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| 1 | Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion显示文摘 | Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han | 2015 | Cell Research2015，25，12： | 195 |
| 2 | Acupuncture and regulation of gastrointestinal function显示文摘In China, acupuncture has been considered an effective method for treating gastrointestinal(GI) dysfunction diseases for thousands of years. In fact, acupuncture has gained progressive acceptance from both practitioners and patients worldwide. However, the therapeutic effects and underlying mechanisms in treating GI dysfunction have not yet been established due to a lack of systematic and comprehensive review articles. Therefore, the aim of this review is to discuss the efficacy of acupuncture as a treatment for GI dysfunction and the associated underlying mechanisms. A search of Pub Med was conducted for articles that were published over the past 10 years using the terms 'acupuncture', 'gastrointestine', and other relevant keywords. In the following review, we describe the effect and underlying mechanisms of acupuncture on GI function from the perspectives of GI motility, visceral sensitivity, the GI barrier, and the brain-gut axis. The dual regulatory effects of acupuncture may manifest by promoting gastric peristalsis in subjects with low initial gastric motility, and suppressing peristalsis in subjects with active initial motility. In addition, the regulation of acupuncture on gastric motility may be intensitydependent. Our findings suggest that further studies are needed to investigate the effects and more systematic mechanisms in treating GI dysfunction, and to promote the application of acupuncture for the treatment of GI diseases. | Hui Li Tian He Qian Xu Zhe Li Yan Liu Fang Li Bo-Feng Yang Cun-Zhi Liu | 2015 | World Journal of Gastroenterology2015，21，27： | 41 |
| 3 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 4 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 5 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 6 | Atorvastatin reduces myocardial fibrosis in a rat model with post- myocardial infarction heart failure by increasing the matrix metaHoproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio显示文摘 | AN Zhe YANG Guang HE Yu-quan DONG Ning GE Li-li LI Shu-mei ZHANG Wen-qi | 2013 | Chinese Medical Journal2013，，11： | 17 |
| 7 | Changes of chlorogenic acid content and its synthesis-associated genes expression in Xuehua pear fruit during development显示文摘According to synthetic pathway of plant chlorogenic acid(CGA),the expression patterns of genes encoding enzymes that are associated with CGA synthesis were studied in normally developed Xuehua pear fruit. The study demonstrated that CGA content in peel and flesh of Xuehua pear decreased as fruit development progressed,with a higher level in peel. The expression levels of PbPAL1,PbPAL2,PbC3H,PbC 4H,Pb4CL1,Pb4CL2,Pb4CL6,PbHCT1 and PbHCT3 genes decreased in fruit,which was consistent with the pattern of variation in CGA content. That indicated that these genes might be key genes for influencing fruit CGA synthesis in Xuehua pear. However,Pb4CL7 gene expression profile is not consistent with variation of CGA content,hence,it may not be a key gene involved in CGA synthesis. | HE Jin-gang CHENG Yu-dou GUAN Jun-feng GE Wen-ya ZHAO Zhe | 2017 | Journal of Integrative Agriculture2017，16，2： | 13 |
| 8 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 9 | Flexible and transparent graphene/silver-nanowires composite ?lm for high electromagnetic interference shielding effectiveness显示文摘Herein, an efficient approach to prepare flexible, transparent, and lightweight films based on graphene nanosheets(GNS) and silver nanowires(AgNWs) for high electromagnetic interference(EMI) shielding effectiveness(SE) has been explained. High-conductive GNS were fabricated by liquid phase stripping and composited with AgNWs by a two-step spin-coating method. Owing to the high transparency, good conductivity, and homogeneous distribution of both GNS and AgNWs, the obtained GNS/AgNWs film exhibits superb EMI SE and light transmittance, yielding a significantly high EMI SE up to 26 dB in both Ku-band and K-band and light transmittance higher than 78.4%. Moreover, this GNS/AgNWs film shows good flexibility and excellent structural stability. The obtained flexible, light and transparent film could have a great potential for transparent EMI shielding and smart electronics. | Ning Zhang Zhe Wang Rongguo Song Qianlong Wang Hongye Chen Bin Zhang Haifei Lv Zhi Wu Daping He | 2019 | Science Bulletin2019，64，8： | 12 |
| 10 | Predictive value of N-terminal pro-brain natriuretic peptide in combination with the sequential organ failure assessment score in sepsis显示文摘 | JU Min-jie ZHU Du-ming TU Guo-wei HE Yi-zhou XUE Zhang-gang LUO Zhe WU Zhao-guang | 2012 | Chinese Medical Journal2012，，11： | 11 |
| 11 | Neddylation of PTEN regulates its nuclear import and promotes tumor development显示文摘PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus.Nucleus–cytoplasm shuttling of PTEN is regulated by ubiquitylation,SUMOylation and phosphorylation,and nuclear PTEN has been proposed to exhibit tumor-suppressive functions.Here we show that PTEN is conjugated by Nedd8 under high glucose conditions,which induces PTEN nuclear import without effects on PTEN stability.PTEN neddylation is promoted by the XIAP ligase and removed by the NEDP1 deneddylase.We identify Lys197 and Lys402 as major neddylation sites on PTEN.Neddylated PTEN accumulates predominantly in the nucleus and promotes rather than suppresses cell proliferation and metabolism.The nuclear neddylated PTEN dephosphorylates the fatty acid synthase(FASN)protein,inhibits the TRIM21-mediated ubiquitylation and degradation of FASN,and then promotes de novo fatty acid synthesis.In human breast cancer tissues,neddylated PTEN correlates with tumor progression and poor prognosis.Therefore,we demonstrate a previously unidentified pool of nuclear PTEN in the Nedd8-conjugated form and an unexpected tumor-promoting role of neddylated PTEN. | Ping Xie Zhiqiang Peng Yujiao Chen Hongchang Li Mengge Du Yawen Tan Xin Zhang Zhe Lu Chun-Ping Cui Cui Hua Liu Fuchu He Lingqiang Zhang | 2021 | Cell Research2021，31，3： | 11 |
| 12 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
| 13 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 14 | Sensitivity-enhanced surface plasmon resonance sensor utilizing a tungsten disulfide (WS_2) nanosheets overlayer显示文摘Tungsten disulfide(WS_2), as a representative layered transition metal dichalcogenide(TMDC) material, possesses important potential for applications in highly sensitive sensors. Here, a sensitivity-enhanced surface plasmon resonance(SPR) sensor with a metal film modified by an overlayer of WS_2 nanosheets is proposed and demonstrated. The SPR sensitivity is related to the thickness of the WS_2 overlayer, which can be tailored by coating a WS_2 ethanol suspension with different concentrations or by the number of times of repeated post-coating.Benefitting from its large surface area, high refractive index, and unique optoelectronic properties, the WS_2 nanosheet overlayer coated on the gold film significantly improves the sensing sensitivity. The highest sensitivity(up to 2459.3 nm∕RIU) in the experiment is achieved by coating the WS_2 suspension once. Compared to the case without a WS_2 overlayer, this result shows a sensitivity enhancement of 26.6%. The influence of the WS_2 nanosheet overlayer on the sensing performance improvement is analyzed and discussed. Moreover, the proposed WS_2 SPR sensor has a linear correlation coefficient of 99.76% in refractive index range of 1.333 to 1.360. Besides sensitivity enhancement, the WS_2 nanosheet overlayer is able to show additional advantages, such as protection of metal film from oxidation, tunability of the resonance wavelength region, biocompatibility, capability of vapor,and gas sensing. | HAO WANG HUI ZHANG JIANGLI DONG SHIQI HU WENGUO ZHU WENTAO QIU HUIHUI LU JIANHUI YU HEYUAN GUAN SHECHENG GAO ZHAOHUI LI WEIPING LIU MIAO HE JUN ZHANG ZHE CHEN YUNHAN LUO | 2018 | Photonics Research2018，6，6： | 8 |
| 15 | Richness of sputum microbiome in acute exacerbations of eosinophilic chronic obstructive pulmonary disease显示文摘Background:The eosinophilic chronic obstructive pulmonary disease(COPD)is known to be more sensitive to corticosteroid.The sputum microbiome has been shown to affect COPD prognosis,but its role in acute exacerbations of eosinophilic COPD is unclear.This study aimed to investigate the dynamic changes of the airway microbiome in patients with acute exacerbations of eosinophilic COPD.Methods:Fifty-seven patients with acute exacerbations of COPD from the First Affiliated Hospital of Guangxi Medical University between June 2017 and June 2018 were divided into two groups.Patients with eosinophils≥300 cells/mL in the peripheral venous blood were assigned to the eosinophilic group(Eos)and the rest to the non-eosinophilic group(Noneos).All patients received similar treatment including inhaled budesonide according to the guidelines.The induced sputum microbiome was analyzed on the 1st and 7th day of treatment using the 16S ribosomal RNA(rRNA)method.The levels of interleukin(IL)-6 and IL-8 were measured in the plasma and the sensitivity to corticosteroids was determined in isolated peripheral blood mononuclear cells.Quantitative data were compared between the two groups using the independent samples t test or Mann-Whitney U test.Categorical data were evaluated using Chi-squared test or Fisher’s exact test.Results:Twenty-six patients were classified into Eos group and 31 patients were classified into Noneos group.Prior to treatment,the alpha diversity(Shannon index)(2.65±0.63 vs.2.56±0.54,t=0.328,P=0.747)and the structure of the sputum microbiome were similar in the Eos group and the Noneos group.After 7 days of treatment,alpha diversity increased in both groups,while the microbiome richness(Ace index)was significantly lower in the Eos group(561.87±109.13 vs.767.88±148.48,t=-3.535,P=0.002).At the same time,IL-6(12.09±2.85 pg/mL vs.15.54±2.45 pg/mL,t=-4.913,P<0.001)and IL-8(63.64±21.69 pg/mL vs.78.97±17.13 pg/mL,t=-2.981,P=0.004)decreased more significantly in the Eos group,and the percentages of inhibition of IL-8 at dexamethasone concentrations 10-8 to 10-6 mol/L were significantly higher in the Eos group than those in the Noneos group(all P<0.05).Conclusions:The induced sputum microbiome richness decreased more significantly following treatment in the Eos patients compared to the Noneos patients.The lower plasma inflammatory factor levels and the higher percentage of inhibition of IL-8 might be due to higher corticosteroid sensitivity in Eos patients. | Yu-Jing Qi Xue-Jiao Sun Zhe Wang Yan-Fei Bin Ying-Hua Li Xiao-Ning Zhong Jing Bai Jing-Min Deng Zhi-Yi He | 2020 | Chinese Medical Journal2020，，5： | 8 |
| 16 | Spatiotemporal Variations of Meteorological Droughts in China During 1961–2014: An Investigation Based on Multi-Threshold Identification显示文摘As a major agricultural country, China suffers from severe meteorological drought almost every year.Previous studies have applied a single threshold to identify the onset of drought events, which may cause problems to adequately characterize long-term patterns of droughts.This study analyzes meteorological droughts in China based on a set of daily gridded(0.5° 9 0.5°) precipitation data from 1961 to 2014. By using a multi-threshold run theory approach to evaluate the monthly percentage of precipitation anomalies index(Pa), a drought events sequence was identified at each grid cell. The spatiotemporal variations of drought in China were further investigated based on statistics of the frequency, duration,severity, and intensity of all drought events. Analysis of the results show that China has five distinct meteorological drought-prone regions: the Huang-Huai-Hai Plain, Northeast China, Southwest China, South China coastal region,and Northwest China. Seasonal analysis further indicates that there are evident spatial variations in the seasonal contribution to regional drought. But overall, most contribution to annual drought events in China come from the winter. Decadal variation analysis suggests that most of China's water resource regions have undergone an increase in drought frequency, especially in the Liaohe, Haihe, and Yellow River basins, although drought duration and severity clearly have decreased after the 1960 s. | Jun He Xiaohua Yang Zhe Li Xuejun Zhang Qiuhong Tang | 2016 | International Journal of Disaster Risk Science2016，7，1： | 7 |
| 17 | Highly sensitive wearable sensor based on a flexible multi-layer graphene film antenna显示文摘The use of advanced carbon nanomaterials for flexible antenna sensors has attracted great attention due to their outstanding electromechanical properties. However, carbon nanomaterial based composites have yet to overcome drawbacks, such as low conductivity and toughness. In this work, a flexible multi-layer graphene film(FGF) with a high conductivity of 10~6 S/m for antenna based wearable sensors is investigated. A 1.63 GHz FGF antenna sensor exhibits significantly high strain sensitivity of 9.8 for compressive bending and 9.36 for tensile bending, which is super than the copper antenna sensor(5.39 for compressive bending and 4.05 for tensile bending). Moreover, the FGF antenna sensor shows very good mechanical flexibility, reversible deformability and structure stability, and thus is well suited for applications like wearable devices and wireless strain sensing. | Danli Tang Qianlong Wang Zhe Wang Quantao Liu Bin Zhang Daping He Zhi Wu Shichun Mu | 2018 | Science Bulletin2018，63，9： | 7 |
| 18 | Characterization of inflammatory factor-induced changes in mesenchymal stem cell exosomes and sequencing analysis of exosomal microRNAs显示文摘BACKGROUND Treatments utilizing stems cells often require stem cells to be exposed to inflammatory environments,but the effects of such environments are unknown.AIM To examine the effects of inflammatory cytokines on the morphology and quantity of mesenchymal stem cell exosomes(MSCs-exo)as well as the differential expression of microRNAs(miRNAs)in the exosomes.METHODS MSCs were isolated from human umbilical tissue by enzymatic digestion.Exosomes were then collected after a 48-h incubation period in a serum-free medium with one of the following the inflammatory cytokines:None(control),vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF)α,and interleukin(IL)6.The morphology and quantity of each group of MSC exosomes were observed and measured.The miRNAs in MSCs-exo were sequenced.We compared the sequenced data with the miRBase and other non-coding databases in order to detect differentially expressed miRNAs and explore their target genes and regulatory mechanisms.In vitro tube formation assays and Western blot were performed in endothelial cells which were used to assess the angiogenic potential of MSCs-exo after inflammatory cytokine stimulation.RESULTS MSCs-exo were numerous,small,and regularly shaped in the VCAM-1 group.TNFαstimulated MSCs to secrete larger and irregular exosomes.IL6 led to a reduced quantity of MSCs-exo.Compared to the control group,the TNFαand IL6 groups had more downregulated differentially expressed miRNAs,particularly angiogenesis-related miRNAs.The angiogenic potential of MSCs-exo declined after IL6 stimulation.CONCLUSION TNFαand IL6 may influence the expression of miRNAs that down-regulate the PI3K-AKT,MAPK,and VEGF signaling pathways;particularly,IL6 significantly down-regulates the PI3K-AKT signaling pathway.Overall,inflammatory cytokines may lead to changes in exosomal miRNAs that abnormally impact cellular components,molecular function,and biological processes. | Chen Huang Wen-Feng Luo Yu-Feng Ye Li Lin Zhe Wang Ming-Hua Luo Qi-De Song Xue-Ping He Han-Wei Chen Yi Kong Yu-Kuan Tang | 2019 | World Journal of Stem Cells2019，11，10： | 7 |
| 19 | Existence of Solutions of Boundary Value Problem Differential a Nonlinear Three-Point for Third-Order Ordinary Equations显示文摘In this paper,existence of solutions of third-order differential equation ■with nonlinear three-point boundary condition ■is obtained by embedding Leray-Schauder degree theory in upper and lower solutions method,where a,b,c ∈ R,a < b < c;f :[a,c]×R3 → R,g :R3 → R,h :R2 → R and I :R3 → R are continuous functions.The existence result is obtained by defining the suitable upper and lower solutions and introducing an appropriate auxiliary boundary value problem.As an application,an example with an explicit solution is given to demonstrate the validity of the results in this paper. | SHEN Jian He ZHOU Zhe Yan YU Zan Pin | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 6 |
| 20 | Dzyaloshinsky–Moriya interaction(DMI)-induced magnetic skyrmion materials显示文摘A magnetic skyrmion is a particle-like spin swirling object with a nontrivial topology that holds great promise for next-generation information carriers in highperformance spintronic devices.It was discovered in a chiral magnet,MnSi with B20 structure,in 2009 and later confirmed as a common feature of magnetic compounds with Dzyaloshinsky-Moriya interaction(DMI).In this work,we provide fundamental insight into the magnetic properties of skyrmion-hosting materials originating from DMI.The relationship between the point groups of the materials and DMI is introduced;then,the common features of magnetic skyrmions experimentally verified in the magnetization and magnetotransport measurements are highlighted.Finally,other particle-like magnetic configurations in chiral magnets and the crossover with a superconductor are discussed. | Wen-Sen Wei Zhi-Dong He Zhe Qu Hai-Feng Du | 2021 | Rare Metals2021，40，11： | 6 |
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