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| 1 | Lipolysis and apoptosis of adipocytes induced by neuropeptide Y—Y5 receptor antisense oligodeoxynucleotides in obese rats显示文摘AIM:To investigate the influence of central administration of neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides(ODN) on the body weight and fat pads of high-energy diet-induced obese rats, and the effects on white adipocyte lipolysis and apoptosis. METHODS: Y5 receptor antisense, sense, mismatched oligodeoxynucleotides (ODN) or vehicle were intracerebroventricularly injected, and average adipocyte area was calculated. DNA ladders were measured to evaluate adipocyte apoptosis, and RT-PCR was used to analyze the expression of bcl-2 and bax gene. RESULTS: (1) Central administration of Y5 receptor antisense ODN significantly decreased body weight, fat pads, and average adipocyte area. (2) DNA fragmentation was presented after electrophoresis at both epididymal and retroperitoneal adipose tissue. (3) The expression of bcl-2 gene was downregulated, while the expression of bax was upregulated. CONCLUSION:Lipolysis and adipocyte apoptosis may be important reasons for Y5 receptor antisense therapy. | GONGHai-Xia GUOXi-Rong FEILi GUOMei LIUQian-Qi CHENRong-Hua | 2003 | Acta Pharmacologica Sinica2003，24，6： | 10 |
| 2 | Generation of coexisting high-energy pulses in a mode-locked all-fiber laser with a nonlinear multimodal interference technique显示文摘We demonstrate a passively mode-locked all-fiber laser incorporating a piece of graded-index multimode fiber as a mode-locking modulator based on a nonlinear multimodal interference technique, which generates two types of coexisting high-energy ultrashort pulses [i.e., the conventional soliton(CS) and the stretched pulse(SP)]. The CS with pulse energy as high as 0.38 n J is obtained at the pump level of 130 mW. When the pump increases to175 mW, the high-energy SP occurs at a suitable nonlinear phase bias and its pulse energy can reach 4 n J at a 610 mW pump. The pulse durations of the generated CS and SP are 2.3 ps and 387 fs, respectively. The theory of nonlinear fiber optics, single-shot spectral measurement by the dispersive Fourier-transform technique, and simulation methods based on the Ginzburg–Landau equation are provided to characterize the laser physics and reveal the underlying principles of the generated CS and SP. A rogue wave, observed between the CS and SP regions, mirrors the laser physics behind the dynamics of generating a high-energy SP from a CS. The proposed all-fiber laser is versatile, cost-effective and easy to integrate, which provides a promising solution for high-energy pulse generation. | GUANGWEI CHEN WENLEI LI GUOMEI WANG WENFU ZHANG CHAO ZENG WEI ZHAO | 2019 | Photonics Research2019，7，2： | 9 |
| 3 | Single-center Experience in the Diagnosis and Treatment of Hepatic Perivascular Epithelioid Cell Neoplasm显示文摘Background and Aims:Perivascular epithelioid cell neo-plasms(PEComas)are a rare type of mesenchymal neo-plasm and their preoperative diagnosis is challenging.In this study,we summarized the experience from a single medical center to study the examinations,clinical presen-tations,and pathological and histological characteristics of PEComas in the liver in order to optimize overall un-derstanding of the diagnosis and treatment of these neo-plasms.Methods:We conducted a retrospective analysis to investigate the clinical and pathological characteristics as well as imaging presentations of 75 patients diagnosed with hepatic PEComa in The First Affiliated Hospital of Zhe-jiang University between April 2010 and April 2020.Re-sults:Among the 75 patients,52 were women,and the median age was 48 years.Most patients had no specific symptoms,and two were admitted to the hospital for a second time owing to relapse.All patients underwent surgi-cal resection.Histologically,38 patients had classical angio-myolipoma(AML)and 37 had epithelioid AML.The PECo-mas were accompanied by positive immunohistochemical expression of HMB45,Melan-A,and smooth muscle actin.Follow-up data were obtained from 47 of the total 75 pa-tients,through October 2020.Two patients had metastasis after surgery.Conclusions:AML is the most common type of hepatic PEComa.There are no specific symptoms of he-patic PEComa,and serological examinations and imaging modalities for accurate preoperative diagnosis are lacking.Epithelioid AML should be considered a tumor of uncertain malignant potential;however,the prognosis of PEComa af-ter resection is promising. | Junjun Jia Jia Luo Cheng-Gen Pan Guomei Ge Meibao Feng Bei Zou Li Liu Shusen Zheng Jun Yu | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 5 |
| 4 | Laboratory information management system for biosafety laboratory:Safety and efficiency显示文摘Laboratory information management system(LIMS)has been widely used to facilitate laboratory activities.However,the current LIMSs do not contain functions to improve the safety of laboratory work,which is the major concern of biosafety laboratories(BSLs).With tons of biosafety information that need to be managed and an increasing number of biosafety-related research projects under way,it is worthy of expanding the current framework of LIMS and building a system that is more suitable for BSL usage.Such a system should carefully trade off between the safety and efficiency of regular lab activities,allowing the laboratory staff to conduct their research as free as possible while ensuring their and the environment’s safety.In order to achieve this goal,the information on the research contents,laboratory personnel,experimental materials and experimental equipment need to be well collected and fully utilized by a centralized system and its databases. | Dingzhong Sun Linhuan Wu Guomei Fan | 2021 | Journal of Biosafety and Biosecurity2021，3，1： | 4 |
| 5 | Decaying evolution dynamics of double-pulse mode-locking显示文摘Taking advantage of the dispersive Fourier transformation technique, the decaying evolution processes of doublepulse mode-locking in a single-walled carbon-nanotube-based Er-doped fiber laser are observed in detail for the first time to our knowledge. The decaying dynamics of the double-pulse mode-locking state is analyzed in the spectral and temporal domains. We reveal that the two pulses in one cluster disappear either simultaneously or one by one during the decaying processes of double-pulse mode-locking states. In addition, the spectral evolution patterns of the special double-pulse states(i.e., bound states) are extremely distinct at different decline rates of the pump power. | GUOMEI WANG GUANGWEI CHEN WENLEI LI CHAO ZENG HUIRAN YANG | 2018 | Photonics Research2018，6，8： | 4 |
| 6 | Synthesis and Characterization of Osmium Polycyclic Aromatic Complexes via Nucleophilic Reactions of Osmapentalyne显示文摘 | Qin Zhu Congqing Zhu Zhihong Deng Guomei He Jiangxi Chen Jun Zhu Haiping Xia | 2017 | Chinese Journal of Chemistry2017，35，5： | 3 |
| 7 | Numerical simulation of predicting and reducing solid particle erosion of solid-liquid two-phase flow in a choke显示文摘Chokes are one of the most important components of downhole flow-control equipment.The particle erosion mathematical model,which considers particle-particle interaction,was established and used to simulate solid particle movement as well as particle erosion characteristics of the solid-liquid two-phase flow in a choke.The corresponding erosion reduction approach by setting ribs on the inner wall of the choke was advanced.This mathematical model includes three parts:the flow field simulation of the continuous carrier fluid by an Eulerian approach,the particle interaction simulation using the discrete particle hard sphere model by a Lagrangian approach and calculation of erosion rate using semi-empirical correlations.The results show that particles accumulated in a narrow region from inlet to outlet of the choke and the dominating factor affecting particle motion is the fluid drag force.As a result,the optimization of rib geometrical parameters indicates that good anti-erosion performance can be achieved by four ribs,each of them with a height(H) of 3 mm and a width(B) of 5 mm equaling the interval between ribs(L). | Li Guomei Wang Yueshe He Renyang Cao Xuewen Lin Changzhi Meng Tao | 2009 | Petroleum Science2009，6，1： | 3 |
| 8 | Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium显示文摘Brain interstitial fluid drainage and extracellular space are closely related to waste clearance from the brain. Different anesthetics may cause different changes of brain interstitial fluid drainage and extracellular space but these still remain unknown. Herein,effects of the inhalational isoflurane, intravenous sedative dexmedetomidine and pentobarbital sodium on deep brain matters’ interstitial fluid drainage and extracellular space and underlying mechanisms were investigated. When compared to intravenous anesthetic dexmedetomidine or pentobarbital sodium, inhalational isoflurane induced a restricted diffusion of extracellular space, a decreased extracellular space volume fraction, and an increased norepinephrine level in the caudate nucleus or thalamus with the slowdown of brain interstitial fluid drainage. A local administration of norepinephrine receptor antagonists, propranolol,atipamezole and prazosin into extracellular space increased diffusion of extracellular space and interstitial fluid drainage whilst norepinephrine decreased diffusion of extracellular space and interstitial fluid drainage. These findings suggested that restricted diffusion in brain extracellular space can cause slowdown of interstitial fluid drainage, which may contribute to the neurotoxicity following the waste accumulation in extracellular space under inhaled anesthesia per se. | Guomei Zhao Hongbin Han Jun Yang Min Sun Dehua Cui Yuanyuan Li Yajuan Gao Jing Zou | 2020 | Science China(Life Sciences)2020，63，9： | 3 |
| 9 | Development of retinol-binding protein 4 immunocolloidal gold fast test strip using high-sensitivity monoclonal antibodies generated by DNA immunization显示文摘DNA 免疫是为高亲密关系的 monoclonal 抗体产生的一个有效方法。这里,我们对松香油绑定蛋白质 4 描述几高质量的 monoclonal 抗体(mAbs ) 的产生(RBP4 ) ,为肾反常和机能障碍的一个重要标记,与 DNA 的一个联合方法, priming 和蛋白质增加。产生的 mAbs 能与高敏感并且用这些 mAbs 绑在 RBP4,一块 immunocolloidal 金牌快测试长带被构造。长带能交上结果 < 5 min 并且与大约 1 ng/ml 的察觉限制是很敏感的。小规模的临床的测试表明这脱衣的结果根据在市场上当前可得到的一个标记酶的 immunosorbent 试金工具包的好。因而,它能为在诊所的更方便、更快的 RBP4 决心是有用的。 | Chao Bian Fang Zhang Feng Wang Zhiyang Ling Min Luo Hongqiang Wu Yizhuo Sun Junhui Li B ingnan Li Jingyan Zhu Linna Tang Yanyan Zhou Qunfang Shi Yongyong Ji Lin Tian Guomei Lin Yu Fan Niansong Wang Bing Sun | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 2 |
| 10 | Novel function of perforin in negatively regulating CD4^+ T cell activation by affecting calcium signaling显示文摘Perforin 是主要从事调停的形成毛孔的蛋白质目标 T 房间死亡并且被细胞毒素的 T 淋巴细胞(CTL ) 和自然漂亮房间采用。然而,它是否也在常规 CD4+ T 房间功能起一个作用,仍然保持不清楚。这里,我们报导那在 perforin 缺乏(PKO ) 老鼠, CD4+ T 房间是响应 T 的 hyperproliferative 房间受体(TCR ) 刺激。hyperproliferation 的这个特征被改进在房间分割并且在 IL-2 分泌物伴随。看起来, perforin 缺乏不在胸腺怒气和淋巴节点影响 T 房间开发。在 vivo, perforin 缺乏导致增加的抗原特定的 T 房间增长和抗体生产。而且, PKO 老鼠更产生试验性的自体免疫的眼色素层炎。探讨分子的机制,我们发现在 TCR 刺激以后,从 PKO 老鼠的 CD4+ T 房间显示增加的细胞内部的钙流动并且随后提高抄写因素 NFAT1 的激活。我们的结果显示 perforin 在由影响 TCR 依赖的 Ca2+ 发信号调整 CD4+ T 房间激活和有免疫力的反应起一个否定作用。 | Enguang Bi Chunjian Huang Yu Hu Xiaodong Wu Weiwen Deng Guomei Lin Zhiduo Liu Lin Tian Shuhui Sun Kairui Mao Jia Zou Yuhan Zheng Bing Sun | 2009 | Cell Research2009，19，7： | 2 |
| 11 | Non-metallic gold nanoclusters for oxygen activation and aerobic oxidation显示文摘In recent decade, Au nanoclusters of atomic precision(Au_nL_m, where L = organic ligand: thiolate and phosphine) have been shown as a new promising nanogold catalyst. The well-de fined Au_nL_m catalysts possess unique electronic properties and frameworks, providing an excellent opportunity to correlate the intrinsic catalytic behavior with the cluster's framework as well as to study the catalytic mechanisms over gold nanoclusters. In this review, we only demonstrate the important roles of the gold nanoclusters in the oxygen activation(e.g.,~3O_2 to ~1O_2) and their selective oxidations in the presence of oxygen(e.g., CO to CO_2, sul fides to sulfoxides, alcohol to aldehyde, styrene to styrene epoxide, amines to imines, and glucose to gluconic acid). The size-speci ficity(Au_(25)(1.3 nm), Au_(38)(1.5 nm), Au_(144)(1.9 nm), etc.), ligand engineering(e.g., aromatic vs aliphatic), and doping effects(e.g., copper, silver, palladium, and platinum)are discussed in details. Finally, the proposed reactions' mechanism and the relationships of clusters' structure and activity at the atomic level also are presented. | Guomei Zhang Ruru Wang Gao Li | 2018 | Chinese Chemical Letters2018，29，5： | 2 |
| 12 | Biosensors for determination of glucose with glucose oxidase immobilized on an eggshell membrane显示文摘 | Baoli Wu Guomei Zhang | 2004 | Talanta2004，64，： | 1 |
| 13 | Interaction of water-soluble calix[4]arene with L-tryptophan studied by fluorescence spectroscopy显示文摘 | Li Wenye Li Hui Zhang Guomei Chao Jianbin Shuang Shaomin | | 0，，： | 1 |
| 14 | Spectroscopic Studies on the Interaction of Safranine T with DNA in β-Cyclodextrin and Carboxymethyl-β-cyclodextrin 显示文摘 | Zhang Guomei Pang Yuehong Shuang Shaomin | 2005 | J Phoroehem Photobio A : Chem2005，169，2： | 1 |
| 15 | Study on vitamin K3-cyclodextrin inclusion complex and analytical application 显示文摘 | Dong Zhenming Liu Xiuping Zhang Guomei | 2002 | Spectrochimica Acta Part A2002，59，： | 1 |
| 16 | Study on vitamin K3-cyclodextrin inclusion complex and analytical application 显示文摘 | DONG Zhenming LIU Xiuping ZHANG Guomei | 2003 | Spectrochimica ACTA2003，59，9： | 1 |
| 17 | Microbial biomass and nutrients in soil at the different stages of secondary forest succession in Ziwuling,northwest China显示文摘 | Jia Guomei Cao Jing Wang Chunyan | | 0，，01： | 1 |
| 18 | Biosensors for determination of glucose with glucose oxidase immobilized on an eggshell membrane显示文摘 | WU Baoli ZHANG Guomei SHUANG Shaomin | 2004 | Talanta2004，64，2： | 1 |
| 19 | A homocysteine biosensor with eggshell membrane as an enzyme immobilization platform显示文摘 | Guomei Zhang Diansheng Liu Shaomin Shuang | 2006 | 114:936-9422006，114，： | 1 |
| 20 | Trichosanthin functions as Th2-type adjuvant in induction of allergic airway inflammation显示文摘理解自然变应原导致的气喘的致病是重要的,它能排除人工的助手的干扰并且在疾病提供自然有免疫力的反应的卓见。在现在的学习,我们证明甚至没有明矾的帮助, Trichosanthin (TCS ) 能导致航线发炎。而且, TCS 显得能够代替明矾支持卵特定的航线发炎。TCS 在一个早阶段在腹膜导致了 IL-4-producing 嗜曙红血球的累积, TCS 的辅助功能被 IL-4 的阻塞在这个阶段消除。最后, TCS 从 WT 鼠标,然而并非从 IL-4-deficient 鼠标触发的嗜曙红血球被显示为卵特定的 Th2 回答的正式就职作为助手工作。我们的数据显示 TCS 是不仅变应原,而且一个 Th2 类型助手 modulating 切换对一条 Th2 小径的有免疫力的回答。事件的这链在整洁 TCS 的一个早阶段由嗜曙红血球源于 IL-4 生产。在结论, TCS 可能作为一个 Th2 助手有用,并且天生的有免疫力的房间例如嗜曙红血球,可以是一个好目标学习 Th2 反应的开始。 | Yuan Wang Kairui Mao Shuhui Sun Guomei Lin Xiaodong Wu Gang Yao Bing Sun | 2009 | Cell Research2009，19，8： | 1 |
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