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| 1 | Acupuncture at Baihui and Dazhui reduces brain cell apoptosis in heroin readdicts显示文摘Acupuncture at Baihui(GV20) and Dazhui(GV14) reduces neuronal loss and attenuates ultrastructural damage in cerebral ischemic rats. However, whether acupuncture can treat addiction and prevent readdiction through changes to brain cell ultrastructure remains unknown. In this study, cell apoptosis was observed in the hippocampus and frontal lobe of heroin readdicted rats by electron microscopy. Immunohistochemical staining displayed a reduction in Bcl-2 expression and an increase in Bax expression in the hippocampus and frontal lobe. After rats were given acupuncture at Baihui and Dazhui, the pathological damage in the hippocampus and frontal lobe was significantly reduced, Bcl-2 expression was upregulated and Bax expression was downregulated. Acupuncture exerted a similar effect with methadone, a commonly used drug for clinical treatment of drug addiction. Experimental findings suggest that acupuncture at Dazhui and Baihui can prevent brain cell apoptosis in heroin readdicted rats. | Xiaorong Hou Rongjun Zhang Hang Lv Xinghui Cai Guangchuan Xie Xiaoge Song | 2014 | Neural Regeneration Research2014，9，2： | 12 |
| 2 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 3 | Robust multifactor speech feature extraction based on gabor analysis显示文摘 | Wu Qiang Zhang Liqing Shi Guangchuan | 2011 | IEEE Transactions on Audio Speech and Language Processing2011，19，4： | 1 |
| 4 | Robust multifactor speech feature extraction based on Gabor analysis显示文摘 | Wu Qiang Zhang Liqing Shi Guangchuan | | 0，，04： | 1 |
| 5 | von Willebrand factor as a novel noninvasive predictor of portal hypertension and esophageal varices in hepatitis B patients with cirrhosis显示文摘 | Hao Wu Shiping Yan Guangchuan Wang Shaobo Cui Chunqing Zhang Qiang Zhu | 2015 | Scandinavian Journal of Gastroenterology2015，，9： | 1 |
| 6 | Coupling plasma plume of a low-power magnetically shielded Hall thruster with a hollow cathode显示文摘The coupling region of a Hall thruster with a hollow cathode is the region between the cathode and the thruster plume.The characteristics of plasma in that region are complicated and strongly associated with the thruster working conditions and the cathode position.In this paper,a laboratory 100 W class magnetically shielded Hall thruster was coupled with a hollow cathode.Optical imaging and electrostatic probe were employed to monitor and scan the plasma plume.Plume characteristics in the coupling region in non-self-sustained mode and self-sustained mode were compared.Evolution of the coupling plume with the cathode position was studied.Experiments show that,when turning the thruster into self-sustained mode or moving the cathode further away axially,the discharge current can be reduced by 6.4–10.6%restraining the electron current and improving ionization.In particular,when the cathode is moved further,the electron conduction near the channel walls is suppressed.The electron current is reduced by 27.4%and the ion beam current is increased by 7%.Overall,this work shows that the working mode of the thruster and the position of the cathode greatly affect the coupling plasma plume.Both play an important role in improving the utilizations of propellant and current. | Guangchuan ZHANG Junxue REN Wei LIANG Ning OUYANG Chao LU Haibin TANG | 2020 | Chinese Journal of Aeronautics2020，33，12： | 1 |
| 7 | Context-dependent responses of food-hoarding to competitors in Apodemus peninsulae:implications for coexistence among asymmetrical species显示文摘Superior species may have distinct advantages over subordinates within asymmetrical interactions among sympatric animals.However,exactly how the subordinate species coexists with superior species is unknown.In the forests west of Beijing City,intense asymmetrical interactions of food competition exist among granivorous rodents(e.g.Apodemus peninsulae,Niviventer confucianus,Sciurotamias davidianus and Tscherskia triton)that have broadly overlapping habitats and diets but have varied body size(range 15-300 g),hoarding habits(scatter vs larder)and/or daily rhythm(diurnal vs nocturnal).The smallest rodent,A.peninsulae,which typically faces high competitive pressure from larger rodents,is an ideal model to explore how subordinate species coexist with superior species.Under semi-natural enclosure conditions,we tested responses of seed-hoarding behavior in A.peninsulae to intraspecific and interspecific competitors in the situations of pre-competition(without competitor),competition(with competitor)and post-competition(competitor removed).The results showed that for A.peninsulae,the intensity of larder-hoarding increased and the intensity of scatter-hoarding declined in the presence of intraspecifics and S.davidianus,whereas A.peninsulae ceased foraging and hoarding in the presence of N.confucianus and T.triton.A.peninsulae reduced intensity of hoarding outside the nest and moved more seeds into the nest for larder-hoarding under competition from intraspecific individuals and S.davidianus.In most cases,the experimental animals could recover to their original state of pre-competition when competitors were removed.These results suggest that subordinate species contextually regulate their food-hoarding strategies according to different competitors,promoting species coexistence among sympatric animals that have asymmetrical food competition. | Hongyu NIU Jie ZHANG Zhiyong WANG Guangchuan HUANG Chao PENG Hongmao ZHANG | 2020 | Integrative Zoology2020，15，2： | 0 |
| 8 | The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions显示文摘The RNA helicase DHX15 is widely expressed in immune cells and traditionally thought to be an RNA splicing factor or a viral RNA sensor.However,the role of DHX15 in NK-cell activities has not been studied thus far.Here,we generated Dhx15-floxed mice and found that conditional deletion of Dhx15 in NK cells(Ncr1CreDhx15fl/fl mice)resulted in a marked reduction in NK cells in the periphery and that the remaining Dhx15-deleted NK cells failed to acquire a mature phenotype.As a result,Dhx15-deleted NK cells exhibited profound defects in their cytolytic functions.We also found that deletion of Dhx15 in NK cells abrogated their responsiveness to IL-15,which was associated with inhibition of IL-2/IL-15Rβ(CD122)expression and IL-15R signaling.The defects in Dhx15-deleted NK cells were rescued by ectopic expression of a constitutively active form of STAT5.Mechanistically,DHX15 did not affect CD122 mRNA splicing and stability in NK cells but instead facilitated the surface expression of CD122,likely through interaction with its 3′UTR,which was dependent on the ATPase domain of DHX15 rather than its splicing domain.Collectively,our data identify a key role for DHX15 in regulating NK-cell activities and provide novel mechanistic insights into how DHX15 regulates the IL-15 signaling pathway in NK cells. | Guangchuan Wang Xiang Xiao Yixuan Wang Xiufeng Chu Yaling Dou Laurie J.Minze Rafik M.Ghobrial Zhiqiang Zhang Xian C.Li | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 9 | Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis(CHESS1904):An international multicenter study显示文摘Aim:To determine the tolerance and acceptance of hepatic venous pressure gradient(HVPG)measurements in patients with liver cirrhosis.Methods:This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG measurement between October 2019 and June 2020.Data related to the tolerance and acceptance of HVPG measurements were collected using descriptive questionnaires.Results:HVPG measurements were technically successful in all 271 patients,with 141(52.0%)undergoing HVPG measurement alone.The complication rate was 0.4%.Postoperative pain was significantly lower than preoperative expected pain(p<0.001)and intraoperative pain(p<0.001),and intraoperative pain was also significantly lower than preoperative expected pain(p=0.036).No,mild,moderate,severe,and intolerable discomfort scores were reported by 36.9%,44.6%,11.1%,6.3%,and 0.4%of these patients,respectively,during HVPG measurement and by 54.6%32.5%,11.4%,1.5%,and 0%,respectively,after HVPG measurement.Of these patients,39.5%had little understanding and 10%had no understanding of the value of HVPG measurement,with 35.1%and 4.1%regarding HVPG measurements as being of little or no help,respectively.Most patients reported that they would definitely(15.5%),probably(46.9%),or possibly(29.9%)choose to undergo additional HVPG measurements again,and 62.7%regarded the cost of the procedure as acceptable.Conclusion:HVPG measurement was safe and well‐tolerated in patients with cirrhosis,but patient education and communication are warranted to improve the acceptance of this procedure. | Jun‐Hui Sun He Zhao Haijun Zhang Lei Li NecatiÖrmeci Zi‐Niu Yu Xun Li Shuangxi Li Xujun Yang Huaping Wei Xiaoliang Zhu Zhengcong Zhang Yajin Wang Zhongwei Zhao Jianting Mao Qiaohong Wu Xiaole Sun Huiling Xiang Kefeng Jia Chao Yang Wei Wu Xiuqing Lin Haixin Yao Changzeng Zuo Jitao Wang Bo Zhang Chunqing Zhang Xiaoling Wu Guangchuan Wang Shengjuan Yao Ruihang Wang Li Zhou Hui Huan Qingli Tu Xue Pu Feng Zhang Qin Yin Linpeng Zhang Ying Guo Jian Wang Kohei Kotani Sawako Uchida‐Kobayashi Norifumi Kawada He Zhu Li Li Wei Wang Guo Zhang Lei Yu Xudong Cui Qingliang Zhu Hailong Zhang Xiaoli Hu Rafael OXimenes Adriano Gonçalves de Araújo Giulliano Gardenghi Yubao Zheng Zebin Wu Mingsheng Huang Xiaoyong Chen Jun Wu Feng Xie Yang Bo Shengjuan Hu Linke Ma Xiao Li Xiaolong Qi | 2022 | Portal Hypertension & Cirrhosis2022，1，1： | 0 |
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