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| 1 | Visible Light Accelerated Vinyl C-H Arylation in Pd-Catalysis:" Application in the Synthesis of ortho Tetra-substituted Vinylarene Atropisomers显示文摘在有 diaryliodonium 盐的乙烯基 arenes 的催化钯的 arylation 的可见轻加速的 C-H functionalization 反应当另外的 photosensitizer 不在时被报导。运动同位素效果(k H /k D ) 从 3.6 被改变(在黑暗下面) 到 1.1 当由可见的光照耀时,它显示 C-H functionalization 步是在黑暗下面决定步的率并且显著地由可见的光的照耀加速了。最后 ortho 的合成有高 enantiospecificity 的代替 tetra 的 vinylarene atropisomers 经由这个协议被认识到。 | Jia Feng Bin Li Julong Jiang Mingkai Zhang Wenbai Ouyang Chunyu Li Yao Fu Zhenhua Gu | 2018 | Chinese Journal of Chemistry2018，36，1： | 7 |
| 2 | Application of chemical vapor-deposited monolayer ReSe2 in the electrocatalytic hydrogen evolution reaction显示文摘 | Shaolong Jiang Zhepeng Zhang Na Zhang Yahuan Huan Yue Gong Mengxing Sun Jianping Shi Chunyu Xie Pengfei Yang Qiyi Fang He Li Lianming Tong Dan Xie Lin Gu Porun Liu Yanfeng Zhang | 2018 | Nano Research2018，11，4： | 6 |
| 3 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 4 | Fingerprint recognition by combi- ning global structure and local cues显示文摘 | Gu Jinwei Zhou Jie Yang Chunyu | 2006 | IEEE Trans on Image Pro- cessing2006，15，7： | 1 |
| 5 | Bystander effect in glioma suicide gene therapy using bone marrow stromal cells显示文摘 | Shaoyi Li Chunyu Gu Yun Gao Shinji Amano Shinichiro Koizumi Tsutomu Tokuyama Hiroki Namba | 2012 | Stem Cell Research2012，，3： | 1 |
| 6 | Study on Transformation of Ideas of Environmental Protection Administration and Construction of Ecological Civilization in China显示文摘The transformation process of ideas of environmental protection administration in China was introduced firstly,and then the connotation and construction of ecological civilization were analyzed. | Fu Baorong Yang Tao He Zhe Zuo Shiwen Gu Chunyu Liu Song Zhang Runjie | 2017 | Meteorological and Environmental Research2017，8，3： | 1 |
| 7 | Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice显示文摘In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation. | Zitao Guo Dalong Yi Bo Hu Lingyu Zhu Ji Zhang Yuliang Yang Chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang | 2023 | Food Science and Human Wellness2023，12，5： | 1 |
| 8 | Ti X-Ray Laser Shadowgraphy Experiment显示文摘An x-ray laser shadowgraphy experiment was conducted on Xingguang-Ⅱ laser facility in 1996.A multi-layer spherical mirror was used as an imaging element and a high sensitivity CCD camera as a detector.We measured the near-field image of the Ti x-ray laser beam.With a Ti x-ray laser beam as a backlight source,we obtained a clear CU mesh image,demonstrating the potential as advanced diagnostic measurements to study high density plasmas in inertial confinement fusion research. | HUANG Wen-zhong LIU Su-ping PENG Han-sheng GU Yu-qiu ZHANG Qi-ren CAI Yu-qin YOU Yong-lu HONG Wei LI Yu-tong CHUNYU Shu-tai YANG Shang-jin ZHANG Chuan-fei ZHAO Yong-kuan WEN Shu-huai ZHANG Jie ZHANG Guo-ping ZHANG Tan-xin | 1996 | Chinese Physics Letters1996，13，12： | 1 |
| 9 | Carnosine concentration and expression profiles of carnosine related genes in Mytilus after beta-alanine injection显示文摘Carnosine and its analogues are histidine-containing dipeptides(HCDs)playing diverse functions in vertebrates.However,the distribution and the metabolism of carnosine in invertebrates are still unknown.In this study,Mytilus coruscus,a shellfish with important economic value in China,was selected for the investigation of HCD content and the expression profiling of carnosine-related genes in various mussel tissues.Quantification of HCD by amino acids analyzer revealed a low concentration of anserine in muscular tissues in Mytilus,indicating the presence of HCD even in an invertebrate.mRNA expression of five carnosine metabolic-related genes was profiled in various tissues,and the results highlighted the relative higher expression level of these genes in muscular tissues.Considering the fact that beta-alanine supplementation can increase the HCD content in vertebrates,a beta-alanine injection was performed and the changes of HCD concentration and the mRNA expression of carnosine related genes were investigated in five mussel tissues.The results revealed the increase of HCD concentration,as well as the up-regulated expression level of related genes,in tested tissues of beta-alanine injected mussels.Transcriptomic analysis for the whole soft tissue of mussel before and after beta-alanine injection were performed,and 3569 differential expression genes(DEGs)were identified in the beta-alanine injected group when compared to their expression levels in the control.These data indicated the complex eff ects of betaalanine on M.coruscus metabolism,and those DEGs enriched in pathways of cancers,muscle contraction,and tyrosine metabolism highlighted the possible functions of beta-alanine in cell proliferation,sports,and melanogenesis,respectively. | Chen PAN Zhi LIAO Jianyu HE Zhongqi GU Chunyue WANG Meihua FAN Isabella BUTTINO Baoying GUO Xiaojun YAN Xiaolin ZHANG | 2022 | Journal of Oceanology and Limnology2022，40，3： | 0 |
| 10 | Response Mechanism of Water Ecosystem under the Influence of Urbanization: A Case Study of the Connection Zone between Shenyang and Fushun显示文摘Taking the connection zone between Shenyang and Fushun as an example,urbanization indicator system was established from the aspects of population,economy,space and society,and the comprehensive evaluation indicator system of water ecological environment was also established from the aspects of water ecological environmental pressure,state and response. Based on the evaluation of comprehensive level of urbanization and the comprehensive quality of water ecological environment,their changing trends during 2000-2014 were analyzed,and the response model between them was established. The composite index of urbanization in the connection zone between Shenyang and Fushun always increased from 2000 to 2014,and urbanization developed rapidly after 2004. The comprehensive quality of water ecological environment decreased firstly and then increased during 2000-2014. The response relationship between urbanization comprehensive index and water ecological comprehensive index during 2000-2014 could be expressed by a cubic curve. | Zhang Runjie Gu Chunyu Zuo Shiwen Qi Yue Tong Lili Fu Baorong | 2018 | Meteorological and Environmental Research2018，9，5： | 0 |
| 11 | Identification,structure elucidation and origin of a common pyridinium-thiocyanate intermediate in electrospray mass spectrometry among the benziamidazole-class proton pump inhibitors显示文摘During the analysis of benziamidazole-class irreversible proton pump inhibitors,an unusual mass spectral response with the mass-to-charge ratio at[Mt10]t intrigued us,as it couldn't be assigned to any literature known relevant structure,intermediate or adduct ion.Moreover,this mysterious mass pattern of[Mt10]t has been gradually observed by series of marketed proton pump inhibitors,viz.omeprazole,pantoprazole,lansoprazole and rabeprazole.All the previous attempts to isolate the corresponding component were unsuccessful.The investigation of present work addresses this kind of signal to a pyridinium thiocyanate mass spectral intermediate(10),which is the common fragment ion of series of labile aggregates.The origin of such aggregates can be traced to the reactive intermediates formed by acid-promoted degradation.These reactive intermediates tend to react with each other and give raise series of complicated aggregates systematically in a water/acetonitrile solution by electrospray ionization.The structure of the corresponding pyridinium thiocyanate species of omeprazole(10a)has been eventually characterized with the help of synthetic specimen(10a′).Our structural proposal as well as its origin was supported by in situ nuclear magnetic resonance,chemical derivatization and colorimetric experiments. | Dong Sun Chunyu Wang Yanxia Fan Jingkai Gu | 2023 | Journal of Pharmaceutical Analysis2023，13，6： | 0 |
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