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| 1 | Integrity assurance of GNSS-based train integrated positioning system显示文摘This paper presents a novel Autonomous Integrity Monitoring and Assurance (AIMA) scheme for integrity assurance of the GNSS-based train integrated positioning system. In this scheme, integrity assurance strategies are combined with a three-stage hierarchical architecture, considering the coupling effects among sensor collection, sensor fusion and matching decision level in train integrated positioning. In sensor collecting stage, the AIMA scheme deals with sensor faults and failures with a PCA-based fault detection, diagnosis and isolation approach. In multi-sensor fusion stage, a novel cubature point H ∞ filter is presented to enhance the fault tolerance capability, and a hybrid approach is applied to indicating and monitoring the protection level of position estimation, concerning both the estimating covariance and measurement slopes. In map matching stage, hypothesis testing with specific test statistic is carried out to determine effectiveness of positioning results. Position calculation will be invalid with an alarm triggered if the specific integrity criterion is not satisfied in any stage. Since independent solutions are applied in AIMA, integrity assurance is closely coupled with information processing in train integrated positioning. Numerical results of the three cases correspond to the hierarchical architecture with field data and simulations are presented to illustrate features and applicability of the proposed AIMA scheme and specific solutions. | LIU Jiang TANG Tao GAI BaiGen WANG Jian CHEN DeWang | 2011 | Science China(Technological Sciences)2011，54，7： | 6 |
| 2 | Inhibition of human gastric carcinoma cell growth by atofluding derivative N_3-o-toluyl-fluorouracil显示文摘AIM: To evaluate the growth inhibition efficacy of atofluding derivative N3-o -toluyl-fluorouracil (TFU) on human gastric carcinoma cell lines SGC-7901 and MKN-45. METHODS: Cell growth inhibition by TFU was measured by MTT and clonogenic assays without or with liver microsomal enzymes. Xenografts of cancer cells in nude mice were employed to study the anti-proliferative effects of TFU in vivo. RESULTS: TFU inhibited the growth of SGC-7901 and MKN-45 cells. However, the inhibitory effects of TFU on cell growth were not significant. The inhibition rates were enhanced in the presence of liver microsomal enzymes, ranging 4.73%-48.57% in SGC-7901 cells and 9.0%-62.02% in MKN-45 cells. In vivo, TFU delayed the growth of SGC-7901 and MKN-45 cells in nude mice. The inhibition rates were 40.49%, 63.24%, and 75.98% in SGC-7901 cells and 40.76%, 61.41%, and 82.07% in MKN-45 cells when the oral doses were 25, 50, and 100 mg/kg, respectively. TFU treatment was generally welltolerated by mice with less than 20% reduction in body weight. CONCLUSION: TFU inhibits the growth of human gastric carcinoma cells. The inhibition rates are increased in the presence of liver microsomal enzymes. The efficacy of TFU may be associated with the sustaining release of 5-fluorouracil (5-FU) mediated by the enzymes. | Jian Liu Wen-Fang Xu Shu-Xiang Cui Yong Zhou Yun-Xia Yuan Ming-Hui Chen Ruo-Han Wang Ruo-Yan Gai Masatoshi Makuuchi Wei Tang Xian-Jun Qu | 2006 | World Journal of Gastroenterology2006，12，42： | 5 |
| 3 | Engineering core–shell Co_(9)S_(8)/Co nanoparticles on reduced graphene oxide: Efficient bifunctional Mott–Schottky electrocatalysts in neutral rechargeable Zn–Air batteries显示文摘It is significant for the rational construction of the high–efficient bifunctional electrocatalysts for in–depth understandings of how to improve the electron transfer and ion/oxygen transport in catalyzing oxygen reduction reaction and oxygen evolution reaction(ORR and OER),but still full of vital challenges.Herein,we synthesize the novel“three–in–one”catalyst that engineers core–shell Mott–Schottky Co_(9)S_(8)/Co heterostructure on the defective reduced graphene oxide(Co_(9)S_(8)/Co–rGO).The Co_(9)S_(8)/Co–rGO catalyst exhibits abundant Mott–Schottky heterogeneous–interfaces,the well–defined core–shell nanostructure as well as the defective carbon architecture,which provide the multiple guarantees for enhancing the electron transfer and ion/oxygen transport,thus boosting the catalytic ORR and OER activities in neutral electrolyte.As expected,the integrated core–shell Mott–Schottky Co_(9)S_(8)/Co–rGO catalyst delivers the most robust and efficient rechargeable ZABs performance in neutral solution electrolytes accompanied with a power density of 59.5 mW cm^(-2) and superior cycling stability at 5 mA cm^(-2) over 200 h.This work not only emphasizes the rational designing of the high–efficient bifunctional oxygen catalysts from the fundamental understanding of accelerating the electron transfer and ion/oxygen transport,but also sheds light on the practical application prospects in more friendly environmentally neutral rechargeable ZABs. | Xingkun Wang Guangming Zhan Yurou Wang Yan Zhang Jian Zhou Ren Xu Huiyu Gai Huanlei Wang Heqing Jiang Minghua Huang | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 4 | Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo显示文摘 | Lin Zheng Yingying Fu Linhan Zhuang Renhua Gai Jian Ma Jianshu Lou Hong Zhu Qiaojun He Bo Yang | 2014 | Int. J. Cancer2014，，： | 1 |
| 5 | Water-bearing characteristics and their effects on the nanopores of overmature coal-measure shales in the Wuxiang area of the Qinshui Basin, north China显示文摘In this study,a group of overmature coal-measure shale core samples was collected in situ from an exploration well located in the Wuxiang area of the Qinshui Basin,north China.The pore water contents(CPW)of the shales under as-received conditions,equilibrium water contents(CEW)of the shales under moisture equilibrium conditions(relative humidity:100%),and nanopore structures of the shales under both as-received and dried conditions were measured.The results indicate that the CPW values of these shales are much lower than their CEW values,which implies that the bulk pore systems of these shales have low water-bearing extents.In addition,approximately half of the total pore volumes and surface areas of the as-received shales are occupied by pore water,and the effects of pore water on shale nanopores with various pore types and widths are different.The average water-occupied percentages(PW)are 59.16%−81.99%and 42.53%−43.44%for the non-micropores and micropores,respectively,and are 83.54%−97.69%and 19.57%−26.42%for the inorganic-matter hosted(IM)and organic-matter hosted(OM)pores,respectively.The pore water in shales not only significantly reduces the storage of shale gas by occupying many pore spaces,but also causes the shale gas,especially the absorbed gas,to be mostly stored in the OM pores;meanwhile,the IM pores mainly store free gas.Therefore,the water-bearing characteristics and their effects on the pore structures and gas-bearing properties of coal-measure shales should be noted for the evaluation and exploration of shale gas in the Qinshui Basin. | Peng CHENG Xianming XIAO Hui TIAN Jian SUN Qizhang FAN Haifeng GAI Tengfei LI | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
| 6 | Metal-organic frameworks with mixed-ligands strategy as heterogeneous nucleation center to assist crystallization for efficient and stable perovskite solar cells显示文摘Deep-level defects and random oriented configuration in perovskite crystallization process would cause the nonradiative recombination and further affect the performance of perovskite solar cells(PSCs).Herein,two metal-organic frameworks(MOFs)with tunable Lewis-base passivation sites have been constructed(Cd-Httb and Cd-Httb-BDC,Httb=5-(4-(1H-1,2,4-triazole-1-yl)benzyl)-1h-tetrazole,BDC=1,4-dicarboxybenzene)to eliminate deep-level defects and simultaneously as nanostructured heterogeneous nucleation seed to assist the growth of large-grained perovskite films.Compared with the control and Cd-Httb,Cd-Httb-BDC designed with mix-ligands strategy exhibited the enhanced inducted effect on the crystallization and nucleation of high-quality perovskite films during annealing process.Consequently,the resultant Cd-Httb-BDC-modified device achieved higher power conversion efficiency(PCE)(22.18%)than the control(20.89%)and Cd-Httb(21.56%).Meanwhile,the unencapsulated Cd-Httb-BDC-modified device still maintained 90%of initial PCE after 1500 h in ambient conditions and exhibited enhanced thermal stability(85℃ in N_(2) atmosphere).This work presented a successful example of mixligands strategy on construction of high-quality MOF-assisted perovskite films for high-efficient and stable PSCs. | Yayu Dong Shuang Gai Jian Zhang Ruiqing Fan Boyuan Hu Wei Wang Wei Cao Jiaqi Wang Ke Zhu Debin Xia Lin Geng Yulin Yang | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 7 | Spatiotemporal evidence of tree-growth resilience to climate variations for Yezo spruce(Picea jezoensis var. komarovii) on Changbai Mountain, Northeast China显示文摘Global warming-induced changes in tree-growth resilience to climate variations have been widely reported for mid-and high-latitude regions around the world. Most studies have focused on the spatial variability of trees in radial growth-climate relationships on Changbai Mountain in Northeast China, but little is known about temporal changes in tree growth in response to climate. We explored the stability of effect of climate variables on radial growth of Yezo spruce [Picea jezoensis Carr. var. komarovii(V.Vassil.) Cheng et L.K.Fu] at 1200, 1400, and 1600 m above sea level, representing low, middle, and upper ranges of the spruce-fir mixed forest on Changbai Mountain. The results showed that the relation between tree growth and climate did not vary with altitude, but the stability of the tree-growth-climate relationship did vary with altitude as the climate changed. Radial growth of Yezo spruce at allthree elevations was influenced primarily by maximum temperature during May(Tmax5) and mean minimum temperature from January to March(Tmin1-3). More specifically, the relationship strengthened significantly at lower elevations, but weakened significantly at higher elevation, and fluctuated at mid elevations since 1980.Increase in Tmin1-3 and decrease in Tmax5 were the main reasons for the decrease in the radial growth at three altitudes. The findings of this study clarified that the decrease in radial growth on Changbai Mountain is not a “divergence problem” of an unexpected decrease in tree growth in response to an increase in mean temperature and provides a reference for using tree-ring data to reconstruct climate patterns and/or predict the growth of trees under various climate change scenarios. | Xuerui Gai Shoule Wang Li Zhou Jian Wu Wangming Zhou Jianhua Bi Linlin Cao Limin Dai Dapao Yu | 2020 | Journal of Forestry Research2020，31，3： | 0 |
| 8 | Investigation of Nitrite Production Pathway in Integrated Partial Denitrification/Anammox Process via Isotope Labelling Technique and the Relevant Microbial Communities显示文摘In this study,the nitrogen removal performance of partial denitrificaiton/anammox(PDA)process was investigated by using an UASB reactor.High total nitrogen(TN)removal efficiency(91.97%)was achieved at an influent nitrogen loading rate of 0.64 kg/(m3·d).Anammox bacteria did execute the function of converting nitrate to nitrite in PDA system according to ^(15)N isotope labeling experiments and the contribution was approximately 36.3%.Candidatus_Brocadia,Candidatus_Kuenenia and Thauera were functional strains for anammox and denitrification process,respectively.Thauera and Candidatus_Brocadia were more important for TN removal at high loading rates(0.64 kg/(m3·d)).This result can provide a theoretical and technical foundation for the application of the PDA process. | Li Yanzhe Gai Jianing Zhang Xiaofei Zhao dongfeng Guo Yadong Yu Gengxing Zhao Chaocheng Liu Fang Zhao Ruiyu Liu Chunshuang | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，1： | 0 |
| 9 | Construction and features of somatology in 9-year Qihuang TCM experimental class显示文摘Nine-year Qihuang experimental class,which is characterized by nine-year direct Ph.D.,was first opened in 2011,which is an exploration of the way of cultivating high-end characteristic talents of Chinese medicine specialty in our University.Under the background of“quality revolution”in higher education,our University has put forward the cultivation idea of“traditional Chinese medicine+”and“+traditional Chinese medicine”according to the orientation of running a school.Based on this,we have taken the lead in the reform of the curriculum integration of normal body science based on form,tissue and function.From the thought to the practice of teaching reform,we have carried on the thorough exploration and the beneficial attempt to train the Chinese medicine high-end talented persons.Furthermore we have accumulated certain experience. | Wang Yuanyuan Sun Hongmei Li Jian Guo Jian Fei Yutong Guo Zhenyu Gai Cong Hu Die Zhang Yi | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | Pharmacokinetics and pharmacodynamics of SCT800, a new recombinant FVIII, in hemophilia A mice显示文摘目的: SCT800 是正在经历有希望的现出症状之前的潜的学习的一个新第三产生的 recombinant FVIII 代理人。试图调查 pharmacokinetic 和 pharmacodynamic 的这研究在出血不止 SCT800 介绍 mice.Methods :在出血不止 A 以后,老鼠静脉内地与 SCT800 ( 80 , 180 ,和 280 IU/kg )或商业地可得到的产品 Xyntha ( 280 IU/kg )的单个剂量被注射, pharmacokinetics 侧面基于测量血浆 FVIII 被评估:C。为药效学学习, SCT800 和 Xyntha ( 1-200 IU/kg )的剂量反应曲线用为监视两个都流血的时间和血 loss.Results 的模型放血的一条尾巴被构造: Pharmacokinetics 侧面分析显示出在测试的剂量从在 SCT800 和 Xyntha 之间的 80~280 IU/kg 和可比较的 pharmacokinetic 侧面 的 SCT800 的剂量独立。药效学学习表明在流血的尾巴的 SCT800 和 Xyntha 的可比较的编辑 50 价值当模特儿:为分别地为时间放血的 14.78 和 15.81 IU/kg;为血损失的 13.50 和 13.58 IU/kg 分别地。而且在测试的剂量,伴随在为模型放血的尾巴的剂量相关的安全评估比 Xyntha.Conclusion 为 SCT800 显示出更低的 hypercoagulable 趋势和更宽的剂量范围潜力: 在里面出血不止 A 老鼠, SCT800 在测试的剂量显示出可比较的 pharmacokinetics 和药效学到 Xyntha,并且可能与更好的安全性质。 | Ruo-lan GU Liang LIU Liang-zhi XIE Wen-lin GAI Si-shuo CAO Zhi-yun MENG Hui GAN Zhuo-na WU Jian LI Ying ZHENG Xiao-xia ZHU Gui-fang DOU | 2016 | Acta Pharmacologica Sinica2016，37，3： | 0 |
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