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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | An electron microscopic-cytochemical localization of plasma membrane Ca^(2+)-ATPase activity in poplar apical bud cells during the induction of dormancy by short-day photoperiods显示文摘Plasma membrane (PM) Ca2+-ATPase activity in poplar apical bud meristematic cells during short-day (SD)-induced dormancy development was examined by a cerium precipitation EM-cytochemical method. Ca2+-ATPase activity, indicated by the status of cerium phosphate precipitated grains, was localized mainly on the interior face (cytoplasmic side) of the PM when plants were grown under long days and reached a deep dormancy. A few reaction products were also observed on the nuclear envelope.When plant buds were developing dormancy after 28 to 42 d of SD exposure, almost no reaction products were present on the interior face of the PM. In contrast, a large number of cerium phosphate precipitated grains were distributed on the exterior face of the PM. After 70 d of SD exposure, when buds had developed a deep dormancy, the reaction products of Ca2+-ATPase activity again appeared on the interior face of the PM. The results seemed suggesting that two kinds of Ca2+-ATPases may be present on the PM during the SD-induced dormancy in poplar.One is the Ca2+-punlping ATPase, which is located on the interior face of the PM, for maintaining and restoring the Ca2+homeostasis. The other might be an ecto-Ca2+-ATPase, which is located on the exterior face of the PM, for the exocytosis of cell wall materials as suggested by the fact of the cell wall thickening during the dormancy developlnent in poplar. | JIAN LING CHENG JI HONG LI PAUL H LI TONY HH CHEN(Tel: 1612 624 1757 Fax: +1612 624 4941 E-mail: lixxx008@tc.umn.edu)(1Laboratory of Plant Hardiness, Department of Horticultural Science and Plant Biological Sciences Program, University of Minnesota, | 2000 | Cell Research2000，10，2： | 9 |
| 3 | A viscoelastic-plastic constitutive model with Mohr-Coulomb yielding criterion for sea ice dynamics显示文摘A new viscoelastic-plastic (VEP) constitutive model for sea ice dynamics was developed based on continuum mechanics. This modelconsists of four components: Kelvin-Vogit viscoelastic model, Mohr-Coulomb yielding criterion, associated normality flow rule forplastic rehololgy, and hydrostatic pressure. The numerical simulations for ice motion in an idealized rectangular basin were made usingsmoothed particle hydrodynamics (SPH) method, and compared with the analytical solution as well as those based on the modified vis-cous plastic(VP) model and static ice jam theory. These simulations show that the new VEP model can simulate ice dynamics accu-rately. The new constitutive model was further applied to simulate ice dynamics of the Bohai Sea and compared with the traditionalVP, and modified VP models. The results of the VEP model are compared better with the satellite remote images, and the simulated iceconditions in the JZ20-2 oil platform area were more reasonable. | JI Shunying SHEN Hung Tao WANG Zhilian SHEN H Hayley YUE Qianjin | 2005 | Acta Oceanologica Sinica2005，24，4： | 9 |
| 4 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 5 | Characteristics of temporal-spatial parameters in quasi-solid-fluid phase transition of granular materials显示文摘The quasi-solid-fluid phase transition of granular materials is closely related to the shear rate and solid concentration in addition to their intrinsic properties. The contact duration and the coordination number are two important temporal-spatial parame-ters to describe the granular interaction in phase transition. In this study, characteristics of the contact duration and the coordination number associated with the transition processes are determined using a 3D discrete element model under different shear rates and concentrations. The resulting macroscopic stress and strain-rate relations are discussed. The temporal and spatial parameters provide a linkage between the macroscopic constitutive law and inter- particle micromechanics. | JI Shunying SHEN H Hayley | 2006 | Chinese Science Bulletin2006，51，6： | 5 |
| 6 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 7 | 缺血期补充硝酸甘油对离体大鼠心脏心肌缺血再灌注损伤的作用显示文摘目的:观察离体大鼠心脏缺血期补充一氧化氮(NO)供体对缺血再灌注损伤的影响。 方法:将26只离体大鼠心脏缺血30分,再灌注60分。分为两组,用药组(15只)及对照组(11 只)。用药组于缺血期给予4.4×10- 3 mm ol/L硝酸甘油(nitroglycerin,NTG,一种NO供体),碳酸氢盐缓冲液灌注。对照组仅给予碳酸氢盐缓冲液灌注。全部心脏均测定NO释放量、肌酸激酶漏出量及(或)心脏功能。 结果:用药组大鼠心脏,使用NTG表现为两种效应。其中部分大鼠心脏(非心室颤动组,n= 7),NTG增加肌酸激酶漏出量,减弱再灌注期心脏功能的恢复,伴随缺血期NO释放量的增加。对另一部分大鼠心脏(心室颤动组,n= 8),NTG减少肌酸激酶的释放,但心脏于再灌注期持续心室颤动,缺血期NO释放量无明显增加。 结论:缺血期给予同一剂量NTG对心肌缺血再灌注损伤产生双重效应,既可增加心肌损伤,又可减轻心肌损伤。 | 刘海波 Takayuki T su ji Fum io Y am amoto Tosh ia Fujisato Hidekazu H irai Fu jio Miyaw aki | 1999 | 中国循环杂志1999，14，4： | 3 |
| 8 | 计算机辅助截骨术指导和预弯钛板改善面部不对称矫正手术的规划显示文摘本研究评估了计算机辅助截骨术和预弯钛板治疗面部不对称患者的手术效果和准确性。纳入13例面部不对称进行双颌手术的患者。如果需要,在术前三维模型上进行Le Fort I型截骨术,下颌支矢状劈开截骨术和颏成形术的虚拟模拟。 | Ji H Du W Xu C 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 3 |
| 9 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 10 | 美国地震学会通报(BSSA)2008年四川汶川地震专集介绍显示文摘 | Klinger Y Ji C Shen Z-K Bakun W H 李平恩(译) 左玉玲(校) | 2010 | 国际地震动态2010，，12： | 3 |
| 11 | Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model显示文摘 | Wang H Zheng MH Zhang HB Zhu J He JR Lu AG Ji YB Zhang MJ Jiang Y Yu BM Li HW | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 12 | A low glitch 10-bit 75-MHz CMOS video D/A converter显示文摘 | WU T JI H C | 1995 | IEEE Journal of Solid-State Circuits1995，30，1： | 2 |
| 13 | Functions and applications of polypyridyl complexes in DNA显示文摘The syntheses and desymmetration of a series of novel polypyridyl ligands as well as their complexes, and their DNA-binding properties are reported in this review. The stresses are focused on the functions and potential applications of such complexes as DNA structural probe, DNA molecular light switches, anti-cancer drugs, and photoactivated cleavage agents. | Ji, LN Zhang, QL Chao, H | 2001 | Chinese Science Bulletin2001，46，16： | 2 |
| 14 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 15 | Cryopreservation of kunming mouse oocytes using slow cooling, ultrarapid cooling and vitrifyication protocols显示文摘 | Men H S Chen J C Ji W Z | 1997 | Theriogenology1997，47，： | 2 |
| 16 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 17 | Concentration and chemical composition of PM 2.5 in Shanghai for a 1-year period显示文摘 | Boming Ye Xueli Ji Haizhen Yang Xiaohong Yao Chak K Chan Steven H Cadle Tai Chan Patricia A Mulawa | 2002 | Atmospheric Environment2002，，4： | 2 |
| 18 | Adaptive output-feedback tracking of stochastic nonlinear systems显示文摘 | Ji H B Xi H S | 2006 | IEEE Transactions on Automatic Control2006，51，2： | 1 |
| 19 | Perforin and lymphohistioeytosis proliferative disorders 显示文摘 | Katono H Cohen JI | 2005 | Br J Haemetol2005，128，6： | 1 |
| 20 | PI3K5 and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?显示文摘 | ROMMEL C CAMPS M JI H | 2007 | Nat Rev Immunot2007，7，3： | 1 |
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