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| 1 | Heyan Kuntai capsule versus dehydroepiandrosterone in treating Chinese patients with infertility caused by diminished ovarian reserve: a multicenter, randomized controlled trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month period.RESULTS: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were observed.CONCLUSION: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA treatment.HYKT might be an alternative to the treatment of infertility caused by DOR. | Gao Hui Xia Tian Ma Ruihong Zhao Zhimei Song Xueru Wang Baojuan Liu Lijing Han Kaimei Wang Guoqing Fu Yu Hao Guimin | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 14 |
| 2 | Microstructural Evolution of 6061 Alloy during Isothermal Heat Treatment显示文摘The semi-solid billet of 6061 aluminum alloy was prepared by the near-liquidus semi-continuous casting(LSC) with rosette or near-spheroide grains.The pre-deformation processing was applied before partial remelting to further improve the microstructure and properties of the semi-solid alloy.The effects of different processing parameters,such as holding temperature and holding time,on the semisolid microstructures during partial remelting have been investigated.It was found that the optimal partial remelting parameters should be 630℃ and 10-15 min for 6061 alloy cold rolled with 60% reduction in height of pre-deformation.The coarsening rates were anasysed by Lifshitz-Slyozov-Wagner(LSW) theory.The pre-deformed 6061 alloy exhibits lower coarsening rate constants than that of the as-cast one,and also lower than other alloys processed by different method found in previous literature.It is because the coarsening rate is associated with the initial microstructure and composition of the alloy.The secondary phases in the alloy inhibit the migration of the liquid film grain boundaries.The microstructure obtained by using the combination of near-liquidus semicontinuous casting and pre-deformation treatment is better than that without pre-deformation processing,which demonstrates that the used method is promising for fabricating high quality semi-solid alloys. | Na Wang Zhimin Zhou Guimin Lu | 2011 | Journal of Materials Science & Technology2011，27，1： | 11 |
| 3 | Satellite Constellation Design with Multi-Objective Genetic Algorithm for Regional Terrestrial Satellite Network显示文摘Constellations design for regional terrestrial-satellite network can strengthen the coverage for incomplete terrestrial cellular network. In this paper, a regional satellite constellation design scheme with multiple feature points and multiple optimization indicators is proposed by comprehensively considering multi-objective optimization and genetic algorithm, and 'the Belt and Road' model is presented in the way of dividing over 70 nations into three regular target areas. Following this, we formulate the optimization model and devise a multi-objective genetic algorithm suited for the regional area with the coverage rate under simulating, computing and determining. Meanwhile, the total number of satellites in the constellation is reduced by calculating the ratio of actual coverage of a single-orbit constellation and the area of targets. Moreover, the constellations' performances of the proposed scheme are investigated with the connection of C++ and Satellite Tool Kit(STK). Simulation results show that the designed satellite constellations can achieve a good coverage of the target areas. | Cuiqin Dai Guimin Zheng Qianbin Chen | 2018 | China Communications2018，15，8： | 10 |
| 4 | Bolt-grouting combined support technology in deep soft rock roadway显示文摘Analyzing the mineral composition, mechanical properties and ground stress testing in surrounding rock,the study investigated the failure mechanism of deep soft rock roadway with high stress. The boltgrouting combined support system was proposed to prevent such failures. By means of FLAC3D numerical simulation and similar material simulation, the feasibility of the support design and the effectiveness of support parameters were discussed. According to the monitoring the surface and deep displacement in surrounding rock as well as bolt axial load, this paper analyzed the deformation of surrounding rock and the stress condition of the support structure. The monitor results were used to optimize the proposed support scheme. The results of field monitors demonstrate that the bolt-grouting combined support technology could improve the surround rock strength and bearing capacity of support structure, which controlled the great deformation failure and rheological property effectively in deep soft rock roadway with high stress. As a result, the long term stability and safety are guaranteed. | Chen Yanlong Meng Qingbin Xu Guang Wu Haoshuai Zhang Guimin | 2016 | International Journal of Mining Science and Technology2016，26，5： | 10 |
| 5 | Impacts of nitrogen and zeolite managements on yield and physicochemical properties of rice grain显示文摘Zeolite(Z)can hold soil water and nutrient to obtain a higher yield on introduction into moist soil.However,the effects of Z and nitrogen(N)managements on rice grain quality is unclear.Therefore,the effects of different amounts of Z(Z0:0 t/hm^(2);Z0.9 and Z0.22:10 t/hm^(2)in different particle sizes of 0.45-0.9 mm and 0.17-0.22 mm in diameter)and N(N0,N52.5,N105,N157.5:0 kg/hm^(2),52.5 kg/hm^(2),105 kg/hm^(2),157.5 kg/hm^(2)),and Z(Z0,Z10:0 t/hm^(2),10 t/hm^(2))and application frequencies of N on rice yield and grain quality were investigated in 2014 and 2015 in Northeast coastal region of China where Z10 was extended to use in large areas.Results showed that both N and Z applications significantly increased the yields of rough rice(RRY),brown rice,milled rice and head rice.However,there was no significant difference between Z0.9 and Z0.22.The chalkiness area,length-width ratio and head rice rate were not influenced by Z and N applications.However,Z application significantly decreased the chalk rate and slightly increased amylose content(AC)but mattered little to taste value(TV)of rice and rice cooking quality.N could significantly increase rice protein content(PC)but lessen the TV and breakdown value;the order of influence degree on rice yield increasing was as follows:CRF2(third-split fertilization with Z10),CRF1(basal fertilization one time with Z10),U2(urea:third-split fertilization without Z)and U1(basal fertilization one time without Z).Both CRF1 and CRF2 greatly enhanced the RRY.However,CRF1 was recommended for clear decrease in labor and fuel for growers.Compared with treatments of U1 and CRF1,CRF2 and U2 significantly decreased the AC.PC exhibited significant negative relation to TV and greatly determined the rice eating quality and cooking quality. | Wu Qi Xia Guimin Chen Taotao Chi Daocai Jin Ye Sun Dehuan | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 10 |
| 6 | Structural Synthesis of Compliant Metamorphic Mechanisms Based on Adjacency Matrix Operations显示文摘A compliant metamorphic mechanism attributes to a new type of metamorphic mechanisms evolved from rigid metamorphic mechanisms. The structural characteristics and representations of a compliant metamorphic mechanism are different from its rigid counterparts, so does the structural synthesis method. In order to carry out its structural synthesis, a constraint graph representation for topological structure of compliant metamorphic mechanisms is introduced, which can not only represent the structure of a compliant metamorphic mechanism, but also describe the characteristics of its links and kinematic pairs. An adjacency matrix representation of the link relationships in a compliant metamorphic mechanism is presented according to the constraint graph. Then, a method for structural synthesis of compliant metamorphic mechanisms is proposed based on the adjacency matrix operations. The operation rules and the operation procedures of adjacency matrices are described through synthesis of the initial configurations composed of s+1 links from an s-link mechanism (the final configuration). The method is demonstrated by synthesizing all the possible four-link compliant metamorphic mechanisms that can transform into a three-link mechanism through combining two of its links. Sixty-five adjacency matrices are obtained in the synthesis, each of which corresponds to a compliant metamorphic mechanism having four links. Therefore, the effectiveness of the method is validated by a specific compliant metamorphic mechanism corresponding to one of the sixty-five adjacency matrices. The structural synthesis method is put into practice as a fully compliant metamorphic hand is presented based on the synthesis results. The synthesis method has the advantages of simple operation rules, clear geometric meanings, ease of programming with matrix operation, and provides an effective method for structural synthesis of compliant metamorphic mechanisms and can be used in the design of new compliant metamorphic mechanisms. | LI Duanling ZHANG Zhonghai CHEN Guimin | 2011 | Chinese Journal of Mechanical Engineering2011，24，4： | 9 |
| 7 | Non-destructive testing and pre-warning analysis on the quality of bolt support in deep roadways of mining districts显示文摘The bolt support quality of coal roadways is one of the important factors for the efficiency and security of coal production. By means of a self-developed technique and equipment of random non-destructive testing, non-destructive detection and pre-warning analysis on the quality of bolt support in deep roadways of mining districts were performed in a number of mining areas. The measured data were obtained in the detection instances of abnormal in-situ stress and support invalidation etc. The corresponding relation between axial bolt load variation and roadway surrounding rock deformation and stability was summarized in different mining service stages. Pre-warning technology of roadway surrounding rock stability is proposed based on the detection of axial bolt load. Meanwhile, pre-warning indicators of axial bolt load in different mining service stages are offered and some successful pre-warning cases are also illustrated.The research results show that the change rules of axial bolt load in different mining service stages are quite similar in different mining areas. The change of axial bolt load is in accord with the adjustment of surrounding rock stress, which can consequently reflect the deformation and stability state of roadway surrounding rock. Through the detection of axial bolt load in different sections of roadways, the status of real-time bolt support quality can be reflected; meanwhile, the rationality of bolt support design can be evaluated which provides reference for bolting parameters optimization. | Zhang Houquan Miao Xiexing Zhang Guimin Wu Yu Chen Yanlong | 2017 | International Journal of Mining Science and Technology2017，27，6： | 9 |
| 8 | Influence of lanthanum on enhancement of mechanical and electrical properties of Cu-Al_2O_3 composites显示文摘Two kinds of Cu-Al_2O_3 composites(with and without La) were prepared via mechanical alloying-spark plasma sintering(MA-SPS) method. Microstructure, mechanical properties and electrical resistivity were investigated systematically using metallography, scanning electron microscopy, transmission electron microscopy, mechanical and electrical properties testing. The results indicate that an appropriate amount of La can homogenize the distribution of Al_2O_3. As such, yield strength, ultimate tensile strength and elongation of Cu-Al_2O_3-La are greatly increased. Some semi-coherent interface between Cu and Al_2O_3 is found, which means a low interface energy. The grain shape of Cu changes to irregular band with the addition of La. This change results in a density decrease of grain boundary and reduces electrical resistance. Lanthanum may exist in the form of La_2O_3. | Yifan Zhang Zhen Ji Chengchang Jia Guimin Liu Farong Wan Qian Zhan | 2019 | Journal of Rare Earths2019，37，5： | 7 |
| 9 | Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer显示文摘MTUS1 (联系微导管的肿瘤 suppressor 1 ) 被识别了那能在许多恶意的肿瘤作为肿瘤 suppressor 基因工作。然而,位于 MTUS1 的规定下面的功能和机制是不清楚的。在现在的学习,我们报导 miR-19a 和 miR-19b (miR-19a/b ) 由指向 MTUS1 支持肺癌症房间的增长和移植。首先, MTUS1 被证明在肺癌症作为肿瘤 suppressor 工作并且被连接到房间增长和移植提升。第二,在 miR-19a/b 表示之间的反的关联和 MTUS1 mRNA/protein 表示在人的肺癌症纸巾被注意。第三, MTUS1 被生物信息学分析作为 miR-19a/b 的一个直接目标估价。第四,由在肺癌症房间的 miR-19a/b 的直接 MTUS1 规定被房间 transfection 试验性地肯定试金和酶记者试金。最后, miR-19a/b 被显示合作地镇压 MTUS1 表示并且 synergistically 调整 MTUS1 表示支持肺癌症房间增长和移植。在结论,我们的调查结果关于 miR-19a/b 的角色提供了第一线索,它看起来由 downregulating MTUS1 在肺癌症作为 oncomirs 工作。 | Yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei Liang Mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen | 2017 | Protein & Cell2017，8，6： | 6 |
| 10 | Intelligent checking model of Chinese radiotelephony read-backs in civil aviation air traffic control显示文摘Federal Aviation Administration(FAA) and NASA technical reports indicate that the misunderstanding in radiotelephony communications is a primary causal factor associated with operation errors, and a sizable proportion of operation errors lead to read-back errors. We introduce deep learning method to solve this problem and propose a new semantic checking model based on Long Short-Time Memory network(LSTM) for intelligent read-back error checking. A meanpooling layer is added to the traditional LSTM, so as to utilize the information obtained by all the hidden activation vectors, and also to improve the robustness of the semantic vector extracted by LSTM. A MultiLayer Perceptron(MLP) layer, which can maintain the information of different regions in the concatenated vectors obtained by the mean-pooling layer, is applied instead of traditional similarity function in the new model to express the semantic similarity of the read-back pairs quantitatively. The K-Nearest Neighbor(KNN) classifier is used to verify whether the read-back pairs are consistent in semantics according to the output of MLP layer. Extensive experiments are conducted and the results show that the proposed model is more effective and more robust than the traditional checking model to verify the semantic consistency of read-backs automatically. | Guimin JIA Fangyuan CHENG Jinfeng YANG Dan LI | 2018 | Chinese Journal of Aeronautics2018，31，12： | 5 |
| 11 | Study of Control rod worth in the TMSR显示文摘Control rod is a primary control part of emergency control and power regulation in nuclear reactor. The main application of it is to control fast change of the reactivity. The theoretical analysis for the worth of control rod is necessary in the stage of design. Based on design requirements, some results are calculated. Firstly, control rod worth with different density of neutron absorber is calculated by MCNP here. Secondly, the study of integral and differential control rod worth is presented in this paper while the control rod is inserted into reactor core and total worth of three rods with different positions are also calculated. Finally, the effect of the axial and radial neutron flux in reactor core which is caused by the control rods is simulated. The simulation results of the control rods meet design requirements for TMSR. | ZHOU Xuemei LIU Guimin | 2013 | Nuclear Science and Techniques2013，24，1： | 5 |
| 12 | Effects of operational and structural parameters on cell voltage of industrial magnesium electrolysis cells显示文摘电场是电解过程的精力基础和在一个镁电解房间的 multiphysical 地的来源。在这研究,一个三维的数字模型被开发并且过去常通过有限元素分析以稳定的状态计算电场。基于电场的模拟,运作、结构的参数例如当前的紧张,阳极厚度,阴极厚度,和阳极阴极距离(ACD ) ,被调查获得最小的房间电压。优化是获得在镁电解过程在精力消费上有重要效果的最小的电阻电压。结果显示电压上的当前的紧张的效果能被忽略, ACD 的效果是明显的。而且,在电压和阳极和阴极的厚度之间有线性减少;并且 anodecathode 工作高度也在电压上有重要效果。 | Ze Sun Chenglin Liu Guimin Lu Xingfu Song Jianguo Yu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 5 |
| 13 | Semi-solid extrusion of aluminum alloy ZL116显示文摘The semi-solid forward-extruding feasibility of reheated ZL116 alloy cast by the near-liquidus semi-continuous casting process was studied by analyzing the microstructures and properties of forward-extruded bars. The results show that the microstructure of the ZL116 alloy billets cast by near-liquidus semi-continuous casting is mainly made up of homogeneous, fine global-or rosette-shaped grains. The microstructure of the billets, reheated and held at 575℃, contains stable and net-spherical grains which are suitable for semi-solid thixoforming. The semi-solid forward-extruded bars of the ZL116 alloy billet are facially smooth, microstructurally fine and homogeneous. Therefore the feasibility of semi-solid forward-extrusion of ZL116 alloy is thus excellent. | Zhao Dazhi Lu Guimin Cui Jianzhong | 2008 | China Foundry2008，5，2： | 5 |
| 14 | Microstructures of an AlSi_7Mg alloy by near-liquidus casting显示文摘Semi-solid ingots of an AlSi7Mg alloy were obtained using the method of near liquidus casting. Their micro- structures exhibit the characteristics of fine, equiaxed, and non-dendrite, which are required for semi-solid forming. The in- fluences of casting temperature, heat preservation time, and cooling rate on the microstructure were also investigated. The results show that in the temperature region near liquidus the grain size becomes small with a decrease in casting temperature. Prolonging the heat preservation time makes grain crassitude at the same temperature. And increasing the cooling rate makes grain fine. The microstructure of the alloy cast with iron mould is finer than that with graphite mould. | GAO Ming WANG Ping LU Guimin CUI Jianzhong | 2007 | Rare Metals2007，26，3： | 5 |
| 15 | Analysis of Commonly and Specifically Dysregulated Pathways in Three Women Cancers显示文摘Breast, ovarian and endometrial cancer are three most prevalent gynaecological malignancies. Identifying their common and specific biomarkers is significant for cancer prediction and therapy in females. We propose a method to identify dysregulated pathways in cancer through scoring pathways based on the molecular interaction data and genomic data. Commonly and specifically dysregulated pathways are analyzed across the above three female cancers, which have not been studied as a whole to the best of our knowledge. Our results demonstrate that all the three cancers have close relationships with Type II diabetes and cell cycle-related biology processes. Breast cancer is specifically related to immune system while ovarian cancer and endometrial cancer are associated with blood vascular-related systems such as renin-angiotensin system and coagulation system. In addition, dysregulated pathways are used to predict potential driver genes effectively according to their topological structure and biological information. | LIU Xiyang AN Yingying YU Baoguo QIN Guimin | 2018 | Chinese Journal of Electronics2018，27，5： | 4 |
| 16 | Simulation and optimization for a 30-MeV electron accelerator driven neutron source显示文摘A neutron source driven by electron accelerator is proposed in Shanghai Institute of Applied Physics (SINAP). The facility is planned for the study of nuclear data in Thorium-Uranium cycling system, and for material research. A detailed simulation of the neutron source is performed for the program to get the neutron generation maximum economically. Several parameters of the facility, which affect the neutron yield and the neutron escape from outer surface of the target, are analyzed respectively. Besides, the yielding neutron spectrum and the escaping neutron angular distribution are calculated and discussed. | LIN Zuokang SUN Guomin CHEN Jingen LIU Guimin DAI Zhimin | 2012 | Nuclear Science and Techniques2012，23，5： | 4 |
| 17 | Biosynthesis of selenosubtilisin: A novel way to target selenium into the active site of subtilisin显示文摘Glutathione peroxidase (GPx, EC1.11.1.9), an important anti-oxidative selenoenzyme, can catalyze the reduction of harmful hydroperoxides with concomitant glutathione, thereby protecting cells and other biological issues against oxidative damage. It captures considerable interest in redesign of its function for either the mechanism study or the pharmacological development as an antioxidant. In order to de- velop a general strategy for specifically targeting and operating selenium in active sites of enzymes, the catalytically essential residue selenocysteine (Sec) was first successfully bioincorporated into the catalytic center of subtilisin by using an auxotrophic expression system. The studies of the catalytic activity and the steady-state kinetics demonstrated that selenosubtilisin is an excellent GPx-like bio- catalyst. In comparison with the chemically modified method, biosynthesis exhibits obvious advan- tages: Sec could be site-directly incorporated into active sites of enzymes to overcome the non-speci- ficity generated by chemical modification. This study provides an important strategy for specifically targeting and operating selenium in the active site of an enzyme. | LI Jing LIU XiaoMan JI YueTong QI ZhenHui GE Yan XU JiaYun LIU JunQiu LUO GuiMin SHEN JiaCong | 2008 | Chinese Science Bulletin2008，53，16： | 3 |
| 18 | Increased BnaMFT-transcript level is associated with secondary dormancy in oilseed rape (Brassica napus L.)显示文摘Brassica napus cultivars have little or no primary dormancy;however,they are prone to sec on dary dorma ncy in ducti on.Secondary dormant seeds can produce volunteer plants,which can result in genetic contamination,reduced quality and biosafety issues.However,informati on regarding the molecular mecha nism un derlyi ng sec on dary dormancy is limited.The MOTHER OF FT AND TFL1(MFT)gene,which is evolutionarily conserved in the plant kingdom,acts in a complex gene network in the seed dormancy or germination processes.In this study,we identified four B.napus genes that share high homology with AtMFT,named as BnaMFT.Analyses of c/s-acting elements showed that BnaMFT promoters contain multiple seed-specific regulatory elements,and various stress-and hormone-responsive elements.Further experiments validated that BnaMFTs were specifically expressed during seed maturation and in the dry seed,with peaks at 35-42 days after pollination.BnaMFTs were not sufficient for primary dormancy;however,they were significantly enhanced by secondary dormancy induction with PEG6000 treatment.Moreover,BnaMFTtranscripts were elevated by treatment with abscisic acid(ABA),which is known to be accumulated duri ng sec on dary dorma ncy.These results collectively suggest that increased BnaMFT tra nscription levels are associated with sec on dary dorma ncy inducti on in an ABA-depe ndent mariner in B.napus. | LIU Lei FAN Wen-qi LIU Fu-xia YI Xin TANG Tang ZHOU Ying TANG Zi-wei CHEN Guimin ZHAO Xiang-xiang | 2020 | Journal of Integrative Agriculture2020，19，6： | 2 |
| 19 | Influence of NO2^- on the Microscopic Structure and Physical Properties of the Binary Nitrate Salts: a Molecular Dynamics Simulation Study显示文摘Molecular dynamics simulation method was used to study the influence of NO2^- on both the structure and properties of the binary nitrate salts(60 wt.% NaNO3 + 40 wt.% KNO3). The density and viscosity of the mixtures were experimentally measured and the simulation results met well with the experimental ones. The simulation results showed that, with the addition of NO2^-, the ionic clusters tended to loose and the mobilities of all the ions tended to increase. The density, viscosity, and heat capacity decreased while the thermal conductivity increased with the increase of NO2^- concentration. The correlation between the microscopic structure and physical properties of the mixtures were discussed and revealed. | NI Haiou WU Jie SUN Ze LU Guimin YU Jianguo | 2020 | Journal of Thermal Science2020，29，2： | 2 |
| 20 | Theoretical prediction on the local structure and transport properties of molten alkali chlorides by deep potentials显示文摘In this work,the local structure and transport properties of three typical alkali chlorides(LiCl,NaCl,and KCl)were investigated by our newly trained deep potentials(DPs).We extracted datasets from ab initio molecular dynamics(AIMD)calculations and used these to train and validate the DPs.Large-scale and long-time molecular dynamics simulations were performed over a wider range of temperatures than AIMD to confirm the reliability and generality of the DPs.We demonstrated that the generated DPs can serve as a powerful tool for simulating alkali chlorides;the DPs also provide results with accuracy that is comparable to that of AIMD and efficiency that is similar to that of empirical potentials.The partial radial distribution functions and angle distribution functions predicted using the DPs are in close agreement with those derived from AIMD.The estimated densities,self-diffusion coefficients,shear viscosities,and electrical conductivities also matched well with the AIMD and experimental data.This work provides confidence that DPs can be used to explore other systems,including mixtures of chlorides or entirely different salts. | Wenshuo Liang Guimin Lu Jianguo Yu | 2021 | Journal of Materials Science & Technology2021，，16： | 2 |
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