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63篇 您的检索式:作者名="Fuxiang Wang"
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1Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu 2020Science China(Life Sciences)2020,63,3:157
2NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian 2012Cell Research2012,22,5:13
3TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang 2016Cell Research2016,26,9:13
4Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities.LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue 2009Journal of Environmental Sciences2009,21,9:13
5Analysis for retrieval and validation results of FY-3 Total Ozone Unit (TOU)显示文摘Retrieval experiment was made for global total column ozone using the first year measurements of Total Ozone Unit (TOU) on board the second generation polar orbiting meteorological satellite of China, FY-3/A. The retrieval results were analyzed and validated by comparison with AURA/OMI, Meteop/GOME-2 global ozone products and ground-based ozone measurement data. The qualititative comparisons over the globe especially over Antarctica and the Tibetan Plateau show that the spatial and temporal distribution characteristics are consistent with OMI and GOME-2 products. The quantitative comparisons with ground-based measurements and AURA/OMI ozone product were made over 74 stations, the TOU total ozone retrieval has a 3% rms relative error compared with AURA/OMI ozone product and 4.2% rms relative error with ground-based measurements. The maximum difference between satellite retrieval and ground-based measurements was found in the Antarctica ozone hole. The TOU global ozone product is operational and distributed to all users.WANG WeiHe ZHANG XingYing AN XingQin ZHANG Yan HUANG FuXiang WANG YongMei WANG YingJian ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang LIU GuoYang 2010Chinese Science Bulletin2010,55,26:12
6FY-3 satellite Ultraviolet Total Ozone Unit显示文摘FY-3 satellites are Chinese second-generation polar orbit meteorological satellite series. Ultraviolet Total Ozone Unit (TOU) is one of the main payloads on FY-3 satellite and the first instrument for daily global coverage of total ozone monitoring in China. The main purpose of TOU is to measure the Earth backscatter ultraviolet radiation for retrieving daily global map of atmospheric ozone. TOU will provide the important parameters for environmental monitoring, climate forecasting and global climate changing research. At present, the in-orbit testing of TOU has accomplished and won a consummation, and it will be delivered to National Satellite Meteorological Center for the operational phase of the project. In this paper we introduce the instrument of TOU and its measuring principle, in general. We also analyze the recent working status of the instrument, including the sensitivity, measuring precision of solar irradiance, diffuser degradation and wavelength drift. The inversion results show that TOU can provide good global ozone maps, and a comparison with the OMI total ozone product shows that their RMS deviation is about 5%. It is indicated that the satisfied global distribution of total ozone can be obtained through TOU observational data and self-developed inversion method.WANG YongMei WANG YingJian WANG WeiHe ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang CHEN Ji WANG JiHong GUAN FengJun HUANG FuXiang ZHANG XingYing 2010Chinese Science Bulletin2010,55,1:9
7Vertical ozone profiles deduced from measurements of SBUS on FY-3 satellite显示文摘The FY-3 satellite is a second-generation Chinese polar-orbit meteorological satellite.The Solar Backscatter Ultraviolet Sounder (SBUS),one of the main payloads on the FY-3 satellite,is the first Chinese ozone-monitoring instrument on a meteorological satellite.As part of the in-orbit validation of FY-3,we carried out a retrieval trial using measurements from SBUS during the period of 17-30 July,2008,and compared those data with measurements and retrieved profiles from the National Oceanic and Atmospheric Administration (NOAA) satellite SBUV/2.The results show that the precision of the measurements and retrieved profiles are quite good.The averaged relative difference percentages of the ozone profiles retrieved from SBUS and those from SBUV/2 are within ±7%.HUANG FuXiang LIU NianQing ZHAO MingXian WANG ShuRong HUANG Yu 2010Chinese Science Bulletin2010,55,10:9
8Monitoring of the 2011 spring low ozone events in the Arctic region显示文摘Data from FY-3B SBUS and NOAA SBUV/2 were used to monitor ozone levels in the Arctic region from March 1 to April 5, 2011. Results revealed a significant ozone depletion in the area, with total ozone levels between 200-250 DU. The ozone levels recorded were 100-200 DU below normal, and in some parts the levels were as low as 200 DU, indicating a mini ozone-hole. During the sampling period, the ozone depletion area underwent identifiable expansion and detraction, a rotation around the North Pole from the west to the east, and a longitudinal movement from the Pole, spreading to the mid latitudes. The effects of these rare low ozone events were not only felt in the Arctic, but also extended to densely populated areas between Europe and the middle of Russia. In this region, rapidly increasing levels of ultraviolet radiation were detected at the Earth's surface. Given the significant risk that this poses to both the environment and people's health, this occurrence has significant global implications.LIU NianQing 1,2 , HUANG FuXiang 1,2 WANG WeiHe 1,2 1 National Satellite Meteorological Center, Beijing 100081, China 2 Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites, China Meteorological Administration, Beijing 100081, China 2011Chinese Science Bulletin2011,56,27:8
9Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang 2020National Science Review2020,7,6:6
10Study on the Metallogenetism of Sub-mantle Plume and Mantle Branches in the Gold Mineralization Concentration Area of Northwest Jiaodong Peninsula显示文摘The northwest of Jiaodong peninsula is characterized by its greatest gold concentration area, enormous gold reserves and limited time interval(115±5Ma) of gold mineralization in China. Studies show that the east area of north China began its mantle plume evolution since the Yanshanian movement, and the Laiyang sub-mantle plume and its surrounding mantle branches such as those in Guojiadian, Aishan and Panshidian were formed in the mineralization concentration area of northwestern Jiaodong peninsula. With the development of mantle plume → sub-mantle plume → mantle branch → favorable expending structures, the deep-derived hydrothermal fluid moved up to the favorable places, such as brittle-ductile or ductile-brittle shearing zones, the internal and external contact zones of intrusions, dense fracturing zones and the contact zones between dikes and countryrocks, and concentrated into deposits. Then the gold mineralization concentration zones that are centralized on mantle branches were formed. This study takes Guojiadian mantle branch as an example to discuss their metallogenetism and conclude the metallogenetic mode.NIU Shuyin CHENG Guangsuo ZHANG Jianzhen SUN Aiqun MA Baojun ZHANG Fuxiang WANG Baode XU Meng WU Jichun ZHAO Rongxin WANG Shanfei 2014Acta Geologica Sinica(English Edition)2014,88,5:4
11The Effect of Netting Solidity Ratio and Inclined Angle on the Hydrodynamic Characteristics of Knotless Polyethylene Netting显示文摘Knotless polyethylene(PE) netting has been widely used in aquaculture cages and fishing gears, especially in Japan. In this study, the hydrodynamic coefficient of six knotless PE netting panels with different solidity ratios were assessed in a flume tank under various attack angles of netting from 0?(parallel to flow) to 90?(perpendicular to flow) and current speeds from 40 cm s^(-1) to 130 cm s^(-1). It was found that the drag coefficient was related to Reynolds number, solidity ratio and attack angle of netting. The solidity ratio was positively related with drag coefficient for netting panel perpendicular to flow, whereas when setting the netting panel parallel to the flow the opposite result was obtained. For netting panels placed at an angle to the flow, the lift coefficient reached the maximum at an attack angle of 50? and then decreased as the attack angle further increased. The solidity ratio had a dual influence on drag coefficient of inclined netting panels. Compared to result in the literature, the normal drag coefficient of knotless PE netting measured in this study is larger than that of nylon netting or Dyneema netting.TANG Hao HU Fuxiang XU Liuxiong DONG Shuchuang ZHOU Cheng WANG Xuefang 2017Journal of Ocean University of China2017,16,5:4
12Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3].Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang 2022National Science Review2022,9,10:3
13Template-directed Synthesis of Three Metal Oxalates via 4-Connected Building Units显示文摘TIAN Ruijing WANG Fuxiang DU Chunyu FENG Lijuan LIU Ying ZHANG Cailing PAN Qinhe 2014Chemical Research in Chinese Universities2014,30,6:3
14Wear Behavior of In-situ TiC Particles Reinforced Aluminum Matrix Composite显示文摘The microstructure, tensile property and wear resistance of 7075 aluminum matrix composite reinforced with TiC particles prepared by in-situ reaction casting were investigated. The effect of TiC reinforcement on wear behavior was analyzed. The wear mechanism was also discussed. A micro-mechanism model of reaction kinetics for synthesis of TiC was acquired. Results show that TiC could increase the tensile and yield strength, but decrease the elongation. Besides, TiC particles improve the property of wear resistance of 7075 aluminum alloy. The wear mechanisms include abrasive wear and adhesive wear in wear test process.隋艳伟 CHEN Xiao WANG Rui QI Jiqiu WEI Fuxiang HE Yezeng MENG Qingkun 孙智 2017Journal of Wuhan University of Technology(Materials Science)2017,32,3:3
15Timing of mineralization at the Shihu gold deposit in the middle segment of the Taihang Mountain, China显示文摘The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 Ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 Ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 Ma.Chao Chen Shuyin Niu Fang Wang Fuxiang Zhang Qinglian Zhang Baojun Ma Aiqun Sun Jianzhen Zhang Yaqi Cao Xiaoqing Zhang 2018Acta Geochimica2018,37,1:3
16Inactivation of Staphylococcus aureus and Enterococcus faecalis by a direct-current,cold atmospheric-pressure air plasma microjet显示文摘Objective:A direct-current,cold atmospheric-pressure air plasma microjet(PMJ)was performed to inactivate Staphylococcus aureus(S.aureus)and Enterococcus faecalis(E.faecalis)in air.The process of sterilization and morphology of bacteria was observed.We wish to know the possible inactivation mechanisms of PMJ and explore a potential application in dental and other temperature sensitive treatment.Methods:In this study,we employed a direct current,atmospheric pressure,cold air PMJ to inactivate bacterias.Scanning electron microscopy was employed to evaluate the morphology of S.aureus and showed rupture of cell walls after the plasma treatment and Optical emission spectrum(OES)were used to understand the possible inactivation mechanisms of PMJ.Results:The inactivation rates could reach 100%in 5 min.When the distance between the exit nozzle of the PMJ device and Petri dish was extended from 1 cm to 3 cm,effective inactivation was also observed with a similar inactivation curve.Conclusion:The inactivation of bacteria is attributed to the abundant reactive oxygen and nitrogen species,as well as ultroviolet radiation in the plasma.Different life spans and defensibilities of these killing agents may hold the key to understanding the different inactivation curves at different treatment distances.Ye Tian Peng Sun Haiyan Wu Na Bai Ruixue Wang Weidong Zhu Jue Lnang Fuxiang Liu 2010The Journal of Biomedical Research2010,24,4:2
17Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China显示文摘Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep processes.The region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic time.At that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its periphery.The core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch structure.This study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment belt.Furthermore,on this basis,this study also pointed out the orientation for further ore prospecting in this region.NIU Shuyin Sun Aiqun ZHANG Jianzhen MA Baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei 2012Chinese Journal Of Geochemistry2012,31,4:2
18Novel infrared and visible image fusion method based on independent component analysis显示文摘目标红外线(红外) 并且可见图象熔化是让熔化图象从 IR 图象包含红外目标特征并且保留可见图象提供的视觉细节。传统的熔化方法的劣势基于独立部件分析(集成通信适配器) 是描述红外的主要特征信息反对,在红外图象的第二等的特征信息被熔化进熔化图象。第二等的特征信息能压抑熔化图象的视觉效果。新奇基于集成通信适配器的红外和可见图象熔化计划在这份报纸被建议。集成通信适配器被采用从红外线的图象提取特征,然后主要、第二等的特征被集成通信适配器基础系数的峭度信息区分。IR 图象的第二等的特征在熔化期间被丢弃。熔化图象被熔化主要特征进可见图象获得。试验性的结果证明建议方法能提供更好的感觉效果。Yin LU Fuxiang WANG Xiaoyan LUO Feng LIU 2014Frontiers of Computer Science2014,8,2:2
19Latest Advances in High-Voltage and High-Energy-Density Aqueous Rechargeable Batteries显示文摘Aqueous rechargeable batteries(ARBs)have become a lively research theme due to their advantages of low cost,safety,environmental friendliness,and easy manufacturing.However,since its inception,the aqueous solution energy storage sys-tem has always faced some problems,which hinders its development,such as the narrow electrochemical stability window of water,poor percolation of electrode materials,and low energy density.In recent years,to overcome the shortcomings of the aqueous solution-based energy storage system,some very pioneering work has been done,which also provides a great inspiration for further research and development of future high-performance aqueous energy storage systems.In this paper,the latest advances in various ARBs with high voltage and high energy density are reviewed.These include aqueous rechargeable lithium,sodium,potassium,ammonium,zinc,magnesium,calcium,and aluminum batteries.Further chal-lenges are pointed out.Xinhai Yuan Fuxiang Ma Linqing Zuo Jing Wang Nengfei Yu Yuhui Chen Yusong Zhu Qinghong Huang Rudolf Holze Yuping Wu Teunis van Ree 2021Electrochemical Energy Reviews2021,4,1:2
20Synthesis and biological activities of 2-oxocycloalkylsulfonamides显示文摘XINGHAI LI XINLING YANG XIAOMEI LIANG ZHENPENG KAI HUIZU YUAN DEKAIYUAN JIANJUN ZHANG RUIQING WANG FUXIANG RAN SHUHUA QI YUN LING FUHENG CHEN DAOQUAN WANG 0,,08:1
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