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| 1 | Plate tectonic control on the formation and tectonic migration of Cenozoic basins in northern margin of the South China Sea显示文摘The tectonic evolution history of the South China Sea(SCS) is important for understanding the interaction between the Pacific Tectonic Domain and the Tethyan Tectonic Domain,as well as the regional tectonics and geodynamics during the multi-plate convergence in the Cenozoic.Several Cenozoic basins formed in the northern margin of the SCS,which preserve the sedimentary tectonic records of the opening of the SCS.Due to the spatial non-uniformity among different basins,a systematic study on the various basins in the northern margin of the SCS constituting the Northern Cenozoic Basin Group(NCBG) is essential.Here we present results from a detailed evaluation of the spatial-temporal migration of the boundary faults and primary unconformities to unravel the mechanism of formation of the NCBG.The NCBG is composed of the Beibu Gulf Basin(BBGB),Qiongdongnan Basin(QDNB),Pearl River Mouth Basin(PRMB) and Taixinan Basin(TXNB).Based on seismic profiles and gravity-magnetic anomalies,we confirm that the NE-striking onshore boundary faults propagated into the northern margin of the SCS.Combining the fault slip rate,fault combination and a comparison of the unconformities in different basins,we identify NE-striking rift composed of two-stage rifting events in the NCBG:an early-stage rifting(from the Paleocene to the Early Oligocene) and a late-stage rifting(from the Late Eocene to the beginning of the Miocene).Spatially only the late-stage faults occurs in the western part of the NCBG(the BBGB,the QDNB and the western PRMB),but the early-stage rifting is distributed in the whole NCBG.Temporally,the early-stage rifting can be subdivided into three phases which show an eastward migration,resulting in the same trend of the primary unconformities and peak faulting within the NCBG.The late-stage rifting is subdivided into two phases,which took place simultaneously in different basins.The first and second phase of the early-stage rifting is related to back-arc extension of the Pacific subduction retreat system.The third phase of the earlystage rifting resulted from the joint effect of slab-pull force due to southward subduction of the proto-SCS and the back-arc extension of the Pacific subduction retreat system.In addition,the first phase of the late-stage faulting corresponds with the combined effect of the post-collision extension along the Red River Fault and slab-pull force of the proto-SCS subduction.The second phase of the late-stage faulting fits well with the sinistral faulting of the Red River Fault in response to the Indochina Block escape tectonics and the slab-pull force of the proto-SCS. | Pengcheng Wang Sanzhong Li Yanhui Suo Lingli Guo Guangzeng Wang Gege Hui M.Santosh Ian D.Somerville Xianzhi Cao Yang Li | 2020 | Geoscience Frontiers2020，11，4： | 10 |
| 2 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 3 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 4 | Efficacy of Sijunzi decoction(四君子汤) on limb weakness in spleen Qi deficiency model rats through adenosine monophosphate-activated protein kinase/unc-51 like autophagy activating kinase 1 signaling显示文摘OBJECTIVE:To investigate the efficacy of Sijunzi decoction(四君子汤)on limb weakness in a rat model of spleen Qi deficiency(SQD),and to study its effect on mitophagy in skeletal muscle through adenosine monophosphate-activated protein kinase(AMPK)/unc-51 like autophagy activating kinase 1(ULK1)signaling.METHODS:SQD model rats were produced by fasting combined with forced swimming method for15 d.After model assessment,rats were randomly divided into four groups of 10[low/middle/high(L/M/H)Sijunzi decoction dose groups and a normal saline(S)group].Limb holding power(HP)and body mass(BM)were measured after 2 weeks of treatment.Following euthanasia,quadriceps femoris were dissected and myofiber and mitochondrial morphology were observed by transmission electron microscopy(TEM).Mitochondrial membrane potential(MMP),adenosine triphosphatase(ATP)and reactive oxygen species(ROS)levels were determined using colorimetric methods,and immunoblot analysis of Microtubule-associated protein light chain 3(LC3)and Sequestosome 1(p62)was performed to monitor mitophagy and AMPK/ULK1 signaling.RESULTS:Compared with control(C)group rats,in the S group,HP was reduced,the myofiber Z line was disordered,mitochondria were scattered,and numerous vacuoles and mitophagy were observed.MMP and ATP levels were reduced,ROS levels were elevated,and LC3B expression,and p-AMPKα(Thr172)/AMPKα,p-ULK1(Ser555)/ULK1,and p-Raptor(Ser792)/Raptor ratios were increased,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were decreased.After treatment,compared with the S group,HP was improved in M and H groups but not in the L group.Mitophagy was reduced in M,H and L groups but the Z line was disordered and vacuolization remained in the L group.ATP levels were elevated in M,H and L groups,and MMPs were elevated in M and H groups but not in the L group.ROS levels were decreased in M,H and L groups,as were LC3B expression and p-Raptor(Ser792)/Raptor ratios,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were increased in M and H groups but not in the L group.p-AMPKα(Thr172)/AMPKαand p-ULK1(Ser555)/ULK1 ratios were decreased in M,H and L groups.CONCLUSIONS:Sijunzi decoction improved HP,possibly by inhibiting mitophagy via suppression of AMPK/ULK1 signaling.This restored mitochondrial morphology and improved oxidative phosphorylation,which contributed to recovery of limb weakness in SQD model rats. | LIU Wenjun XU Xinzhu DUAN Zhiyuan LIANG Xicai MA Dan LI Gege XIE Xin CHAI Jiyan CHEN Jing SHAN Dehong | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 2 |
| 5 | Antitumor effect of dobutamine on multiple myeloma via mitogen-activated protein kinase pathway in vitro显示文摘多重骨髓瘤(公里) 是最恶意的癌症之一并且被房间, monoclonal 免疫球蛋白的分泌物和 osteolytic 损害,和它的发生在中年、老的病人正在增加的血浆被骨头髓的渗入描绘[1 ] 。作为公里房间异构并且药抵抗、起始的公里通常进行到 relapsed/refractory 阶段。尽管象镇静药, bortezomib,和 lenalidomide 那样的存在治疗能延长公里病人的幸存,公里是是仍然考虑了医不好。因此,建立新有效治疗对待 relapsed/refractory 公里是必要的。 | Bingqian Xie Zhijian Xu Guang Yang Gege Chen Bo Li Liangning Hu Wenqin Xiao Xi Sun Minjie Gao Lu Gao Xiaosong Wu Yi Tao Weiliang Zhu Jumei Shi | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 1 |
| 6 | Linkage between reactivation of the sinistral strike-slip faults and 28 September 2018 Mw7.5 Palu earthquake, Indonesia显示文摘On September 28, 2018, a Mw7.5 earthquake occurred near Sulawesi, Indonesia as a result of strike-slip faulting at shallow depth within the interior of the Molucca Sea Microplate that forms a part of the broader Sunda Plate. Focal mechanism solutions and distribution for the earthquakes indicate rupture occurred on a left-lateral NNW-SSE-to N-S-striking fault. This region has been characterized by complex tectonics in which motions of numerous small microplates are accommodating large-scale convergence between the Australia, Sunda, Pacific and Philippine Sea plates. In this paper, the Coulomb stress calculation verified the WNW-, nearly E-W-trending sinistral strike slip receiver fault in Sulawesi, which is consistent with the giant sinisterly strike-slip fault system across New Guinea, Pacific Tectonic System and the Tethys Tectonic System caused by the oblique convergence. The result has been reconciled within the modern GPS velocity field. | Gege Hui Sanzhong Li Pengcheng Wang Yanhui Suo Qian Wang Ian D.Somerville | 2018 | Science Bulletin2018，63，24： | 1 |
| 7 | Distributed implantation of a flexible microelectrode array for neural recording显示文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions. | Chunrong Wei Yang Wang Weihua Pei Xinyong Han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang | 2022 | Microsystems & Nanoengineering2022，8，3： | 1 |
| 8 | Research on Link Prediction Algorithms Based on Multichannel Structure Modelling显示文摘Today’s link prediction methods are based on the network structure using a single-channel approach for prediction,and there is a lack of link prediction algorithms constructed from a multichannel approach,which makes the features monotonous and noncomplementary.To address this problem,this paper proposes a link prediction algorithm based on multichannel structure modelling(MCLP).First,the network is sampled three times to construct its three subgraph structures.Second,the node representation vectors of the network are learned separately for each subgraph on a single channel.Then,the three node representation vectors are combined,and the similarity matrix is calculated for the combined vectors.Finally,the performance of the MCLP algorithm is evaluated by calculating the AUC using the similarity matrix and conducting multiple experiments on three citation network datasets.The experimental results show that the proposed link prediction algorithm has an AUC of 98.92%,which is better than the performance of the 24 link prediction comparison algorithms used in this paper.The experimental results sufficiently prove that the MCLP algorithm can effectively extract the relationships between network nodes,and confirm its effectiveness and feasibility. | Gege Li Lin Zhou Zhonglin Ye Haixing Zhao | 2023 | 国际计算机前沿大会会议论文集2023，，2： | 0 |
| 9 | Influence of nano-mechanical evolution of Ti_(3)AlC_(2) ceramic on the arc erosion resistance of Ag-based composite electrical contact material显示文摘Al-containing MAX phase ceramic has demonstrated great potential in the field of high-performance low-voltage electrical contact material.Elucidating the anti-arc erosion mechanism of the MAX phase is crucial for further improving performance,but it is not well-understood.In this study,Ag/Ti_(3)AlC_(2) electrical contact material was synthesized by powder metallurgy and examined by nanoindentation techniques such as constant loading rate indentation,creep testing,and continuous stiffness measurements.Our results indicated a gradual degradation in the nano-mechanical properties of the Ti_(3)AlC_(2) reinforcing phase with increasing arc erosion times,although the rate of this degradation appeared to decelerate over arc erosion times.Specifically,continuous stiffness measurements highlighted the uneven mechanical properties within Ti_(3)AlC_(2),attributing this heterogeneity to the phase’s decomposition.During the early(1-100 times)and intermediate(100-1000 times)stages of arc erosion,the decline in the nano-mechanical properties of Ti_(3)AlC_(2) was primarily ascribed to the decomposition of Ti_(3)AlC_(2) and limited surface oxidation.During the later stage of arc erosion(1000-6200 times),the inner region of Ti_(3)AlC_(2) also sustained arc damage,but a thick oxide layer formed on its surface,enhancing the mechanical properties and overall arc erosion resistance of the Ag/Ti_(3)AlC_(2). | Xuelian Wu Chengzhe Wu Xinpeng Wei Wanjie Sun Chengjian Ma Yundeng Zhang Gege Li Liming Chen Dandan Wang Peigen Zhang Zhengming Sun Jianxiang Ding | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
| 10 | Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults显示文摘This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method. | Li-Ying Hao Gege Dong Tieshan Li Zhouhua Peng | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，4： | 0 |
| 11 | Determination of Triazine Herbicides in Environmental Water Samples by Acetonitrile Inorganic Salt Aqueous Two-Phase Microextraction System显示文摘Acetonitrile inorganic salt aqueous two-phase extraction method was established for the determination of triazine herbicides(simeton,cyanazine,desmetryn,terbumeton,terbuthylazine and dimethametryn)in environmental water samples by high-performance liquid chromatography(HPLC).The extraction solvents types and volume of acetonitrile,the inorganic salt types and amount of(NH_(4))_(2)SO_(4),extraction time and pH of sample solution were optimized by single-factor experiment and central composite design.Under the optimum extraction conditions,all linear ranges were obtained with coefficients of determination(r)≥0.9993.The limits of detection for this proposed method were in the range of 0.16-0.28μg/L for six triazine herbicides.The developed method has been successfully applied to the analysis of target triazine herbicides from lake,canal and moat in real-world water samples.The recoveries of target analytes were in the range from 87.0 to 110.9%and the relative standard deviation was lower than 7.3%. | Shiqian Gao Gege Wu Xiaomeng Li Jie Chen Youyi Wu Junxia Wang Zhanen Zhang | 2018 | Journal of Analysis and Testing2018，2，4： | 0 |
| 12 | Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells显示文摘Diffuse large B-cell lymphoma(DLBCL)is the most common category and disease entity of non-Hodgkin lymphoma.Osalmide and pterostilbene are natural products with anticancer activities via different mechanism.In this study,using a new synthetic strategy for the two natural products,we obtained the compound DCZ0801,which was previously found to have anti-multiple myeloma activity.We performed both in vitro and in vivo assays to investigate its bioactivity and explore its underlying mechanism against DLBCL cells.The results showed that DCZ0801 treatment gave rise to a dose-and time-dependent inhibition of cell viability as determined by CCK-8 assay and flow cytometry assay.Western blot analysis results showed that the expression of caspase-3,caspase-8,caspase-9 and Bax was increased,while BCL-2 and BCL-XL levels were decreased,which suggested that DCZ0801 inhibited cell proliferation and promoted intrinsic apoptosis.In addition,DCZ0801 induced G0/G1 phase arrest by downregulating the protein expression levels of CDK4,CDK6 and cyclin D1.Furthermore,DCZ0801 exerted an anti-tumor effect by down-regulating the expressions of p-PI3K and p-AKT.There also existed a trend that the expression of p-JNK and p-P38 was restrained.Intraperitoneal injection of DCZ0801 suppressed tum or development in xenograft mouse models.The preliminary metabolic study showed that DCZ0801 displayed a rapid metabolism within 30 min.These results demonstrated that DCZ0801 may be a new potential anti-DLBCL agent in DLBCL therapy. | Mengyu Xi Wan He Bo Li Jinfeng Zhou Zhijian Xu Huiqun Wu Yong Zhang Dongliang Song Liangning Hu Ye Lu Wenxuan Bu Yuanyuan Kong Gege Chen Shuaikang Chang Jumei Shi Weiliang Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，4： | 0 |
| 13 | antitumor activity in bortezomib-resistant multiple myeloma cells through inhibition of JAK2/STAT3 pathway显示文摘Multiple myeloma(MM),the second most common haematological malignancy,is currently incurable because patients often develop multiple drug resistance and experience subsequent relapse of the disease.This study aims to identify a potential therapeutic agent that can counter bortezomib(BTZ)resistance in MM.DCZ0358,a novel alkaloid compound,is found to exert potent cytotoxic effects against BTZ-resistant MM cells in vivo and in vitro.The antimyeloma activity of DCZ0358 is associated with inhibition of cell proliferation,promotion of cell apoptosis via caspase-mediated apoptotic pathways,and induction of G0/G1 phase arrest via downregulation of cyclin D1,CDK4,and CDK6.Further investigation of the molecular mechanism shows that DCZ0358 suppresses the JAK2/STAT3 signaling pathway.In conclusion,DCZ0358 can successfully counter BTZ resistance in MM cells.This study provides evidence that warrants future preclinical assessments of DCZ0358 as a therapeutic agent against BTZ resistance in MM. | Bibo Zhang Bo Li Yongsheng Xie Shuaikang Chang Zhijian Xu Huifang Hu Gege Chen Ting Zhang Jun He Xiaosong Wu Huabin Zhu Weiming Lai Dongliang Song Ying Lu Xinyan Jia Weiliang Zhu Jumei Shi | 2023 | Acta Biochimica et Biophysica Sinica2023，55，2： | 0 |
| 14 | A non-uniform quadtree map building method including dead-end semantics extraction显示文摘To reduce the complexity of large-scene high-resolution maps while using the dead-end information distributed in the unmanned vehicle driving environment,we propose a novel non-uniform quadtree map-building method including dead-end semantic information extraction.By utilizing quadtree data structures,submaps and a positive-order tree depth organization approach,our proposed map can adapt to the large-scale high-resolution requirement and expand more easily to larger environments.To verify the practicality of our proposed map,we have successfully implemented map matching and path planning in real environments.Additionally,we effectively extract the dead-end semantic information that widely distributes in the environment,which can help unmanned vehicles avoid collisions and improve the search efficiency of the planning procedure.We evaluate our method with KITTI datasets,CARLA Simulator,and our self-collected real-world datasets.The experimental results show that our proposed method significantly reduces the complexity of large-scale high-resolution maps,effectively extracts dead-end semantic information,and has good practicality in real environments.The implementation of our method is released here:http://gffzz188fe103f8f1460ascok0c5nf9cbu6cnx.ffgz.tsg.suse.edu.cn/biter0088/Non-uniform-quadtree-map. | Xiuzhong Hu Guangming Xiong Junyi Ma Gege Cui Quanfu Yu Shihao Li Zijie Zhou | 2023 | Green Energy and Intelligent Transportation2023，2，2： | 0 |
| 15 | A novel silicone derivative of natural osalmid(DCZ0858)induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway显示文摘Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous malignant tumor characterized by diffuse growth.DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL.This study explored in depth the inhibitory effect of DCZ0858 on DLBCL cell lines.Cell Counting Kit-8(CCK-8)and plate colony formation assays were used to evaluate cell proliferation levels.Flow cytometry was employed to analyze apoptosis and the cell cycle,and western blotting was used to quantify the expression of cell cycle regulators.The results indicated that DCZ0858 inhibited cell growth in a concentration-dependent and time-dependent manner while inducing no significant toxicity in normal cells.Moreover,DCZ0858 initiated cell apoptosis via both internal and external apoptotic pathways.DCZ0858 also induced cell cycle arrest in the G0/G1 phase,thereby controlling cell proliferation.Further investigation of the molecular mechanism showed that the JAK2/STAT3 pathway was involved in the DCZ0858-mediated antitumor effects and that JAK2 was the key target for DCZ0858 treatment.Knockdown of JAK2 partly weakened the DCZ0858-mediated antitumor effect in DLBCL cells,while JAK2 overexpression strengthened the effect of DCZ0858 in DLBCL cells.Moreover,a similar antitumor effect was observed for DCZ0858 and the JAK2 inhibitor ruxolitinib,and combining the two could significantly enhance cancer-suppressive signaling.Tumor xenograft models showed that DCZ0858 inhibited tumor growth in vivo and had low toxicity in important organs,findings that were consistent with the in vitro data.In summary,DCZ0858 is a promising drug for the treatment of DLBCL. | Kang Lu Bo Li Hui Zhang Zhijian Xu Dongliang Song Lu Gao Haiguo Sun Liping Li Yingcong Wang Qilin Feng Gege Chen Liangning Hu Rong Wei Yongsheng Xie Dandan Yu Xiaosong Wu Weiliang Zhu Jumei Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 16 | Dihydrocelastrol induces antitumor activity and enhances the sensitivity of bortezomib in resistant multiple myeloma by inhibiting STAT3-dependent PSMB5 regulation显示文摘Multiple myeloma(MM)is characterized by excessive aggregation of B-cell-derived malignant plasma cells in the hematopoietic system of bone marrow.Previously,we synthesized an innovative molecule named dihydrocelastrol(DHCE)from celastrol,a triterpene purified from medicinal plant Tripterygium wilfordii.Herein,we explore the therapeutic properties and latent signal transduction mechanism of DHCE action in bortezomib(BTZ)-resistant(BTZ-R)MM cells.In this study,we first report that DHCE shows antitumor activities in vitro and in vivo and exerts stronger inhibitory effects than celastrol on BTZ-R cells.We find that DHCE inhibits BTZ-R cell viability by promoting apoptosis via extrinsic and intrinsic pathways and suppresses BTZ-R MM cell proliferation by inducing G0/G1 phase cell cycle arrest.In addition,inactivation of JAK2/STAT3 and PI3K/Akt pathways are involved in the DHCE-mediated antitumor effect.Simultaneously,DHCE acts synergistically with BTZ on BTZ-R cells.PSMB5,a molecular target of BTZ,is overexpressed in BTZ-R MM cells compared with BTZ-S MM cells and is demonstrated to be a target of STAT3.Moreover,DHCE downregulates PSMB5 overexpression in BTZ-R MM cells,which illustrates that DHCE overcomes BTZ resistance through increasing the sensitivity of BTZ in resistant MM via inhibiting STAT3-dependent PSMB5 regulation.Overall,our findings imply that DHCE may become a potential therapeutic option that warrants clinical evaluation for BTZ-R MM. | Shuhan Jin Bo Li Bibo Zhang Xuejie Gao Xinyan Jia Li Xu Shuaikang Chang Ke Hu Guanli Wang Zhijian Xu Ting Zhang Dongliang Song Guang Yang Xiaosong Wu Huabin Zhu Cheng Huang Yumeng Lu Jumei Shi Weiliang Zhu Gege Chen | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 17 | Spatially Isolated Noble-Metal-Free Redox Cocatalysts on CdS Nanorods for Increased Photocatalytic Hydrogen Generation显示文摘Spatially isolated oxidation and reduction cocatalysts on a semiconductor can realize efficient charge separation and thereby lead to increased photocatalytic hydrogen generation. However, the effective preparation of such photocatalysts has proven challenging.Herein, we report the facile synthesis of a novel noblemetal-free CdS/MoS/CoPi ternary photocatalyst via a visible light-induced synthesis route, in which MoSreduction cocatalysts were precisely grown on the two terminals of CdS nanorods, while CoPi oxidation cocatalysts were preferentially anchored onto the sidewalls of CdS nanorods. Such spatially isolated MoSand CoPi redox cocatalysts endow CdS nanorods with a rapid charge separation, which enhances their hydrogen generation activity. The CdS/MoS/CoPi photocatalyst with optimized CoPi amount achieves the highest Hgeneration rate of 206 μmol/h, which is 21 and 2 times higher than that achieved by using CdS alone(9.7 μmol/h) and CdS/MoS(105 μmol/h), respectively. The present work highlights the effectiveness of the spatial isolation of reduction and oxidation sites for efficient charge separation and thereby provides a promising strategy for the preparation of highly active photocatalysts. | Xiaomeng Zhang Gege Zhao Zhongfei Li Liang Zhu Yingpeng Cheng Haiwei Du Chuhong Zhu Ya Dang Daochuan Jiang Yupeng Yuan | 2022 | Chinese Journal of Structural Chemistry2022，41，9： | 0 |
| 18 | Design and simulation of an electromagnetic balance head for electric spindle显示文摘The electromagnetic balance head is used for balancing the electric spindle. This paper analyzes the internal structure of the electromagnetic balance head and introduces the structure of the counterweight plate and the range of the balance in the moving ring.The principle of how the electromagnetic field generated by the static coil acts on the moving ring is also investigated. The model is built in Ansoft Maxwell and the excitation parameters and boundary conditions are set up. Through the analysis of the magnetic field generated by the static coil in the position of the moving ring, it is verified that the static loop coil can drive the counterweight plate. | Lv Gege Xu Juan Kong Weidong Zhang Li | 2017 | Computer Aided Drafting,Design and Manufacturing2017，27，1： | 0 |
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