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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Plasmon-tunable Au@Ag core-shell spiky nanoparticles for surfaceenhanced Raman scattering显示文摘A facile synthetic approach has been developed to prepare uniform and size-tunable spiky Au@Ag core-shell nan oparticles (NPs) to tailor the localized surface plasm on res onance (LSPR) properties. The gradual assembly of small Au nano crystals allows the size of spiky Au NPs to be modulated from tens to several hundreds of nano meters by tuning the concentration of initial Au seeds and Au source;and the thick ness of the Ag shell can be adjusted with stepwise reduction of Ag(l)ions. The LSPR bands of such spiky Au@Ag core-shell NPs resemble those of pure spiky Au NP cores of similar sizes in near-infrared region, and increasing the Ag shell thickness results in a blue shift and broadening of the LSPR band in the n ear-i nfrared regi on. Additi on ally, the spiky Au@Ag core-shell NPs exhibit improved surface-e nhan ced Rama n scattering (SERS) activity as compared to the bare spiky Au NPs and spherical Ag@Au NPs. This work has offered a facile route to synthesize plasmonic metal NPs with LSPR band in 650 to 800 nm that show strong enhancement of localized electromagnetic field, which provides an effective SERS substrate for SERS imaging and detection in biological fluids and tissues. | Zhulin Huang Guowen Meng Xiaoye Hu Qijun Pan Dexian Huo Hongjian Zhou Yan Ke Nianqiang Wu | 2019 | Nano Research2019，12，2： | 4 |
| 3 | Effect of Friction Reclaimed Materials of Waste Brake-shoe on Basic Performance of Mortar显示文摘Discarded train brake shoes mainly consist of steel-backed friction material. To be better reutilized, its essential features and its interaction in cement-based material need to be studied. Consequently, particle size analysis, SEM, IR and TGA were used to investigate two types of waste brake shoes, i e, mechanical grinding friction reclaimed material of waste brake-shoe(G-FRMWBS) and pyrolysis-friction reclaimed materials of waste brake-shoe(P-FRMWBS). The latter exhibited less organic content, larger range of particle size distribution and smaller medium particle diameter. Both types contained inorganic particles of spherical and irregular shapes, striped with steel fiber. Upon isometric substituting fine aggregates, G-FRMWBS lifted the strength of mortar effectively that was increased by 16.6% and 17.5% when the replacing rate was 5%; the value went up to 19.2% and 19.2% when the replacing rate was 10%. Moreover, inclusion of FRMWBS enhanced the chloride penetration resistance, and optimized the pore characteristic and ITZ(interfacial transition zone) as well. | 王彩辉 HUANG Dongjie FU Hua WU Hongya QIN Guoqiang SUN Guowen GUO Na | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 3 |
| 4 | ZnO-nanotaper array sacrificial templated synthesis of noble-metal building-block assembled nanotube arrays as 3D SERS-substrates显示文摘这份报纸描述一个 ZnO-nanotaper 数组为有试管墙的 nanotubes 的数组的制造的合成途径由 Ag-nanoplates, Au-nanorods, Pt-nanothorns 或 Pd-nanopyramids 的大楼块装配了的牺牲的 templated,因此拥有高密度的 3D 在有 nano 尖端,角落或边的附近的积木的 sub-10-nm 差距的热点。另外,这些层次 nanostructure 数组与富有的表面化学拥有高表面区域,对捕获 analyte 有益。Ag-nanoplateassembled nanotube 数组能被用作散布的敏感提高表面的拉曼(重量的单位) 有好信号一致性和重制度的底层。用如此的 Ag ,层次 nanostructure 作为重量的单位底层穿,不是仅仅有 10 <啜class=“ a-plus-plus ”> 14 M 玫瑰精 6G 识别,而且 10 <啜class=“ a-plus-plus ”> 7 M polychlorinated 联本基(印刷电路板,坚持的器官的污染物质的一个臭名昭著的班)被认出,并且甚至印刷电路板的二同种的物能在混合物被识别,在环境器官的污染物质的基于重量的单位的快速的察觉显示出材料的潜在的应用。 | Chuhong Zhu Guowen Meng Qing Huang Xiujuan Wang Yiwu Qian Xiaoye Hu Haibin Tang Nianqiang Wu | 2015 | Nano Research2015，8，3： | 3 |
| 5 | Synthesis of Phenyl Acetate from Phenol and Acetic Anhydride over Synthetic TS-1 Containing Template显示文摘In this article, phenyl acetate was synthesized from phenol and acetic anhydride over titanium silicalite-1, in which the organic structure-directing agents were immobilized(TS-1-U). The reaction conditions were specified at a phenol to acetic anhydride molar ratio of 1:1.2, a catalyst dosage of 6 m%, and a reaction temperature of 70 ℃. A total of 96.5% of phenol was converted to phenyl acetate without producing any byproducts after 2.5 h of reaction. Besides, although the catalyst deactivation is inevitable, TS-1-U could be recycled for at least four times. | Wu Guowen Shi Chunfeng Lin Min Zhu Bin | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，4： | 1 |
| 6 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition显示文摘Sphingosine-1-phosphate(S1P)is an important bioactive lipid molecule in cell membrane metabolism and binds to G proteincoupled S1P receptors(S1PRs)to regulate embryonic development,physiological homeostasis,and pathogenic processes in various organs.S1PRs are lipid-sensing receptors and are therapeutic targets for drug development,including potential treatment of COVID-19.Herein,we present five cryo-electron microscopy structures of S1PRs bound to diverse drug agonists and the heterotrimeric Gi protein.Our structural and functional assays demonstrate the different binding modes of chemically distinct agonists of S1PRs,reveal the mechanical switch that activates these receptors,and provide a framework for understanding ligand selectivity and G protein coupling. | Yuan Yuan Guowen Jia Chao Wu Wei Wang Lin Cheng Qian Li Ziyan Li Kaidong Luo Shengyong Yang Wei Yan Zhaoming Su Zhenhua Shao | 2021 | Cell Research2021，31，12： | 1 |
| 7 | Impact of hepatitis B vaccination among children in Guangdong Province, China显示文摘 | Jianpeng Xiao Jikai Zhang Chenggang Wu Xiaoping Shao Guowen Peng Zhiqiang Peng Wenjun Ma Yonghui Zhang Huizhen Zheng | 2012 | International Journal of Infectious Diseases2012，，9： | 1 |
| 8 | MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin显示文摘 | Zhisen Shen Guowen Zhan Dong Ye Yuan Ren Lixin Cheng Zhenhua Wu Junming Guo | 2012 | Medical Oncology2012，，： | 1 |
| 9 | Isolation of antioxidants from Psoralea corylifolia fruits using high-speed counter-current chromatography guided by thin layer chromatography-antioxidant autographic assay显示文摘 | Guodong Xiao Guowen Li Liang Chen Zijia Zhang Jun-Jie Yin Tao Wu Zhihong Cheng Xiaohui Wei Zhengtao Wang | 2010 | Journal of Chromatography A2010，，34： | 1 |
| 10 | ∑HfF_5^- current monitoring with off-axis Faraday cup in AMS measurement of ^(182)Hf at CIAE显示文摘In order to reduce the systematic uncertainties caused by the sequential injection in AMS measurement of ^(182)Hf,a technique for instantaneous monitoring of off-axis∑HfF_5^- current was developed in the AMS laboratory at China Institute of Atomic Energy(CIAE).The stability and reliability of this method have been experimentally verified.As a result,the accuracy for AMS measurement of^(182)Hf was significantly improved. | LI Zhenyu HE Ming DONG Kejun LI Chaoli HE Guozhu HE Xianwen ZHANG Wei HU Hao ZHENG Guowen LI Heng WU Shaoyong JIANG Shan | 2012 | Nuclear Science and Techniques2012，23，4： | 1 |
| 11 | Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies显示文摘The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium.HH signaling pathway has important functions in embryonic development and tissue homeostasis.It plays a central role in the regulation of the proliferation and differentiation of adult stem cells.Importantly,it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence,malignant progression,poor prognosis and even increased mortality.Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer.A variety of drugs have been developed,including small molecule inhibitors,natural compounds,and long non-coding RNA(LncRNA),some of which are approved for clinical use.This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer.Furthermore,we address status quo and limitations of targeted therapies of HH signaling pathway.Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer,as well as opportunities and challenges of therapeutic targets for cancer. | Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 12 | FedNRM:A Federal Personalized News Recommendation Model Achieving User Privacy Protection显示文摘In recent years,the type and quantity of news are growing rapidly,and it is not easy for users to find the news they are interested in the massive amount of news.A news recommendation system can score and predict the candidate news,and finally recommend the news with high scores to users.However,existing user models usually only consider users’long-term interests and ignore users’recent interests,which affects users’usage experience.Therefore,this paper introduces gated recurrent unit(GRU)sequence network to capture users’short-term interests and combines users’short-term interests and long-terminterests to characterize users.While existing models often only use the user’s browsing history and ignore the variability of different users’interest in the same news,we introduce additional user’s ID information and apply the personalized attention mechanism for user representation.Thus,we achieve a more accurate user representation.We also consider the risk of compromising user privacy if the user model training is placed on the server side.To solve this problem,we design the training of the user model locally on the client side by introducing a federated learning framework to keep the user’s browsing history on the client side.We further employ secure multiparty computation to request news representations from the server side,which protects privacy to some extent.Extensive experiments on a real-world news dataset show that our proposed news recommendation model has a better improvement in several performance evaluation metrics.Compared with the current state-of-the-art federated news recommendation models,our model has increased by 0.54%in AUC,1.97%in MRR,2.59%in nDCG@5%,and 1.89%in nDCG@10.At the same time,because we use a federated learning framework,compared with other centralized news recommendation methods,we achieve privacy protection for users. | Shoujian Yu Zhenchi Jie Guowen Wu Hong Zhang Shigen Shen | 2023 | Intelligent Automation & Soft Computing2023，37，8： | 0 |
| 13 | The history of agriculture in the mountainous areas of the lower Yangtze River since the late Neolithic显示文摘Understanding the role of agriculture in the development of human societies around the world is an important field of study with many unanswered questions.As a step toward that greater understanding,we have studied the archeobotanical remains at the Jingshuidun site in the mountainous areas of the lower reaches of the Yangtze River in southern Anhui Province which are part of the core area of rice cultivation today.Our analyses of macrobotanical remains and phytoliths formed the basis for the reconstruction of the subsistence economy of ancient humans at the Jingshuidun site from the late Neolithic to early historical times.When our data are combined with that of previous archeobotanical work,we obtain a clearer picture of the development of rice and millet agriculture in the southern Anhui Province region,as well as the spread of millet cultivation.Macrobotanical remains and phytoliths of domesticated rice are present in layers at the Jingshuidun site dated to 4874–4820 cal.yr B.P.(middle-late Liangzhu Period)and 2667–2568 cal.yr B.P.(late Western Zhou Dynasty to the early Spring and Autumn Period).Moreover,macrobotanical remains and phytoliths from the site document the earliest remains of foxtail millet(Setaria italica)in southern Anhui Province,from a layer dating to the late Western Zhou Dynasty and the early Spring and Autumn Period(2667–2568 cal.yr B.P.).These results suggest that the people occupying the Jingshuidun site used single rice farming as far back as 4874–4820 cal.yr B.P.,and they began to plant millet by at least 2667–2568 cal.yr B.P.,documenting the spread of millet agriculture to the southern area by that time. | Jingyi WANG Xiaochun CHEN Guilin ZHANG Guowen ZHANG Yan WU | 2022 | Frontiers of Earth Science2022，16，3： | 0 |
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