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| 1 | Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly显示文摘Dear Editor,The African swine fever(ASF)is a highly contagious hemorrhagic and lethal disease in domestic pigs.The ASF outbreaks of in many Asia countries,including China,Vietnam,Mongolia,and South Korea,have posed a huge threat to the pig indusry.In the attempt to stop ASF from spreading further in China's Mainland,more than 10 million pigs have been culled since August 2018.The causative agent for ASF is a DNA virus,African swine fever virus(ASFV).Although this deadly disease has been reported in Kenya nearly one hundred years ago,there has been no vaccine for protection from ASFV infection or effective treatments to cure ASF until now. | Guobang Li Dan Fu Guangshun Zhang Dongming Zhao Mingyu Li Xue Geng Dongdong Sun Yuhui Wang Cheng Chen Peng Jiao Lin Cao Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 2 | Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding显示文摘Dear Editor, African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approaching 90%-100%.The first ASF case was described in 1921 in Kenya.Over the past decades, ASF has spread from Sub-Saharan Africa to Europe and Asia, and pose a huge threat to global food safety.Since the first ASF case reported in August 2018, more than 10 million pigs had been culled in China at an enormous economic loss.The risk of ASFV mutating to infect humans is extremely low.However, ASF not only threatens food security but also severely strikes the world economy in many fields, such as the global supply of the blood thinner heparin,most of which is produced from pigs.Hence, ASF is a strictly monitored infectious animal disease by OIE (World Organization for Animal Health), unfortunately, there is no approved drug or vaccine against this lethal viral disease. | Dan Fu Dongming Zhao Wei Zhang Guangshun Zhang Mingyu Li Zheng Zhang Yuhui Wang Dongdong Sun Peng Jiao Cheng Chen Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 3 | Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2显示文摘Dear Editor,Lassa virus(LASV)belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups-Old World(OW)and New World(NW)-based on virus genetics,serology,antigenic properties and geographical relationships.The OW LASV and Lujo virus(LUJV),as well as NW Jurn'n virus(JUNV),Machupo virus(MACV),Guanarito virus(GTOV),Sabia virus(SABV)and Chapare virus(CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4(BSL-4)agents.The arenavirus glycoprotein complex(GPC)contains three subunits-the retained stable-signal peptide(SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2(Lenz et al.,2001).Notably,the proximate external membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors(Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).Among these inhibitors,ST-161 is LASV specific(Burgeson et al.,2013a).In this study,we conducted structure-activity relationship(SAR)optimization of ST-161.As a result,21 derivatives with IC50 values<1 pmol/L are presented in Table S1.Hit compounds 21,29 and 57 exhibiting robust inhibition of the LASV pseudotype virus(LASVpv,VSV backbone enveloped by LASV GPC with single cycle infection)entry with IC50 values lower than 0.2 nmol/L(Figs.1A and S1),as well as hit compound 72 with an ester bond instead of acylhydrazone,were further investigated.To test whether the four hit compounds inhibit LASV entry by blocking the GPC-mediated membrane fusion,the inhibition effects of these compounds against LASV GPC mediated fusion were quantitatively determined by dual-luciferase assay(Thomas et al.,2011;Wang et al.,2018). | Guangshun Zhang Junyuan Cao Yan Cai Yang Liu Yanli Li Peilin Wang Xiaoying Jia Mengmeng Zhang Gengfu Xiao Yu Guo Wei Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 4 | A comparison of food habits and prey preferences of Amur tiger(Panthera tigris altaica)at the southwest Primorskii Krai in Russia and Hunchun in China显示文摘A small,isolated Amur tiger population ranges across the southwest Primorskii Krai region in Russia and Hunchun region in China.Many individuals,with“dual nationality,”cross the border frequently.Formulating effective conservation strategies requires a clear understanding of tiger food requirements in both countries.While the diets of tigers ranging in Russia is clearly understood,little is known of the tigers’feeding habits in China..We used scat analysis combined with data on the abundance of 4 prey species to examine Amur tiger diet and prey preferences in Hunchun.We examined 53 tiger scat samples from 2011 to 2016 and found that tigers preyed on 12 species(11 species in winter),4 of which were domestic animals with 33.58%biomass contribution;this was the first record of Amur tigers eating lynx in this area.Tigers showed a strong preference for wild boar(Jacobs index:+0.849),which were also the most frequently consumed prey,and a strong avoidance of roe deer(Jacobs index:–0.693).On the Russian side,domestic animals(just dog)were rarely found in tiger scat,and tigers did not show strong avoidance of roe deer,but of sika deer.We also found red deer footprints during winter surveys and that tigers ate red deer on the Chinese side,while there was no record of red deer feeding on the Russian side.Reducing or eliminating human disturbance,such as grazing,is essential to recovering tiger prey and habitat in this area and the Sino–Russian joint ungulate annual survey is indispensable for prey estimates of this small,isolated Amur tiger population. | Jiayin GU Lan YU Yan HUA Yao NING Bao HENG Jinzhe QI Zexv LONG Mingyuan YAO Chong HUANG Zhilin LI Jianming LANG Guangshun JIANG Jianzhang MA | 2018 | Integrative Zoology2018，13，5： | 1 |
| 5 | Climate warming increases biodiversity of small rodents by favoring rare or less abundant species in a grassland ecosystem显示文摘Our Earth is facing the challenge of accelerating climate change,which imposes a great threat to biodiversity.Many published studies suggest that climate warming may cause a dramatic decline in biodiversity,especially in colder and drier regions.In this study,we investigated the effects of temperature,precipitation and a normalized difference vegetation index on biodiversity indices of rodent communities in the current or previous year for both detrended and nondetrended data in semi-arid grassland of Inner Mongolia during 1982-2006.Our results demonstrate that temperature showed predominantly positive effects on the biodiversity of small rodents;precipitation showed both positive and negative effects;a normalized difference vegetation index showed positive effects;and cross-correlation function values between rodent abundance and temperature were negatively correlated with rodent abundance.Our results suggest that recent climate warming increased the biodiversity of small rodents by providing more benefits to population growth of rare or less abundant species than that of more abundant species in Inner Mongolia grassland,which does not support the popular view that global warming would decrease biodiversity in colder and drier regions.We hypothesized that higher temperatures might benefit rare or less abundant species(with smaller populations and more folivorous diets)by reducing the probability of local extinction and/or by increasing herbaceous food resources. | Guangshun JIANG Jun LIU Lei XU Guirui YU Honglin HE Zhibin ZHANG | 2013 | Integrative Zoology2013，8，2： | 1 |
| 6 | Study on Superheavy Nuclide 271Ds显示文摘 | Zhang Zhiyuan Gan Zaiguo Ma Long Huang Minghui Huang Tianheng Wu Xiaolei Jia Guobin Li Guangshun Yu Lin Ren Zhongzhou Zhou Shangui Zhang Yuhu Zhou Xiaohong Xu Hushan Zhang Huanqiao Xiao Guoqing Zhan Wenlong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 7 | An Efficient and Secure Aggregation Encryption Scheme in Edge Computing显示文摘Edge computing is a highly virtualized paradigm that can services the Internet of Things(Io T)devices more efficiently.It is a non-trivial extension of cloud computing,which can not only meet the big data processing requirements of cloud computing,but also collect and analyze distributed data.However,it inherits many security and privacy challenges of cloud computing,such as:authentication and access control.To address these problem,we proposed a new efficient privacy-preserving aggregation scheme for edge computing.Our scheme consists of two steps.First,we divided the data of the end users with the Simulated Annealing Module Partition(SAMP)algorithm.And then,the end sensors and edge nodes performed respectively differential aggregation mechanism with the Differential Aggregation Encryption(DAE)algorithm which can make noise interference and encryption algorithm with trusted authority(TA).Experiment results show that the DAE can preserve user privacy,and has significantly less computation and communication overhead than existing approaches. | Junhua Wu Xiaofei Sheng Guangshun Li Kan Yu Junke Liu | 2022 | China Communications2022，19，3： | 0 |
| 8 | Packet Scheduling in Rechargeable Wireless Sensor Networks under SINR Model显示文摘Two packet scheduling algorithms for rechargeable sensor networks are proposed based on the signal to interference plus noise ratio model.They allocate different transmission slots to conflicting packets and overcome the challenges caused by the fact that the channel state changes quickly and is uncontrollable.The first algorithm proposes a prioritybased framework for packet scheduling in rechargeable sensor networks.Every packet is assigned a priority related to the transmission delay and the remaining energy of rechargeable batteries,and the packets with higher priority are scheduled first.The second algorithm mainly focuses on the energy efficiency of batteries.The priorities are related to the transmission distance of packets,and the packets with short transmission distance are scheduled first.The sensors are equipped with low-capacity rechargeable batteries,and the harvest-store-use model is used.We consider imperfect batteries.That is,the battery capacity is limited,and battery energy leaks over time.The energy harvesting rate,energy retention rate and transmission power are known.Extensive simulation results indicate that the battery capacity has little effect on the packet scheduling delay.Therefore,the algorithms proposed in this paper are very suitable for wireless sensor networks with low-capacity batteries. | Baogui Huang Jiguo Yu Chunmei Ma Guangshun Li Anming Dong | 2023 | China Communications2023，20，3： | 0 |
| 9 | Development of the electric automatic steering system for agricultural vehicles显示文摘Automatic guidance of agricultural vehicles requires automatic execution of operation commands received from the navigation controller by using electronically controlled mechanisms for wheel steering,speed changing and work implementing.Automatic steering contributes as a prerequisite technique in automatic and semi-automatic agricultural navigation.This research aimed to develop an electric automatic steering system that was compact in its structure and integrated into original steering mechanism in a simply and convenient way for aftermarket modification.A brushless motor and reducer assembly was utilized to provide an adequate steering torque instead of manual maneuver.A rapid assembling approach was proposed by passing the steering shaft through the hollow output shaft.A digital proportional-integral-differential(PID)algorithm was implemented to calculate the rotation speeds and directions by comparing the desired angle and the actual angle,which was implemented in a printed circuit board with a microcontroller unit(MCU)and interface chips.An unmanned wheeled tractor was applied as test platform to integrate the newly developed electric automatic steering system.Tests were conducted to evaluate its performance in terms of stability and responsiveness.An autonomous navigation system guided the tractor along target paths in the field by sending steering commands to the electric automatic steering system.The results show that the steering angle error was less than 0.81°when desired steering angle was less than 10°.The lateral error difference was no more than 4.76 cm when repeating following the same target path,which indicated that the electric automatic steering system responded accurately and robustly to steering commands. | Guangshun An Chong Yu Juan Du Xiang Yin Youliang Ni Chengqian Jin | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
| 10 | A highly selective and sensitive upconversion nanoprobe for monitoring hydroxyl radicals in living cells and the liver显示文摘Excessive reactive oxygen species(ROS)would attack living cells and cause a series of oxidative stress related diseases,such as liver damage.Hydroxyl radicals(·OH)are currently known as one of the most toxic and harmful free radicals to organisms.Therefore,studies involving hydroxyl radicals have become important research topics in the fields of biology,biochemistry,and biomedicine.In addition,imaging of analytes using upconversion nanoparticles(UCNPs)possesses significant advantages over that using general fluorescent dyes or nanoparticles due to its high spatial resolution,reduced photodamage,and deep tissue penetration properties.Herein,we designed a highly selective and sensitive hydroxyl radical nanoprobe based on the luminescence resonance energy transfer between upconversion nanoparticles and methylene blue(MB).The concentration of·OH could be determined by the fluorescence recovery of the UCNPs due to the oxidative damage of MB.Using this nanoprobe,the·OH in living cells or in liver tissues could be monitored with high sensitivity and selectivity. | Guangshun Yu Na Feng Dan Zhao Hao Wang Yi Jin Dandan Liu Zhenhua Li Xinjian Yang Kun Ge Jinchao Zhang | 2021 | Science China(Life Sciences)2021，64，3： | 0 |
| 11 | 2-3 Lifetime Measurement of the First 7/2^+State in 143Eu Based on Gas-flled Spectroscopy显示文摘The application of Lanthanum Bromide(LaBr3)detectors provides a unique opportunity to measure lifetime of excited states in picosecond-nanosecond region.Reducing the background is of critical importance to get precise results.For some excited states feeding from isomers with lifetime longer than 1μs,it can be achieved by the Spectrometer for Heavy Atom and Nuclear Structure(SHANS)[1].143Eu nuclei were populated via the 123Sb(24Mg,4n)fusion-evaporation reaction.Most of the evaporation residues at ground state or long-lived isomers were transferred to detection terminal after a flight of about 1.4μs in SHANS.In the case of 143Eu,three transitions have been observed(Fig.1). | Guo Song Wang Kailong Liu Minliang Zheng Yong Zhou Xiaohong Wang Jianguo Qiang Yunhua Zhang Yuhu Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Ding Bing Jiang Jian Fang Yongde Li Guangshun Zheng Kuankuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 12 | A Distributed Power Trading Scheme Based on Blockchain and Artificial Intelligence in Smart Grids显示文摘As an emerging hot technology,smart grids(SGs)are being employed in many fields,such as smart homes and smart cities.Moreover,the application of artificial intelligence(AI)in SGs has promoted the development of the power industry.However,as users’demands for electricity increase,traditional centralized power trading is unable to well meet the user demands and an increasing number of small distributed generators are being employed in trading activities.This not only leads to numerous security risks for the trading data but also has a negative impact on the cost of power generation,electrical security,and other aspects.Accordingly,this study proposes a distributed power trading scheme based on blockchain and AI.To protect the legitimate rights and interests of consumers and producers,credibility is used as an indicator to restrict untrustworthy behavior.Simultaneously,the reliability and communication capabilities of nodes are considered in block verification to improve the transaction confirmation efficiency,and a weighted communication tree construction algorithm is designed to achieve superior data forwarding.Finally,AI sensors are set up in power equipment to detect electricity generation and transmission,which alert users when security hazards occur,such as thunderstorms or typhoons.The experimental results show that the proposed scheme can not only improve the trading security but also reduce system communication delays. | Yue Yu Junhua Wu Guangshun Li Wangang Wang | 2023 | Intelligent Automation & Soft Computing2023，，7： | 0 |
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