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| 1 | Clinical application of a new device for minimally invasive circumcision显示文摘瞄准:与 phimosis 或过量包皮在不同年龄的男病人的治疗学习一台可处理的割礼设备的临床的效果。方法:在 5 和 95 年的年龄之间的 1200 个病人在在 2005 年 10 月和 2007 年 9 月之间的 2 年的时期用这个过程经历了割礼。这些盒子, 904 有过量包皮, 296 是 phimosis 的盒子。结果:在 96.33% 盒子中,切口愈合了,离开没有使好化妆结果留下疤痕并且生产的内部包皮的最小的数量。没有到系带的设备脱臼或损坏的事件。平均起作用的时间为 phimosis 是为过量包皮,和 3.5 min 的 2.5 min。在穿设备的 7 天期间,对中等浮肿温和与 phimosis 与过量包皮并且在那些的 2.58 % 发生在盒子的 10.08 % 。在系带的浮肿在 1.67% 病人被看见,并且仅仅, 0.67% 有切口的感染。86.25% 病人的一个总数由于阴茎勃起报导了疼痛。在设备的移动以后, 0.58% 案例有在切口附近的最小的流血,并且 2.42% 弯屈裂开。结论:新设备能与 phimosis 和过量包皮被用于病人的一个压到优势的多数。这种技术相对简单表现,并且经历了这个手术的病人有很少的复杂并发症。抗菌素没比用常规方法被割除的那些被要求,病人们报导了更少的疼痛。有这台设备的割礼要求最小的组织操作,并且比用常规技术的割礼更快、安全。 | Yi-Feng Peng Yue Cheng Guo-Yao Wang Suo-Qun Wang Chao Jia Ben-Hai Yang Ru Zhu Shu-Chuan Jian Qing-Wen Li Da-Wei Geng | 2008 | Asian Journal of Andrology2008，10，3： | 105 |
| 2 | The Serum Exosome Derived MicroRNA-135a,-193b, and-384 Were Potential Alzheimer's Disease Biomarkers显示文摘Objective MicroR NAs(mi Rs) are attractive molecules to be considered as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer's disease(AD). The goal of this study was to explore their potential value as biomarkers for the diagnosis of AD. Methods The expression levels of exosomal miR-135 a,-193 b, and-384 in the serum from mild cognitive impairment(MCI), dementia of Alzheimer-type(DAT), Parkinson's disease with dementia(PDD), and vascular dementia(VaD) patients were measured with a real-time quantitative reverse transcriptase PCR(qR T-PCR) method. Results Both serum exosome mi R-135 a and miR-384 were up-regulated while miR-193 b was down-regulated in serum of AD patients compared with that of normal controls. Exosome miR-384 was the best among the three miR s to discriminate AD, VaD, and PDD. Using the cut-off value could better interpret these laboratory test results than reference intervals in the AD diagnosis. ROC curve showed that the combination of mi R-135 a,-193 b, and-384 was proved to be better than a particular one for early AD diagnosis. Conclusion Our results indicated that the exosomal miR s in the serum were not only potential biomarker of AD early diagnosis, but might also provide novel insights into the screen and prevention of the disease. | YANG Ting Ting LIU Chen Geng GAO Shi Chao ZHANG Yi WANG Pei Chang | 2018 | Biomedical and Environmental Sciences2018，31，2： | 35 |
| 3 | Soil respiration is driven by fine root biomass along a forest chronosequence in subtropical China显示文摘Aims Soil respiration(Rs)is a major process controlling soil carbon loss in forest ecosystems.However,the underlying mechanisms leading to variation in Rs along forest successional gradients are not well understood.In this study,we investigated the effects of biotic and abiotic factors on Rs along a forest successional gradient in southeast China.Methods We selected 16 plots stratified by forest age,ranging from 20 to 120 years.In each plot,six shallow collars and six deep collars were permanently inserted into the soil.Shallow and deep collars were used to measure Rs and heterotrophic respiration(Rh),respectively.Autotrophic soil respiration(Ra)was estimated as the difference between Rs and Rh.Litter layer respiration(R_(L))was calculated by subtracting soil respiration measured in collars without leaf litter layer(R_(NL))from Rs.Rs was measured every 2 months,and soil temperature(ST)and soil volumetric water content(SVWC)were recorded every hour for 19 months.We calculated daily Rs using an exponential model dependent on ST.Daily Rs was summed to obtain cumulative annual Rs estimates.Structural equation modelling(SEM)was applied to identify the drivers of Rs during forest succession.Important Findings Rs showed significant differences among three successive stages,and it was the highest in the young stage.Ra was higher in the young stage than in the medium stage.Cumulative annual Rs and Ra peaked in the young and old stages,respectively.Cumulative annual Rh and respiration measured from soil organic matter(R_(SOM))decreased,whereas R_(L)increased with forest age.The SEM revealed that cumulative annual Rs was influenced by fine root biomass and SVWC.Our results indicated that the dominant force regulating Rs on a seasonal scale is ST;however,on a successional scale,belowground carbon emerges as the dominant influential factor. | Chao Wang Yinlei Ma Stefan Trogisch Yuanyuan Huang Yan Geng Michael Scherer-Lorenzen Jin-Sheng He | 2017 | Journal of Plant Ecology2017，10，1： | 13 |
| 4 | Facile synthesis of Fe/Ni bimetallic oxide solid-solution nanoparticles with superior electrocatalytic activity for oxygen evolution reaction显示文摘懒惰的氧进化反应(OER ) 是电气化学的切开水的反应的重要一半反应。非结晶的 Fe/Ni 合成氧化物举办高活动。在这个工作,我们修改了喷雾器帮助水花的途径和获得的非结晶的 Fe-Ni-O x 稳固答案的 nanoparticles (Fe-Ni-O x -NPs) 在由作为原料选铁 / 镍为 acetylacetonates 而不是无机的盐的尺寸的约 20 nm。小型的 Fe-Ni-O x -NPs 被扫描电子描绘显微镜学(SEM ) ,传播电子显微镜学(TEM ) , X 光检查衍射(XRD ) 分析,精力散的 X 光检查光谱学(EDX ) ,和 X 光检查光电子光谱学(XPS ) 。而且,电气化学的 OER 性能的调查建议小型的 Fe-Ni-O x -NPs 比大尺寸的 Fe-Ni-O x -MPs 举办更高的活动。0.315 V 的小过电位被要求获得 50 妈 / 厘米 2, 的工作当前的密度, Tafel 斜坡象 38 mV/dec 一样低。 | Lingxiao Wang Jing Geng Wenhai Wang Chao Yuan Long Kuai Baoyou Geng | 2015 | Nano Research2015，8，12： | 12 |
| 5 | Effects of embedding direct reduction followed by magnetic separation on recovering titanium and iron of beach titanomagnetite concentrate显示文摘Embedding direct reduction followed by magnetic separation was conducted to fully recover iron and titanium separately from beach titanomagnetite(TTM).The influences of reduction conditions,such as molar ratio of C to Fe,reduction time,and reduction temperature,were studied.The results showed that the TTM concentrate was reduced to iron and iron-titanium oxides,depending on the reduction time,and the reduction sequence at 1 200°C was suggested as follows:Fe_(2.75)Ti_(0.25)O_4→Fe_2TiO_4→FeTiO_3→FeTi_2O_5.The reduction temperature played a considerable role in the reduction of TTM concentrates.Increasing temperature from 1 100 to 1 200°C was beneficial to recovering titanium and iron,whereas the results deteriorated as temperature increased further.The results of X-ray diffraction and scanning electron microscopy analyses showed that low temperature(≤1 100°C)was unfavorable for the gasification of reductant,resulting in insufficient reducing atmosphere in the reduction process.The molten phase was formed at high temperatures of 1 250-1 300°C,which accelerated the migration rate of metallic particles and suppressed the diffusion of reduction gas,resulting in poor reduction.The optimum conditions for reducing TTM concentrate are as follows:molar ratio of C to Fe of 1.68,reduction time of 150 min,and reduction temperature of 1 200°C.Under these conditions,direct reduction iron powder,assaying 90.28 mass%TFe and 1.73 mass% TiO_2 with iron recovery of 90.85%,and titanium concentrate,assaying 46.24mass% TiO_2 with TiO_2 recovery of 91.15%,were obtained. | Chao Geng Ti-chang Sun You-wen Ma Cheng-yan Xu Hui-fen Yang | 2017 | Journal of Iron and Steel Research(International)2017，24，2： | 10 |
| 6 | Effect of Sodium Sulfate on Direct Reduction of Beach Titanomagnetite for Separation of Iron and Titanium显示文摘The effect of sodium sulfate on direct reduction of beach titanomagnetite,followed by magnetic separation,to separate iron and titanium was investigated. Direct reduced iron( DRI) with a high Fe content,low TiO_2 content and low iron recovery was obtained after adding sodium sulfate. When the sodium sulfate dosage was increased from 0 to 10 mass%,the Fe content of the DRI increased from 90. 00 mass% to 93. 55 mass% and the TiO_2 content decreased from 1. 27 mass% to 0. 70 mass%. The reduction mechanism of sodium sulfate was investigated by X-ray diffraction( XRD) and scanning electron microscopy( SEM) with energy dispersive spectrometer( EDS). Results revealed that the metallic iron grains in the reduced ore with sodium sulfate were larger than those in the ore without sodium sulfate. Sodium sulfate promoted the migration of iron as well as the accumulation and growth of metallic iron grains by low-melting-point carnegieite and troilite formed in the redox system. Low-melting-point carnegieite decreased the melting point of the system and then promoted liquefaction. Troilite could decrease the surface tension and melting point of metallic iron grains. | En-xia GAO Ti-chang SUN Zhi-guo LIU Chao GENG Cheng-yan XU | 2016 | Journal of Iron and Steel Research(International)2016，23，5： | 7 |
| 7 | The effect of sintering and cooling process on geometry distortion and mechanical properties transition of PTFE/Al reactive materials显示文摘In this research,the effect of the sintering and cooling process on geometry distortion and mechanical properties of PTFE/Al reactive material is investigated.Six particularly selected sintering temperatures,three different cooling modes(annealing cooling,normalizing cooling and rapid cooling),three different initial cooling temperature s,as well as six different final cooling temperatures were designed to compare the effects of sintering temperature,cooling rate,initial cooling temperature and final cooling temperature on the properties of reactive materials.Geometry distortion was quantitatively analyzed by a statistic on the dimensional changes of the specimens and microscopic morphology.A mechanical response properties transition from brittle to ductile was found and analyzed.By combining the thermodynamic properties of PTFE and unsteady heat conduction theory,mechanisms of cooling induced morphology change,temperature induced distortion and strength decrease were obtained.The results showed that the cooling rate has the most significant effect on the morphology transformation,while initial cooling temperature has more significant effect on the dimensional distortion than final cooling temperature.As to the mechanical properties transition from brittle to plastic,a more prominent effect of initial cooling temperature than cooling rate and final temperature was revealed. | Hai-fu Wang Bao-qun Geng Huan-guo Guo Yuan-feng Zheng Qing-bo Yu Chao Ge | 2020 | Defence Technology(防务技术)2020，16，3： | 7 |
| 8 | Heavy-ion and pulsed-laser single event effects in 130-nm CMOS-based thin/thick gate oxide anti-fuse PROMs显示文摘Single event effects of 1-T structure programmable read-only memory(PROM) devices fabricated with a 130-nm complementary metal oxide semiconductorbased thin/thick gate oxide anti-fuse process were investigated using heavy ions and a picosecond pulsed laser. The cross sections of a single event upset(SEU) for radiationhardened PROMs were measured using a linear energy transfer(LET) ranging from 9.2 to 95.6 MeV cm^2mg^(-1).The result indicated that the LET threshold for a dynamic bit upset was ~ 9 MeV cm^2mg^(-1), which was lower than the threshold of ~ 20 MeV cm^2mg^(-1) for an address counter upset owing to the additional triple modular redundancy structure present in the latch. In addition, a slight hard error was observed in the anti-fuse structure when employing209 Bi ions with extremely high LET values(~ 91.6 MeV cm^2mg^(-1)) and large ion fluence(~ 1×10~8 ions cm^(-2)). To identify the detailed sensitive position of a SEU in PROMs, a pulsed laser with a 5-μm beam spot was used to scan the entire surface of the device.This revealed that the upset occurred in the peripheral circuits of the internal power source and I/O pairs rather than in the internal latches and buffers. This was subsequently confirmed by a ^(181)Ta experiment. Based on the experimental data and a rectangular parallelepiped model of the sensitive volume, the space error rates for the used PROMs were calculated using the CRèME-96 prediction tool. The results showed that this type of PROM was suitable for specific space applications, even in the geosynchronous orbit. | Chang Cai Tian-Qi Liu Xiao-Yuan Li Jie Liu Zhan-Gang Zhang Chao Geng Pei-Xiong Zhao Dong-Qing Li Bing Ye Qing-Gang Ji Li-Hua Mo | 2019 | Nuclear Science and Techniques2019，30，5： | 7 |
| 9 | Effects and mechanisms of fluorite on the co-reduction of blast furnace dust and seaside titanomagnetite显示文摘The co-reduction roasting and grinding-magnetic separation of seaside titanomagnetite and blast furnace dust was investigated with and without fluorite addition at a reduction roasting temperature of 1250°C for 60 min, a grinding fineness of-43 μm accounting for 69.02 wt% of the total, and a low-intensity magnetic field strength of 151 kA/m. The mineral composition, microstructure, and state of the roasted products were analyzed, and the concentrations of CO and CO_2 were analyzed in the co-reduction roasting. Better results were achieved with a small fluorite dosage(≤4 wt%) in the process of co-reduction. In addition, F^- was found to reduce the melting point and viscosity of the slag phase because of the high content of aluminate and silicate minerals in the blast furnace dust. The low moisture content of the blast furnace dust and calcic minerals inhibited the hydrolysis of CaF_2 and the loss of F^-. Compared with the blast furnace dust from Chengdeng, the blast furnace dusts from Jiugang and Jinxin inhibited the diffusion of F-when used as reducing agents, leading to weaker effects of fluorite. | Tian-yang Hu Ti-chang Sun Jue Kou Chao Geng Yong-qiang Zhao | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，11： | 7 |
| 10 | Recovery of iron and copper from copper tailings by coal-based direct reduction and magnetic separation显示文摘A technique comprising coal-based direct reduction followed by magnetic separation was presented to recover iron and copper from copper slag flotation tailings.Optimal process parameters,such as reductant and additive ratios,reduction temperature,and reduction time,were experimentally determined and found to be as follows:a limestone ratio of 25%,a bitumite ratio of 30%,and reduction roasting at 1473 Kfor 90 min.Under these conditions,copper-bearing iron powders(CIP)with an iron content of 90.11% and copper content of 0.86%,indicating iron and copper recoveries of87.25% and 83.44%respectively,were effectively obtained.Scanning electron microscopy and energy dispersive spectroscopy of the CIP revealed that some tiny copper particles were embedded in metal iron and some copper formed alloy with iron,which was difficult to achieve the separation of these two metals.Thus,the copper went into magnetic products by magnetic separation.Adding copper into the steel can produce weathering steel.Therefore,the CIP can be used as an inexpensive raw material for weathering steel. | Chao Geng Hua-jun Wang Wen-tao Hu Li Li Cheng-shuai Shi | 2017 | Journal of Iron and Steel Research(International)2017，24，10： | 6 |
| 11 | Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts显示文摘 | You, Y. P. Geng, X. Z. Zhao, P. FU, Z. Wang, C. Z. Chao, S. W. Liu, N. Lu, A. L. Gardner, K. Pu, P. Y. Kong, C. S. Ge, Y. Judge, S. I. V. Li, Q. D. Q | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 6 |
| 12 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 13 | Biological and molecular characterization of tomato brown rugose fruit virus and development of quadruplex RT-PCR detection显示文摘Tomato brown rugose fruit virus(ToBRFV) is a novel tobamovirus firstly reported in 2015 and poses a severe threat to the tomato industry. So far, it has spread to 10 countries in America, Asia, and Europe. In 2019, ToBRFV was identified in Shandong Province(ToBRFV-SD), China. In this study, it was shown that ToBRFV-SD induced mild to severe mosaic and blistering on leaves, necrosis on sepals and pedicles, and deformation, yellow spots, and brown rugose necrotic lesions on fruits. ToBRFV-SD induced distinct symptoms on plants of tomato, Capsicum annumm, and Nicotiana benthamiana, and caused latent infection on plants of Solanum tuberosum, Solanum melongena, and N. tabacum cv. Zhongyan 102. All the 50 tomato cultivars tested were highly sensitive to ToBRFV-SD. The complete genomic sequence of ToBRFV-SD shared the highest nucleotide and amino acid identities with isolate IL from Israel. In the phylogenetic tree constructed with the complete genomic sequence, all the ToBRFV isolates were clustered together and formed a sister branch with tobacco mosaic virus(TMV). Furthermore, a quadruplex RT-PCR system was developed that could differentiate ToBRFV from other economically important viruses affecting tomatoes, such as TMV, tomato mosaic virus, and tomato spotted wilt virus. The findings of this study enhance our understanding of the biological and molecular characteristics of ToBRFV and provide an efficient and effective detection method for multiple infections, which is helpful in the management of ToBRFV. | YAN Zhi-yong ZHAO Mei-sheng MA Hua-yu LIU Ling-zhi YANG Guang-ling GENG Chao TIAN Yan-ping LI Xiang-dong | 2021 | Journal of Integrative Agriculture2021，20，7： | 5 |
| 14 | Production and emission of phosphine gas from wetland ecosystems显示文摘Phosphine is a part of an atmospheric link of phosphorus cycle on earth, which could be an important pathway for phosphorus transport in environment.Wetland ecosystems are important locations for global biogeochemical phosphorus cycle.In this study, production and emission fluxes of free phosphine from four wetlands types in southern China were observed in different seasons.The results showed that the concentration of phosphine liberated from wetlands was at pg/m3-ng/m3 level.The emission concentrations of different wetlands followed the sequence:paddy field(51.83 ± 3.06) ng/m3 marsh(46.54 ± 20.55) ng/m3 > lake(37.05 ± 22.74) ng/m3 coastal wetland(1.71 ± 0.73) ng/m3, the positive phosphine emission flux occurred in rice paddy field(6.67 ± 5.18) ng/(m2·hr) and marsh(6.23 ± 26.9) ng/(m2·hr), while a negative phosphine flux of(-13.11 ± 35.04) ng/(m2·hr) was observed on the water-air interface of Lake Taihu, suggesting that paddy field and marsh may be important sources for phosphine gas in atmosphere, while lake may be a sink of atmospheric phosphine gas during the sampling period.Atmospheric phosphine levels and emission flux from Yancheng marsh and rice paddy field varied in different seasons and vegetational zones.Both diffusion resistance in aqueous phase and temperature were dominating factors for the production and transportation of phosphine to atmosphere. | Chao Han Xueyuan Gu Jinju Geng Yuning Hong Rui Zhang Xiaorong Wang Shixiang Gao | 2010 | Journal of Environmental Sciences2010，22，9： | 5 |
| 15 | Diffusion mechanism simulation of cloud manufacturing complex network based on cooperative game theory显示文摘Cloud manufacturing is a specific implementation form of the 'Internet + manufacturing' strategy. Why and how to develop cloud manufacturing platform(CMP), however, remains the key concern of both platform operators and users. A microscopic model is proposed to investigate advantages and diffusion forces of CMP through exploration of its diffusion process and mechanism. Specifically, a three-stage basic evolution process of CMP is innovatively proposed. Then, based on this basic process, a more complex CMP evolution model has been established in virtue of complex network theory, with five diffusion forces identified. Thereafter, simulations on CMP diffusion have been conducted. The results indicate that, CMP possesses better resource utilization,user satisfaction, and enterprise utility. Results of simulation on impacts of different diffusion forces show that both the time required for CMP to reach an equilibrium state and the final network size are affected simultaneously by the five diffusion forces. All these analyses indicate that CMP could create an open online cooperation environment and turns out to be an effective implementation of the 'Internet + manufacturing' strategy. | GENG Chao QU Shiyou XIAO Yingying WANG Mei SHI Guoqiang LIN Tingyu XUE Junjie JIA Zhengxuan | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 4 |
| 16 | Complex behaviour of trivalent rare earth elements by humic acids显示文摘ComplexbehaviouroftrivalentrareearthelementsbyhumicacidsGengAnchaoResearchInstituteofEnvironmentalEngineering,FushunPetrole... | Geng An chaoResearch Institute of Environmental Engineering,Fushun Petroleum Institute,Liaoning 113001,ChinaZhang Shen Institute of Geography,Chinese Academy of Sciences,Beijing 100101,ChinaHarald Hфiland Department of Chemistry,Univers | 1998 | Journal of Environmental Sciences1998，10，3： | 4 |
| 17 | Process Intensification in Pneumatically Agitated Slurry Reactors显示文摘Pneumatically agitated slurry reactors,including bubble column reactors and airlift loop reactors(ALRs),are important gas-liquid-solid multiphase reactors.These reactors have been widely applied in many processes,especially in the biological fermentation and energy chemical industry,due to their low shear stress,good mixing,perfect mass-/heat-transfer properties,and relatively low costs.To further improve the performance of slurry reactors(i.e.,mixing and mass/heat transfer)and to satisfy industrial require-ments(e.g.,temperature control,reduction of back-mixing,and product separation),the process intensi-fication of slurry reactors is essential.This article starts by reviewing the latest advancements in the intensification of mixing and mass/heat transfer in these two types of reactors.It then summarizes process-intensification methods for mixing and separation that allow continuous production in these slurry reactors.Process-intensification technology that integrates directional flow in an ALR with simple solid-liquid separation in a hydrocyclone is recommended for its high efficiency and low costs.This arti-cle also systematically addresses vital considerations and challenges,including flow regime discrimina-tion,gas spargers,solid particle effects,and other concerns in slurry reactors.It introduces the progress of numerical simulation using computational fluid dynamics(CFD)for the rational design of slurry reactors and discusses difficulties in modeling.Finally,it presents conclusions and perspectives on the design of industrial slurry reactors. | Shujun Geng Zai-Sha Mao Qingshan Huang Chao Yang | 2021 | Engineering2021，7，3： | 4 |
| 18 | Effects of L-arginine during ischemia-reperfusion injury in rat orthotopic liver transplantation显示文摘EfectsofLarginineduringischemiareperfusioninjuryinratorthotopiclivertransplantationDIAOTongJin1,YAOXiaoPing2,JIBing1,YANG... | DIAO Tong Jin 1, YAO Xiao Ping 2, JI Bing 1, YANG Jia Mei 2, WU Meng Chao 2 and ZHANG Shao Geng 3 1Department of General Surgery, Chinese PLA 401 Navy Hospital, Qingdao 266071, Shandong Province, China 2Eastern Hospital of Hepa | 1998 | World Journal of Gastroenterology1998，4，3： | 4 |
| 19 | Open N-doped carbon coated porous molybdenum phosphide nanorods for synergistic catalytic hydrogen evolution reaction显示文摘Molybdenum phosphide is a potential hydrogen evolution reaction(HER)catalyst.However,traditional high-temperature phosphating preparation methods are prone to damage of material morphology and agglomeration.Using the carbon skeleton to limit the size and morphology of MoP and to improve the conductivity of the material is an effective method to improve the performance of the catalyst.However,there is a lack of research on the effect of carbon skeleton and MoP composite structure on the catalytic mechanism of HER.We coated ZIF-8 on the surface of MoP nanorods,and obtained open N-doped carbon-coated porous MoP nanorods(N/C/MoP)through carbonization and phosphating.Studies have shown that the ZIF-8 coating effectively limits the size and morphology of the material and avoids agglomeration.Under alkaline conditions,N/C/MoP has a low overpotential of 169 mV for HER at 10 mA/cm2,which is 55 mV lower than MoP without a carbon layer.At the same time,its Tafel slope(51.3 mV/dec)is smaller than Pt/C(59.9 mV/dec),and it has good stability.Density functional theory(DFT)studies have shown that under alkaline conditions,there is a synergistic effect between the open N-doped carbon layer and the exposed MoP active surface,which reduces the activation energy of water and improves the catalytic performance of HER.It is worth noting that a tight coating will hinder the exposure of active sites and reduce catalytic activity. | Chao Wang Wen Li Xiaodan Wang Nan Yu Hongxia Sun Baoyou Geng | 2022 | Nano Research2022，15，3： | 3 |
| 20 | Retinoic acid ameliorates high-fat diet-induced liver steatosis through Sirt1显示文摘In this study, treatment of C57 BL/6 J(wild type, WT) mice fed a high-fat diet(HFD) with retinoic acid(RA) decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosis, and reduced hepatic intracellular triglyceride and serum alanine transaminase(ALT) and aspartate aminotransferase(AST) concentrations. Moreover, RA treatment improved glucose tolerance and insulin sensitivity in WT mice fed a HFD. However, these RA-induced effects in WT mice fed a HFD were alleviated in liver specific Sirtuin 1(Sirt1) deficient(LKO) mice fed a HFD. Furthermore,RA also could not improve glucose tolerance and insulin sensitivity in LKO mice fed a HFD. The mechanism studies indicated that RA indeed increased the expression of hepatic Sirt1 and superoxide dismutase 2(Sod2), and inhibited the expression of sterol regulatory element binding protein 1 c(Srebp-1 c) in WT mice in vivo and in vitro. RA decreased mitochondrial reactive oxygen species(ROS) production in WT primary hepatocytes and increased mitochondrial DNA(mtDNA) copy number in WT mice liver. However, these RA-mediated molecular effects were also abolished in the liver and primary hepatocytes from LKO mice. In summary, RA protected against HFD-induced hepato steatosis by decreasing Srebp-1 c expression and improving antioxidant capacity through a Sirtl-mediated mechanism. | Chao Geng Haifeng Xu Yinliang Zhang Yong Gao Meixia Li Xiaoyan Liu Mingyue Gao Xiaojuan Wang Xiaojun Liu Fude Fang Yongsheng Chang | 2017 | Science China(Life Sciences)2017，60，11： | 3 |
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