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| 1 | Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing显示文摘Niacin metal-organic frameworks(MOFs)encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfuidic electrospray approach for wound healing.As the alginate shells were bacteriaresponsively degradable,the niacin MOFs encapsulated microcapsules could intelligently,controllably,and programmably release calcium,copper,and zinc ions,depending on the degree of infections.Te released ions could not only kill microbes by destroying their membrane and inducing the outfow of nutrient substance,but also activate copper/zinc superoxide dismutase(Cu/ZnSOD)to eliminate oxygen free radicals and rescue the cells from oxidative stress injury.Furthermore,the simultaneously released niacin could promote hemangiectasis and absorption of functional metal ions.Tus,the niacin MOFs encapsulated microcapsules were imparted with outstanding antibacterial,antioxidant,and angiogenesis properties.Based on an in vivo study,we have also demonstrated that the chronic wound healing process of an infected full-thickness skin defect model could be signifcantly enhanced by using the niacin MOFs encapsulated microcapsules as therapeutic agent.Terefore,the microfuidic electrospray niacin MOFs encapsulated microcapsules are potential for clinical applications. | Guopu Chen Yunru Yu Xiuwen Wu Gefei Wang Guosheng Gu Feng Wang Jianan Ren Huidan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 21 |
| 2 | Geophysical-Geological Interpretation and Deep-Seated Gold Deposit Prospecting in Sanshandong-Jiaojia Area, Eastern Shandong Province, China显示文摘Integrated gravitational, electrical-magnetic surveys and data processing carried out in the Sanshandao-Jiaojia area, Eastern Shandong Province, northeast China, aim to illuminate the geological characteristics of this shallow-covered area and delineate deep-seated gold prospecting targets. In this region, altogether 12 faults exert critical control on distribution of three types of Early Precambrian metamorphic rock series, i.e. those in the metamorphic rock area, in the granitic rock area underlying the metamorphic rock, and in the remnant metamorphic rock area in granites, respectively. Additionally, the faults have major effects on distribution of four Mesozoic Linglong rock bodies of granite, i.e. the Cangshang, Liangguo, Zhuqiao-Miaojia and Jincheng granites. The Sanshandao and Jiaojia Faults are two well-known regional ore-controlling faults; they have opposite dip direction, and intersect at a depth of 4500 m. Fracture alteration zones have striking geophysical differences relative to the surrounding county rocks. The two faults extend down along dip direction in a gentle wave form, and appear at some steps with different dips. These steps comprise favorable gold prospecting areas, consistent with a step metallogenic model. Six deep-seated gold-prospecting targets are delineated, i.e. Jincheng-Qianchenjia, Xiaoxizhuang-Zhaoxian, Xiyou-Wujiazhuangzi, Xiangyangling-Xinlicun, Panjiawuzi and Miaojia-Pinglidian. | SONG Mingchun WAN Guopu CAO Chunguo HE Chunyan | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 15 |
| 3 | Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery显示文摘Microneedles have attracted increasing interest among various medical fields due to their painless,noninvasive,and efficient way of drug delivery.However,practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity.Here,inspired by the antibacterial strategy of Paenibacillus polymyxa and adhesion mechanisms of mussel byssi and octopus tentacles,we develop hierarchical microneedles with multifunctional adhesive and antibacterial abilities.With polydopamine hydrogel as the microneedle base and a loop of suctioncup-structured concave chambers encircling each microneedle,the generated microneedles can fit the skin well;keep strong adhesion in dry,moist,and wet environments;and realize self-repair after being split into two parts.Besides,as polymyxin is loaded into both the hydrogel tips and the polydopamine base,the microneedles are endowed with excellent ability to resist common bacteria during storage and usage.We have demonstrated that these microneedles not only showed excellent adhesion when applied to knuckles and ideal antibacterial activity but also performed well in drug-sustained release and treatment for the osteoarthritis rat model.These results indicate that bioinspired multifunctional microneedles will break through the limitation of traditional methods and be ideal candidates for versatile transdermal drug delivery systems. | Xiaoxuan Zhang Guopu Chen Yunru Yu Lingyu Sun Yuanjin Zhao | 2020 | Research2020，，1： | 14 |
| 4 | Bio-inspired clamping microneedle arrays from flexible ferrofluid-configured moldings显示文摘Microneedle(MN)arrays have demonstrated value for cosmetics,diagnosis,transdermal drug delivery,and other biomedical areas.Much effort has been devoted to developing simple stratagem for creating versatile moldings and generating functional MN arrays.Here,inspired by the serrated microstructure of mantises’forelegs,we present a novel serration-like clamping MN array based on ferrofluidconfigured moldings.Benefiting from the flexibility and versatility of ferrofluids,negative microhole array moldings with various sizes and angles toward the midline could be created easily.The corresponding biocompatible polymer MN arrays with both isotropic and anisotropic structures could then be produced feasibly and cost-effectively by simply replicating these moldings.It was found that the resultant serrated clamping MN arrays had the ability to adhere to skin firmly,enabling them to be used over a relatively long time and while the recipient was moving.This proposed technology performed well in minimally invasive drug administration and sustained glucocorticoids release during treatment for imiquimod-induced psoriasis in mice.These features indicated that such MN arrays could play important roles in wearable transdermal drug delivery systems and in other applications. | Xiaoxuan Zhang Fengyuan Wang Yunru Yu Guopu Chen Luoran Shang Lingyu Sun Yuanjin Zhao | 2019 | Science Bulletin2019，64，15： | 11 |
| 5 | MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing显示文摘Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization.Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials.In this paper,we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing.Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine,3-(acrylamido)phenylboronic acid-(PBA-)integrated polyethylene glycol diacrylate(PEGDA)hydrogel is utilized as the host material of microneedle patches.Benefitting from photothermal conversion capacity of MXene,the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site.In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis.When applied for treating animal models,it is demonstrated that the microneedle patches efficiently promote angiogenesis,which is conductive to wound healing.These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields. | Lingyu Sun Lu Fan Feika Bian Guopu Chen Yuetong Wang Yuanjin Zhao | 2021 | Research2021，，1： | 6 |
| 6 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 7 | Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide显示文摘Lipopolysaccharide(LPS)plays an important role in metabolic syndrome(MetS)and other gut-derived diseases,and detoxifying LPS is considered to be a fundamental approach to prevent and treat these diseases.Here,inspired by the feeding behaviour of scavenger,novel microfluidic microcapsules with alkaline phosphatase(ALP)encapsulation and the scavenger-like molecular sieve shell are presented for cleaning intestinal LPS.Benefiting from the precisely controlled of the pore size and microfluidic electrospray,the generated microcapsules were imparted with porous molecular-sieve shells and ALP encapsulated active cores.These microcapsules could continuously work as an intestinal scavenger after colonized in intestine.It has been demonstrated that the microcapsules could englobe LPS while inhibit the permeation of digestive enzyme,and this ability contributes to promising ALP’s activity,protecting cells at the presence of LPS and reducing inflammation.In addition,this scavenger inspired microcapsule could effectively decrease the LPS in organs,reduce inflammation and regulating fat metabolism in vivo.These features make the ALP encapsulated microcapsules an ideal candidate for treating MetS and other LPS related diseases. | Cheng Zhao Guopu Chen Huan Wang Yuanjin Zhao Renjie Chai | 2021 | Bioactive Materials2021，6，6： | 5 |
| 8 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | Guopu Zhu Sam Kwong | 2010 | Applied Mathematics and Computation2010，，7： | 3 |
| 9 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | Guopu Zhu Sam Kwong | 2010 | Applied Mathematics and Computation2010，，7： | 3 |
| 10 | Bio-inspired adhesive porous particles with human MSCs encapsulation for systemic lupus erythematosus treatment显示文摘Mesenchymal stem cells(MSCs)therapy is a promising treatment for Systemic lupus erythematosus(SLE)patients.However,this method is encumbered by suboptimal phenotype of MSCs used in clinical settings,and a short in vivo persistence time.Herein,inspired by the natural microstructure of the sand tower worm nest,we proposed novel adhesive porous particles with human MSCs encapsulation via microfluidic electrospray technology for SLE treatment.The porous microparticles were formed by immediate gelation reaction between sodium alginate(ALG)and poly-D-lysine(PDL),and then sacrificed polyethylene oxide(PEO)to form the pores.The resultant microparticles could protect MSCs from immune cells while maintain their immune modulating functions,and achieve rapid exchange of nutrients from the body.In addition,owing to the electrostatic adsorption and covalent bonding between PDL and tissues,the porous microparticles could adhere to the bowel surfaces tightly after intraperitoneal injection.Through in vivo imaging system(IVIS)methods and in vivo study,it was demonstrated that the MSCs-encapsulated porous adhesive microparticles could significantly increase the cellular half-life,turn activated inflammatory macrophages into an anti-inflammatory profile,and ameliorate disease progression in MRL/lpr mice.Thus,the MSCs-encapsulated porous microparticles showed distinctive functions in chronic SLE treatment,with additional potential to be used in a variety of biomedical applications. | Min Nie Guopu Chen Cheng Zhao Jingjing Gan Mihribangvl Alip Yuanjin Zhao Lingyun Sun | 2021 | Bioactive Materials2021，6，1： | 2 |
| 11 | Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery显示文摘Microparticles with strong adherence are expected as efficient drug delivery vehicles.Herein,we presented an ingenious hydrogel microparticle recapitulating the adhesion mechanism of Boston ivy tendrils adhesive discs(AD)for durable drug delivery.The particles were achieved by replicating a silica colloidal crystal aggregates assembled in a droplet template after rapid solvent extraction.Due to their unique shape,the nanostructure,and the sticky hydrogel component,such novel microparticles exhibited prominent adhesive property to the wet tissue environment.It was demonstrated that the bioinspired microcarriers loading with dexamethasone had a good therapeutic effect for ulcerative colitis due to the strong adhesion ability for prolonging the maintenance of drug availability.These virtues make the biomimetic microparticles potentially ideal for many practical clinical applications,such as drug delivery,bioimaging,and biodiagnostics. | Lijun Cai Guopu Chen Yuetong Wang Cheng Zhao Luoran Shang Yuanjin Zhao | 2021 | Research2021，，1： | 2 |
| 12 | Living Bacterial Microneedles for Fungal Infection Treatment显示文摘Fungal infections are everlasting health challenges all over the world,bringing about great financial and medical burdens.Here,inspired by the natural competition law of beneficial bacteria against other microbes,we present novel living microneedles(LMNs)with functionalized bacteria encapsulation for efficient fungal infection treatment.The chosen beneficial bacterial components,Bacillus subtilis(B.subtilis),which are naturally found on the human skin and widely used for food processing,can get nutrients from the skin and escape from the immune system with the help of microneedles.Besides,the encapsulated B.subtilis can continuously produce and secrete various potential antifungal agents which can directly bind to fungal cell surfaceassociated proteins and destruct the cell membranes,thus avoiding drug resistance.After immobilization in the LMNs,the bacteria can stay within the LMNs without invasion and the encapsulated bacteria together with microneedles can be removed after application.Thus,the side effects,especially the risk for subsequent bacterial infections,are controlled to a minimum to ensure security.In addition,strong penetrability of the microneedles enhances penetration of antifungal agents,and their heights can be adjusted according to the infected depth to acquire better therapeutic effects.These features make the LMNs potentially valuable for clinical applications. | Fengyuan Wang Xiaoxuan Zhang Guopu Chen Yuanjin Zhao | 2020 | Research2020，，1： | 2 |
| 13 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | Zhu Guopu Kwong Sam | 2010 | Applied Mathematics and Computation2010，，217： | 1 |
| 14 | A study on the randomness measure of imageHashing显示文摘 | Guopu Zhu Jiwu Huang Sam Kwong Jianquan Yang | 2009 | IEEE Transcations on Information Forensics and Security2009，4，4： | 1 |
| 15 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | Zhu Guopu Kwong S | 2010 | Applied Mathematics and Computation2010，217，： | 1 |
| 16 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | Zhu Guopu Kwong Sam | 2010 | Applied Mathematics and Computation2010，217，： | 1 |
| 17 | Gbest-guided artificial bee colony algorithm for numerical function optimization显示文摘 | ZHU Guopu KWONG S | 2010 | Applied Mathematics and Computation2010，217，7： | 1 |
| 18 | Boundary-based Image Segmentation Using Binary Level Set Method显示文摘 | Zhu Guopu Zhang Shuqunqun Zeng Qingshuang | | 0，，： | 1 |
| 19 | Heating Mechanism of Spark Plasma Sintering显示文摘 | Song Shixue Wang Zhi Shi Guopu | 2013 | Ceramics International2013，39，2： | 1 |
| 20 | Gbest-guided artificial bee colony algorithm for numerical function optimization 显示文摘 | ZHU Guopu KWONG S | 2010 | Applied Mathematics and Computation2010，217，7： | 1 |
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