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20篇 您的检索式:作者名="Guo Hongling"
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1Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency.Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen 2018Science Bulletin2018,63,24:12
2Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source.Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang 2020Cell Research2020,30,1:7
3Comparison of thermal and light performance in two typical Chinese solar greenhouses in Beijing显示文摘Solar greenhouses have been used for producing vegetables in northern China during early spring,late autumn or over-winter.To improve the thermal performance of solar greenhouses,a traditional type and a retrofitted design were comparatively evaluated.In the retrofitted design,three adjustments were incorporated:the material and structure of the walls,south-facing roof angle,and structure of the north-facing back-roof.The results indicated that the thermal and light performance of the retrofitted greenhouse was much better than that of the traditional greenhouse.Specifically,the daily mean temperature,minimum air temperature,and soil temperature inside the greenhouses after retrofit ting were increased by 1.3,2.4,and 1.9℃,respectively,meanwhile,the daily total solar radiation and PAR were increased by 28.2%and 9.2%,respectively.The wall temperature and its daily variation range were reduced with increasing depth and height.The characteristic analysis of heat storage and release indicated that higher locations have longer heat storage,and shorter heat release time in vertical direction,as well as a lower ratio of heat release to storage.In horizontal direction,the western wall has the shortest heat storage time but the highest heat release flux density.Altogether,the heat storage time of the wall is 1.5 h less than that of the soil.The heat storage flux density of the wall is 1.5 times of that of the soil,but the heat release flux is only 61%of the soil’s value.The total wall heat storage is half of that of the soil in the greenhouse;the total wall heat release amount is only a quarter of that of the soil.Therefore,the thermal environment of solar greenhouses can be further improved by improving the thermal insulation properties of the wall.Fan Xu Chao Shang Hongling Li Xuzhang Xue Weituo Sun Hong Chen Yinkun Li Zhenhe Zhang Xinxu Li Wenzhong Guo 2019International Journal of Agricultural and Biological Engineering2019,12,1:4
4Na-doping-induced modification of the Cu_(2)ZnSn(S,Se)_(4)/CdS heterojunction towards efficient solar cells显示文摘It is very important to understand why a small amount of alkali metal doping in Cu_(2)ZnSn(S,Se)_(4)(CZTSSe)solar cells can improve the conversion efficiency.In this work,Na-doped CZTSSe is prepared by a simple solution method,and then the effects on the surface properties of the absorber layer,the buffer layer growth,and the modifications of the solar cell performance induced by the Na doping are studied.The surface of the absorber layer is more Cu-depletion and less roughness due to the Na doping.In addition,the contact angle of the surface increases because of Na doping.As a consequence,the thickness of the CdS buffer layer is significantly reduced and the optical losses in the CdS buffer layer are decreased.The difference of quasi-Fermi levels(EFn-EFp) increases with a small amount of Na doping in the CZTSSe solar cell,so that open circuit voltage(VOC) increased significantly.This work offers new insights into the effects of Na doping on CZTSSe via a solution-based approach and provides a deeper understanding of the origin of the efficiency improvement of Na-doped CZTSSe thin film solar cells.Yali Sun Hongling Guo Pengfei Qiu Shengli Zhang Siyu Wang Li Wu Jianping Ao Yi Zhang 2021Journal of Energy Chemistry2021,30,6:2
5Flotation performance of a novel Gemini collector for kaolinite at low temperature显示文摘How to sustainably produce bauxite by effective reverse froth flotation of kaolinite at low temperature is an urgent problem to be solved in the field of mineral processing.In this work,a novel amino-based Gemini surfactant butadiyl-1,4-bis(dimethyl dodecylammonium bromide)(BBDB) was prepared and first utilized as a novel collector for kaolinite flotation.Its flotation performance for kaolinite was compared with that of the common monomolecular surfactant 1-dodecylamine(DDA) by micro-flotation tests.The tests results indicated that 95% kaolinite recovery was obtained using 2.0×10^(-4) mol/L BBDB at 25℃ which was half of the dosage when DDA obtained the maximum kaolinite recovery of81%.At extremely low temperature(0℃),3.0×10^(-4) mol/L BBDB could still collect 91% kaolinite,while DDA showed a frustrating ability.The contact angle tests indicated that BBDB could still significantly improve the hydrophobicity of the kaolinite surface(contact angle 71.7°) than DDA(contact angle only25.8°) at 0℃.The Krafft point comparison tests indicated that BBDB had a much lower Krafft point(below0℃) than DDA.Fourier transform infrared spectroscopy(FTIR)-spectrum analysis and zeta potential measurements showed that BBDB was physically adsorbed on the surface of kaolinite through electrostatic interaction.Shiyong Zhang Zhiqiang Huang Hongling Wang Rukuan Liu Chen Cheng Shuyi Shuai Yajing Hu Zhiqun Guo Xinyang Yu Guichun He Weng Fu 2021International Journal of Mining Science and Technology2021,31,6:2
6Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2显示文摘As a product of HSVI immediate-early gene, ICP22 is capable of interacting with various cellular tran-scriptive and regulatory molecules during viral infection so as to impact the normal cellular molecular mechanism. ICP22 expressed in transfected cells can push the cells’ entering into S phase with binding to mdm-1 promoter region and impact its trans-transcription activating effect by P53. Consequently, the MDM-2 binds to P53, and the degradation effects by the ubiquitous pathway are decreased, improving indirectly the P53 levels in cells and making the cells progress into the S phase.GUO HongXiong, CUN Wei, LIU LongDing, WANG LiChun, ZHAO HongLing, DONG ChengHong & LI QiHan Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China These authors contributed equally to this work 2007Science China(Life Sciences)2007,50,4:2
7Artesunate and Dihydroartemisinin Inhibit Rabies Virus Replication显示文摘Rabies is caused by infection of rabies virus(RABV)and remains a serious threat to the global public health.Except for the requirement for cold chain and high cost of human rabies immune globulin,no small molecule drugs are currently available for clinical treatment of rabies.So,it is of great importance to identify novel compounds that can effectively inhibit RABV infection.Artesunate(ART)and dihydroartemisinin(DHA),two derivatives of artemisinin,are widely used for treatment of malaria in adults and children,showing high safety.In this study,we found that both ART and DHA were able to inhibit RABV replication in host cells at a low concentration(0.1μmol/L).The antiviral effects of ART and DHA were independent of viral strains and cell lines.Pre-treatment with ART or DHA for 2 h in vitro did not affect the viral replication in host cells,implying that ART and DHA neither reduced the viability of RABV directly nor inhibited the binding and entrance of the virus to host cells.Further studies revealed that ART and DHA inhibited RABV genomic RNA synthesis and viral gene transcription.Treatment with ART or DHA(5 mg/kg)by intramuscular injection improved,to some extent,the survival rate of RABV-challenged mice.Combination treatment with derivatives of artemisinin and mannitol significantly improved the survival rate of RABV-challenged mice.The results suggest that ART and DHA have a great potential to be explored as new anti-rabies agents for treatment of rabies.Jun Luo Yue Zhang Yang Wang Qing Liu Jiesen Li Hongling He Yongwen Luo Shile Huang Xiaofeng Guo 2021Virologica Sinica2021,36,4:2
8Molecular characteriza- tion of isoniazid-resistant clinical isolates of Mycobaeterium tuber- culosis from the USA 显示文摘Guo Hongling Seet Q Denkin S 2006J Med Microbiol2006,55,11:1
9Growth and fabrication of AlGaN/GaN HEMT based on Si(1<ce:hsp sp='0.16'/>1<ce:hsp sp='0.16'/>1) substrates by MOCVD显示文摘Weijun Luo Xiaoliang Wang Hongling Xiao Cuimei Wang Junxue Ran Lunchun Guo Jianping Li Hongxin Liu Yanling Chen Fuhua Yang Jinmin Li 2008Microelectronics Journal2008,,9:1
10Li_(2)S doping into CZTSe drives the large improvement of V_(OC) of solar cell显示文摘Alkali metal doping or sulfurization are commonly applied in Cu_(2)ZnSnSe_(4) (CZTSe) solar cell to improve the open-circuit voltage (VOC). However, alkali metal sulfide affording both alkali metal and sulfur is seldom to be studied, which restrains the development of kesterite solar cells. In this study, we evaporate Li_(2)S during selenization process and hope to provide both alkali metal and sulfur to CZTSe film. The result indicates that Li shows a gradient distribution near the surface of CZTSe film and the content of S is slight. The film quality is improved and the recombination at grain boundaries is decreased after Li_(2)S treatment. Besides, the bandgap of the absorber gets wider. Under the synergy of sulfur and lithium (mainly from lithium), the work function of the treated absorber gets higher and the conduction band offset (CBO) is in the ideal range. Combined with these contributions, the V_(OC) of the champion device treated by Li_(2)S dramatically increase by 120 mV. This study discloses that alkali metal brings the main effect on the performance of the kesterite solar cell even an alkali metal sulfide is evaporated, which deepens the understanding of sulfurization of CZTSe and also promote the progress of kesterite solar cells.Zhan Shen Siyu Wang Yue Liu Yali Sun Jianyu Wu Hongling Guo Kaizhi Zhang Shengli Zhang Fangfang Liu Yi Zhang 2021Journal of Energy Chemistry2021,30,11:1
11Discrimination of Car Headlight Plastic by Gel Permeation Chromatography显示文摘Car headlight plastic as a kind of evidence often can be seen in traffic accidents and some other cases.We tested 20 brands of car headlight plastic using gel chromatography.The data were processed using the Statistical Package for the Social Sciences(SPSS)one‑way analysis of variance(ANOVA)and the discrimination rate was 97.14%.This indicated that we could discriminate between different headlights by the molecular weight of their headlight plastic.Gel permeation chromatography is an effective method of discriminating between headlights,particularly in the case of a traffic accident.Bo Wang Yangke Quan Hongling Guo 2015Journal of Forensic Science and Medicine2015,1,1:1
12Tribological performance of ionic liquid-lubricated carbon brush/collector ring current-carrying friction system显示文摘The lubricity and anti-wear ability of ionic liquids(ILs)were studied by a current-carrying friction test on IL-lubricated carbon brushes.The results indicated that the conductivity and wear resistance of different ILs are different,and may vary for different carbon brushes.The E468e carbon brush was found to be more sensitive to IL lubrication than D172 carbon brush.Importantly,an analysis of the wear surfaces of the D172 and E468e carbon brushes revealed that,due to the different materials of the two carbon brushes and the composition of the IL,the lubrication effect on the carbon brushes was different.The viscosity of the IL will affect its wettability on the carbon brush surface.The better the wettability,the easier the movement of ions on the surface,which makes it easier to form a conductive physical adsorption film.Therefore,in practice,a better IL must be selected by considering the wettability of IL and carbon brushes.Yang Fu Hongling Qin Xiang Xu Xiaolong Zhang Zhiguang Guo 2020Biosurface and Biotribology2020,6,4:1
13Inffuence of the near field of secondary source and the elasticity of pipe wall on active noise control performance of liquid-filled pipe显示文摘The numerical models of liquid-filled straight pipe system with active silencers are established. The inffuence of the near field of secondary source in the active silencers and the elasticity of pipe wall on active noise control performance under sound excitation is analyzed.The results show that the near field of secondary source is non-uniform, and the active control effect of some frequencies is poor or even the sound pressure level will increase when the error points are located in this region. The noise reduction can be increased by more than 10 d B when the error points are in the region of uniform sound field. The noise reduction of most frequencies can be increased by more than 5 d B by increasing the number of error points. The coupling between secondary source and pipe wall is strong because of the elasticity of pipe wall. Asymmetrically distributed secondary sources tend to excite the pipe wall vibration,which causes the troughs of control effect. The symmetrically distributed secondary sources can significantly improve the control effect. Increasing the number of secondary sources can improve the active-passive hybrid control effect of the system. However, it makes the sound field in the pipe more complex, and the active silencing effect of the models with multiple secondary sources decreases with increasing frequency.GUO Gege SUN Hongling SUN Luyang CAO Shengnan YANG Jun 2023Chinese Journal of Acoustics2023,42,4:0
14T cell regeneration: an update on progress and challenges显示文摘T cells play essential roles in antitumor therapy.Via gene engineering technique to enhance tumor-antigen specificity,patient peripheral blood-derived T cells(PBT)show encouraging clinical outcomes in treating certain blood malignancies.However,the high costs,functionality exhaustion,and disease-condition-dependent availability of PBT prompt the attempts of exploring alternative T cell sources.Theoretically,induced T cells from pluripotent stem cells(PSC)are ideal candidates that integrate plenty of advantages that primary T cells lack,including unlimited off-the-shelf cell source and precision gene editing feasibility.However,researchers are still struggling with developing a straightforward protocol to induce functional and immunocompetent human T cells from PSC.Based on stromal cell-expressing or biomaterial-presenting Notch ligands DLL1 or DLL4,natural and induced blood progenitors can differentiate further toward T lineage commitment.However,none of the reported T induction protocols has yet translated into any clinical application,signaling the existence of numerous technical barriers for regenerating T cells functionally matching their natural PBT counterparts.Alternatively,new approaches have been developed to repopulate induced T lymphopoiesis via in vivo reprogramming or transplanting induced T cell precursors.Here,we review the most recent progress in the T cell regeneration field,and the remaining challenges dragging their clinical applications.Rongqun Guo Hongling Wu Juan Du Jinyong Wang 2020Blood Science2020,2,1:0
15The complete and fully-phased diploid genome of a male Han Chinese显示文摘Since the release of the complete human genome,the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity.Here,we present a fully phased and well-annotated diploid human genome from a Han Chinese male individual(CN1),in which the assemblies of both haploids achieve the telomere-to-telomere(T2T)level.Comparison of this diploid genome with the CHM13 haploid T2T genome revealed significant variations in the centromere.Outside the centromere,we discovered 11,413 structural variations,including numerous novel ones.We also detected thousands of CN1 alleles that have accumulated high substitution rates and a few that have been under positive selection in the East Asian population.Further,we found that CN1 outperforms CHM13 as a reference genome in mapping and variant calling for the East Asian population owing to the distinct structural variants of the two references.Comparison of SNP calling for a large cohort of 8869 Chinese genomes using CN1 and CHM13 as reference respectively showed that the reference bias profoundly impacts rare SNP calling,with nearly 2 million rare SNPs miss-called with different reference genomes.Finally,applying the CN1 as a reference,we discovered 5.80 Mb and 4.21 Mb putative introgression sequences from Neanderthal and Denisovan,respectively,including many East Asian specific ones undetected using CHM13 as the reference.Our analyses reveal the advances of using CN1 as a reference for population genomic studies and paleo-genomic studies.This complete genome will serve as an alternative reference for future genomic studies on the East Asian population.Chentao Yang Yang Zhou Yanni Song Dongya Wu Yan Zeng Lei Nie Panhong Liu Shilong Zhang Guangji Chen Jinjin Xu Hongling Zhou Long Zhou Xiaobo Qian Chenlu Liu Shangjin Tan Chengran Zhou Wei Dai Mengyang Xu Yanwei Qi Xiaobo Wang Lidong Guo Guangyi Fan Aijun Wang Yuan Deng Yong Zhang Jiazheng Jin Yunqiu He Chunxue Guo Guoji Guo Qing Zhou Xun Xu Huanming Yang Jian Wang Shuhua Xu Yafei Mao Xin Jin Jue Ruan Guojie Zhang 2023Cell Research2023,33,10:0
16Pulmonary Vein Stenosis:A Review显示文摘Pulmonary vein stenosis(PVS)is an extremely rare and lethal disease caused by multiple etiologies.PVS has a bimodal distribution in the population,affecting children and adults.Congenital PVS is the usual PVS type in children,which sometimes develops after cardiothoracic surgery.Acquired PVS,in turn,is the most common PVS type in adults.A review of the relevant literature has shown that PVS after radiofrequency ablation of atrial fibrillation is the most common,as well as that caused by compression of proliferative fibrous tissues or tumor in the mediastinum(eg,PVS caused by fibrosing mediastinitis,lung tumors,metastases,etc).This article provides a comprehensive review of PVS in terms of embryology and anatomy,etiology and triggers,classification,clinical symptoms and signs,treatment,and prognosis,intending to promote the understanding and treatment of this disease.Mengfei Jia Juan Wang Kaiyu Jiang Hongling Su Yu Li Zhaoxia Guo Hai Zhu Aqian Wang Xin Pan Yunshan Cao 2023Cardiology Discovery2023,3,2:0
17Application and measurement of underwater acoustic reciprocity transfer functions in reverberant sound field显示文摘The reciprocity measurement theory in anomalous reverberant sound fields was investigated.An improved method Was proposed due to the interrelated errors.The source volume velocity Was corrected by spatial average of measurement results and evaluation of the reverberant sound field influence on acoustic energy density.The result was validated in underwater experiment,corrected reciprocity measurement results were almost the same as direct measurement results.It indicates that reverberant sound field does not affect the validitv of the principle,but influences the obtainment of source volume velocity,then influences the measurement of transfer functions with the principle.The proposed method is simple and effective in anomalous reverberant sound fields.The study mav be valuable for the applications which are based on the principle.CHENG Guo XU Rongwu HE Lin SUN Hongling 2014Chinese Journal of Acoustics2014,33,4:0
18CIDNP study of the photochemistry of 1-acetylindole-2,3-dione显示文摘Chemically Induced Dynamic Nuclear Polarization (CIDNP) technique is applied to study the photochemical reactions of 1-acetylindole-2,3-dione (AID) with several hydrogen do- nors (1—13). These reactions take place by direct hydrogen abstraction of triplet excited AID from the corresponding 1—13 to give neutral radical pair intermediates, which afford polarized starting materials by back hydrogen transfer and give polarized coupling products by radical pair recombination.GUO Hongling YAN Baozhen WANG Xinyan WANG Ting 2005Science China Chemistry2005,48,2:0
19Improving Federated Learning through Abnormal Client Detection and Incentive显示文摘Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their behavior.The central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective clients.To reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize them.In this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated learning.We build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection problem.Among them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational complexity.Additionally,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively participate.Three training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in experiments.According to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.Hongle Guo Yingchi Mao Xiaoming He Benteng Zhang Tianfu Pang Ping Ping 2024Computer Modeling in Engineering & Sciences2024,139,4:0
20Development and Validation of a Prognostic Risk Score System for COVID-19 Inpatients:A Multi-Center Retrospective Study in China显示文摘Coronavirus disease 2019(COVID-19)has become a worldwide pandemic.Hospitalized patients of COVID-19 suffer from a high mortality rate,motivating the development of convenient and practical methods that allow clinicians to promptly identify high-risk patients.Here,we have developed a risk score using clinical data from 1479 inpatients admitted to Tongji Hospital,Wuhan,China(development cohort)and externally validated with data from two other centers:141 inpatients from Jinyintan Hospital,Wuhan,China(validation cohort 1)and 432 inpatients from The Third People’s Hospital of Shenzhen,Shenzhen,China(validation cohort 2).The risk score is based on three biomarkers that are readily available in routine blood samples and can easily be translated into a probability of death.The risk score can predict the mortality of individual patients more than 12 d in advance with more than 90%accuracy across all cohorts.Moreover,the Kaplan-Meier score shows that patients can be clearly differentiated upon admission as low,intermediate,or high risk,with an area under the curve(AUC)score of 0.9551.In summary,a simple risk score has been validated to predict death in patients infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2);it has also been validated in independent cohorts.Ye Yuan Chuan Sun Xiuchuan Tang Cheng Cheng Laurent Mombaerts Maolin Wang Tao Hu Chenyu Sun Yuqi Guo Xiuting Li Hui Xu Tongxin Ren Yang Xiao Yaru Xiao Hongling Zhu Honghan Wu Kezhi Li Chuming Chen Yingxia Liu Zhichao Liang Zhiguo Cao Hai-Tao Zhang Ioannis Ch.Paschaldis Quanying Liu Jorge Goncalves Qiang Zhong Li Yan 2022Engineering2022,8,1:0
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