|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Entransy dissipation number and its application to heat exchanger performance evaluation显示文摘Based on the concept of the entransy which characterizes heat transfer ability, a new heat exchanger performance evaluation criterion termed the entransy dissipation number is established. Our analysis shows that the decrease of the entransy dissipation number always increases the heat exchanger effectiveness for fixed heat capacity rate ratio. Therefore, the smaller the entransy dissipation number, the better the heat exchanger performance is. The entransy dissipation number in terms of the number of exchanger heat transfer units or heat capacity rate ratio correctly exhibits the global performance of the counter-, cross-and parallel-flow heat exchangers. In comparison with the heat exchanger performance evaluation criteria based on entropy generation, the entransy dissipation number demon-strates some distinct advantages. Furthermore, the entransy dissipation number reflects the degree of irreversibility caused by flow imbalance. | GUO JiangFeng CHENG Lin XU MingTian | 2009 | Chinese Science Bulletin2009，54，15： | 58 |
| 2 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 3 | Principle of equipartition of entransy dissipation for heat exchanger design显示文摘In the present work,a principle of equipartition of entransy dissipation(EoED) for heat exchanger design is established,which says that for a heat exchanger design with given heat duty and heat transfer area,the total entransy dissipation rate reaches the minimum when the local entransy dissipation rate is uniformly distributed along the heat exchanger.When the heat transfer coefficient is unfixed,the total entransy dissipation obtained by the EoED principle is less than that obtained by the principle of equipartition of temperature difference(EoTD).Furthermore,the exchanger effectiveness obtained by the EoED principle is larger than that obtained by the EoTD principle.When the heat transfer coefficient is fixed,the EoED principle is equivalent to the EoTD principle.We show that the equipartition of entropy production(EoEP) and EoED principles give rise to difference in entropy generation and entransy dissipation for a heat exchanger optimization design.The discrepancies are caused by distinct features of entropy production minimization and entransy dissipation minimization principles,the former is to optimize the design of heat exchanger by making the lost available work minimum,while the latter is not involved with heat-work conversion.It is found that the entropy generation number is not suitable for evaluating heat exchanger performance,since it directly depends on the inlet and outlet temperatures of working fluids.On the contrary,the entransy dissipation number is not directly related to the inlet and outlet temperatures of working fluids.Therefore,the entransy dissipation number is more suitable for serving as a criterion to evaluate heat exchanger performance. | GUO JiangFeng,XU MingTian & CHENG Lin Institute of Thermal Science and Technology,Shandong University,Jinan 250061,China | 2010 | Science China(Technological Sciences)2010，53，5： | 46 |
| 4 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 5 | Analysis of Paraquat Intoxication Epidemic (2002-2011) within China显示文摘Paraquat, is a Bipy herbicide have been widely used in last decade in China. Because of its high human toxicity and mortality characteristics, paraquat has been gained considerable attention in recent years. In order to evaluate the epidemic status of paraquat harm to human health in China, | YIN Yu GUO Xiang ZHANG Shou Lin SUN Cheng Ye | 2013 | Biomedical and Environmental Sciences2013，26，6： | 43 |
| 6 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 7 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 8 | Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study显示文摘 | Ying Zheng Guang-Yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song Wang Gui-Hua Jian Xu-Sheng Liu Yu-Ning Liu Zhao-Hui Ni Jing-Ai Fang Han-Lu Ding Wang Guo Ya-Ni He Li-Hua Wang Ya-Ping Wang Hong-Tao Yang Zhi-Ming Ye Ren-Huan YU Li-Juan Zhao Wen-Hua Zhou Wen-Ge Li Hui-Juan Mao Yong-Li Zhan Zhao Hu Chen Yao Ri-Bao Wei Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，20： | 21 |
| 9 | Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis显示文摘Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese population.Many patients are not well controlled by conventional treatments,thus there is need for new treatment regimens.In this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis.Methods:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or placebo.The co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week 12.Results:A total of 441 Chinese patients were enrolled in this study.Co-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week 12.Treatment efficacy was maintained until Week 52.There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period.Conclusion:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis. | Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing Guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li Zai-Pei Guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu Pascaline Regnault Pascal Charef Ratal Mazur Manmath Patekar | 2020 | Chinese Medical Journal2020，，22： | 21 |
| 10 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 11 | Calculation of the yield and tensile strength in the alloying non quenched-tempered steel by the electron structure parameters显示文摘Based on the phase transformations and strengthening mechanisms during rolling, the strength increments Δσ_b under different strengthening mechanisms are calculated with the covalent electron number n_A of the strongest bond in phase cells of alloys and the interface electron density difference Δρ matching the interface stress in alloys. The calculation method of the finishing rolling yield strength is proposed, and it is integrated with the proposed calculation formulas of strength of non quenched-tempered steel. Therefore, the general formulas to simultaneously calculate both the finishing rolling strength and the yield strength of the continuous casting-rolling and non quenched-tempered steel are given. Taken the pipeline steel X70 as an example, the predictions of properties and technological parameters are performed before production or online. | LIU Zhilin LIN Cheng LIU Yan GUO Yanchang | 2005 | Progress in Natural Science:Materials International2005，15，9： | 17 |
| 12 | Entransy dissipation minimization for optimization of heat exchanger design显示文摘In this paper,by taking the water-water balanced counterflow heat exchanger as an example,the entransy dissipation theory is applied to optimizing the design of heat exchangers.Under certain conditions,the optimal duct aspect ratio is determined analytically.When the heat transfer area or the duct volume is fixed,analytical expressions of the optimal mass velocity and the minimal entransy dissipation rate are obtained.These results show that to reduce the irreversible dissipation in heat exchangers,the heat exchange area should be enlarged as much as possible,while the mass velocity should be reduced as low as possible. | LI XueFang GUO JiangFeng XU MingTian CHENG Lin | 2011 | Chinese Science Bulletin2011，56，20： | 16 |
| 13 | Geographical characteristics of China’s wetlands derived from remotely sensed data显示文摘In this paper, we report the first wetland mapping of the entire China using Landsat enhanced thematic mapper plus (ETM+) data. These data were obtained from the Global Land Cover Facility at the University of Maryland spanning from 1999 to 2002. A total of 597 scenes of Landsat images were georeferenced and mosaiced. Manual image interpretation of satellite images was aided with elevation data, soil data, land cover/land use data and Google Earth. The minimum mapping unit is 10 pixel × 10 pixel, equivalent to 9 ha. The aim of our first round of mapping was only targeted at the boundary delineation of any type of wetland except those wetlands that are under agricultural use (i.e., paddy fields), which has already been well mapped by others. Our interpretation results indicate that a total of 359478 km2 of wetlands are of non-agricultural use. Among our preliminarily mapped wetland, 339353 km2 are inland wetland, 2786 km2 are non-agricultural artificial wetland, and 17609 km2 are coastal wetland. Because low-tide is rarely captured in satellite images, an under-estimation of coastal wetland is inevitable. We conducted some statistics based on our mapped wetlands and compared them with those previously obtained from a number of sources including a land cover/land use map made with satellite images during the late 1990s and early 2000s, a marshland map developed in approximately the same period, survey data of coastal wetland in early 1980s, and area data for approximately 400 larger patches of marshland in China compiled in 1996. Because some inconsistencies exist in the guidelines of those different wetland surveys, difference in area is expected. Some further comparison indicates that the wetland distributions derived from the preliminary wetland map are reasonable and more objective than other sources. The mapping process also indicated that the method adopted by us was efficient and cost-effective. We also found that in order to ensure comparability of the wetland maps developed at different times, a set of standard guidelines on the wetland categories to be mapped, and the mapping methods to be used must be well conceived, developed and effectively employed. We carried out some initial geographical analysis on the distribution of wetlands. | NIU ZhenGuo GONG Peng CHENG Xiao GUO JianHong WANG Lin HUANG HuaBing SHEN ShaoQing WU YunZhao WANG XiaoFeng WANG XianWei YING Qing LIANG Lu ZHANG LiNa WANG Lei YAO Qian YANG ZhenZhong GUO ZiQi DAI YongJiu | 2009 | Science China Earth Sciences2009，52，6： | 15 |
| 14 | Use of intravenous tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials显示文摘收到全部的膝关节造形术(TKA ) 的病人上的 tranexamic 酸(TA ) 的 ObjectiveThe 效果在许多小临床的试用被报导了。但是单个试用不是足够足够的澄清 TA 的有效性和安全。那么,我们执行了使随机化的控制试用的元分析调查功效,在 TKA.MethodsLiteratures 的 TA 的静脉内的使用的安全在 Cochrane 图书馆,奥维德, PubMed, EMBASE, CNKI 和 Wanfang 数据被检索。所有相关文学被二个独立调查者检查,仅仅高质量的使随机化的控制试用被注册。相关数据用 RevMan 5.1 被分析比较在 TA 组之间的血损失,输送和复杂并发症的差别,控制 group.ResultsThere 是 353 相关文学,仅仅, 22 使随机化控制试用满足了包括标准。在 TKA 的 TA 的使用显著地由 435.41 的一个平均数减少了全部的血损失; ml (95% CI 300.62-570.21, P < 0.01 ) ,由 406.69 的一个平均数的手术后的血损失; ml (95% CI 333.16480.22, P < 0.01 ) 。TA 显著地也降低了输送率(风险差别 0.30, 95% CI 0.21-0.39, P < 0.01 ) 并且输送体积(意味着差别 0.95 单位, 95% CI 0.531.37, P < 0.01 ) 。在 TA 之间的风险在统计上开发血栓和肺的栓塞不是的深静脉组织并且控制组 significant.ConclusionTA 为经历 TKA 的病人是有益的,它能显著地减少全部的血损失,手术后的血损失,输送率,和输送体积。同时, TA 被建议减少深静脉血栓和肺的栓塞追随者 TKA。 | FU De-jie CHEN Cheng GUO Lin, YANG Liu | 2013 | Chinese Journal of Traumatology2013，16，2： | 14 |
| 15 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 16 | Chinese Hα Solar Explorer(CHASE)——a complementary space mission to the ASO-S显示文摘The Chinese HαSolar Explorer(CHASE)is designed to test a newly developed satellite platform and conduct solar observations.The scientific payload of the satellite is an Hαimaging spectrograph(HIS),which can,for the first time,acquire full-disk spectroscopic solar observations in the Hαwaveband.This paper briefly introduces CHASE/HIS including its scientific objectives,technical parameters,scientific application system,etc.The CHASE mission is scheduled to launch in 2021.It will complement the observations by on-orbit solar spacecraft(such as SDO,IRIS,STEREO and PSP),as well as future solar missions of the Solar Orbiter and Advanced Space-based Solar Observatory(ASO-S). | Chuan Li Cheng Fang Zhen Li Ming-De Ding Peng-Fei Chen Zhe Chen Liang-Kui Lin Chang-Zheng Chen Chang-Ya Chen Hong-Jiang Tao Wei You Qi Hao Yu Dai Xin Cheng Yang Guo Jie Hong Min-Jie An Wei-Qiang Cheng Jian-Xin Chen Wei Wang Wei Zhang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 12 |
| 17 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 18 | The influence of viscous heating on the entransy in two-fluid heat exchangers显示文摘In the present work, water and olive oil are taken as working fluids to study the influence of viscous heating on the entransy dissipation caused by heat transfer in two-fluid heat exchangers. The results show that the influence of viscous heating on the entransy loss associated with heat transfer can not be neglected for the liquids having large dynamic viscosity. The viscous heating effect maintains the heat transfer ability of the working fluids, relatively reduces the entransy loss in heat exchangers; the viscous heating effect relatively augments the entropy generation due to heat transfer and the available energy destruction in heat exchangers. For the working fluid having large dynamic viscosity, the increasing rates of the entransy and entropy generation contributed by the viscous heating are even larger than those contributed by heat transfer, when the mass flow rate of working fluid reaches a certain value under the fixed heat transfer area condition. Thus, the entransy loss rate decreases and the growth rate of entropy generation increases as the mass flow rate of the working fluid increases. Under the same other conditions, the heat transfer entransy loss rate and entropy generation rate per unit heat transfer rate obtained when the fluid having a smaller heat capacity rate is cold fluid are less than those obtained when the fluid having a smaller heat capacity rate is hot fluid. | GUO JiangFeng XU MingTian CHENG Lin | 2011 | Science China(Technological Sciences)2011，54，5： | 11 |
| 19 | Condition-based maintenance policy for gamma deteriorating systems显示文摘A condition-based maintenance model for gamma deteriorating system under continuous inspection is studied. This methodology uses a gamma distribution to model the material degradation, and the impact of imperfect maintenance actions on the system reliability is investigated. The state of a degrading system immediately after the imperfect maintenance action is assumed as a random variable and the maintenance time follows a geometric process. Furthermore, the explicit expressions for the long-run average cost and availability per unit time of the system are evaluated, an optimal policy (ξ*) could be determined numerically or analytically according to the optimization model. At last, a numerical example for a degrading system modeled by a gamma process is presented to demonstrate the use of this policy in practical applications. | Lin Tan Zhijun Cheng Bo Guo Shiyu Gong | 2010 | Journal of Systems Engineering and Electronics2010，21，1： | 10 |
| 20 | The entransy dissipation minimization principle under given heat duty and heat transfer area conditions显示文摘Under given heat duty and heat transfer area conditions, the equipartition of the entransy dissipation (EoED) principle, the equipartition of the temperature difference (EoTD) principle, and the equipartition of the heat flux (EoHF) principle are applied to the optimization design of a heat exchanger with a variable heat transfer coefficient. The results show that the difference between the results obtained using the EoED and EoTD principles is very small, far smaller than that between the results obtained using the EoED and EoHF principles. The correct entransy dissipation minimization principle is chosen to optimize the parameters in the hot and cold fluids in a two-fluid heat exchanger, under given heat duty and heat transfer area conditions. The results indicate that the proper choice of the two alternative fluids has an important role in the successful application of the entransy dissipation minimization principle. The fluid that could improve the total heat transfer coefficient should be chosen, or the fluid that makes the temperature profiles of the hot and cold fluids parallel and decreases the temperature difference between the hot and cold fluids after optimization simultaneously, could be the proper one. | GUO JiangFeng XU MingTian CHENG Lin | 2011 | Chinese Science Bulletin2011，56，19： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员