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| 1 | Olfactory ensheathing cell transplantation improves sympathetic skin responses in chronic spinal cord injury显示文摘Forty-three patients with chronic spinal cord injury for over 6 months were transplanted with embryonic olfactory ensheathing cells, 2–4 × 106, into multiple sites in the injured area under the surgical microscope. The sympathetic skin response in patients was measured with an electromyography/evoked potential instrument 1 day before transplantation and 3–8 weeks after transplantation.Spinal nerve function of patients was assessed using the American Spinal Injury Association impairment scale. The sympathetic skin response was elicited in 32 cases before olfactory ensheathing cell transplantation, while it was observed in 34 cases after transplantation. Concomitantly,sympathetic skin response latency decreased significantly and amplitude increased significantly after transplantation. Transplantation of olfactory ensheathing cells also improved American Spinal Injury Association scores for movement, pain and light touch. Our findings indicate that olfactory ensheathing cell transplantation improves motor, sensory and autonomic nerve functions in patients with chronic spinal cord injury. | Zuncheng Zheng Guifeng Liu Yuexia Chen Shugang Wei | 2013 | Neural Regeneration Research2013，8，30： | 6 |
| 2 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 3 | Genetic variation and selection of introduced provenances of Siberian Pine(Pinus sibirica) in frigid regions of the Greater Xing'an Range,Northeast China显示文摘Siberian Pine(Pinus sibirica) is an ecologically and economically important species in pristine forests throughout northern Russia. Four provenances of P. sibirica were introduced from Mongolia and Russia to the Greater Xing'an Range(the Daxing'anling), northeast China in 1993. The aim of this research was to study genetic variation and selection of the introduced four Pinus sibirica provenances. Heights(H), basal diameters(BD), survival rates(SR) and crown lengths(CL) of different families were measured as primary outcomes in different growth years. Results of data analyses demonstrated high coefficients of phenotypic variation(PCV) and heritability(H2) for H, BD and CL at 18 years after introduction. PCV and H2 increased with age. Correlations of growth traits between any two growth years were all significantly positive, but the correlation coefficient was smaller when the growth year interval was larger. Correlations between H and the original environment factors decreased gradually, indicating that with long-term subsistence in the new environment, the influence of the source environment declined. Colligation of multiple traits to estimate provenances showed that Novosibirsk, Tomsk, and Altai Mountains had higher survival rates and biomass, and proved more suitable for introduction and plantation in the Greater Xing'an Range in China. | Xiyang Zhao Cheng Wang Shuchun Li Wei Hou Shiqing Zhang Guijie Han Deng Pan Ping Wang Yufei Cheng Guifeng Liu | 2014 | Journal of Forestry Research2014，25，3： | 6 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans显示文摘Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012). | Hao Chang Mei Han Wenming Huang Guifeng Wei Juanjuan Chen Peng R.Chen Runsheng Chen Junlong Zhang Tao Xu Pingyong Xu | 2013 | Protein & Cell2013，4，12： | 2 |
| 6 | Spatial, seasonal and species variations of harmful algal blooms in the South Yellow Sea and East China Sea显示文摘 | Tang Dangling Di Baoping Wei Guifeng | 2006 | Hydrobiologia2006，568，： | 1 |
| 7 | A systems biology approach identifies a regulator,BplERF1,of cold tolerance in Betula platyphylla显示文摘Cold is an abiotic stress that can greatly affect the growth and survival of plants.Here,we reported that an AP2/ERF family gene,BplERF1,isolated from Betula platyphylla played a contributing role in cold stress tolerance.Overexpression of BplERF1 in B.platyphylla transgenic lines enhanced cold stress tolerance by increasing the scavenging capability and reducing H_(2)O_(2) and malondialdehyde(MDA)content in transgenic plants.Construction of BplERF-mediated multilayered hierarchical gene regulatory network(ML-hGRN),using Top-down GGM algorithm and the transcriptomic data of BplERF1 overexpression lines,led to the identification of five candidate target genes of BplERF1 which include MPK20,ERF9,WRKY53,WRKY70,and GIA1.All of them were then verified to be the true target genes of BplERF1 by chromatin-immunoprecipitation PCR(ChIP-PCR)assay.Our results indicate that BplERF1 is a positive regulator of cold tolerance and is capable of exerting regulation on the expression of cold signaling and regulatory genes,causing mitigation of reactive oxygen species. | Kaiwen Lv Wenqi Wu Hairong Wei Guifeng Liu | 2021 | Forestry Research2021，1，1： | 1 |
| 8 | Time-course analyses of abscisic acid level and the expression of genes involved in abscisic acid biosynthesis in the leaves of Betula platyphylla显示文摘 | Rongshu Zhang Chuanping Yang Chao Wang Zhigang Wei Dean Xia Yuefeng Wang Guifeng Liu Yucheng Wang | 2012 | Molecular Biology Reports2012，，3： | 1 |
| 9 | Spatial, seasonal and species variations of harmful algal blooms in the South Yellow Sea and East China Sea显示文摘 | TANG Danling DI Baoping WEI Guifeng | 2006 | Hydrobiologia2006，568，： | 1 |
| 10 | Distribution of chlorophyll and harmful algal blooms (HABs) : a review on space based studies in the coastal environments of Chinese marginal seas 显示文摘 | WEI Guifeng TANG Danling WANG Sufen | 2008 | Advances in Space Research2008，41，1： | 1 |
| 11 | Wetting Behavior of a Novel Al-Si-Ti Active Brazing Filler Metal Foil on Aluminum Matrix Composite显示文摘 | Guifeng Zhang Wei Su Jianxun Zhang Akio Suzumura | 2013 | Journal of Materials Engineering and Performance2013，，7： | 1 |
| 12 | Distribution of chlorophyll and harmful algal blooms (HABs): A review on space based studies in the coastal environments of Chinese marginal seas 显示文摘 | Wei Guifeng 'Fang Danling Wang Sufen | 2008 | Advances in Space Research2008，41，1： | 1 |
| 13 | Wetting Behavior of a Novel Al-Si-Ti Active Brazing Filler Metal Foil on Aluminum Matrix Composite显示文摘 | Guifeng Zhang Wei Su Jianxun Zhang Akio Suzumura | 2013 | Journal of Materials Engineering and Performance2013，，7： | 1 |
| 14 | Friction Stir Brazing: a Novel Process for Fabricating Al/Steel Layered Composite and for Dissimilar Joining of Al to Steel显示文摘 | Zhang Guifeng Su Wei Zhang Jianxun Wei Zhongxin | 2011 | EN2011，，： | 1 |
| 15 | Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis显示文摘 | Guifeng Xu Jin Jing Katherine Bowers Buyun Liu Wei Bao | 2014 | Journal of Autism and Developmental Disorders2014，，4： | 1 |
| 16 | Genome sequence and evolution of Betula platyphylla显示文摘Betula L.(birch)is a pioneer hardwood tree species with ecological,economic,and evolutionary importance in the Northern Hemisphere.We sequenced the Betula platyphylla genome and assembled the sequences into 14 chromosomes.The Betula genome lacks evidence of recent whole-genome duplication and has the same paleoploidy level as Vitis vinifera and Prunus mume.Phylogenetic analysis of lignin pathway genes coupled with tissue-specific expression patterns provided clues for understanding the formation of higher ratios of syringyl to guaiacyl lignin observed in Betula species.Our transcriptome analysis of leaf tissues under a time-series cold stress experiment revealed the presence of the MEKK1–MKK2–MPK4 cascade and six additional mitogen-activated protein kinases that can be linked to a gene regulatory network involving many transcription factors and cold tolerance genes.Our genomic and transcriptome analyses provide insight into the structures,features,and evolution of the B.platyphylla genome.The chromosome-level genome and gene resources of B.platyphylla obtained in this study will facilitate the identification of important and essential genes governing important traits of trees and genetic improvement of B.platyphylla. | Su Chen Yucheng Wang Lili Yu Tao Zheng Sui Wang Zhen Yue Jing Jiang Sapna Kumari Chunfang Zheng Haibao Tang Jun Li Yuqi Li Jiongjiong Chen Wenbo Zhang Hanhui Kuang Jon SRobertson Patrick XZhao Huiyu Li Shengqiang Shu Yordan SYordanov Haijiao Huang David MGoodstein Ying Gai Qi Qi JiuMeng Min ChunYan Xu SongBo Wang Guan-Zheng Qu Andrew HPaterson David Sankoff Hairong Wei Guifeng Liu Chuanping Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 17 | Promoting Cotton Green Production in Shandong through Accelerating Simplified Cultivation Technique显示文摘At present,the comparative benefits and comparative labor productivity of cotton production are relatively low,and cotton production and industrial development of cotton get seriously frustrated. The fundamental reason is that the quality of cotton production development and the development mode are not suitable for the market demands. In this situation,the cotton production and development must take the road of green development concept as the guidance,and improve the quality and benefits of cotton development. Finally,it came up with the basic idea,technical approach and industrial mode of taking simplified cultivation technique as the support,to promote green and efficient cotton production in Shandong Province. | Guifeng WANG Xuewen WEI Yan WANG Wenquan DONG | 2018 | Asian Agricultural Research2018，10，1： | 0 |
| 18 | Analysis of the p53/CEP-1 regulated non-coding transcriptome in C. elegans by an NSR-seq strategy显示文摘在最近的年里,大量非编码的 RNA (ncRNAs ) 在 C 被识别了。elegans 但是他们的功能仍然不好被学习。在 C。elegans, CEP-1 是基因的 p53 家庭的唯一的相当或相同的事物。为了获得 ncRNAs 的抄写侧面,在正常、紫外的强调条件下面由 CEP-1 调整了,我们把 not-so-random hexamers priming 策略用于在 C 定序的 RNA。elegans,这 NSR-seq 策略高效地弄空从样品的 rRNA 抄本和显示出的高技术的 replicability。我们识别了其明显的表示被 CEP-1 镇压的超过 1,000 ncRNAs,当约 200 被激活时。在 40% CEP-1 附近,激活的 ncRNAs 倡导者包含一个通常认为的 CEP-1-binding 地点。调整 ncRNAs 经常是的 CEP-1 聚类并且专注于 X 染色体。这些结果显示众多的 ncRNAs 涉及 CEP-1 transcriptional 网络并且这些特别在 C 在 X 染色体上被充实。elegans。 | Derong Xu Guifeng Wei Ping Lu Jianjun Luo Xiaomin Chen Geir Skogerbo Runsheng Chen | 2014 | Protein & Cell2014，5，10： | 0 |
| 19 | ACE2-Targeting antibody suppresses SARS-CoY-2 Omicron and Delta variants显示文摘Dear Editor,The pandemic of COVID-19 continues worldwide with many variants arising,especially SARS-CoV-2 Delta(B.1.617.2)and Omicron(B.1.1.529)variants of concern(VOCs).According to WHO,Omicron has spread in almost all the countries with a doubling time less than Delta VOC. | Jianxia Ou Yanan Zhang Yongmei Wang Zherui Zhang Hongping Wei Junping Yu Qi Wang Guifeng Wang Bo Zhang Chunhe Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 20 | Stable Development Path Choice of Shandong Cotton Production in the Context of Supply-side Reform显示文摘Due to low efficiency resulted from the unduly high cost,intractable climatic and market risk of cotton production,the development of cotton industry suffers a setback in Shandong Province. Based on analyzing the importance of Shandong cotton industry for the economic and social development under the new situation,we put forward the basic idea and effective way for stable and continuous development of Shandong cotton production from the perspective of supply side structural reform. | Guifeng WANG Xuewen WEI Yan WANG Wenquan DONG | 2018 | Asian Agricultural Research2018，10，2： | 0 |
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