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| 1 | A novel colloidal gold immunochromatography assay strip for the diagnosis of schistosomiasis japonica in domestic animals显示文摘Background:Schistosomiasis remains a major public health concern in China and an epidemiological survey has revealed that schistosome-infected bovines and goats are the main transmission sources for the disease.Therefore,development of a sensitive technique for the diagnosis of schistosomiasis in domestic animals is necessary.Method:A novel colloidal gold immunochromatography assay(GICA)strip was developed for detecting Schistosoma japonicum in domestic animals.The colloidal gold was conjugated with recombinant streptococcal protein G(rSPG).As the test and control lines,the schistosome soluble egg antigen and rSPG,respectively,were blotted on nitrocellulose membrane.Results:The lowest detectable serum dilution was 1∶640 for schistosome-infected buffaloes.The cross-reaction rate of GICA was 14.29%with Paramphistomum sp.in buffaloes,16.67%with Haemonchus sp.in goats,and 33.33%with Orientobilharzia sp.in goats.These results were slightly lower and similar to those obtained through ELISA.Moreover,the strips for detecting S.japonicum in mice,rabbits,buffaloes,and goats showed high sensitivity(100.00%,100.00%,100.00%,and 100.00%,respectively)and specificity(100.00%,100.00%,94.23%,and 88.64%,respectively).And the sensitivity or specificity of the GICA strips did not present any significant differences after storage for 12 months at room temperature.When compared with ELISA,the GICA strips exhibited similar sensitivity and specificity in the diagnosis of schistosomiasis in mice,rabbits,buffaloes,and goats.Besides,only 5μl of serum are required for the test and the detection can be completed within 5 min.Conclusion:This study is the first to develop a GICA strip using gold-rSPG conjugate for the diagnosing of schistosomiasis in domestic animals,and preliminary results showed that the developed strip may be suitable for large-scale screening of schistosomiasis in endemic areas. | Rui Xu Jintao Feng Yang Hong Chao Lv Dengyun Zhao Jiaojiao Lin Ke Lu Hao Li Jinming Liu Xiaodan Cao Tao Wang Jinli Zai Zhaozhe Wang Bingguang Jia Qian Han Chuangang Zhu | 2017 | Infectious Diseases of Poverty2017，6，1： | 12 |
| 2 | Disinfection efficiency of positive pressure respiratory protective hood using fumigation sterilization cabinet显示文摘Concerns have been raised about both the disinfection and the reusability of respiratory protective equipment following a disinfection process.Currently,there is little data available on the effects of disinfection and decontamination on positive pressure respiratory protective hoods(PPRPH).In this study,we evaluated the effect of vaporized hydrogen peroxide(VHP)on the disinfection of PPRPH to determine applicability of this method for disinfection of protective equipment,especially protective equipment with an electric supply system.A hydrogen peroxide-based fumigation sterilization cabinet was developed particularly for disinfection of protective equipment,and the disinfection experiments were conducted using four PPRPHs hung in the fumigation chamber.The pathogenic microorganism Geobacillus stearothermophilus ATCC 7953 was used as a biological indicator in this study and the relationship between air flow(the amount of VHP)and disinfection was investigated.Both function and the material physical properties of the PPRPH were assessed following the disinfection procedure.No surviving Geobacillus stearothermophilus ATCC 7953,both inside and outside of these disinfected PPRPHs,could be observed after a 60 min treatment with an air flow of 10.5–12.3 m^(3)/h.Both function and material physical properties of these PPRPHs met the working requirements after disinfection.This study indicates that air flow in the fumigation chamber directly influences the concentration of VHP.The protective equipment fumigation sterilization cabinet developed in this paper achieves the complete sterilization of the PPRPHs when the air flow is at 10.5–12.3 m^(3)/h,and provides a potential solution for the disinfection of various kind of protective equipment. | Limei Hao Jinhui Wu Enlei Zhang Ying Yi Zongxing Zhang Jinming Zhang Jiancheng Qi | 2019 | Biosafety and Health2019，1，1： | 5 |
| 3 | A new interpolation method based on satellite physical character in using IGS precise ephemeris显示文摘Due to the deficiency of sliding Lagrange polynomial interpolation,the author proposes a new interpolation method,which considers the physical character of satellite movement in coordinate transformation and reasonable selection of interpolation function.Precision of the two methods is compared by a numerical example.The result shows that the new method is superior to the sliding Lagrange polynomial interpolation in interpolation and extrapolation,especially in extrapolation that is over short time spans. | Liu Weiping Hao Jinming | 2014 | Geodesy and Geodynamics2014，5，3： | 4 |
| 4 | Development of a negative pressure hood for isolation and transportation of individual patient with respiratory infectious disease显示文摘The frequent and sudden occurrence of both known and unknown infectious diseases can cause global social panic.If the source of infection can be effectively controlled in the early stages of an outbreak,the spread of infectious diseases can be prevented.In view of this situation,this study developed for infectious or suspected infectious patients a negative pressure isolation hood which effectively achieves direct individual isolation during the early stages of disease outbreak,and facilitates long-distance transport.The hood body is made of flexible transparent polyvinyl chloride(PVC)material,and the combination of the hood material is airtight.The unique inflatable column support structure and the design of the inflatable neck sleeve effectively ensure both stiffness and air tightness of the hood body.The electrical exhaust system maintains a stable negative pressure environment inside the hood,and polluted air inside the hood can be purified by a high efficiency filter.Test results showed that the internal noise of the hood was 68±1 dB(A),the air exhaust volume of the electric exhaust system was not<200 L/min,and the filtration efficiency of the filter to 0.3μm particles was>99.99%,indicating that the hood achieved effective isolation protection for patients with respiration infectious diseases. | Limei Hao Jinhui Wu Jinming Zhang Zhangyi Liu Ying Yi Zongxing Zhang Enlei Zhang Jiancheng Qi | 2019 | Biosafety and Health2019，1，3： | 3 |
| 5 | Comparative Study of Single-phase Phase-locked Loops for Grid-connected Inverters Under Non-ideal Grid Conditions显示文摘In renewable power generation systems,ensuring the synchronization of the inverter and the power grid is crucial for the stable operation of grid-connected inverters.Nowadays,the phase-locked loop(PLL)technology has become a widely used grid synchronization method because of its simple implementation and robustness under various grid conditions.Even though a lot of PLLs have been proposed,an overview and comparative analysis of multiple PLLs can be helpful for practical applications.In addition,the weak grid condition is a great challenge for the system.Therefore,this study first presents an overview of the existing PLLs together with their general structures and basic working principles.Depending on the implementation of the phase detector,the PLL can be divided into three categories:power-based PLL(pPLL),orthogonal-signalgenerator-based PLL(OSG-PLL)and adaptive-filter-based PLL(AF-PLL).Then,from the above classification,seven typical single-phase PLLs are selected for further study.Finally,some test results are given,and a comprehensive evaluation of the selected PLLs under different grid conditions is conducted. | Jinming Xu Hao Qian Shenyiyang Bian Yuan Hu Shaojun Xie | 2022 | CSEE Journal of Power and Energy Systems2022，8，1： | 2 |
| 6 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 7 | Designation of Acide Rain and SO2 Control Zones and Control Policies in China显示文摘 | Hao Jinming Wang Shuxiao | 2000 | J Environ Sci Health Part A2000，35，10： | 1 |
| 8 | Ceria promotion on the potassium resistance of MnOx/TiO, SCR catalysts: an experimental and DFT study显示文摘 | Peng Yue Li Junhua Si Wenzhe Li Xiang Shi Wenbo Luo Jinming Fu Jie Crittenden J Hao Jiming | 2015 | Chemical Engineering Journal2015，269，： | 1 |
| 9 | Designation of aeide rain and SO2 control zones and control policies in China 显示文摘 | Hao Jinming Wang Shuxiao | 2000 | J Environ Sei Health Part A2000，35，10： | 1 |
| 10 | Atomic Fe-N4 sites on electrospun hierarchical porous carbon nanofibers as an efficient electrocatalyst for oxygen reduction reaction显示文摘Porous carbon materials doped with atomically dispersed metal sites(ADMSs)are promising electrocatalysts for oxygen reduction reaction(ORR)electrocatalysis.In this work,we fabricated hierarchical porous nitrogen-doped carbon nanofibers with atomically dispersed Fe-N4 sites by carbonization of electrospinning iron-based metal-organic frameworks(MOFs)/polyacrylonitrile nanofibers for ORR electrocatalysis.Remarkably,the re sultant carbon nanofibers with atomically dispersed FeN4 sites exhibit extraordinary electrochemical performance with an onset potential of 0.994 V and a halfwave potential of 0.876 V in alkaline electrolyte,comparable to the benchmark commercial Pt/C catalyst.The high catalytic performance is originated from the unique hierarchically porous 1 D carbon structure and abundant highly active atomically dispersed Fe-N4 sites. | Ruiqin Zhong Chenxu Zhi Yingxiao Wu Zibin Liang Hassina Tabassum Hao Zhang Tianjie Qiu Song Gao Jinming Shi Ruqiang Zou | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 11 | NMR spectroscopic stud- ies of cellobiose solvation in EmimAc aimed to understand the dis- ~olution mechanism of cellulose in ionic liquids 显示文摘 | Zhang Jinming Zhang Hao Wu Jin | 2010 | Phys Chem Chem Phys2010，12，： | 1 |
| 12 | Lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer显示文摘Metastatic triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Combination of systemic chemotherapy and immune checkpoint blockade is effective but of limited benefit due to insufficient intratumoral infiltration of cytotoxic T lymphocytes(CTLs)and the accumulation of immunosuppressive cells.Herein,we designed a lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein(LV-sHDL)for combinational immunochemotherapy of metastatic TNBC.The LV-sHDL targeted scavenger receptor class B type 1-overexpressing 4T1 cells in the tumor after intravenous injection.The multitargeted tyrosine kinase inhibitor(TKI)lenvatinib induced immunogenic cell death of the cancer cells,and the stimulator of interferon genes(STING)agonist vadimezan triggered local inflammation to facilitate dendritic cell maturation and antitumor macrophage differentiation,which synergistically improved the intratumoral infiltration of total and active CTLs by 33-and 13-fold,respectively.LV-sHDL inhibited the growth of orthotopic 4T1 tumors,reduced pulmonary metastasis,and prolonged the survival of animals.The efficacy could be further improved when LV-sHDL was used in combination with antibody against programmed cell death ligand 1.This study highlights the combination use of multitargeted TKI and STING agonist a promising treatment for metastatic TNBC. | Chao Zheng Wen Zhang Jinming Wang Yihui Zha Fengqin Xiong Ying Cai Xiang Gong Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 13 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 14 | Fish Assemblage Responses to a Low-head Dam Removal in the Lancang River显示文摘Dam removal is becoming an effective approach for aquatic biodiversity restoration in damming river in order to balance the aquatic ecosystem conservation with large-scale cascade damming. However, the effects of dam removal on fish communities in Asian mountainous rivers, which are dominated by Cypriniformes fishes, are still not well known. To determine whether dam removal on a mountainous river benefit restoration of fish diversity, we investigated the response of fish assemblage to dam removal using a before-after-control-impact design in two tributaries of the Lancang River(dam removal river: the Jidu River, and control river: the Fengdian River). Fish surveys were conducted one year prior to dam removal(2012) and three years(2013–2015) following dam removal. We observed rapidly and notably spatio-temporal changes in fish biodiversity metrics and assemblage structure, occurring in the Jidu River within the first year after dam removal. Overall, fish species richness, density and Shannon-Wiener diversity all increased immediately in above-and below-dam sites, and maintained a stable level in subsequent years, compared to unchanged situation in the control river. All sites in the Jidu River experienced shifts in fish composition after dam removal, with the greatest temporal changes occurred in sites below-and above-the former dam, resulting in a temporal homogenization tendency in the dam removed river. These findings suggest that dam removal can benefit the recovery of habitat conditions and fish community in Asian mountainous rivers, but the results should be further evaluated when apply to other dammed rivers since the dam age, fluvial geomorphology and situation of source populations could all affect the responses of fish assemblages. | DING Chengzhi JIANG Xiaoming WANG Lieen FAN Hui CHEN Liqiang HU Jinming WANG Hailong CHEN Yifeng SHI Xiaotao CHEN Hao PAN Bohui DING Liuyong ZHANG Chao HE Daming | 2019 | Chinese Geographical Science2019，29，1： | 1 |
| 15 | Soft Electronics for Health Monitoring Assisted by Machine Learning显示文摘Due to the development of the novel materials,the past two decades have witnessed the rapid advances of soft electronics.The soft electronics have huge potential in the physical sign monitoring and health care.One of the important advantages of soft electronics is forming good interface with skin,which can increase the user scale and improve the signal quality.Therefore,it is easy to build the specific dataset,which is important to improve the performance of machine learning algorithm.At the same time,with the assistance of machine learning algorithm,the soft electronics have become more and more intelligent to realize real-time analysis and diagnosis.The soft electronics and machining learning algorithms complement each other very well.It is indubitable that the soft electronics will bring us to a healthier and more intelligent world in the near future.Therefore,in this review,we will give a careful introduction about the new soft material,physiological signal detected by soft devices,and the soft devices assisted by machine learning algorithm.Some soft materials will be discussed such as two-dimensional material,carbon nanotube,nanowire,nanomesh,and hydrogel.Then,soft sensors will be discussed according to the physiological signal types(pulse,respiration,human motion,intraocular pressure,phonation,etc.).After that,the soft electronics assisted by various algorithms will be reviewed,including some classical algorithms and powerful neural network algorithms.Especially,the soft device assisted by neural network will be introduced carefully.Finally,the outlook,challenge,and conclusion of soft system powered by machine learning algorithm will be discussed. | Yancong Qiao Jinan Luo Tianrui Cui Haidong Liu Hao Tang Yingfen Zeng Chang Liu Yuanfang Li Jinming Jian Jingzhi Wu He Tian Yi Yang Tian-Ling Ren Jianhua Zhou | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 16 | A General Strategy toward Synthesis of Well-Defined Polypeptides with Complex Chain Topologies显示文摘The precise synthesis of polypeptides with varying chain topologies has attracted significant interest due to their diverse functional applications.However,conventional polymerization of environment-susceptible N-carboxylic anhydride monomers using primary amine initiators suffers from inevitable side reactions,which greatly compromise chain-end fidelity,thereby disabling access to polypeptides with high-order architectures.Herein,we have developed a general and robust strategy based on normal aminemechanism for the synthesis of various topological polypeptides via polymerization of moisture-insensitive and airtolerant N-phenoxycarbonyl-functionalizedα-amino acid precursors using primary amine hydrochloride as initiators.This strategy enabled the synthesis of a block,star,star-block,brush-type,and multiblock(co)polypeptides with desired sequences,predictable molecular weights,low polydispersity,and high-fidelity chain ends even under open-air conditions.Remarkably,the robustness of this approach has been exemplified by the precise synthesis of welldefined photoresponsive decablock copolypeptides,exhibiting a spontaneous morphological evolution from polymersomes to lamellae nanostructures upon light irradiation.This work provides a general and reliable tool for synthesizing polypeptides with varying topologies,shedding light on the development of synthetic polypeptide-based materials. | Lei Li Jie Cen Wenjin Li Wenhao Pan Yuben Zhang Hao Yin Jinming Hu Shiyong Liu | 2022 | CCS Chemistry2022，4，12： | 0 |
| 17 | Energy band engineering via“Bite”defect located on N=8 armchair graphene nanoribbons显示文摘Graphene nanoribbons(GNRs)not only share many superlative properties of graphene but also display an exceptional degree of tunability of their electronic properties.The bandgaps of GNRs depend greatly on their widths,edges,etc.Herein,we report the synthesis path and the physical properties of atomic accuracy staggered narrow N=8 armchair graphene nanoribbons(sn-8AGNR)with alternating'Bite'defects on the opposite side.The intermediate structures in the surface physicochemical reactions from the precursors to the sn-8AGNR are characterized by scanning tunneling microscopy.The electronic properties of the sn-8AGNR are characterized by scanning tunneling spectroscopies and 6//6V mappings.Compared with the perfect N=8 armchair graphene nanoribbons(8AGNR),the sn-8AGNR has a larger bandgap,indicating that the liB\Xen edges can effectively regulate the electronic structures of GNRs. | Shijie Sun Yurou Guan Zhenliang Hao Zilin Ruan Hui Zhang Jianchen Lu Lei Gao Xiaoqing Zuo Jinming Cai | 2022 | Nano Research2022，15，1： | 0 |
| 18 | Evaluation of global navigation satellite system spoofing efficacy显示文摘The spoofing capability of Global Navigation Satellite System(GNSS)represents an important confrontational capability for navigation security,and the success of planned missions may depend on the effective evaluation of spoofing capability.However,current evaluation systems face challenges arising from the irrationality of previous weighting methods,inapplicability of the conventional multi-attribute decision-making method and uncertainty existing in evaluation.To solve these difficulties,considering the validity of the obtained results,an evaluation method based on the game aggregated weight model and a joint approach involving the grey relational analysis and technique for order preference by similarity to an ideal solution(GRA-TOPSIS)are firstly proposed to determine the optimal scheme.Static and dynamic evaluation results under different schemes are then obtained via a fuzzy comprehensive assessment and an improved dynamic game method,to prioritize the deceptive efficacy of the equipment accurately and make pointed improvement for its core performance.The use of judging indicators,including Spearman rank correlation coefficient and so on,combined with obtained evaluation results,demonstrates the superiority of the proposed method and the optimal scheme by the horizontal comparison of different methods and vertical comparison of evaluation results.Finally,the results of field measurements and simulation tests show that the proposed method can better overcome the difficulties of existing methods and realize the effective evaluation. | WANG Yue SUN Fuping HAO Jinming ZHANG Lundong WANG Xian | 2022 | Journal of Systems Engineering and Electronics2022，33，6： | 0 |
| 19 | Full-domain collaborative deployment method of multiple interference sources and evaluation of its deployment effect显示文摘This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality. | Yue Wang Fuping Sun Xian Wang Jinming Hao Kai Xiao | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 20 | Radioimmunotherapy-induced intratumoral changes in cervical squamous cell carcinoma at single-cell resolution显示文摘Dear Editor,Increasing numbers of studies have revealed the immunomodulating effects of radiotherapy when combined with immune checkpoint inhibitors,as radioimmunotherapy has proven to be a promising treatment[1].Radioimmunotherapy has shown significantly improved tumor responses than radiotherapy or immunotherapy alone in various malignant tumors[2–4].It has also been applied to cervical cancer in multiple ongoing clinical trials(NCT03612791[5]and NCT02635360[6]).However,tumor recurrence andmetastasis are often unavoidable.As such,investigations into radioimmunotherapy-induced tumor ecosystem evolution are essential for guiding improvements in treatment strategies that achieve better long-term disease control.To date,several studies have investigated radiochemotherapy-induced tumor ecosystem evolution using bulk RNA-sequencing and immune staining[7,8].However,these findings were limited owing to the cellular heterogeneity in cancers.Single-cell RNA-sequencing(scRNA-seq)enables the characterization of cell compositions and transcriptomic states in the tumor at single-cell resolution. | Chao Liu Hao Yu Rui Huang Tianyu Lei Xiaohui Li Ming Liu Qingyu Huang Qilian Du Ligang Xing Jinming Yu | 2022 | Cancer Communications2022，42，12： | 0 |
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