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| 1 | Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer显示文摘Objective: To explore the effect of early enteral nutrition (EN) on postoperative nutritional status, intestinal permeability, and immune function in elderly patients with esophageal cancer or cardiac cancer. Methods: A total of 96 patients with esophageal cancer or cardiac cancer who underwent surgical treatment in our hospital from June 2007 to December 2010 were enrolled in this study. They were divided into EN group (n=50) and parenteral nutrition (PN) group (n=46) based on the nutrition support modes. The body weight, time to first flatus/defecation, average hospital stay, complications and mortality after the surgery as well as the liver function indicators were recorded and analyzed. Peripheral blood samples were collected on the days 1, 4 and 7 after surgery. The plasma diamine oxidase (DAO) activity and D-lactate level were determined to assess the intestinal permeability. The plasma endotoxin levels were determined using dynamic turbidimetric assay to assess the protective effect of EN on intestinal mucosal barrier. The postoperative blood levels of inflammatory cytokines and immunoglobulins were determined using enzyme- linked immunosorbent assay (ELISA). Results: After the surgery, the time to first flatus/defecation, average hospital stay, and complications were significantly less in the EN group than those in the PN group (P<0.05), whereas the EN group had significantly higher albumin levels than the PN group (P<0.05). On the 7th postoperative day, the DAO activity, D-lactate level and endotoxin contents were significantly lower in the EN group than those in the PN group (all P<0.05). In addition, the EN group had significantly higher IgA, IgG, IgM, and CD4 levels than the PN group (P<0.05) but significantly lower IL-2, IL-6, and TNF-α levels (P<0.05). Conclusions: In elderly patients with esophageal cancer or cardiac cancer, early EN after surgery can effectively improve the nutritional status, protect intestinal mucosal barrier (by reducing plasma endoxins), and enhance the immune | Guiping Yu Guoqiang Chen Bin Huang Wenlong Shao Guangqiao Zeng | 2013 | Chinese Journal of Cancer Research2013，25，3： | 67 |
| 2 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 3 | Fracture detection by using full azimuth P wave attributes显示文摘特定的折断的烃水库的一种类型,页岩折断了水库,在 Shengli 油矿存在。由于这种类型,到石油化学的性质参数的变化的低敏感,和强壮的 anisotropy 的很小的孔,为他们探索是很困难的。到目前为止,没有为由综合分析的破裂的方向,分发,和密度的识别的成熟方法的集合地质,地球物理,井木头,钻的数据,和等等。这篇论文与方位角(IPVA ) 为声学的阻抗变化论述一个新方法,基于存在破裂察觉方法。地震获得,处理,并且识别技术为在 Luojia 区域与页岩破裂的地震、地质的特征在联合用多方位角 P 波浪数据检测方向性的垂直破裂被开发。IPVA 研究为认识到基于有方位角(VVA ) 的速度变化和有为完整的方位角 P 的方位角(AVA ) 的振幅变化的学习的破裂的分发,罢工,和密度在不同 CMP 位置挥动数据被执行。通过在 Luojia 区域的实际申请,主要结果被获得了它证实 IPVA 方法为平行、高角度的量的察觉提供好潜力,页岩破裂。 | Qu Shouli Ji Yuxin Wang Xin Wang Xiuling Chen xinrong Shen Guoqiang | 2007 | Applied Geophysics2007，4，3： | 15 |
| 4 | An experimental study on variation of thermal fields during the deformation of a compressive en echelon fault set显示文摘温度变化在变丑期间一在在一件岩石样品的军队飞机差错集合压缩被表面测量系统 th 测量多点的铂电阻温度计和一个红外线的 theirnal 图象系统。二个系统获得的大小与对方一致,显示在 then-nd 领域的时间空间的变化和应力和紧张的变化之间的一种关系。在岩石样品的改变的 sfructurd 位置,温度升起是不同的,暗示在这些位置的不同压力分布。在实验,样品的 defoirmation 过程包括了三个阶段:有弹性的变丑,粘住滑倒,和 nipture。Grrespondingly,温度的变化过程也有三个阶段,其各个有它的 oq 温度升起侧面。并且热放射领域显示出一个类似的过程。这些现象意味着在变丑的 sJl 阶段升起的温度的主导的机制是不同的。试验性的结果 prode 由使用卫星的数据的当前的差错活动的学习的一个物理基础红外线的图象。 | LIU Peixun MA Jin LIU Liqiang MA Shengli CHEN Guoqiang | 2007 | Progress in Natural Science:Materials International2007，17，3： | 14 |
| 5 | Theoretical and experimental study on relationship between stress-strain and temperature variation显示文摘Principle on temperature response to the stress-strain variation is fundamental to the relationship between thermal radiation variation and stress-strain field. Current research indicates that temperature has a sensitive response to rock deformation under the condition of normal temperature background. However, the basic physical relationship between deformation and temperature variation is not clear and need to be investigated further. In this paper, principle on temperature response to stress-strain variation is studied in detail, based on thermodynamics, elastic strain theory, and experiments on both ideal material and rock. In the stage of elastic deformation, results indicate that: 1) temperature increment is positively correlated with volume strain variation. Temperature rises with hydrostatic pressure increase. In other words, temperature rises when the specimen is under the compressive state whereas temperature drops under the tensile state. 2) Pure shear deformation does not contribute to tempera- ture variation. Namely, shape change of specimen does not produce temperature variation. However, there exist the relative tensile area and the compressive one in the specimen under the state of pure shear. Temperature drops within the relative tensile area while temperature rises within the compressive areas during the process of loading. | CHEN ShunYun LIU LiQiang LIU PeiXun MA Jin CHEN GuoQiang | 2009 | Science China Earth Sciences2009，52，11： | 13 |
| 6 | Impacts of Climatic Factors on Runoff Coefficients in Source Regions of the Huanghe River显示文摘Runoff coefficients of the source regions of the Huanghe River in 1956–2000 were analyzed in this paper. In the 1990s runoff of Tangnaihai Hydrologic Station of the Huanghe River experienced a serious decrease, which had at- tracted considerable attention. Climate changes have important impact on the water resources availability. From the view of water cycling, runoff coefficients are important indexes of water resources in a particular catchment. Kalinin baseflow separation technique was improved based on the characteristics of precipitation and streamflow. After the separation of runoff coefficient (R/P), baseflow coefficient (Br/P) and direct runoff coefficient (Dr/P) were estimated. Statistic analyses were applied to assessing the impact of precipitation and temperature on runoff coefficients (including Dr/P, Br/P and R/P). The results show that in the source regions of the Huanghe River, mean annual baseflow coefficient was higher than mean annual direct runoff coefficient. Annual runoff coefficients were in direct proportion to annual pre- cipitation and in inverse proportion to annual mean temperature. The decrease of runoff coefficients in the 1990s was closely related to the decrease in precipitation and increase in temperature in the same period. Over different sub-basins of the source regions of the Huanghe River, runoff coefficients responded differently to precipitation and temperature. In the area above Jimai Hydrologic Station where annual mean temperature is –3.9oC, temperature is the main factor in- fluencing the runoff coefficients. Runoff coefficients were in inverse relation to temperature, and precipitation had nearly no impact on runoff coefficients. In subbasin between Jimai and Maqu Hydrologic Station Dr/P was mainly affected by precipitation while R/P and Br/P were both significantly influenced by precipitation and temperature. In the area be-tween Maqu and Tangnaihai hydrologic stations all the three runoff coefficients increased with the rising of annual precipitation, while direct runoff coefficient was inversely proportional to temperature. In the source regions of the Huanghe River with the increase of average annual temperature, the impacts of temperature on runoff coefficients be-come insignificant. | CHEN Liqun LIU Changming LI Yanping WANG Guoqiang | 2007 | Chinese Geographical Science2007，17，1： | 12 |
| 7 | The program structure designing and optimizing tests of GRAPES physics显示文摘According to the modularization and standardization of program structure in Global/Regional Assimilation and Prediction System (GRAPES), the plug-compatible and transplantable regional meso-scale and global middle-range physics software package is established. The package's component integrality is comparative with the other advanced models physics. A three-level structure of connecting GRAPES physics and dynamic frame has been constructed. The friendly interface is designed for users to plug in their own physics packages. Phenomenon of grid-point storm rainfall in numerical prediction is analyzed with the numerical tests. The scheme of air vertical velocity calculation is improved. Optimizing tests of physics schemes are performed with the correlative parameters adjusting. The results show that the false grid-point storm rainfall is removed by precipitation scheme improving. Then the score of precipitation forecast is enhanced. | XU GuoQiang CHEN DeHui XUE JiShan SUN Jian SHEN XueShun SHEN YuanFang HUANG LiPing WU XiangJun ZHANG HongLiang WANG ShiYu | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 8 | Substrate-induced changes in microbial community-level physiological profiles and their application to discriminate soil microbial communities显示文摘The addition of simple substrates could affect the microbial respiration in soils. This substrate-induced respiration is widely used to estimate the soil microbial biomass, but little attention has been paid to its influence on the changes of community-level physiological profiles. In this study, the process of microbial communities responding to the added substrate using sole-carbon-source utilization (BIOLOG) was investigated. BIOLOG is biased toward fast-growing bacteria; this advantage was taken to detect the prompt response of the active microbial communities to the added substrate. Four soil samples from agricultural fields adjacent to heavy metal mines were amended with L-arginine, citric acid, or D-glucose. Substrate amendments could, generally, not only increase the metabolic activity of the microbial communities, but also change the metabolic diverse patterns compared with no-substrate control. By tracking the process, it was found that the variance between substrate-induced treatment and control fluctuated greatly during the incubation course, and the influences of these three substrates were different. In addition, the application of these induced changes to discriminate soil microbial communities was tested. The distance among all samples was greatly increased, which further showed the functional variance among microbial communities in soils. This can be very useful in the discrimination of microbial communities even with high similarity. | CHEN Jian XIE Huijun ZHUANG Xuliang ZHUANG Guoqiang BAI Zhihui ZHANG Hongxun | 2008 | Journal of Environmental Sciences2008，20，6： | 10 |
| 9 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 10 | Novel fluorescent probes of 10-hydroxyevodiamine:autophagy and apoptosis-inducing anticancer mechanisms显示文摘Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. | Shuqiang Chen Guoqiang Dong Shanchao Wu Na Liu Wannian Zhang Chunquan Shengn | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 9 |
| 11 | Sumoylation of hypoxia inducible factor-1α and its significance in cancer显示文摘Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia,a common feature of the microenvironment in solid tumors.The transcriptional activity,protein stabilization,protein-protein interactions and cellular localization of HIF-1α,an oxygen-sensitive subunit of HIF-1,are mainly modulated by various post-translational modifications.Recently,we reported that polycomb chromobox 4(Cbx4)governs the transcriptional activity of HIF-1αby enhancing its sumoylation at K391 and K477,through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma.This review summarizes the current knowledge of HIF-1α sumoylation and its roles in the pathogenesis of cancer. | LI Jie XU Ying JIAO HuiKe WANG Wei MEI Zhu CHEN GuoQiang | 2014 | Science China(Life Sciences)2014，57，7： | 9 |
| 12 | Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L显示文摘We recently report that the expression of polycomb chromobox 4(Cbx4)is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma(HCC)patients and it enhances hypoxia-induced vascular endothelial growth factor(VEGF)expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha(HIF-1α).Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell line MHCC97L.Our results show that Cbx4 overexpression in the cell line increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner,and promotes the in vitro migration of the cancer cell,which can be effectively abrogated by anti-VEGF antibody.Although Cbx4 expression does not impact the in vitro growth of MHCC97L cells,it still promotes the progression and metastasis of orthotopically transplanted tumors in nude mice.These results further support the role of Cbx4 as a SUMO E3 ligase in the progression and metastasis of HCC. | MEI Zhu JIAO HuiKe WANG Wei LI Jie CHEN GuoQiang XU Ying | 2014 | Science China(Life Sciences)2014，57，6： | 9 |
| 13 | Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease显示文摘To date,we still lack disease-modifying therapies for Alzheimer's disease(AD).Here,we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD.Five patients with mild to moderate AD received oral benfotiamine(300 mg daily) over 18 months.All patients were examined by positron emission tomography with Pittsburgh compound B(PiB-PET) and exhibited positive imaging with pamyloid deposition,and three received PiB-PET imaging at follow-up.The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination(MMSE) with an average increase of 3.2 points at month18 of benfotiamine administration.The three patients who received follow-up PiB-PET had a 36.7%increase in the average standardized uptake value ratio in the brain compared with that in the first scan.Importantly,the MMSE scores of these three had an average increase of 3 points during the same period.Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation.Our study provides new insight to the development of diseasemodifying therapy. | Xiaoli Pan Zhichun Chen Guoqiang Fei Shumei Pan Weiqi Bao Shuhua Ren Yihui Guan Chunjiu Zhong | 2016 | Neuroscience Bulletin2016，32，6： | 9 |
| 14 | Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway显示文摘在 C2C12 myoblasts 的导致的 lipogenesis 和它的规定仍然保持大部分不清楚。这里,我们发现鸡尾酒 methodcould 显著地通过调整类脂化合物导致 lipogenesis 在 myoblasts 的新陈代谢的基因和 Erk1/2 phosphorylation。同时, CTRP6 的表示和分泌物在宫外的 lipogenesis 期间被增加。而且, CTRP6 击倒下面调整 lipogenic 基因的层次和在早 lipogenic 的 phosphorylated Erk1/2 (p-Erk1/2 ) 上演,而在终端区别的起来调整的 p-Erk1/2。有趣地, CTRP6 siRNA 的效果在 myoblasts 是稀释 byU0126 (一个特殊 p-Erk1/2 禁止者) 。而且, AdipoR1,不是 AdipoR2,首先在有丝分裂的同种细胞的扩大的过程期间作为受体 ofCTRP6 被识别。一起,我们建议 CTRP6 调停通过在 myoblasts 表明小径的 AdipoR1/Erk/PPAR 的宫外的 lipogenesis。我们的调查结果将流轻在小说生物在 myoblast lipogenesis 期间 CTRP6 工作并且提供由 lipogenic regulationin 改进家畜的肉质量的一个有希望的方向骨胳的肌肉 myoblasts。 | Wenjing Wu Yunmei Sun Chen Zhao Cunzhen Zhao Xiaochang Chen Guoqiang Wang Weijun Pang Gongshe Yang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 9 |
| 15 | Mechanism of low thermal conductivity of xonotlite-silica aerogel nanoporous super insulation material显示文摘In an effort to incorporate the low thermal conductivity of the silica aerogel and the superior structure strength of the xonotlite,a composite material of these two was produced. It was synthesized under vacuum condition and dried by supercritical drying technique. The thermal conductivity of the new material,which is at 298K with the gas pressure ranging from 1.01×105 to 1×10-2Pa,was measured using the transient hot-strip method. The mechanism of the low thermal conductivity was studied. The re-sults indicate that the low thermal conductivity mainly results from the significant decrease of gaseous thermal conductivity of the new material due to the restriction of the motion of gas molecules in its fine structures. The formation of the fine structures is be-cause the new material takes the pore structure of the silica aerogel which consists of mainly nanometer-sized pores. | Hailong Yang Wen Ni Deping Chen Guoqiang Xu Tao Liang Li Xu | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 8 |
| 16 | Development and Analysis of an Electrically Actuated Lower Extremity Assistive Exoskeleton显示文摘一架电子上激活的更低的极限皮骨骼被开发,在哪个当有弹性的元素连接的另外的关节消极地被激活时,仅仅膝关节活跃地被激活。这份报纸描述批评设计标准并且介绍设计的进程和使活动系统的计算。一台灵活物理 Human-Robot-Interaction (pHRI ) 测量设备被设计并且适用检测人的运动,它包括纳入连接手铐的内部表面的二个力量传感器和二个气囊。联机适应 pHRI 最小化控制策略被建议并且实现了驱使机器的皮骨骼系统跟随人的手足的运动轨道。测量 pHRI 信息被变化加权的一般水准(VWA ) 方法熔化。pHRI 和控制转矩的吝啬的方形的价值(MSV ) 被利用评估皮骨骼的表演。改进舒适水平和还原剂精力消费,当控制法律被设计时,严肃赔偿被考虑。最后,实际实验在健康用户上被执行。试验性的结果证明建议系统能帮助人走,构画出的控制策略有效、有效。 | Yi Long Zhijiang Du Chaofeng Chen Weidong Wang Long He Xiwang Mao Guoqiang Xu Guangyu Zhao Xiaoqi Li Wei Dong | 2017 | Journal of Bionic Engineering2017，14，2： | 7 |
| 17 | Ferromagnetism at 230 K in(Ba_(0.7)K_(0.3))(Zn_(0.85)Mn_(0.15))_2As_2 diluted magnetic semiconductor显示文摘We report the ferromagnetism with Cure temperature Tcat 230 K in a new diluted magnetic semiconductor(DMS)(Ba0.7K0.3)(Zn0.85Mn0.15)2As2isostructural to ferropnictide 122 superconductors synthesized via low temperature sintering.Spin is doped by isovalence substitution of Mn2+for Zn2+,while charge is introduced by heterovalence substitution of K1+for Ba2+in(Ba0.7K0.3)(Zn0.85Mn0.15)2As2DMS,being different from(Ga,Mn)As where both spin&charge are induced simultaneously by heterovalence substation of Mn2+for Ga3+.The(Ba0.7K0.3)(Zn0.85Mn0.15)2As2DMS shows spontaneous magnetization following T3/2dependence expected for a homogeneous ferromagnet with saturation moment 1.0μB for each Mn atom. | Kan Zhao Bijuan Chen Guoqiang Zhao Zhen Yuan Qingqing Liu Zheng Deng Jinlong Zhu Changqing Jin | 2014 | Chinese Science Bulletin2014，59，21： | 7 |
| 18 | Integrated Chinese-western therapy versus western therapy alone on survival rate in patients with non-small-cell lung cancer at middlelate stage显示文摘OBJECTIVE: To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate prognostic factors. METHODS: We selected 98 inpatients with middle-late stage NSCLC diagnosed from March 2009 to March 2011 and randomly divided them into two groups, with 49 cases in each group, and the clinical data were analyzed retrospectively.The control group was treated by the combined methods of Western Medicine, including chemotherapy, supportive treatment and symptomatic treatment. The observation group was treated by injection and prescriptions of Chinese medicine based on Traditional Chinese Medicine syndrome differentiation and by the same combined methods of western treatment used in the control group. After treatment, the survival rates of the patients were compared by the stage of cancer and evaluation of 24 prognostic factors analyzed by a Cox regressionmodel, and the clinical data were statistically analyzed. RESULTS: The survival rates of all patients were over 90.0% at 1 and 3 months after treatment with no significant differences between the two groups (P>0.05); In the observation group the survival rates at 6 months and 1 year were 93.4% and 42.8%, respectively, being superior to 85.6% and 18.3% in the control group (P<0.05). The median survival time in the observation group was superior to the control group (P<0.05); The effects of 24 prognostic factors were significantly better in the observation group than in the control group (P<0.05). CONCLUSION: Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone. | Guoqiang Lin Yingqiu Li Shengxi Chen Haihe Jiang | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 7 |
| 19 | Wide-steering-angle high-resolution optical phased array显示文摘Optical phased array(OPA)technology is considered a promising solution for solid-state beam steering to supersede the traditional mechanical beam steering.As a key component of the LIDAR system for long-range detection,OPAs featuring a wide steering angle and high resolution without beam aliasing are highly desired.However,a wide steering range requires a waveguide pitch less than half of the wavelength,which is easily subjected to cross talk.Besides,high resolution requires a large aperture,and it is normally achieved by a high count number of waveguides,which complicates the control system.To solve the mentioned issues,we design two high-performance 128-channel OPAs fabricated on a multilayered SiN-on-SOI platform.Attributed to the nonuniform antenna pitch,only 128 waveguides are used to achieve a 4 mm wide aperture.Besides,by virtue of innovative dual-level silicon nitride(Si_(3)N_(4))waveguide grating antennas,the fishbone antenna OPA achieves a 100°×19.4°field of view(FOV)with divergence of 0.021°×0.029°,and the chain antenna OPA realizes a 140°×19.23°FOV with divergence of 0.021°×0.1°.To our best knowledge,140°is the widest lateral steering range in two-dimensional OPA,and 0.029°is the smallest longitudinal divergence.Finally,we embed the OPA into a frequency-modulated continuous-wave system to achieve 100 m distance measurement.The reflected signal from 100 m distance is well detected with 26 dBm input transmitter power,which proves that OPA serves as a promising candidate for transceiving optical signal in a LIDAR system. | YINGZHI LI BAISONG CHEN QUANXIN NA QIJIE XIE MIN TAO LANXUAN ZHANG ZIHAO ZHI YUXUAN LI XIAOBIN LIU XIANSHU LUO GUOQIANG LO FENGLI GAO XUEYAN LI JUNFENG SONG | 2021 | Photonics Research2021，9，12： | 7 |
| 20 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6sx5b9bxx0unxn6qf5.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
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