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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Deformation Behavior of Medium-strength TA18 High-pressure Tubes During NC Bending with Different Bending Radii显示文摘To improve the forming quality and forming limit of the numerical control (NC) bending of high-pressure titanium alloy tubes, in this study, using three-dimensional (3D) finite element method, deformation behavior of medium-strength TA18 high-pressure tubes during NC bending with different bending radii is investigated. The results show that the cross-sectional deformation and the wall thickness variation during NC bending of TA18 tubes using a small bending radius (less than 2 times of tube outside diameter) are clearly different from that using a normal bending radius (between 2 and 4 times of tube outside diameter). For bending with a normal bending radius, with or without a mandrel, the distribution of the flattening in the bending area resembles a platform and an asymmetric parabola, respectively. For bending with a small bending radius, with or without a mandrel, the flattening both distributes like a parabola, but the former has a stable peak which deflects toward the initial bending section, and the latter has a more pronounced peak with a bending angle and deflects slightly toward the bending section. The wall thickness variations with a normal bending radius, with and without a mandrel, both resemble a platform when the bending angle exceeds a certain angle. For the bending with a small radius, the distribution of the wall thickness variation without a mandrel follows an approximate parabola which increases in value as the bending angle increases. If a mandrel is used, the thickening ratio increases from the initial bending section to the bending section. | JIANG Zhiqiang ZHAN Mei YANG He XU Xudong LI Guangjun | 2011 | Chinese Journal of Aeronautics2011，24，5： | 16 |
| 3 | Numerically controlled bending performance of medium strength TA18 titanium alloy tubes under different die sets显示文摘The rapid development of aviation and aerospace technologies has led to increased interest in the application of numerically controlled(NC) technology for bending light-weight titanium alloy tubes.In order to study and develop advanced NC bending technology,it is necessary to understand the bending performance of medium strength TA18(Ti-3Al-2.5V,ASTM Gr.9) titanium alloy tubes during NC bending under different die sets.This paper focuses on the bending performance of medium strength TA18 tubes under different NC bending die sets,including the variations in the stress,strain,wall thickness,cross sectional deformation,and defects.The results show that adding a wiper die to the base die set decreases the radial,hoop,and tangential compressive stress and the tangential compressive strain,and adding a mandrel to the base die set also decreases these stresses,but increases the radial and hoop tensile stress and decreases the hoop compressive strain obviously,and brings about a three-dimensional tensile stress concentration where the mandrel provides support.For the NC bending of medium strength TA18 tubes,the flattening of cross section is more sensitive index than the thinning of wall thickness.Introducing a mandrel can improve the flattening of cross section obviously but it has a little worse effect on the thinning of wall thickness,and adding a wiper die to the base die set can inhibit the occurrence of the inside bulge but worsen the flattening of the cross section remarkably.Considering the above effects of the mandrel and wiper die on bending performance,it is reasonable to apply the die set comprising a bending die,clamp die,and pressure die for tubes with a small diameter and the die set including an appropriate mandrel additionally for tubes with a larger diameter,in order to bend the medium strength TA18 tubes with high quality and at low cost. | ZHAN Mei JIANG ZhiQiang YANG He XU XuDong LI GuangJun | 2011 | Science China(Technological Sciences)2011，54，4： | 13 |
| 4 | A novel approach to design microwave medium of negative refractive index and simulation verification显示文摘In this paper, a novel approach is presented to synthesize microwave medium of negative refractive index by incorporating metallic wire array with negative effective permittivity into the host media such as ferrimagnet-YIG (yttrium iron garnet) applied by external magnetic field whose permeability is negative. We have designed the composite medium having negative refractive index in C/X band frequencies, analyzed and simulated its electromagnetic (EM) properties by use of EM EDA package based on time-domain finite integration method. The simulation results show that: ① the effective permittivity of the designed metallic wire array is negative in the frequency range from 7.02 GHz to 9.80 GHz; ② the permeability of YIG substrate immersed into an external magnetic field is negative in the frequency range from 5.22 GHz to 8.14 GHz; ③ EM wave can pass through the composite medium synthesized by the above designed metallic wire array and YIG substrate, and ④ the negative refraction behavior occurs on the interface between the composite medium and the normal material with positive refractive index in 7.51―8.13 GHz frequency range, in which the effective permittivity of the metallic wire array and the permeability of YIG substrate are negative simultaneously. The full wave simulation has demonstrated that the effective refractive index of the designed composite medium is indeed negative and ascertained that the proposed approach to design microwave medium with negative refractive index is viable. | CAO YunJian WEN GuangJun WU KaiMin XU XinHe | 2007 | Chinese Science Bulletin2007，52，4： | 6 |
| 5 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 6 | Effects of freeze-drying and spray drying processes on functional properties of phosphorylation of egg white protein显示文摘Egg white protein(EWP)was phosphorylated with Sodium Tripolyphosphate(STP)at pH 4.5.Freeze drying and spray drying were used for drying purpose and the effects of these drying methods on the functional properties were investigated.The functional properties of native and modified proteins were also determined.The results demonstrated that phosphorylation of EWP markedly improved its functional properties,and that it was more effective for the food industry.The freeze-dried STP-EWP powders were superior in terms of solubility,emulsion stability,water holding capacity,oil and water absorption capacity and heat gel strength than spray-dried STP-EWP powders.The results in viscosity showed no significant differences between freeze-dried and spray dried.The spray-dried powders were better in terms of foaming ability and foam stability than freeze-dried powders.However,the spray drying required the longest time to produce.Freeze drying was found to be the best method in terms of production of modified EWP powders with superior functional properties. | Liu Lili Wang Huan Ren Guangyue Duan Xu Li Dan Yin Guangjun | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 6 |
| 7 | Sub-Wavelength Virtual Imaging Using a Pair of 2-D L Loaded and C Loaded Transmission-Line Metamaterial Slabs显示文摘 | XU Xinhe WEN Guangjun GAN Yuehong | 2008 | Chinese Journal of Electronics2008，17，3： | 4 |
| 8 | The recent progress of wide bandgap donor polymers towards non-fullerene organic solar cells显示文摘This review summarized the recent progress of highly efficient wide bandgap(WBG) donor polymers and their applications in non-fullerene polymer solar cells(NF-PSCs). A brief introduction of the background of WBG donor polymer developments was given. Then the research progress of the reported WBG donor polymers by classification of D-type and DààA type molecular backbones was reviewed. The resulting structure-property correlations of the WBG donor polymers were also discussed to highlight the importance of chemical modifications, which have promoted the great progress of NF-PSC field. Finally,an outlook for future innovations of WBG donor polymers and their NF-PSCs was provided. | Xiaopeng Xu Guangjun Zhang Ying Li Qiang Peng | 2019 | Chinese Chemical Letters2019，30，4： | 4 |
| 9 | Direct self-assembly of CTAB-capped Au nanotriangles显示文摘浓密地收拾行李并且命令 suprastructures 是展出宽广应用的 nanomaterials 的新类型。cetyltrimethylammonium 溴化物(CTAB ) 直接自己组装形成 suprastructures 的盖住的金 nanotriangles 被改变温度系统地调查并且倾斜在汇编进程使用的硅晶片的角度。在最佳的条件下面, nanotriangles 变成常规模式,维持他们的正直,并且形成 edge-to-edge,点对点,并且在几百方形的微米的一个区域以内形成订的 suprastructures 的面对面连接,完成整齐的高水平。在最佳的条件下面的 suprastructures 的形成能主要被归因于在多重温度依赖者因素之间的复杂平衡,包括原子散开率,溶剂蒸发率,自己组装率,和 nanoparticle 呆在湿媒介的时间。 | Qiang Fu Guangjun Ran Weilin Xu | 2016 | Nano Research2016，9，11： | 3 |
| 10 | Design of Wireless Energy-Harvested UHF WSN Tag for Cellular IoT显示文摘In this paper,a wireless energy-harvested ultra-high frequency(UHF)wireless sensor network(WSN)tag is designed and implemented for cellular Io T applications.The WSN tag is made up of a wireless energy harvesting circuit,a temperature sensing circuit,and a radio frequency identification(RFID)tag.The developed WSN tag is compatible with the ISO/IEC18000-6C protocol.The WSN tag can receive the GSM RF energy operating in China GSM900 and GSM1800 bands in the surrounding environment and the solar energy,then converts the RF energy to direct current(DC)by schottky diode-based rectifying circuit,and finally stores the DC energy in a supercapacitor through a DC-DC booster circuit.The DC-DC booster circuit drives the front-end circuit,TI MSP430 microcontroller,temperature sensing circuit,and other active circuits in the tag.The MSP430 works in low-power mode when it is powered up,and it can also reduce power consumption more by reducing main clock(MCLK)frequency according to different forward link rates.The implemented WSN tag demonstrated that the RF-to-DC conversion efficiency is higher than 39% when the receiving 900 MHz RF signal power is from -14 dBm to 0 dBm and could make the tag work normally.The signal receiving sensitivity of the WSN tag is up to-32 dBm at the rate of 40 kbit/s from the Reader to the WSN tag.The WSN tag supports Miller coding and extended Miller coding.This wireless energy harvested UHF WSN tag,compared with conventional UHF passive tags and battery-powered active UHF RFID Tags,has many advantages,such as far communication distance,long service life,and sensing functionality.It will have wide applications in the Internet of Things(IoT). | LI Gang XU Rui LI Zhenbing ZHOU Jie LI Jian WEN Guangjun | 2018 | ZTE Communications2018，16，1： | 2 |
| 11 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 12 | Circ_ASPH promotes cholangiocarcinoma growth and metastasis through the miR-581/ATP-binding cassette transporter G1 signaling pathway显示文摘Dear Editor,Cholangiocarcinoma(CCA)is an aggressive malignant tumor of the hepatobiliary system,mainly originating from the cholangiocytes of small intrahepatic bile ducts[1].The overall survival of patients with CCA is still unfavorable[1].Circular RNAs(circRNAs)are a type of non-coding RNAs with limited protein-coding capacity[2]and have shown to exert regulatory effects in multiple diseases by interacting with certain miRNAs to inhibit their expression and functions[3].Emerging evidence indicates that circRNAs can directly bind to several RNA-binding proteins to execute their biological functions.Hence,determining the mechanisms underlying the progression of CCA and searching for new drugs from the perspective of circRNAs are imperative. | Yi Xu Pengcheng Kang Kaiming Leng Yue Yao Guanqun Liao Yi Han Guangjun Shi Xiangyu Zhong Yunfu Cui | 2020 | Cancer Communications2020，40，10： | 1 |
| 13 | Comments on subwavelength focusing using a negative-refractive-index transmission line显示文摘 | Xu Xinhe Wen Guangjun Gan Yuehong | 2007 | IEEE Antennas and Wireless Propagation Letters2007，6，： | 1 |
| 14 | Cu(Ⅱ)and Ni(Ⅱ)-1,10-phenanthroline-5,6-dione-amino acidternary complexes exhibiting pH-sensitive redox properties显示文摘 | Xu Guangjun Kou Yingying Yan Shiping | 2006 | Appl Organometal Chem2006，20，： | 1 |
| 15 | Analytical methods for nano-bio interface interactions显示文摘Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level. | Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie | 2016 | Science China Chemistry2016，59，11： | 1 |
| 16 | Colon hydrotherapy plus Traditional Chinese Medicine to treat non-alcoholic fatty liver disease:a pilot study显示文摘OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD. | Xiao Huanming Jiang Junmin Xie Yubao Shi Meijie Tian Guangjun Zhao Pengtao Zhang Chaozhen Chen Huijun Xu Chanyuan Chi Xiaoling | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 1 |
| 17 | Growth of epitaxial substrate Gd3Ga5O12(GGG) single crystal through pure GGG phase polycrystalline material 显示文摘 | Guangjun Zhao Tao Li Jun Xu | 2002 | Journal of Crystal Growth2002，，： | 1 |
| 18 | Comments on Subwavelength Focusing Using a Negative - Refractive - Index Transmission Line显示文摘 | Xu Xinhe Wen Guangjun | 2007 | IEEE Antennas and Wireless Propagation Letters2007，，6： | 1 |
| 19 | Comments on subwavelength focusing using a negative-refractiveindex transmission line显示文摘 | XU Xinhe WEN Guangjun | 2007 | IEEE Antennas and Wireless Propagation Letters2007，6，： | 1 |
| 20 | Photoluminescence characteristics of ZnS nanocrystallites co-doped with Co 2+ and Cu 2+显示文摘 | Ping Yang Mengkai Lü Guangjun Zhou DuoRong Yuan Dong Xu | 2001 | Inorganic Chemistry Communications2001，，12： | 1 |
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