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| 1 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 2 | Possible linkage between winter extreme low temperature events over China and synoptic-scale transient wave activity显示文摘Based on NECP/NCAR reanalysis data and daily temperature data of 743 stations in China, possible causes of winter extreme low temperature events are explored from the perspective of the synoptic-scale transient wave (STW) activity. Results suggest that there is a close linkage between STW activity and extreme low temperature events. Firstly, case studies are carried out on the years with the most and least frequent extreme low temperature events. In the winter of 1967, two strong and stable STW trains were maintained over the Eurasian continent, and the strong westerly jet provided a good channel for the propagation of STW. Located in the downstream area of those two STW trains, China was significantly influenced by them and experienced frequent extreme low temperature events. Further analysis suggest that the intensity of the upstream transient wave and the areas where the transient waves reached are completely consistent with the intensity of extreme low temperature and the areas where frequent extreme low temperature event happened, respectively. In contrast, Westerly jet in 2006 was weaker and the path of transient wave propagation was shorter and weaker, resulting in the low frequency of extreme temperature. Secondly, in their long term variations, westerly jet is also consistent with the extreme low temperature frequency. The transient wave path changed before and after the 1980s. Further investigation suggests that transient wave intensities in key areas exhibit in-phase changes with the frequency of extreme low temperature events in the periods of 1959-1979 and 1986-2006. Meanwhile, the main features of transient wave activities in high-frequent years and low-frequent years of extreme low temperature events are similar to those of 1967 and 2006, respectively. Results indicate that winter extreme low temperature events in China have a very close relationship with the transient wave activity, implying the propagation and activity of STW are important factors affecting the winter extreme low temperature events in China. This study can also provide a new clue for better understanding the mechanisms of the extreme temperature events. | CHEN HaiShan LIU Lei ZHU YueJia | 2013 | Science China Earth Sciences2013，56，7： | 11 |
| 3 | ^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor显示文摘In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging preoperatively.The chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 MBq.The diagnosis precision,sensitivity and specificity among these methods were compared.The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and 6.leimyoma;and 2,esophageal tuberculosis.The accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,respectively.Abnormal accumulation of radiotracer in 29 malignant lesions is observed.The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic.The99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell percentage of integrin αvβ3(r=0.976),demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma. | GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan | 2013 | Nuclear Science and Techniques2013，24，4： | 3 |
| 4 | Sub-seasonal to Seasonal Hindcasts of Stratospheric Sudden Warming by BCC_CSM1.1(m):A Comparison with ECMWF显示文摘This study focuses on model predictive skill with respect to stratospheric sudden warming(SSW) events by comparing the hindcast results of BCC_CSM1.1(m) with those of the ECMWF's model under the sub-seasonal to seasonal prediction project of the World Weather Research Program and World Climate Research Program. When the hindcasts are initiated less than two weeks before SSW onset, BCC_CSM and ECMWF show comparable predictive skill in terms of the temporal evolution of the stratospheric circumpolar westerlies and polar temperature up to 30 days after SSW onset. However, with earlier hindcast initialization, the predictive skill of BCC_CSM gradually decreases, and the reproduced maximum circulation anomalies in the hindcasts initiated four weeks before SSW onset replicate only 10% of the circulation anomaly intensities in observations. The earliest successful prediction of the breakdown of the stratospheric polar vortex accompanying SSW onset for BCC_CSM(ECMWF) is the hindcast initiated two(three) weeks earlier. The predictive skills of both models during SSW winters are always higher than that during non-SSW winters, in relation to the successfully captured tropospheric precursors and the associated upward propagation of planetary waves by the model initializations. To narrow the gap in SSW predictive skill between BCC_CSM and ECMWF, ensemble forecasts and error corrections are performed with BCC_CSM. The SSW predictive skill in the ensemble hindcasts and the error corrections are improved compared with the previous control forecasts. | Jian RAO Rongcai REN Haishan CHEN Xiangwen LIU Yueyue YU Yang YANG | 2019 | Advances in Atmospheric Sciences2019，36，5： | 3 |
| 5 | Modification of Cellulose by Hydrophobic Long-chain Molecules: Advances and Prospects显示文摘Cellulose,a natural polymer material with abundant natural sources,is non-toxic,renewable,and biodegradable,making it one of the most promising green materials.Its inherent hydrophilicity dramatically limits the development and application of cellulose products.Hydrophobic modification can significantly change cellulose properties and endow it with additional functions depending on the types of modifying molecules.Controlled modification of cellulose by long-chain hydrophobic molecules is challenging.Significant advances took advantage of new reaction systems and copolymerization.This paper reviews recent innovations in long-chain cellulose hydrophobic modification.A brief value-adding assessment provides a reference for green changes of cellulose to make it fit for future applications. | Yuyuan Wang Haishan Zhang Leyi Lin Rui Wu Xiaohui Wang Junli Ren Chuanfu Liu Xiaoying Wang | 2020 | Paper And Biomaterials2020，5，3： | 3 |
| 6 | Naringenin nanocrystals for improving antirheumatoid arthritis activity显示文摘Naringenin(NAR)is recognized for its anti-inflammatory activity.However,the clinical application of NAR is limited by low bioavailability,which is attributed to its poor aqueous solubility.In this study,we aimed to improve the therapeutic efficacy of NAR by formulating it into nanocrystals(NCs)via wet milling.The obtained NARNCs exhibited superior dissolution behaviors,increased cellular uptake,and enhanced transcellular diffusion relative to those of bulk NAR.Oral administration of NARNCs also significantly improved bioavailability in rats.In addition,the NARNCs effectively improved rheumatoid arthritis treatment in collagen-induced arthritic rats by reducing inflammatory cell infiltration and synovial damage.These results indicate that NARNCs provides a promising strategy for rheumatoid arthritis treatment. | Guangshuai Zhang Guangyuan Sun Haishan Guan Mo Li Yanhua Liu Baocheng Tian Zhonggui He Qiang Fu | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 7 | Fine-scale activity patterns of large-and medium-sized mammals in a deciduous broadleaf forest in the Qinling Mountains,China显示文摘The composition of animal species and interactions among them are widely known to shape ecological communities and fine-scale(e.g.,<1 km)monitoring of animal communities is essential for understanding the relationships among animals and plants.Although the co-existence of large-and medium-sized species has been studied across different scales,research on fine-scale interactions of herbivores in deciduous broadleaf forests is limited.Camera trapping of large-and medium-sized mammals was carried out over a 1 year period within a 25 ha deciduous broadleaf forest dynamics plot in the Qinling Mountains,China.Fourteen species of large-and medium-sized mammals,including six carnivores,six ungulates,one primate and one rodent species were found.Kernel density estimations were used to analyse the diel or 24 h activity patterns of all species with more than 40 independent detections and general linear models were developed to explore the spatial relationships among the species.The combination of overlapping diel activity patterns and spatial associations showed obvious niche separation among six species:giant panda(Ailuropoda melanoleuca David),takin(Budorcas taxicolor Hodgson),Reeves’s muntjac(Muntiacus reevesi Ogilby),tufted deer(Elaphodus cephalophus Milne-Edwards),Chinese serow(Capricornis milneedwardsii David)and wild boar(Sus scrofa Linnaeus).Long-term fine-scale monitoring is useful for providing information about the co-existence of species and their interactions.The results demonstrate the importance for fine-scale monitoring of animals and plants for improving understanding of species interactions and community dynamics. | Yuke Zhang Xiangbo He Xuehua Liu Melissa Songer Haishan Dang Quanfa Zhang | 2021 | Journal of Forestry Research2021，32，6： | 1 |
| 8 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 9 | A Dual Gauss-Seidel Iteration Method in Calculation of Cost Tree of Power Project Budget RECENT ADVANCES IN SYSTEMS显示文摘 | Chen yuchen Cao Minnian Liu Haishan | | 0，，： | 1 |
| 10 | Effect of Processing and Aging on Particle Size of Explosives显示文摘 | Liu Shijun Dong Haishan | 2003 | Chinese Journal of Chemistry2003，21，： | 1 |
| 11 | Application of two-dimensional near-infrared correlation spectroscopy to the discrimination of Chinese herbal medicine of different geographic regions显示文摘 | Jun Lu Bingren Xiang Hao Liu Suyun Xiang Shaofei Xie Haishan Deng | 2007 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2007，，2： | 1 |
| 12 | A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma显示文摘The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma.In this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent.The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging.Tumor samples for detectingαvβ3 were collected by surgical operations two weeks after the scintigraphy.The results of CT and SPECT scanning were merged and compared.The correlation between tumor occupation(T/N ratio) andαvβ3 expression level were analyzed.The T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage(R2=0.9253,p<0.05).This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma.The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials. | GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing CHEN Zuowei ZHANG Haishan | 2013 | Nuclear Science and Techniques2013，24，2： | 1 |
| 13 | Novel computer-assisted approach to quick prediction and optimization of gradient separation for online enrichment-reversed phase liquid chromatography tandem system显示文摘An algorithm capable of predicting and optimizing the gradient separation of LC×LC system was developed in this paper.Two groups of structural analogues,five ginsenosides as well as eight bisphenols,which were difficult to discriminate in routine analysis,were used to verify the effectiveness of the proposed algorithm in fast separation optimization.Average errors of retention times below 1%were found in the retention prediction for all types of gradient programs,implying that the theory could lead to high quality in prediction of the retention times under gradients elution.Meanwhile,84%of relative average deviations(RADs)between the predicted peak width and the measured ones were less than 20%.The larger deviation occurred at the time when the peak appeared while the gradient of the mobile phase changed,which led the deviations increased to 20%–42%.In all,method development and optimization for LC×LC tandem system was realized by the homemade user-friendly software.The present protocol may turn on great opportunities for the convenient method development in analysis of trace structural analogues in environmental,food and biological samples. | Shuying Han Yilin Song Xinyi Jiang Junqin Qiao An Kang Haishan Deng Dong Zhu Rui Liu Hongzhen Lian | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 14 | An innovative three-layer strategy in response to a quartan malaria outbreak among forest goers in Hainan Island,China:a retrospective study显示文摘Background:An outbreak of Plasmodium malariae infection among forest goers in Sanya City of Hainan Island,China was reported in 2015.In response to this outbreak,an innovative three-layer strategy(TLS)targeted forest goers was adapted based on the 1-3-7 approach.Main text:Key elements of TLS are:(i)The village with fve malaria cases and adjacent villages were set as the frst layer.All residents including forest goers were taken as the high-risk population(HRP).Active case detection(ACD)by blood smear microscopy and PCR was selected as the primary measure,and passive case detection(PCD)as complementary measure.One case was identifed under TLS implementation.(ii)The township with cases(Gaofeng Town)and the nearby towns were chosen as the second layer.Only forest goers were screened by ACD,while PCD as a routine screening method.7831 blood smears collected by ACD and PCD and tested with negative results.(iii)The city with cases(Sanya City)and others 12 counties/county-level cities were selected as the third layer.Malaria cases were monitored passively.A total of 77,555 blood slides were screened by PCD with zero positive sample.For each layer,the malaria vector mosquitoes were monitored using light traps,cattle-baited/human-bait traps.Anopheles minimus(dominant species),An.sinensis and An.dirus were captured.Vector control measures mainly include insecticide residual spraying and long-lasting insecticide nets.The capacity of clinicians,public health practitioners and laboratory technicians has been improved through training.During 2016‒2018,TLS and chemoprophylaxis were implemented in the same areas.In the frst layer,all residents were monitored by ACD,and malaria chemoprophylaxis were distributed,89.5%of forest goers were using chemoprophylaxis against malaria.The blood smears(3126 by ACD plus 1516 by PCD)were with zero positive results.Chemoprophylaxis and ACD were ofered to forest goers once a year,and PCD in residents as a complementary measure in the second and third layer,77.8%and 95.1%of forest goers received chemoprophylaxis.In each layer,vector surveillance and control of malaria and trainings for medical staf Conclusions:TLS was efective in blocking the outbreak by P.malariae among forest goers in Hainan in malaria elimination stage.However,whether it could prevent the malaria resurgence in the post-elimination phase needs to be further assessed. | Yuchun Li Yingjuan Huang Renqiang Chen Weizhen Huang Huanzhi Xu Rongshen Ye Shaoling Huang Ji Zhen Xiaodan Wen Guoyi Wang Yong Liu Haishan Li Zaichun Zheng Jian Wang Guoshen Wang Chong Chen Wen Zeng Feng Meng Xiaoming Huang Guangze Wang Bing Yang Yan Chen | 2022 | Infectious Diseases of Poverty2022，11，5： | 0 |
| 15 | The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior显示文摘The secondary motor cortex(M2)encodes choice-related information and plays an important role in cue-guided actions.M2 neurons innervate the dorsal striatum(DS),which also contributes to decision-making behavior,yet how M2 modulates signals in the DS to influence perceptual decision-making is unclear.Using mice performing a visual Go/No-Go task,we showed that inactivating M2 projections to the DS impaired performance by increasing the false alarm(FA)rate to the reward-irrelevant No-Go stimulus.The choice signal of M2 neurons correlated with behavioral performance,and the inactivation of M2 neurons projecting to the DS reduced the choice signal in the DS.By measuring and manipulating the responses of direct or indirect pathway striatal neurons defined by M2 inputs,we found that the indirect pathway neurons exhibited a shorter response latency to the No-Go stimulus,and inactivating their early responses increased the FA rate.These results demonstrate that the M2-to-DS pathway is crucial for suppressing inappropriate responses in perceptual decision behavior. | Jing Liu Dechen Liu Xiaotian Pu Kexin Zou Taorong Xie Yaping Li Haishan Yao | 2023 | Neuroscience Bulletin2023，39，10： | 0 |
| 16 | Roles of effective stabilizers in improving oral bioavailability of naringenin nanocrystals:Maintenance of supersaturation generated upon dissolution by inhibition of drug dimerization显示文摘Nanocrystals(NCs),a colloidal dispersion system formulated with stabilizers,have attracted widespread interest due to their ability to effectively improve the oral bioavailability of poorly water-soluble drugs.The stabilizer plays a key role because it can affect the physical stability and even the oral bioavailability of NCs.However,how stabilizers affect the bioavailability of NCs remains unknown.In this study,F68,F127,HPMC,and PVP were each used as a stabilizer to formulate naringenin NCs.The NCs formulated with PVP exhibited excellent release behaviors,cellular uptake,permeability,oral bioavailability,and anti-inflammatory effects.The underlying mechanism is that PVP effectively inhibits the formation of naringenin dimer,which in turn improves the physical stability of the supersaturated solution generated when NC is dissolved.This finding provides insights into the effects of stabilizers on the in vivo performances of NCs and supplies valuable knowledge for the development of poorly water-soluble drugs. | Guangshuai Zhang Haishan Guan Jianfeng Li Mo Li Xiaofan Sui Baocheng Tian Huiming Dong Bingyang Liu Zhonggui He Ning Li Mingming Zhao Qiang Fu | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 17 | Habitat heterogeneity and biotic interactions mediate climate influences on seedling survival in a temperate forest显示文摘Seedling stage has long been recognized as the bottleneck of forest regeneration,and the biotic and abiotic processes that dominate at seedling stage largely affect the dynamics of forest.Seedlings might be particularly vulnerable to climate stress,so elucidating the role of interannual climate variation in fostering community dynamics is crucial to understanding the response of forest to climate change.Using seedling survival data of 69 woody species collected for five consecutive years from a 25-ha permanent plot in a temperate deciduous forest,we identified the effects of biotic interactions and habitat factors on seedling survival,and examined how those effects changed over time.We found that interannual climate variations,followed by biotic interactions and habitat conditions,were the most significant predictors of seedling survival.Understory light showed a positive impact on seedling mortality,and seedling survival responded differently to soil and air temperature.Effects of conspecific neighbor density were significantly strengthened with the increase of maximum air temperature and vapor pressure deficits in the growing season,but were weakened by increased maximum soil temperature and precipitation in the non-growing season.Surprisingly,seedling survival was strongly correlated with interannual climate variability at all life stages,and the strength of the correlation increased with seedling age.In addition,the importance of biotic and abiotic factors on seedling survival differed significantly among species-trait groups.Thus,the neighborhood-mediated effects on mortality might be significantly contributing or even inverting the direct effects of varying abiotic conditions on seedling survival,and density-dependent effects could not be the only important factor influencing seedling survival at an early stage. | Haikun Liu Hang Shi Quan Zhou Man Hu Xiao Shu Kerong Zhang Quanfa Zhang Haishan Dang | 2023 | Forest Ecosystems2023，10，5： | 0 |
| 18 | Influence of Recent Trial History on Interval Timing显示文摘Interval timing is involved in a variety of cognitive behaviors such as associative learning and decision-making.While it has been shown that time estimation is adaptive to the temporal context,it remains unclear how interval timing behavior is influenced by recent trial history.Here we found that,in mice trained to perform a licking-based interval timing task,a decrease of inter-reinforcement interval in the previous trial rapidly shifted the time of anticipatory licking earlier.Optogenetic inactivation of the anterior lateral motor cortex(ALM),but not the medial prefrontal cortex,for a short time before reward delivery caused a decrease in the peak time of anticipatory licking in the next trial.Electrophysiological recordings from the ALM showed that the response profiles preceded by short and long inter-reinforcement intervals exhibited task-engagement-dependent temporal scaling.Thus,interval timing is adaptive to recent experience of the temporal interval,and ALM activity during time estimation reflects recent experience of interval. | Taorong Xie Can Huang Yijie Zhang Jing Liu Haishan Yao | 2023 | Neuroscience Bulletin2023，39，4： | 0 |
| 19 | DEVELOPMENT OF CHINA’S OFSHORE OIL RESOURCES显示文摘Compared with the traditional exploitation of land-based oil and gas, to explore offshore oil and gas might exert certain influences by high-risk, high-tech | Jin Xiaojian You Xuegang Liu Haishan | 2008 | China Oil & Gas2008，15，3： | 0 |
| 20 | Passive imaging through dense scattering media显示文摘Imaging through non-static and optically thick scattering media such as dense fog,heavy smoke,and turbid water is crucial in various applications.However,most existing methods rely on either active and coherent light illumination,or image priors,preventing their application in situations where only passive illumination is possible.In this study we present a universal passive method for imaging through dense scattering media that does not depend on any prior information.Combining the selection of small-angle components out of the incoming information-carrying scattering light and image enhancement algorithm that incorporates timedomain minimum filtering and denoising,we show that the proposed method can dramatically improve the signal-to-interference ratio and contrast of the raw camera image in outfield experiments. | YAOMING BIAN FEI WANG YUANZHE WANG ZHENFENG FU HAISHAN LIU HAIMING YUAN GUOHAI SITU | 2024 | Photonics Research2024，12，1： | 0 |
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