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| 1 | Whole-Genome Sequencing and Analysis of the Chinese Herbal Plant Panax notoginseng显示文摘 | Wei Chen Ling Kui Guanghui Zhang Shusheng Zhu Jing Zhang Xiao Wang Min Yang Huichuan Huang Yixiang Liu Yong Wang Yahe Li Lipin Zeng Wen Wang Xiahong He Yang Dong Shengchao Yang | 2017 | Molecular Plant2017，10，6： | 21 |
| 2 | Direction synthesis in DOA estimation for monostatic multiple input multiple output (MIMO) radar based on synthetic impulse and aperture radar (SIAR) and its performance analysis显示文摘A new direction synthetic method for monostatic multiple input multiple output (MIMO) radar is presented based on synthetic impulse and aperture radar (SIAR) system. Concerned with the monostatic MIMO radar which simultaneously emits orthogonal signals with multi-carrier-frequency and possesses sparsely distributed transmitting and receiving arrays with respective location, as well as the situation for the presence of multipath propagation in the low flying target’s echo, the method integrates the aperture of the transmitting arrays with the receiving arrays to form the digital beam-forming (DBF) in azimuth and elevation dimensions. And a study has been made of planar general MUSIC algorithm based on decorrelating the multipath signals of multi-carrier-frequency MIMO radar. Through compensat-ing the phase delay of both the transmitting and the receiving arrays and synthe-sizing the transmitting beam in two dimensions at the receiver, the angular resolu-tion and measurement accuracy are improved and the computational complexity is reduced after transforming the three-dimensional (3D) parameter estimation prob-lem into a two-dimensional (2D) one. Finally, the Cramer-Rao Bounds (CRBs) of DOA estimation for azimuth and elevation is put forward with the exsiting multipath propagation. Results of computer simulation demonstrate the validity of the new method. | ZHAO GuangHui CHEN BaiXiao ZHU ShouPing | 2008 | Science China(Technological Sciences)2008，51，6： | 9 |
| 3 | Enzyme extraction by ultrasound from sludge flocs显示文摘Enzymes play essential roles in the biological processes of sludge treatment.In this article,the ultrasound method to extract enzymes from sludge flocs was presented.Results showed that using ultrasound method at 20 kHz could extract more types of enzymes than that at 40 kHz and ethylenediamine tetraacetic acid(EDTA) methods.The optimum parameters of ultrasound extraction at 20 kHz were duration of 10 min and intensity of 552 W/g TSS.Under the optimum condition,ultrasound could break the cells and extract both the extracellular and a small part of intercellular enzymes.Ultrasound intensity was apparently more susceptive to enzyme extraction than duration,suggesting that the control of intensity during ultrasound extraction was more important than that of duration.The Pearson correlation analysis between enzyme activities and cation contents revealed that the different types of enzymes had distinct cation binding characteristics. | YU Guanghui,HE Pinjing,SHAO Liming,ZHU Yishu State Key Laboratory of Pollution Control and Resource Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China. | 2009 | Journal of Environmental Sciences2009，21，2： | 8 |
| 4 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 5 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 6 | Using Genome-Referenced Expressed Sequence Tag Assembly to Analyze the Origin and Expression Patterns of Gossypium hirsutum Transcripts显示文摘我们装配了 297,239 Gossypium hirsutum 的一个总数(Gh,一朵 tetraploid 棉花, AADD ) 在公民是可得到的表示顺序标签(EST ) 序列为生物工学信息数据库集中,与最近出版的 G 的参考。raimondii (Gr,一朵双棉花, DD ) 染色体,并且获得了 49,125 UniGenes。UniGenes 的平均长度在当前的分析在二个以前的 EST 集会从 804 和 791 bp 被增加到 1,019 bp。有一些 3kb 或更多的通常认为的棉花 UniGenes 的数字从 25 或 34 ~ 1,223 增加了。作为结果,几千原来独立的 G。hirsutum EST 被排列生产与很长开的读物框架编码抄本的大 contigs,显示 G。raimondii 染色体顺序提供了显著优点装配 tetraploid 棉花 transcriptome。在几以内的重要不同分发模式去包括抄写因素活动,术语在导出 D 、导出 A 的集会之间被观察。当时, Transcriptome 分析证明在一个 tetraploid 棉花房间, 29,547 UniGenes 可能从 D subgenome 被导出另一 19,578 可以来自 A subgenome。最后,一些在里面 silico 数据被聚合酶链反应试验为知道在棉花起关键作用的几个基因家庭在抄本层次显示出变化的反向的抄写证实纤维开发。我们相信我们的工作在棉花为功能、进化的 genomic 研究提供一个有用平台。 | Xiang Jin Qin Li Guanghui Xiao Yu-Xian Zhu | 2013 | Journal of Integrative Plant Biology2013，55，7： | 6 |
| 7 | Single-Nucleotide Resolution Mapping of the Gossypium raimondii Transcriptome Reveals a New Mechanism for Alternative Splicing of Introns显示文摘其他的拼接(作为) 是提高真核细胞的 transcriptomes 的差异的重要基因机制。这里, wegenerated 从棉花(Gossypium raimondii ) 的 8.3 Gb 高质量的定序 RNA 数据并且执行了系统的、比较分析作为事件。我们印射 85%定序 RNA 数据到 referencegenome 上并且鉴别 154368 拼接有 16437 的连接作为在 10197 基因的事件。Intron 保留在 G 作为事件组成了所有的多数(40%) 。raimondii。越过 11 优核质种类的比较是证明 intron 保留是最普通的在更高的植物的类型。Althoughtransposable 元素(TE ) 被发现在仅仅 2.9% 所有 G。raimondii introns,他们在 43% 保留的 introns 是在场的,建议那 TE 插入可以是重要机制 forintron 保留在期间作为。TE 插入的多数被集中 3-splice 地点在上游的 040 nt,分支的分发从比较喜欢的位置削尖的 substantiallyaltering 并且减少由 decreasingRNA 拼接的 intron 的效率第二等的结构灵活性。我们的数据建议 TE-insertion-induced 是在为 intron 保留类型重要的分支点地点 distributionare 变化。我们的调查结果可以帮助在 intron 保留 frequenciesbetween 脊椎动物和更高的 plants.Key 词解释广阔差别: | Qin Li Guanghui Xiao Yu-Xian Zhu | 2014 | Molecular Plant2014，7，5： | 6 |
| 8 | QSPR study about sampling rates of semipermeable membrane devices for monitoring of organochlorine pesticides in Alps air显示文摘Organochlorine pesticides (OCP) were monitored at the Weissfluhjoch site (Switzerland) and the top of Mt. Sonnblick (Austria) with a low volume active air sampler and semipermeable membrane devices (SPMD). The air sampling rates (Rair) of the SPMD for OCP were calculated. Statistical tests showed that there was no significant difference between Rair at the two different sampling sites. Quantitative structure-property relationship (QSPR) models of the Rair of the SPMD were developed for OCP using partial least square (PLS) regression. Quantum chemical descriptors computed by the semi-empirical PM6 method were used as predictor variables. The cumulative variance of the dependent variable explained by the PLS components and determined by cross-validation (Q2cum) was >0.818 for each optimal model. This indicates that the model has good predictive ability and robustness. The Rair of the SPMD for OCP is related to the total energy, the van der Waals area and the total dipole moment of the OCP molecules. The main factors governing Rair values of OCP are intermolecular interactions and the energy required for cavity-formation in dissolution of OCP into triolein of the SPMD. The linear correlation coefficient between predicted and experimental values were all >0.921. | ZHU XiuHua DING GuangHui LEVY Walkiria JAKOBI Gert OFFENTHALER Ivo MOCHE Wolfang WEISS Peter SCHRAMM Karl-Werner | 2011 | Chinese Science Bulletin2011，56，18： | 5 |
| 9 | Migration of Some Elements and Radionuclides across aGranite-Granite Contact Zone: A Natural Analoguefor Safe Disposal of High-Level Radwastes显示文摘Elements and natural radionuclides in the contact zone of two granites with different ages would migrate from one to the other because of the difference in their chemical contents and later water-rock interactions. This migration could serve as an analogue for the near-field process of radwastes in a high-level radwaste deep geological disposal repository.In the contact between the Indosinian granite (whole-rock Rb-Sr isochron age at 214@3 Ma) and Hercynian granite (zircon U-Pb isochron age at 296@31 Ma) located in Ziyuan County, Guangxi, the O and Pb isotope characteristics and the activity ratios of 234U/238U, 230Th/238U, 230Th/234U and 226Ra/230Th show that, based on the whole-rock chemical contents, both of the two granites have maintained a relatively open chemical system in their evolution processes. However, as there is no obvious open fault, the migration of major elements, trace elements and natural U-series nu-clides takes place within only 1-2 m in the contact zone, and water-rock | LUO Xingzhang MIN Maozhong ZHANG Guanghui LI Xianguo YANG Zhe ZHAI Liying Zhu Deling | 1999 | Acta Geologica Sinica(English Edition)1999，73，4： | 4 |
| 10 | Angular-based spatially resolved laser-induced breakdown spectroscopy: a new technique for the effective enhancement of signals without an external time delay system显示文摘In this study, we developed a novel angularbased spatially resolved laser-induced breakdown spectroscopy(ABSR-LIBS) technique. This new method allows the spatially resolved spectroscopic properties of laserinduced plasma to be investigated using different angles and polar distances with a spatially adjustable fiber optics probe. The experimental evaluations suggested that the intensity of the Al signal distributions in the ‘‘side-view''depended greatly on the angle of the collection probe. The location of a collection probe at 50° would facilitate efficient spectral collection and minimize the disturbance of the plasma plume. The spectral signals in the plasma emissions had different distribution at various polar distances using the same collection angle, and the highest signal intensity was observed between 15 and 35 mm polar distances. This ABSR-LIBS technique improved both the LIBS signal and the maximum emission intensity of Al atoms by several times at the best spatial position in our experimental conditions. Furthermore, we successfully obtained well-resolved line emission spectroscopy signals without any external time delay using a nongated spectrometer based on the ABSR-LIBS system. We consider that the ABSR-LIBS technique has great potential for obtaining new insights with laser-induced plasma instruments and it could facilitate the development of a low-cost instrument. | Qingyu Lin Xu Wang Guanghui Niu Hongjun Lai Xiaoqin Zhu Kunping Liu Tao Xu Yixiang Duan | 2014 | Chinese Science Bulletin2014，59，27： | 3 |
| 11 | A brief review of forensically important flesh flies (Diptera: Sarcophagidae)显示文摘Forensic entomology could provide valuable data for the minimum postmortem interval (PMImin) estimation and other relevant information,such as causes and circumstances of death.Some representatives of flesh flies are one of the dominant necrophagous insects during early stages of decomposition,demonstrating unique biological characteristics compared with other necrophagous flies.Moreover,they lead to global health concerns as carriers of various pathogenic micro-organisms,and dominantly result in the traumatic myiasis.Thus,sarcophagid flies are considered important in decomposition processes for PMImin estimation.However,the utility of sarcophagid flies has been seriously hampered by limited ecological,biological and taxonomic knowledge of them.The aim of this paper is to provide a brief review on the species,distribution and biological habit of forensically important sarcophagid flies.In addition,the relation between traumatic myiasis and flesh flies,molecular identification methods and developmental pattern of flesh flies are summarized. | Lipin Ren Yanjie Shang Wei Chen Fanming Meng Jifeng Cai Guanghui Zhu Lushi Chen Yong Wang Jianqiang Deng Yadong Guo | 2018 | Forensic Sciences Research2018，3，1： | 3 |
| 12 | Importers Drive Leaf-to-Leaf Jasmonic Acid Transmission in Wound-Induced Systemic Immunity显示文摘The transmission of mobile wound signals along the phloem pathway is essential to the activation of wound-induced systemic response/resistance,which requires an upsurge of jasmonic acid(JA)in the distal undamaged leaves.Among these mobile signals,the electrical signal mediated by the glutamate-dependent activation of several clade three GLUTAMATE RECEPTOR-LIKE(GLR3)proteins is involved in the stimulation of JA production in distal leaves.However,whether JA acts as a mobile wound signal and,if so,how it is transmitted and interacts with the electrical signal remain unclear.Here,we show that JA was translocated from the local to distal leaves in Arabidopsis,and this process was predominantly regulated by two phloem-expressed and plasma membrane-localized jasmonate transporters,AtJAT3 and AtJAT4.In addition to the cooperation between AtJAT3/4 and GLR3.3 in the regulation of long-distance JA translocation,our findings indicate that importer-mediated cell-cell JA transport is important for driving the loading and translocation of JA in the phloem pathway in a self-propagating manner. | Mengya Li Feifei Wang Shuangzhang Li Guanghui Yu Lijian Wang Qingqing Li Xiangyu Zhu Zhen Li Lixing Yuan Pei Liu | 2020 | Molecular Plant2020，13，10： | 3 |
| 13 | NEW FIXED POINT THEOREMS OF CONDENSING MAPPINGS SATISFYING THE INTERIOR CONDITION IN BANACH SPACES显示文摘In this paper, based on a basic result on condensing mappings satisfying the interior condition, some new fixed point theorems of the condensing mappings of this kind are obtained. As a result, the famous Altman’s theorem, Roth’s theorem and Petryshyn’s theorem are extended to condensing mappings satisfying the interior condition. | Shaoyuan Xu Chongjun Zhu Guanghui Zhou | 2010 | Analysis in Theory and Applications2010，26，1： | 3 |
| 14 | Retinoic acid can improve autophagy through depression of the PI3K-Akt-mTOR signaling pathway via RARαto restore spermatogenesis in cryptorchid infertile rats显示文摘Cryptorchidism-caused adult infertility is a common component of idiopathic reasons for male infertility.Retinoic acid(RA)has a vital effect on the spermatogenesis process.Here,we found that the expression of c-Kit,Stra8,and Sycp3 could be up-regulated via the activation of retinoic acid receptorα(RARα)after RA supplementation in neonatal cryptorchid infertile rats.We also demonstrated that the protein expression of PI3K,p-Akt/pan-Akt,and p-mTOR/mTOR was higher in cryptorchid than in normal testes,and could be suppressed with RA in vivo.After RA treatment in infertile cryptorchid testis in vivo,the levels of the autophagy proteins LC3 and Beclin1 increased and those of P62 decreased.Biotin tracer indicated that the permeability of blood-testis barrier(BTB)in cryptorchid rats decreased after RA administration.Additionally,after blocking the RARαwith AR7(an RARαantagonist)in testicle culture in vitro,we observed that compared with normal testes,the PI3K-Akt-mTOR signaling pathway and the autophagy pathway was increased and decreased,respectively,which were coincident with cryptorchisd testes in vivo.Additionally,the appropriate concentrations of RA treatment could depress the PI3K-Akt-mTOR signaling pathway and improve the autophagy pathway.The results confirmed that RA can rehabilitate BTB function and drive key protein levels in spermatogonial differentiation through depressing the PI3K-Akt-mTOR signaling pathway via RARα. | Chunlan Long Yu Zhou Lianju Shen Yihang Yu Dong Hu Xing Liu Tao Lin Dawei He Tao Xu Deying Zhang Jing Zhu Guanghui Wei | 2022 | Genes & Diseases2022，9，5： | 2 |
| 15 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
| 16 | Even-odd-dependent optical transitions of zigzag monolayer black phosphorus nanoribbons显示文摘We analytically study the electronic structure and optical properties of zigzag-edged phosphorene nanoribbons(ZPNRs) using the tight-binding Hamiltonian and Kubo formula. By directly solving the discrete Schrodinger equation, we obtain the energy spectra and wavefunctions for N-ZPNR(where N is the number of transverse zigzag atomic chains) and classify the eigenstates according to the lattice symmetry. Then, we obtain the optical transition selection rule of ZPNRs on the basis of symmetry analysis and analytical expressions of optical transition matrix elements. Under incident light that is linearly polarized along the ribbon, we determine that the optical transition selection rule for N-ZPNR with even-or odd-N is qualitatively different. Specifically, for even-N ZPNRs, the inter-(intra-) band selection rule is ?n =odd(even) because the parity of the wavefunction corresponding to the n-th subband in the conduction(valence) band is(-1)~n[(-1)~((n+1))] owing to the presence of C(2x) symmetry. However, the optical transitions between any subbands are possible owing to the absence of C(2x) symmetry. Our results provide a further understanding on the electronic states and optical properties of ZPNRs, which are useful for explaining the optical experiment data on ZPNR samples. | Pu Liu XianZhe Zhu XiaoYing Zhou GuangHui Zhou Kai Chang | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，1： | 1 |
| 17 | Different analysis techniques for fluorescence exeitation-emission matrix spectroscopy to assess compost maturity 显示文摘 | TANG Zhu YU Guanghui LIU Dongyang | 2011 | Chemosphere2011，82，8： | 1 |
| 18 | Major trends in human parasitic diseases in China显示文摘 | Ting Li Shenyi He Hong Zhao Guanghui Zhao Xing-Quan Zhu | 2010 | Trends in Parasitology2010，，5： | 1 |
| 19 | Changes in biochemical and microbiological parameters during the period of rapid composting of dairy manure with rice chaff显示文摘 | Dongyang Liu Ruifu Zhang Hongsheng Wu Dabing Xu Zhu Tang Guanghui Yu Zhihui Xu Qirong Shen | 2011 | Bioresource Technology2011，，19： | 1 |
| 20 | Mercury and other metal and metalloid soil contamination near a Pb/Zn smelter in east Hunan province, China显示文摘 | Zhonggen Li Xinbin Feng Guanghui Li Xiangyang Bi Guangyi Sun Jianming Zhu Haibo Qin Jianxu Wang | 2010 | Applied Geochemistry2010，，2： | 1 |
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