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| 1 | Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ显示文摘AIM: To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis,spontaneous abortion,allo-and xeno-graft rejection by mediating 'immune coagulation'. METHODS: Tumor tissues from 133 patients with six types of distinct cancers and the animal tumor tissues from human hepatocellular carcinoma (HCC) model on nude mice (established from high metastasis HCC cell line MHCC97LM6) were obtained. RESULTS: Hfgl2 was detected in tumor tissues from 127 out of 133 patients as well as tumor tissues collected from human HCC nude mice. Hfgl2 was highly expressed both in cancer cells and interstitial inflammatory cells including macrophages,NK cells,and CD8+ T lymphocytes and vascular endothelial cells. Hfgl2 mRNA was localized in cells that expressed hfgl2 protein. Fibrin (nogen) co-localization with hfgl2 expression was determined by dual immunohistochemical staining. In vitro,IL-2 and IFN-γ increased hfgl2 mRNA by 10-100 folds and protein expression in both THP-1 and HUVEC cell lines. One-stage clotting assays demonstrated that THP-1 and HUVEC cells expressing hfgl2 had increased procoagulant activity following cytokines stimulation. CONCLUSION: The hfg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction. | Kai Su Fang Chen Wei-Ming Yan Qi-Li Zeng Li Xu Dong Xi Bin Pi Xiao-Ping Luo Qin Ning | 2008 | World Journal of Gastroenterology2008，14，39： | 20 |
| 2 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 3 | Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity显示文摘 | Hong-Yi Zhao Shu-Di Zhang Kai Zhang Xi Wang Qing-Yan Zhao Shu-Juan Zhang Zi-Xuan Dai Yong-Sheng Qian You-Jing Zhang Hao-Tian Wei Yan-Hong Tang Cong-Xin Huang | 2017 | Chinese Medical Journal2017，，2： | 15 |
| 4 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 5 | Pollution characteristics of atmospheric dustfall and heavy metals in a typical inland heavy industry city in China显示文摘Through field sampling of atmospheric dustfall in regions of Zhuzhou City, China for a period of one year, the deposition fluxes of atmospheric dustfall and five heavy metals contained inside, including Cr, As, Cd, Hg and Pb, were analyzed. Meanwhile the enrichment factor and index methods were used to analyze the pollution characteristics of heavy metals of atmospheric dustfall in Zhuzhou. The annual deposition flux of atmospheric dustfall in Zhuzhou was 50.79 g/(m^2·year), while the annual deposition fluxes of Cr, As, Cd, Hg and Pb were 9.80, 59.69, 140.09, 0.87 and 1074.91 mg/(m^2·year), respectively.The pollution level of atmospheric dustfall in Zhuzhou was relatively lower compared with most other cities in China, but the deposition fluxes of As, Cd, Hg and Pb in atmospheric dustfall in Zhuzhou were much higher than that in most cities and regions around the world. Cd is the typical heavy metal element in atmospheric dustfall in Zhuzhou, and both the enrichment factor and pollution index of Cd were the highest. Cd, Hg, Pb and As in atmospheric dustfall were mainly from human activities. According to the single-factor index, Nemerow index and pollution load index analyses, the atmospheric dustfall in Zhuzhou could easily cause severe heavy metal pollution to urban soil, and the most polluting element was Cd, followed by Pb, As and Hg. Only the pollution level of Cr lay in the safety region and mainly originated from natural sources. | Jinhe Wang Xi Zhang Qing Yang Kai Zhang Yue Zheng Guanhua Zhou | 2018 | Journal of Environmental Sciences2018，30，9： | 14 |
| 6 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 7 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 8 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 9 | Type D personality negatively associated with self-care in Chinese heart failure patients显示文摘 | Xi CAO Xiu-Hua WANG Eliza ML Wong Choi Kai Chow Sek Ying Chair | 2016 | Journal of Geriatric Cardiology2016，13，5： | 9 |
| 10 | Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats显示文摘Background:Cardiac remodeling after acute myocardial infarction(AMI)is an important process.The present study aimed to assess the protective effects of astaxanthin(ASX)on cardiac remodeling after AMI.Methods:The study was conducted between April and September 2018.To create a rat AMI model,rats were anesthetized,and the left anterior descending coronary artery was ligated.The rats in the ASX group received 10 mg·kg-1·day-1 ASX by gavage for 28 days.On the 1st day after AMI,but before ASX administration,six rats from each group were sacrificed to evaluate changes in the heart function and peripheral blood(PB)levels of inflammatory factors.On the 7th day after AMI,eight rats from each group were sacrificed to evaluate the PB levels of inflammatory factors and the M2 macrophage count using both immunofluorescence(IF)and flow cytometry(FC).The remaining rats were observed for 28 days.Cardiac function was examined using echocardiography.The inflammatory factors,namely,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and IL-10,were assessed using enzyme-linked immunosorbent assay.The heart weight/body weight(BW),and lung weight(LW)/BW ratios were calculated,and myocardial fibrosis in the form of collagen volume fraction was measured using Masson trichrome staining.Hematoxylin and eosin(H&E)staining was used to determine the myocardial infarct size(MIS),and TdT-mediated dUTP nick-end labeling staining was used to analyze the myocardial apoptosis index.The levels of apoptosis-related protein,type I/III collagen,transforming growth factorβ1(TGF-β1),metalloproteinase 9(MMP9),and caspase 3 were assessed by Western blotting.Unpaired t-test,one-way analysis of variance,and non-parametric Mann-Whitney test were used to analyze the data.Results:On day 1,cardiac function was worse in the ASX group than in the sham group(left ventricular end-systolic diameter[LVIDs]:0.72±0.08 vs.0.22±0.06 cm,t=-11.38;left ventricular end-diastolic diameter[LVIDd]:0.89±0.09 vs.0.48±0.05 cm,t=-9.42;end-systolic volume[ESV]:0.80[0.62,0.94]vs.0.04[0.03,0.05]mL,Z=-2.89;end-diastolic volume[EDV]:1.39[1.03,1.49]vs.0.28[0.22,0.32]mL,Z=-2.88;ejection fraction[EF]:0.40±0.04 vs.0.86±0.05,t=10.00;left ventricular fractional shortening[FS]rate:0.19[0.18,0.20]%FS vs.0.51[0.44,0.58]%FS,Z=-2.88,all P<0.01;n=6).The levels of inflammatory factors significantly increased(TNF-α:197.60[133.89,237.94]vs.50.48[47.2157.10]pg/mL,Z=-2.88;IL-1β:175.23[160.74,215.09]vs.17.78[16.83,19.56]pg/mL,Z=-2.88;IL-10:67.64[58.90,71.46]vs.12.33[11.64,13.98]pg/mL,Z=-2.88,all P<0.01;n=6).On day 7,the levels of TNF-αand IL-1βwere markedly lower in the ASX group than in the AMI group(TNF-α:71.70[68.60,76.00]vs.118.07[106.92,169.08]pg/mL,F=42.64;IL-1β:59.90[50.83,73.78]vs.151.60[108.4,198.36]pg/mL,F=44.35,all P<0.01,n=8).Conversely,IL-10 levels significantly increased(141.84[118.98,158.36]vs.52.96[42.68,74.52]pg/mL,F=126.67,P<0.01,n=8).The M2 macrophage count significantly increased(2891.42±211.29 vs.1583.38±162.22,F=274.35,P<0.01 by immunofluorescence test;0.96±0.18 vs.0.36±0.05,F=46.24,P<0.05 by flowcytometry test).On day 28,cardiac function was better in the ASX group than in the AMI group(LVIDs:0.50[0.41,0.56]vs.0.64[0.56,0.74]cm,Z=-3.60;LVIDd:0.70[0.60,0.76]vs.0.80[0.740.88]cm,Z=-2.96;ESV:0.24[0.18,0.45]vs.0.58[0.44,0.89]mL,Z=-3.62;EDV:0.76[0.44,1.04]vs.1.25[0.82,1.46]mL,Z=-2.54;EF:0.60±0.08 vs.0.50±0.12,F=160.48;%FS:0.29[0.24,0.31]vs.0.20[0.17,0.21],Z=-4.43,all P<0.01;n=16).The MIS and LW/BW ratio were markedly lower in the ASX group than in the AMI group(myocardial infarct size:32.50±1.37 vs.50.90±1.73,t=23.63,P<0.01,n=8;LW/BW:1.81±0.15 vs.2.17±0.37,t=3.66,P=0.01,n=16).The CVF was significantly lower in the ASX group than in the AMI group:12.88±2.53 vs.28.92±3.31,t=10.89,P<0.01,n=8.The expression of caspase 3,TGF-β1,MMP9,and type I/III collagen was lower in the ASX group than in the AMI group(caspase 3:0.38±0.06 vs.0.66±0.04,t=8.28;TGF-β1:0.37±0.04 vs.0.62±0.07,t=6.39;MMP9:0.20±0.06 vs.0.40±0.06,t=4.62;type I collagen:0.42±0.09 vs.0.74±0.07,t=5.73;type III collagen:0.13±0.02 vs.0.74±0.07,t=4.32,all P<0.01;n=4).Conclusions:ASX treatment after AMI may promote M2 macrophages and effectively attenuate cardiac remodeling by inhibiting inflammation and reducing myocardial fibrosis. | Xia Pan Kai Zhang Cheng Shen Xi Wang Long Wang Ya-Yi Huang | 2020 | Chinese Medical Journal2020，，15： | 8 |
| 11 | Comparison of detrital mineral compositions between stream sediments of the Yangtze River (Changjiang) and the Yellow River (Huanghe) and their provenance implication显示文摘A comparative comparative study on the detrital mineral composition of stream sediments of the Yangtze River (Changjiang) and Yellow River (Huanghe) shows that, light minerals of the Yangtze River basin were mainly quartz, feldspar, and detritus, the compositional characteristics of light minerals differed among tributaries, the main stream had a generally higher maturity index than tributaries;heavy mineral content tended to decrease progressively from the upper stream to lower stream of the Yangtze River, the primary assemblage was magnetite-hornblende-augite-garnet-epidote, and diagnostic minerals of different river basins were capable of indicating the nature and distribution of the source rock. Detrital mineral assemblages in sediments of tributaries and the main stream of the Yellow River were basically similar, Primary heavy mineral assemblage was opaque mineral-garnet-epidote-carbonate mineral and alteration mineral. Variations in the contents of garnet, opaque mineral, and hornblende mainly reflected the degree of sedimentary differentiation in suspended sediment and the hydrodynamic intensity of a drainage system. The heavy mineral differentiation index F revealed sedimentary differentiation of diagnostic detrital mineral composition due to changes in regional hydrodynamic intensity and can serve as an indicator for studying the dynamic sedimentary environment of a single-provenance river and the degree of sedimentary differentiation of its detrital minerals. Changes in detrital mineral content of the Yellow River was not completely controlled by provenance but reflected gravity sorting of the detrital mineral due to variations in the ephemeral river hydrodynamic intensity and sedimentary environment, however the index changing of Yangtze River were mainly influenced by the complex sediment sources. Therefore caution must be exercised in using the detrital mineral composition of marginal sea to determine the contribution of the Yangtze River and Yellow River. | Zhong-bo Wang Ri-hui Li Shou-ye Yang Feng-long Bai Xi Mei Jian Zhang Kai Lu | 2019 | China Geology2019，2，2： | 8 |
| 12 | MiRNA-203 suppresses tumor cell proliferation, migration and invasion by targeting Slug in gastric cancer显示文摘 | Liuqing Yang Hongwei Liang Yanbo Wang Shanting Gao Kai Yin Zhijian Liu Xi Zheng Ying Lv Lei Wang Chen-Yu Zhang Xi Chen Guifang Xu Weijie Zhang Xiaoping Zou | 2016 | Protein & Cell2016，7，5： | 7 |
| 13 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 14 | Monte Carlo simulation based on Geant4 of single event upset induced by heavy ions显示文摘The present work is a computational simulation of single event upset(SEU) induced by heavy ions passing through the device with Geant4-tool based on Monte Carlo transport code.Key parameters affecting SEU occurrence are examined,and related geometrical construction and critical charge are quantified.The MUlti-Functional Package for SEU Analysis(MUFPSA) has been successfully programmed and applied for SEU occurrence after the completion of device geometrical construction,critical charge,and SEU cross section calculation.The proposed MUFPSA has yielded a good agreement with MRED.Specifically,the results show that higher LET incident ions lead to increased SEU vulnerability due to more diffusion and higher energy deposition.In addition,the analytical method of radial ionization profile provides a good complementary interpretation. | GENG Chao LIU Jie ZHANG ZhanGang HOU MingDong SUN YouMei XI Kai GU Song DUAN JingLai YAO HuiJun MO Dan LUO Jie | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 6 |
| 15 | Self-Healing,Self-Adhesive and Stable Organohydrogel-Based Stretchable Oxygen Sensor with High Performance at Room Temperature显示文摘With the advent of the 5G era and the rise of the Internet of Things,various sensors have received unprecedented attention,especially wearable and stretchable sensors in the healthcare field.Here,a stretchable,self-healable,self-adhesive,and room-temperature oxygen sensor with excellent repeatability,a full concentration detection range(0-100%),low theoretical limit of detection(5.7 ppm),high sensitivity(0.2%/ppm),good linearity,excellent temperature,and humidity tolerances is fabricated by using polyacrylamide-chitosan(PAM-CS)double network(DN)organohydrogel as a novel transducing material.The PAM-CS DN organohydrogel is transformed from the PAM-CS composite hydrogel using a facile soaking and solvent replacement strategy.Compared with the pristine hydrogel,the DN organohydrogel displays greatly enhanced mechanical strength,moisture retention,freezing resistance,and sensitivity to oxygen.Notably,applying the tensile strain improves both the sensitivity and response speed of the organohydrogel-based oxygen sensor.Furthermore,the response to the same concentration of oxygen before and after self-healing is basically the same.Importantly,we propose an electrochemical reaction mechanism to explain the positive current shift of the oxygen sensor and corroborate this sensing mechanism through rationally designed experiments.The organohydrogel oxygen sensor is used to monitor human respiration in real-time,verifying the feasibility of its practical application.This work provides ideas for fabricating more stretchable,self-healable,self-adhesive,and high-performance gas sensors using ion-conducting organohydrogels. | Yuning Liang Zixuan Wu Yaoming Wei Qiongling Ding Meital Zilberman Kai Tao Xi Xie Jin Wu | 2022 | Nano-Micro Letters2022，14，3： | 5 |
| 16 | The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts显示文摘Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium(pTi)implants effectively.In this study,a three-layered composite coating,i.e.outer layer of hydroxyapatite(HA),middle layer of loose titanium dioxide(L-TiO2)and inner layer of dense TiO2(D-TiO2),was fabricated on pTi by a combined processing procedure of pickling,alkali heat(AH),anodic oxidation(AO),electrochemical deposition(ED)and hydrothermal treatment(HT).After soaking in simulated body fluid for 48 h,the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite layer.Using MC3T3-E1 pro-osteoblasts as cell model,the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment,growth and proliferation of the cells.Compared to the pTi sample,the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells,including alkaline phosphatase,Type I collagen,osteopontin,osteoclast inhibitor,osteocalcin and zinc finger structure transcription factor.As thus,besides the good corrosion resistance,the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity,showing good potential in practical application for bone defect repair. | Xi Fu Xingyu Zhou Pin Liu Hewei Chen Zhanwen Xiao Bo Yuan Xiao Yang Xiangdong Zhu Kai Zhang Xingdong Zhang | 2020 | Regenerative Biomaterials2020，7，5： | 5 |
| 17 | Functionalized graphene oxide based on p-phenylenediamine as spacers and nitrogen dopants for high performance supercapacitors显示文摘p-Phenylenediamine(PPD)functionalized graphene oxide(GO)materials(PPDG)were prepared through a one-step solvothermal process and their application as supercapacitors(SCs)were studied.The PPD is not only as the spacers to prevent aggregating and restacking of the graphene sheets in the preparing process but also as nitrogen sources to obtain the nitrogen-doped graphene.The structures of PPDG were characterized by Fourier transformed infrared spectroscopy(FT-IR),X-ray diffraction spectroscopy(XRD),Raman spectroscopy and X-ray photoelectron spectroscopy(XPS)and the results show that the nitrogen-doped graphene was achieved with nitrogen content as high as 10.85 at.%.The field emission scanning electron microscopy(FE-SEM)and high resolution transmission electron microscopy(HR-TEM)have confirmed that the morphologies of PPDG were loose layered with less aggregation,indicating that PPD molecules,as spacers,effectively prevent the graphene sheets from restacking during the solvothermal reaction.The special loose textures make PPDG materials exhibit excellent electrochemical performance for symmetric SCs with superior specific capacitance(313 F/g at 0.1 A/g),rate capability and cycling stability.The present synthesis method is convenient and may have potential applications as ultrahigh performance SCs. | Yanhong Lu Yi Huang Fan Zhang Long Zhang Xi Yang Tengfei Zhang Kai Leng Mingjie Zhang Yongsheng Chen | 2014 | Chinese Science Bulletin2014，59，16： | 5 |
| 18 | Dynamic impact experiment and response characteristics analysis for 1:2 reduced-scale model of hydraulic support显示文摘It is significant to research the impact resistance properties of hydraulic support due to its key support role in the fully mechanized mining face.However,it is difficult for the entire hydraulic support to implement the impact experiment underground and analyze the response characteristic.Therefore,a dynamic impact experiment for the entire hydraulic support was proposed in this paper,where a 1:2 reducedscale model of hydraulic support was designed and its response characteristics under dynamic impact load were analyzed.Firstly,a comprehensive monitoring scheme was proposed to achieve an effective monitoring for dynamic response of hydraulic support.Secondly,a multi-scale impact experiment was carried out for the entire hydraulic support and dynamic behaviors of hydraulic support under the multi-scale impact load were revealed by experimental data.Then a dynamic impact experiment of the entire hydraulic support was simulated in ADAMS with the same experiment conditions,and the experimental and simulation data were verified mutually.Finally,the characteristics of energy conversion and dissipation of the entire experiment system after impact were analyzed.The experiment results showed that the impact resistance properties of hydraulic support largely depended on the initial support conditions and different vertical rigidities affected energy distribution proportion of the entire support system. | Huaiwei Ren Desheng Zhang Shixin Gong Kai Zhou Chenyang Xi Ming He Tijian Li | 2021 | International Journal of Mining Science and Technology2021，31，3： | 5 |
| 19 | Total ionizing dose effects and annealing behaviors of HfO2-based MOS capacitor显示文摘With the continuously scaling down of semiconductor technology,the traditional SiO_2as gate dielectric is approaching the physical and electrical limits.Some problems,such as the increasing leakage current and reliability issues,seriously affect the transistor performance[1].HfO_2 has been considered to be one of the reasonable alternative solutions due to a suitable dielectric constant(about 25),the relatively large band gap(5.68 e V) | Yannan XU Jinshun BI Gaobo XU Kai XI Bo LI Ming LIU | 2017 | Science China(Information Sciences)2017，60，12： | 4 |
| 20 | Effects of neural stem cell transplantation on the motor function of rats with contusion spinal cord injuries:a meta-analysis显示文摘Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically relevant,standardized rat model of contusion SCI were identified by searching the PubMed,Embase and Cochrane databases,and the extracted data were analyzed by Stata 14.0.Data selection:Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the Basso,Beattie,and Bresnahan lo-comotor rating scale.Exclusion criteria included a follow-up of less than 4 weeks and the lack of control groups.Outcome measures:The restoration of motor function was assessed by the Basso,Beattie,and Bresnahan locomotor rating scale.Results:We identified 1756 non-duplicated papers by searching the aforementioned electronic databases,and 30 full-text articles met the inclusion criteria.A total of 37 studies reported in the 30 articles were included in the meta-analysis.The meta-analysis results showed that transplanted NSCs could improve the motor function recovery of rats following contusion SCIs,to a moderate extent(pooled standardized mean difference(SMD)=0.73;95%confidence interval(CI):0.47–1.00;P<0.001).NSCs obtained from different donor species(rat:SMD=0.74;95%CI:0.36–1.13;human:SMD=0.78;95%CI:0.31–1.25),at different donor ages(fetal:SMD=0.67;95%CI:0.43–0.92;adult:SMD=0.86;95%CI:0.50–1.22)and from different origins(brain-derived:SMD=0.59;95%CI:0.27–0.91;spinal cord-derived:SMD=0.51;95%CI:0.22–0.79)had similar efficacies on improved functional recovery;however,adult induced pluripotent stem cell-derived NSCs showed no significant efficacies.Furthermore,the use of higher doses of transplanted NSCs or the administration of immunosuppressive agents did not promote better locomotor function recovery(SMD=0.45;95%CI:0.21–0.70).However,shorter periods between the contusion induction and the NSC transplantation showed slightly higher efficacies(acute:SMD=1.22;95%CI:0.81–1.63;subacute:SMD=0.75;95%CI:0.42–1.09).For chronic injuries,NSC implantation did not significantly improve functional recovery(SMD=0.25;95%CI:–0.16 to 0.65).Conclusion:NSC transplantation alone appears to be a positive yet limited method for the treatment of contusion SCIs. | Kai Qian Tuo-Ye Xu Xi Wang Tao Ma Kai-Xin Zhang Kun Yang Teng-Da Qian Jing Shi Li-Xin Li Zheng Wang | 2020 | Neural Regeneration Research2020，15，4： | 4 |
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