis of multiplicative rule of probability,exhibits the relation between the failure probability of the non-linear LSF and that of the linear LSF,and it can be fast computed by utilizing the Markov chain algorithm to directly simulate the samples distributed in the failure regions of the non-linear LSF and those of the linear LSF.Moreover,the expectation and variance of the failure probability estimate are derived.The results of several examples demonstrate that the presented method has wide applicability,can be easily implemented,and possesses high precision and high efficiency. | YUAN XiuKai,LU ZhenZhou & QIAO HongWei School of Aeronautics,Northwestern Polytechnical University,Xi’an 710072,China | 2010 | Science China(Technological Sciences)2010，53，5： | 8 |
| 17 | Comparative Analysis of Three Types of Peaches:Identification of the Key Individual Characteristic Flavor Compounds by Integrating Consumers' Acceptability with Flavor Quality显示文摘In order to recognize the key flavor compounds influencing the consumers' choice for honey peach, nectarine, and flat peach and provide important information for orientation breeding, sugars, organic acids, and aroma volatiles in 3 types of peaches were examined by high performance liquid chromatography(HPLC) and gas chromatography–mass spectrometry(GC–MS) and their key individual characteristic flavor compounds were identified by multivariate analysis integrated with consumers' evaluation. No significant differences in sugar and organic acid were observed between 3 types of peaches. In hierarchical clustering analysis(HCA) and principal component analysis(PCA)models, 3 types of peaches could not be differentiated by sugars or organic acids, but could be identified completely by aroma volatiles or by flavor compounds. A partial least squares regression(PLSR) model revealed that the key individual characteristic volatiles in nectarine, honey peach, and flat peach are C9 compounds and terpenic compounds, norisoprenoids and C6 compounds, and benzaldehyde, γ-decalactone, andδ-dodecalactone, respectively. These results suggest that sugars and organic acids form the background flavor of peach fruit and lactones shape the typical peach aroma. However, the individual aroma volatiles play the decisive role in unique flavor determination of different types of peaches. | XI Wanpeng ZHENG Qiao LU Juanfang QUAN Junping | 2017 | Horticultural Plant Journal2017，3，1： | 8 |
| 18 | Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)显示文摘The fall armyworm(FAW),Spodoptera frugiperda(J.E.Smith),is native to the Americas.It has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in 2016.It is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous characteristics.The inherently superior biological characteristics of FAW contribute to its invasiveness.Integrated pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and botanicals.Knowledge gaps remain to be filled to:(1)understand the invasive mechanisms of S.frugiperda;(2)understand how to prevent its further spread and(3)provide better management strategies.This review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management. | Jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao | 2021 | Journal of Integrative Agriculture2021，20，3： | 7 |
| 19 | Promoting hepatic growth factor in the treatment of heavy type hepatitis and severe chronic hepatitis: a multicenter clinical study显示文摘BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hepatic growthfactor (PHGF) in the treatment of heavy type hepatitis andsevere chronic hepatitis.METHODS: 347 patients with heavy type hepatitis and 324with severe chronic hepatitis were subjected to administra-tion of 120 μg of PHGF per day for 4 weeks on the basis ofgeneral treatment. Those who were being effectively treat-ed would last additional 2 to 4 weeks. Blood routine, urineroutine, blood urea nitrogen (BUN), blood creatinine(Cr), blood ammonia, alpha fetoprotein (AFP), electro-lyte, alanine transaminase (ALT), aspartate transaminase(AST), serum total bilirubin (TBIL), serum direct biliru-bin (DBIL), prothrombin time activity (PTA), total pro-tein (TP) and albumin (ALB) were detected in the pa-tients before treatment, 2 weeks after treatment, and at theend of the treatment. Any side-effect would be recorded.RESULTS: In the patients with severe chronic hepatitis, thetotal effective rate of the treatment was 88. 9% The levelsof ALT, AST and TBIL decreased significantly (P<0.001),whereas those of PTA and ALB increased significantly (P <0.001), and the level of AFP increased slightly. In patientswith heavy type hepatitis, the total effective rate of thistreatment was 78.4%, and patients at different stage showeddifferent results. The total effective rates of patients withearly, medium and terminal stage heavy type hepatitis were89.9%, 84.8% and 27.5%, respectively. No severe side-effect was shown.CONCLUSION: PHGF is effective and safe in the treat-ment of patients with heavy type hepatitis and severe chro-nic hepatitis. But it should be administered early in patientswith heavy type hepatitis so as to get better curative effects. | Jing-Hang Xu, Yan-Yan Yu, Chong-Wen Si, Zheng Zeng, Qin-Huan Wang, Duan-De Luo,Yong-Xing Zhou, Min-De Zeng, Guang-Yan Qiao, Ji-Lu Yao and Wei-Lun Lu Department of Infectious Diseases, First Hospital ofBeijing University, Beijing 100034, China Department of Gastroenterology, Wuhan UnionHospital, Wuhan 430022, China Department of Gastroentero-logy , Affiliated Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China Department of Gastroenterology, RenjiHospital, Shanghai 200001 , China Department of InfectiousDiseases, Second Affiliated Hospital, China Medical University, Shenyang110004, China Department of Gastroenterology, Third Affilia-ted Hospital, China Medical University, Shenyang 110004 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 7 |
| 20 | Incidence and mortality of corpus uteri cancer in China,2008-2012显示文摘Objective: To analyze the incidence and mortality rates of corpus uteri cancer in China using 2008-2012 data from the National Central Cancer Registry(NCCR) of China.Methods: We analyzed 2008-2012 data from 135 cancer registries using NCCR screening methods and criteria.The Chinese standard population in 2000 and Segi’s world population were applied to determine age-standardized incidence and mortality rates. The annual percentage change(APC) in rate was calculated using the Joinpoint Regression Program.Results: The crude incidence of corpus uteri cancer was 9.58/100,000, making corpus uteri cancer the ninth most common malignancy in females. The crude mortality was 2.97/100,000, making corpus uteri cancer the 13 th leading cause of death from malignant tumors in females. The incidence was higher in urban than in rural areas, but the mortality was higher in rural than in urban areas. The crude incidence was higher in eastern areas than in middle and western areas, while the crude mortality was higher in middle areas than in eastern and western areas.During 2003-2012, the age-standardized incidence rate based on the Chinese standard population in 2000(ASIRC)with uterine cancer increased significantly by 3.0% annually, while the age-standardized mortality rate based on the Chinese standard population in 2000(ASMRC) decreased by 0.4% annually, but the decrease was not statistically significant. The APC in incidence rate in the age groups of 30-44 years was 4.2%, which was statistically significant;increases/decreases in other age groups were not statistically significant. From 2003 to 2004, the age groups of 60-74 years showed high incidence, while from 2005 to 2012, the age groups of 45-59 years had high incidence.Conclusions: The incidence and mortality rates of corpus uteri cancer in China from 2008 to 2012 were relatively low compared with other countries. However, the significant increase in incidence rates and marked decrease in patient age suggest the need to strengthen China’s efforts toward prevention and control of corpus uteri cancer. | Yunfeng Xi Wenrui Wang Wenjie Chen Ke Han Liying Qiao Wanqing Chen | 2019 | Chinese Journal of Cancer Research2019，31，3： | 7 |
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