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| 1 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 2 | Genome-and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus显示文摘Seed oil content(SOC)is a highly important and complex trait in oil crops.Here,we decipher the genetic basis of natural variation in SOC of Brassica napus by genome-and transcriptome-wide association studies using 505 inbred lines.We mapped reliable quantitative trait loci(QTLs)that control SOC in eight environments,evaluated the effect of each QTL on SOC,and analyzed selection in QTL regions during breeding.Six-hundred and ninety-two genes and four gene modules significantly associated with SOC were identified by analyzing population transcriptomes from seeds.A gene prioritization framework,POCKET(prioritizing the candidate genes by incorporating information on knowledge-based gene sets,effects of variants,genome-wide association studies,and transcriptome-wide association studies),was implemented to determine the causal genes in the QTL regions based on multi-omic datasets.A pair of homologous genes,BnPMT6s,in two QTLs were identified and experimentally demonstrated to negatively regulate SOC.This study provides rich genetic resources for improving SOC and valuable insights toward understanding the complex machinery that directs oil accumulation in the seeds of B.napus and other oil crops. | Shan Tang Hu Zhao Shaoping Lu Liangqian Yu Guofang Zhang Yuting Zhang Qing-Yong Yang Yongming Zhou Xuemin Wang Wei Ma Weibo Xie Liang Guo | 2021 | Molecular Plant2021，14，3： | 6 |
| 3 | Strategies in Precursors and Post Treatments to Strengthen Carbon Nanofibers显示文摘The limited mechanical properties of carbon nanofibers(CNFs)have become a severe problem hindering their wide range applications.The restricting issues are found in the whole fabrication process,including the precursor design,spinning and collection techniques,post treatments like stretching and aligning,and complicated thermal treatments involving stabilization and carbonization.Here we access the CNF development by focusing on the mechanical properties,and systematically discuss the strengthening strategies during the different fabrication stages. | Guofang Hu Xiaohua Zhang Xiaoyan Liu Jianyong Yu Bin Ding | 2020 | Advanced Fiber Materials2020，2，2： | 2 |
| 4 | Progress of Geological Survey Using Airborne Hyperspectral Remote Sensing Data in the Gansu and Qinghai Regions显示文摘Hyperspectral remote sensing is now a frontier of the remote sensing technology.Airborne hyperspectral remote sensing data have hundreds of narrow bands to obtain complete and continuous ground-object spectra.Therefore,they can be effectively used to identify | ZHAO Yingjun QIN Kai SUN Yu LIU Dechang TIAN Feng PEI Chengkai YANG Yanjie YANG Guofang ZHOU Jiajing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 5 | Operation of silicon-germanium heterojunction bipolar transistors with different structures at deep cryogenic temperature显示文摘In this work, the device performances of discrete and integrated SiGe heterojunction bipolar transistors(HBTs) with different device structures from 300 to 4.8 K were investigated. The turn-on voltages of baseemitter and base-collector junctions increased non-linearly with temperature cooled to 4.8 K. Energy bandgap engineering was taken into account for the analytical model of the turn-on voltage versus temperature. Incomplete ionization occurred in the base-collector junction because of the low doping concentration. The trap-assisted tunneling current in the forward base current was clearly observed below20 K. The ideality factor and saturation current were shown to be temperature dependence. The ideality factor was much larger than 2 below 40 K, indicating that the current is not only contributed by drift, diffusion and recombination, but also by tunneling. The peak current gain of the discrete SiGe HBTs achieved the maximum value of 3,388 at 80 K, while that of the integrated was 546 at 140 K. The transconductance in logarithm was linearly dependent on reciprocal temperature above 50 K, but flattened below 50 K.Early effect was evidently observed below 77 K in the fixed base current output characteristics of the discrete SiGe HBTs, and it was not obvious for the integrated SiGe HBTs. | Guofang Yu Renrong Liang Xiawa Wang Jun Xu Tian-Ling Ren | 2019 | Science Bulletin2019，64，7： | 1 |
| 6 | Variation in plant diversity and dominance across dune fixation stages in the Chinese steppe zone显示文摘Aims Our aim was to study how diversity and dominance of plant species and plant functional types(PFTs)change and covary across three dune fixation stages in the Chinese steppe zone.Methods In the Chinese steppe zone,we measured coverage,mean height and density of each plant species in three types of dunes(mobile,semi-fixed and fixed dunes)in four sites(Mu Us,Otindag,Hulunbeir and Horqin).Plant species were grouped into 24 PFTs according to their lifespan,photosynthetic pathway,reproductive mode and life form.Dominance of each plant species and PFT were determined,and species diversity and PFT diversity were quantified using Shannon–Wiener index.Important Findings PFT diversity was positively related to plant species diversity in each dune stage,but PFT diversity increased more with increasing plant species diversity in the mobile and semi-fixed dunes than in the fixed dunes.Dune fixation stage explained 87.2%of the variation in plant species diversity and 84.8%of the variation in PFT diversity.Dominant species and PFTs differed among the three dune fixation stages;the more fixed the dunes were,the more perennial,shrubby,clonal and C3 species co-dominated.Specifically,in mobile dunes annual C4 non-clonal herbs were the most dominant,and in semi-fixed and fixed dunes perennial C3 clonal shrubs were most dominant. | Jianjiang Qiao Weiwei Zhao Xiufang Xie Guofang Liu Xuehua Ye Yu Chu Hui He Ming Dong | 2012 | Journal of Plant Ecology2012，5，3： | 1 |
| 7 | Constraining self-interacting dark matter with the full dataset of PandaX-II显示文摘Self-interacting dark matter(SIDM)is a leading candidate proposed to solve discrepancies between predictions of the prevailing cold dark matter theory and observations of galaxies.Many SIDM models predict the existence of a light force carrier that mediates strong dark matter self-interactions.If the mediator couples to the standard model particles,it could produce characteristic signals in dark matter direct detection experiments.We report searches for signals of SIDM models with a light mediator using the full dataset of the PandaX-II experiment,basing on a total exposure of 132 tonne-days.No significant excess over background is found,and our likelihood analysis leads to a strong upper limit on the dark matter-nucleon coupling strength.We further combine the PandaX-II constraints and those from observations of the light element abundances in the early universe,and show that direct detection and cosmological probes can provide complementary constraints on dark matter models with a light mediator. | Jijun Yang Abdusalam Abdukerim Wei Chen Xun Chen Yunhua Chen Chen Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Shengming He Di Huang Yan Huang Ran Huo Yanlin Huang Zhou Huang Xiangdong Ji Yonglin Ju Shuaijie Li Qing Lin Huaxuan Liu Jianglai Liu Xiaoying Lu Wenbo Ma Yugang Ma Yajun Mao Yue Meng Nasir Shaheed Kaixiang Ni Jinhua Ning Xuyang Ning Xiangxiang Ren Changsong Shang Guofang Shen Lin Si Andi Tan Anqing Wang Hongwei Wang Meng Wang QiuHong Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Shiyong Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Yong Yang Chunxu Yu Hai-Bo Yu Jumin Yuan Ying Yuan Xinning Zeng Dan Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 0 |
| 8 | Electrospun Nanofibers Withstandable to High-Temperature Reactions: Synergistic Effect of Polymer Relaxation and Solvent Removal显示文摘Fiber breakage is found to be a ubiquitous phenomenon during the thermal treatments for electrospun nanofibers,because of the presence of solvent molecules and unrelaxed assembly of polymer chains.Here a strengthening strategy is designed by introducing a pre-heating stage for the as-spun nanofibers.At a temperature above the polymer’s glass transition temperature,the chains can get sufficiently relaxed by the aid of hot solvent,and at the same time,the solvent confined in the entangled chains can fully and steadily evaporate,but not erupt,off the nanofiber,when the temperature is just as high as the boiling point.Therefore,the nanofibers become more uniform in structure and can withstand the subsequent thermal reactions.For polyacrylonitrile-based electrospinning,such strategy can improve the final tensile strength from 42 to 112 MPa for the nanofiber films. | Guofang Hu Xiaohua Zhang Xiaoyan Liu Jianyong Yu Bin Ding | 2021 | Advanced Fiber Materials2021，3，1： | 0 |
| 9 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 10 | Apelin aggravates the migration and invasion of non-small cell lung cancer cells via YAP1显示文摘Background:Apelin,an endogenous ligand of G-protein coupled receptor(GPCR),is a secreted peptide involved in the development of various tumors.However,the relationship between apelin and non-small cell lung cancer(NSCLC)is not quite clear.This study was designed to investigate the effect and mechanism of apelin on cell proliferation,migration and invasion of NSCLC cells.Methods:Twelve NSCLC specimens were collected for hematoxylin-eosin(HE)staining and immunohistochemistry analyses.Cell proliferation was examined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and cell migration and invasion were assessed using wound-healing and transwell assays.The subcellular location of yes associated protein 1(YAP1)in A549 cells was determined by immunofluorescence.The mRNA and protein levels in NSCLC tissues and cell lines were measured by qRT-PCR and western blot,respectively.Results:Apelin was upregulated in tumor tissues compared with the adjacent tissues.Apelin promoted proliferation,migration,and invasion of A549 and H460 cells,which was reversed by competitive apelin receptor(APJ)antagonist ML221.Additionally,apelin upregulated YAP1 expression,whereas silence of YAP1 by small interfering RNA(siRNA)attenuated apelin-induced cell proliferation,migration and invasion and suppressed epithelial-mesenchymal transition progression.Conclusion:Apelin promotes NSCLC cells proliferation,migration,and invasion by modulating YAP1 and might be a potential therapeutic target for NSCLC treatment. | Wenchao Ma Di Zhu Tong Yu Junwen Xue Xiang Sun Guofang Zhang Yumeng Hou Jinrui Li Yingzhun Chen Hongli Shan Haihai Liang | 2022 | Frigid Zone Medicine2022，2，1： | 0 |
| 11 | Geometry characteristics and wide temperature behavior of silicon-based GaN surface acoustic wave resonators with ultrahigh quality factor显示文摘Surface acoustic wave(SAW)resonators with an ultrahigh Q-factor are designed and fabricated on silicon-based gallium nitride(GaN/Si).The temperature-dependent performance is characterized over a wide range,from 10 to 500 K.Finite element analysis is employed to guide the design of the SAW resonator from indications of the Rayleigh mode and weak propagation direction dependence of SAW in the c-plane of GaN/Si.The SAW resonator with 100 pairs of interdigital transducers(IDT),100 pairs of grating reflectors(GR)for each side,aperture size of 80μm,metallization ratio of 0.5,and electrode width of 500 nm resonates at 1.9133 GHz accordingly with an ultrahigh Q-factor of 7622 at room temperature,which contributes the f_(r)×Q_(r),up to 14.583×10^(12)Hz.A resonator operating over 10 to 500 K indicates an approximately linear decreasing temperature dependence above 280 K while being approximately constant below 40 K.The fitting to resonator characteristics using the modified Butterworth Van Dyke(mBVD)model reveals a reduction in both the electrode and mechanical losses while worsening the dielectric loss with cooling down. | Guofang YU Renrong LIANG Haiming ZHAO Lei XIAO Jie CUI Yue ZHAO Wenpu CUI Jing WANG Jun XU Jun FU Tianling REN | 2024 | Science China(Information Sciences)2024，67，2： | 0 |
| 12 | CTAB Assisted Synthesis of CuS Microcrystals:Synthesis,Mechanism,and Electrical Properties显示文摘CuS microcrystals were successfully prepared through a mild solvothermal reaction in ethylene glycol(EG) with the assistance of cationic surfactant cetyltrimethylammonium bromide(CTAB).An interesting morphology evolution from flower-like microspheres to hollow microspheres,and finally to smooth nanoflakes was observed when increasing the amount of CTAB.The products were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and UV—vis spectroscopy.It was found that the amount of CTAB played an important role in determining the morphology of the CuS microcrystals.Electrical measurement reveals that the as-prepared CuS microspheres were of high conductivity,which might favor their device applications.It is expected that CuS microcrystals with controlled morphologies and structures will have important applications in solar cells.This simple but effective method could also be extended to the controlled growth of other inorganic microcrystals. | Chunyan Wu Guofang Zhou Dun Mao Zihan Zhang Yiliang Wu Wenjian Wang Linbao Luo Li Wang Yongqiang Yu Jigang Hu Zhifeng Zhu Yan Zhang Jiansheng Jie | 2013 | Journal of Materials Science & Technology2013，29，11： | 0 |
| 13 | Quasi-Solid-State Composite Electrolytes with Multifunctional 2D Molecular Brush Fillers for Long-Cycling Lithium Metal Batteries显示文摘The ever-growing demand for next-generation high-energy-density devices drives the development of lithium metal batteries with enough safety and high performance,in which quasi-solid-state composite electrolytes(QSCEs)with high ionic conductivity and lithium ion transference number(urn:x-wiley:1001604X:media:cjoc202300232:cjoc202300232-math-0001)are highly desirable.Herein,we successfully synthesize a kind of two-dimensional(2D)molecular brush(GO-g-PFIL)via grafting poly(ionic liquid)side-chain(poly(3-(3,3,4,4,4-pentafluorobutyl)-1-vinyl-1H-imidazol-3-ium bis(trifluoromethanesulfonyl)imide),denoted as PFIL)on the surface of 2D graphene oxide(GO)sheet.GO-g-PFIL is used as multifunctional filler to prepare novel composite membranes and corresponding QSCEs(e.g.,QSCE-PH/GPFIL3/P).The as-obtained QSCE-PH/GPFIL3/P integrates features of PFIL side-chain-enhanced lithium ion conduction,poly(vinylidene fluoride-co-hexafluoropropene)backbone-induced flexibility,and GO-strengthened mechanical property.As a result,our ultrathin(21μm)self-supporting QSCE-PH/GPFIL3/P exhibits high ionic conductivity(3.24×10^(−4)S·cm^(−1))and excellent urn:x-wiley:1001604X:media:cjoc202300232:cjoc202300232-math-0002(0.82)at room temperature,and Li/LFP full cell with QSCE-PH/GPFIL3/P shows superior rate performance(high specific capacities of 79 mAh·g^(−1)at 30°C and 5 C)and excellent cycling performance(high capacity retention of 91%after 500 cycles at 80°C and 1 C). | Yin Cui Guofang Yu Ruliang Liu Dongtian Miao Dingcai Wu | 2023 | Chinese Journal of Chemistry2023，41，21： | 0 |
| 14 | Simultaneous gap arthroplasty combined with distraction osteogenesis in the treatment of unilateral temporo-mandibular joint ankylosis with micrognathia deformity显示文摘 | Hong Bo Yu Steve Guofang Shen Shi Lei Zhang Xu Dong Wang You Sheng Tang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
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