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| 1 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 2 | Studies and advances on joint source-channel encoding/decoding techniques in flow media communications显示文摘Joint source-channel coding/decoding (JSCC/JSCD) techniques in flow media communications have become a state-of-the-art and one of the challenging research subjects in the spatial communication area. They have great application prospective and deep impact in various manned space flights, satellite missions, mobile radio communications and deep-space explorations. In the last few years, there have been influential achievements in JSCC/JSCD studies. This paper aims at an introduction to the basic principles of joint source-channel optimal design. A general summarization and classification for various existing JSCC/JSCD methods is addressed. Also presented is a JSCD scheme based on variable-length coding, capable of providing reliable resolutions for flow media data transmission in spatial communications. | TU GuoFang LIU JianJun ZHANG Can GAO ShaoShuai LI ShiDong | 2010 | Science China(Information Sciences)2010，53，1： | 8 |
| 3 | Single phase A2B7-type La-Mg-Ni alloy with improved electrochemical properties prepared by melt-spinning and annealing显示文摘La-Mg-Ni alloys were prepared by melt-spinning with different cooling rates and followed by annealing.Elevation of the cooling rate leads to refinement of the grains size and increasing of the abundance of LaNis.Annealing is favorable to formation of the A2 B7-type phase and promotes the discharge capacity,cycling stability and high rate discharge ability of the as-spun alloys.Phase constitution of the annealed alloys is found to be closely related to the microstructure of the as-spun alloys.A single phase A2 B7-type microstructure is obtained in the annealed alloy which is attributed to the lower abundance of the LaNis of the original alloy spun with lower cooling rate.Formation of the single phase A2 B7-type microstructure is also ascribed to the isolated and homogeneous distribution of the morphology of the as-spun alloy.The single phase alloy presents higher discharge capacity and better cycling stability compared with other annealed alloys. | Yiming Li Zhuocheng Liu Guofang Zhang Yanghuan Zhang Huiping Ren | 2019 | Journal of Rare Earths2019，37，12： | 6 |
| 4 | Amniotic fluid-derived stem cells mixed with platelet rich plasma for restoration of rat alveolar bone defect显示文摘从羊膜的液体孤立的干细胞作为房间治疗和织物工程的一个有希望的候选人被显示出。然而, maxillofacial 骨头织物工程的地里的羊膜的导出液体的干细胞(AFSC ) 的试验性、现出症状之前的潜的应用仍然是有限的。在这研究,老鼠 AFSC 成功地在 vitro 被收获并且描绘。老鼠 AFSC 显示出典型 fibroblastoid 形态学,稳定的增长活动和多区别潜力。Flow-cytometry 分析为象 CD34 和 CD45 那样的造血的标记证明这些房间为 CD29, CD44,和 CD90 是积极的,当否定时。与血小板富人一起的 AFSCs-premixed 的再生表演在牙槽的骨头缺点的恢复的血浆(PRP ) 胶化进一步用一只修改老鼠被调查颚的牙槽的缺点模型。微型电脑断层摄影术和组织学的检查在操作与控制组作比较以后在 4 和 8 个星期与 PRP 胶化显示出 AFSCs-premixed 的一个优异再生能力。而且,植入的 AFSC 能在缺点地点幸存并且直接参予骨头织物新生。一起拿,这些结果为牙槽的缺点恢复显示了基于 AFSCs 的牙槽的骨头织物工程策略的可行性。 | Minjiao Wang Hongliang Li Jiawen Si Jiewen Dai Jun Shi Xudong Wang Lihe Guo Guofang Shen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 5 |
| 5 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 6 | Differential expression of meat quality and intramuscular fat deposition related genes in Hanjiang black pigs显示文摘 | Guofang Wu Xin'e Shi Jiping Zhou Lei Wang Yuefeng Li Chengchuang Song Aoqi Xiang Peiyue Dong Shiduo Sun | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 3 |
| 7 | LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis显示文摘NORAD is a newly identified long non-coding RNA(lncRNA)that plays an important role in cancers.NORAD has been found to be highly expressed in the mouse model of acute myocardial infarction(AMI).However,the role of NORAD in the regulation of AMI remains unknown.In the present study,we aimed to investigate the function of NORAD in AMI and explore the potential regulatory mechanisms.A mouse model of AMI was established and NORAD was knocked-down.The infarcted size of heart tissues and the cardiac function were evaluated.In addition,two cardiomyocyte cell lines were treated with hypoxia/re-oxygenation(H/R)to mimic AMI in vitro.Luciferase reporter assay,RNA pull-down assay,fluorescence in situ hybridization,qRT-PCR,and western blot analysis were performed.Apoptotic cells and the levels of L-lactate dehydrogenase(LDH)and malondialdehyde(MDA)were detected.Our results show that downregulation of NORAD efficiently attenuates heart damage in the AMI mouse model.NORAD interacts with miR-22-3p.Knock-down of NORAD inhibits H/R-induced cell apoptosis and reduces LDH and MDA levels,while its effects are abolished by miR-22-3p inhibitor.MiR-22-3p interacts with PTEN and inhibits its expression.Overexpression of miR-22-3p inhibits H/R-induced cell apoptosis and reduces LDH and MDA levels,while its effects are abolished by overexpression of PTEN.Finally,overexpression of NORAD inhibits the AKT/mTOR signaling pathway,and its effects are attenuated by overexpression of miR-22-3p.Taken together,our study reveals that NORAD promotes the progression of AMI by regulating the miR-22-3p/PTEN axis,and the AKT/mTOR signaling may also be involved in the regulatory processes. | Chunxia Li Lihui Zhang Xingpeng Bu Guofang Chu Xiaofang Zhao Yaru Liu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 3 |
| 8 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 9 | The design and construction of a pulsed beam generation system based on high intensity cyclotron显示文摘In order to perform the studies on a pulsed beam generation system based on a high intensity cyclotron, a test beam line with a pulsed beam generation for a 10 MeV compact cyclotron (CYCIAE-10) has been designed and constructed at China Institute of Atomic Energy (CIAE). A 70 MHz continuous H- beam can be pulsed to the pulse length of less than 10 ns with a repetition rate of 4.4 MHz. The sine waveform with a frequency of 2.2 MHz is adopted for the chopper and a mesh structure with single drift and dual gaps is used for the 70 MHz buncher. A helical resonator is designed and constructed based on simulations and experiments on the RF matching for the chopper. A helical inductance loop that is exceptionally large of its kind and equipped with water cooling for the resonator has been successfully wound and a 500 W solid RF amplifier has been manufactured. A special measuring device has been designed, which can be used to measure both the DC beam and the pulsed beam. The required pulsed beam was obtained after pulsed beam tuning. | AN ShiZhong YIN ZhiGuo LI PengZhan SONG GuoFang WU LongCheng GUAN FengPing XIE HuaiDong JIA XianLu LU YinLong ZHANG TianJue | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 10 | Satb2 expression in Foxci-promoted osteogenic differentiation of MC3T3-E1 cells is negatively regulated by microRNA-103-3p显示文摘The forkhead tran scripti on factor C1 (Foxci) is a cell-fate-determining factor that controls cranial bone development and osteogenic differentiation. Previously, it was demonstrated that various microRNAs (miRNAs) play important roles in osteogenesis and regulate the complex process of osteogenic differentiation. However, it remains unclear how miRNA expression changes during Foxci-promoted osteogenic differentiation. In this study, we successfully overexpressed the Foxci gene in MC3T3-E1 cells and investigated the alterations in the miRNA expression profile on day 3 after osteogenic induction by using a miRNA microarray. Nine downregulated miRNAs and eight upregulated miRNAs were found to be differentially expressed. Among these miRNAs, miR-103-3p was consistently downregulated in the Foxc7-overexpressing MC3T3-E1 cells and was identified as a negative regulator of osteogenic differentiation by using a gain-and Iose-of-funotion assay. The special AT-rich sequence-binding protein 2 (Satb2), a pivotal osteogenic transcription factor, was identified as the miR-103-3p targeting gene and was verified by real-time polymerase chain reaction, western blot analysis, and luciferase assay. Overexpression of miR-103-3p markedly inhibited the expression of Satb2 and attenuated Foxci-promoted osteogenic differentiation. Taken together, our results elucidated the miRNA expression profiles of MC3T3-E1 cells in the early stage of Foxc 1-promoted osteogenic differentiation and suggested that miR-103-3p acts as a negative regulator of the osteogenic differentiation of MC3T3-E1 cells by directly targeting Satb2. | Hongzhou Shen Chenpei Lu Jun Shi Hongliang Li Jiawen Si Guofang Shen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 3 |
| 11 | A rapid and efficient method for primary culture of human adipose-derived stem cells显示文摘 | Guofang Zeng Kuan Lai Jin Li Yaqin Zou Haili Huang Jie Liang Xudong Tang Jing Wei Peihua Zhang | 2013 | Organogenesis2013，，4： | 2 |
| 12 | Physicochemical properties and volatile components of pea flour fermented by Lactobacillus rhamnosus L08显示文摘Pea(Pisum sativum L.)is an important source of plant proteins.However,the use of pea flour as a food ingredient is greatly limited due to its strong beany flavor.In this work,we investigated the effects of Lactobacillus rhamnosus L08(L.rhamnosus L08)fermentation on the physicochemical characteristics,amino acids composition and volatile flavor compounds of pea flour.We found that L.rhamnosus L08 had the probiotic potential of utilizing pea flour as fermentation substrate.L.rhamnosus L08 fermentation significantly increased the content of most amino acids,and total amino acid content increased from 222.18 mg/g at 0 h to 262.35 mg/g at 6 h.A total of 44 volatile compounds were identified in pea flour.L.rhamnosus L08 fermentation increased the variety of acids and esters,while reduced the unpleasant flavor such as nonanal,decanal,octanal,1-hexanol and 2-ethyl-1-hexanol.The emulsifying stability and foam stability of pea flour were slightly enhanced during fermentation.Our results illustrate that lactic acid bacteria fermentation is a promising approach to eliminate undesirable aroma of pea flour.Moreover,this study provides theoretical support for the application of peas as high-quality protein source. | Mengqi Pei Zifu Zhao Song Chen E.I.Reshetnik S.L.Gribanova Chun Li Guofang Zhang Libo Liu Lin Zhao | 2022 | Food Bioscience2022，46，2： | 2 |
| 13 | Game-theoretic approach to power and admission control in hierarchical wireless sensor networks显示文摘Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs' utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm. | Guofang Nan Zhifei Mao Minqiang Li | 2012 | Journal of Systems Engineering and Electronics2012，23，2： | 2 |
| 14 | Over-expression of miR-125a-5p inhibits proliferation in C2C12 myoblasts by targeting E2F3显示文摘MicroRNAs miRNAs 是在长度的 2025 核苷酸的小非编码的 RNA 的一个班。miRNAs 在房间的许多类型的增长起重要作用,这被显示出,包括 myoblasts。在这研究,我们使用了即时量的聚合酶链反应,西方的弄污,在 C2C12 myoblasts 的增长期间探索 miR-125a-5p 的角色的 EdU,流动 cytometry,和 CCK-8 试金。miR-125a-5p 的表示在 C2C12 myoblast 增长期间被减少,这被发现。miR-125a-5p 的在表示上禁止了由 EdU 染色,流动 cytometry,和 CCK8 试金显示了的 C2C12 myoblast 增长。miR-125a-5p 能否定地在 posttranscriptional 水平调整 E2F3 表示,这也被发现,经由在 3 untranslated 区域的一个特定的目标地点。显示出的 E2F3 击倒 C2C12 myoblast 增长上的类似的禁止的效果。因此,我们的调查结果建议 miR-125a-5p 可以由指向 E2F3 充当 C2C12 myoblast 增长的一个否定管理者。 | Chengchuang Song Guofang Wu Aoqi Xiang Qiangling Zhang Wanhua Li Gongshe Yang Xin'e Shi Shiduo Sun Xiao Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 1 |
| 15 | Genome-wide Identification and Expression Analysis of Half-size ABCG Genes in Malus × domestica显示文摘Half-size adenosine triphosphate-binding cassette transporter subgroup G(ABCG) genes play crucial roles in regulating the movements of a variety of substrates and have been well studied in several plants. However, half-size ABCGs have not been characterized in detail in apple(Malus × domestica Borkh.). Here, we performed a genome-wide identification and expression analysis of the half-size ABCG gene family in apple.A total of 46 apple half-size ABCGs were identified and divided into six clusters according to the phylogenetic analysis. A gene structural analysis showed that most half-size ABCGs in the same cluster shared a similar exon–intron organization. A gene duplication analysis showed that segmental, tandem and whole-genome duplications could account for the expansion of half-size ABCG transporters in M. domestica. Moreover, a promoter scan, digital expression analysis and RNA-seq revealed that Md ABCG21 may be involved in root's cytokinin transport and that ABCG17 may be involved in the lateral bud development of M. spectabilis ‘Bly114’ by mediating cytokinin transport. The data presented here lay the foundation for further investigations into the biological and physiological processes and functions of half-size ABCG genes in apple. | MA Juanjuan ZHENG Liwei ZHAO Caide LI Guofang SHEN Yawen AN Na ZHANG Dong HAN Mingyu | 2018 | Horticultural Plant Journal2018，4，2： | 1 |
| 16 | Optimal extent of fluorination enabling strong temperature-dependent aggregation, favorable blend morphology and high-efficiency polymer solar cells显示文摘Temperature-dependent aggregation is a key property for some donor polymers to realize favorable bulk-heterojunction(BHJ)morphologies and high-efficiency(>10%) polymer solar cells.Previous studies find that an important structural feature that enables such temperature-dependent aggregation property is the 2nd position branched alkyl chains sitting between two thiophene units.In this report,we demonstrate that an optimal extent of fluorination on the polymer backbone is a second essential structural feature that enables the strong temperature-dependent aggregation property.We compare the properties of three structurally similar polymers with 0,2 or 4 fluorine substitutions in each repeating unit through an in-depth morphological study.We show that the non-fluorinated polymer does not aggregate in solution(0.02 mg mL^(-1) in chlorobenzene) at room temperature,which results in poor polymer crystallinity and extremely large polymer domains.On the other hand,the polymer with four fluorine atoms in each repeating unit exhibits an excessively strong tendency to aggregate,which makes it difficult to process and causes a large domain.Only the polymer with two fluorine atoms in each repeating unit exhibits a suitable extent of temperature-dependent aggregation property.As a result,its blend film achieves a favorable morphology and high power conversion efficiency.This provides another key design rationale for developing donor polymers with suitable temperature-dependent aggregation properties and thus high performance. | Guofang Yang Zhengke Li Kui Jiang Jie Zhang Jianya Chen Guangye Zhang Fei Huang Wei Ma He Yan | 2017 | Science China Chemistry2017，60，4： | 1 |
| 17 | Optimization of Ultrasonic Extraction and Clean-up Protocol for the Determination of Polycyclic Aromatic Hydrocarbons in Marine Sediments by High-performance Liquid Chroma-tography Coupled with Fluorescence Detection显示文摘The procedures of ultrasonic extraction and clean-up were optimized for the determination of polycyclic aromatic hydrocarbons (PAHs) in marine sediments. Samples were ultrasonically extracted, and the extracts were purified with a miniaturized silica gel chromatographic column and analyzed with high performance liquid chromatography (HPLC) with a fluorescence detector. Ultrasonication with methanol-dichloromethane (2:1, v/v) mixture gave higher extraction efficiency than that with dichloromethane. Among the three elution solvents used in clean-up step, dichloromethane-hexane (2:3, v/v) mixture was the most satisfactory. Under the optimized conditions, the recoveries in the range of 54.82% to 94.70% with RSDs of 3.02% to 23.22% for a spiked blank, and in the range of 61.20% to 127.08% with RSDs of 7.61% to 26.93% for a spiked matrix, were obtained for the 15 PAHs studied, while the recoveries for a NIST standard reference SRM 1941b were in the range of 50.79% to 83.78% with RSDs of 5.24% to 21.38%. The detection limits were between 0.75 ng L-1 and 10.99 ng L-1for different PAHs. A sample from the Jiaozhou Bay area was examined to test the established methods. | PENG Xuewei YAN Guofang LI Xianguo GUO Xinyun ZHOU Xiao WANG Yan | 2012 | Journal of Ocean University of China2012，11，3： | 1 |
| 18 | Analysis about the effect of an on - chip all - optical analogue to electromagneti- cally induced transparency in the two resonators system 显示文摘 | Fan Guofang Li Yuan Liu Xinhou | 2012 | Infrared Physics & Technology2012，55，23： | 1 |
| 19 | Effect of quinoicl redox mediators on the aerobic decolorization of azo dyes by cells and cell extracts from Escherichia coli 显示文摘 | CUI Daizong LI Guofang ZHAO Dan | 2015 | Environmen- tal Science and Pollution Research2015，22，6： | 1 |
| 20 | Long - term water - level fore- casting and real - time correction models in the tidal reachof the Yan- gtze River显示文摘 | Li Guofang Xiang Xinyi Wu Jie | 2013 | Journal of Hydrologic Engineering2013，18，11： | 1 |
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