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| 1 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 2 | Wheat-RegNet:An encyclopedia of common wheat hierarchical regulatory networks显示文摘Dear Editor,Common wheat(Triticum aestivum,2n=6×=42,AABBDD)is the staple crop worldwide.Elucidating the gene regulatory network provides essential information for mechanism studies and targeted manipulation of gene activity for breeding.However,it is a challenging task given the extremely large(16 Gb)and complicated allohexaploid genome of common wheat.Integrating multi-omics data is a compelling approach to construct the hierarchical regulatory network. | Tengfei Tang Shilong Tian Haoyu Wang Xiaotong Lv Yilin Xie Jinyi Liu Meiyue Wang Fei Zhao Wenli Zhang Hao Li Yijing Zhang | 2023 | Molecular Plant2023，16，2： | 1 |
| 3 | Positivity and Stability of Fractional-Order Linear Time-Delay Systems显示文摘This article focuses on the positivity and the asymptotic stability of fractional-order linear time-delay systems(FOLTDSs)which are composed of N(N≥2)subsystems.Firstly,a sufficient and necessary condition is given to ensure the positivity of FOLTDSs.The solutions of the studied systems are obtained by using the Laplace transform method,and it can be observed that the positivity of FOLTDSs is completely determined by the series of matrices and independent of the magnitude of time-delays.Secondly,a theorem is given to prove the asymptotic stability of positive FOLTDSs.By considering the monotonicity and asymptotic properties of systems with constant time-delay,it is further shown that the asymptotic stability of positive FOLTDSs is independent of the time-delay.Next,a state-feedback controller,whose gain matrix is derived by resolving a linear programming question,is designed such that the state variables of the systems are nonnegative and asymptotically convergent.When the order of the FOLTDSs is greater than one,by utilizing a proposed property of Caputo derivative,a sufficient condition for the positivity of FOLTDS is presented.Finally,simulation examples are presented to verify the validity and practicability of the theoretical analysis. | HAO Yilin HUANG Chengdai CAO Jinde LIU Heng | 2022 | Journal of Systems Science & Complexity2022，35，6： | 1 |
| 4 | Fast Prediction Mode Selection for H.264/AVC Video Coding显示文摘 | SONG Bin QIN Hao CHANG Yilin | 2007 | Chinese Journal of Electronics2007，16，3： | 1 |
| 5 | Nanoliposome-encapsulated caged-GABA for modulating neural electrophysiological activity with simultaneous detection by microelectrode arrays显示文摘Effective and precise neural modulation with real-time detection in the brain is of great importance and represents a significant challenge.Nanoliposome-encapsulated light-sensitive compounds have excellent characteristics such as high temporal and spatial resolution,delayed drug clearance,and restricted drug biodistribution for neural modulation.In this study,we developed a nanoliposome-based delivery system for ruthenium-based caged GABA compounds(Nanolipo-Ru)to modulate neural activity and allow for real-time monitoring using the microelectrode arrays(MEAs).The Nanolipo-Ru nanoparticles had an average size of 134.10±4.30 nm and exhibited excellent stability for seven weeks.For the in vivo experiment in the rat,release of GABA by Nanolipo-Ru under blue light illumination resulted in an average firing rate reduction in interneurons and pyramidal neurons in the same brain region of 79.4%and 81.6%,respectively.Simultaneously,the average power of local field potentials in the 0–15 Hz range degraded from 4.34 to 0.85 mW.In addition,the Nanolipo-Ru nanoparticles have the potential to provide more flexible timing of modulation than unencapsulated RuBi-GABA in the experiments.These results indicated that Nanolipo-Ru could be an effective platform for regulating neuronal electrophysiology.Furthermore,nanoliposomes with appropriate modifications would render promising utilities for targeting of specific types of neurons in the future. | Jingyu Xie Yilin Song Yuchuan Dai Ziyue Li Fei Gao Xuanyu Li Guihua Xiao Yu Zhang Hao Wang Zeying Lu Xingyu Jiang Wenfu Zheng Xinxia Cai | 2020 | Nano Research2020，13，6： | 0 |
| 6 | Experimental study on the desulfurization and evaporation characteristics of Ca(OH)_(2) droplets显示文摘The experiments were conducted to focus on the desulfurization and evaporation characteristics of lime slurry droplets at 298-383 K. We designed an evaporation-reaction chamber with quartz glass windows.The monodisperse slurry droplet stream was injected into the evaporation reaction chamber, and the inlet gas components(air, air + SO_(2)) were introduced into the chamber. We applied the magnified digital in-line holography to measure the droplet parameters and calculated the evaporation rate. The effects of temperature, droplet concentration, and SO_(2) concentration on the evaporation rate of Ca(OH)_(2) droplets were discussed. Moreover, the Ca(OH)_(2) droplets under different experimental conditions were sampled,and the droplets were observed and analyzed using an off-line microscope. The evaporation rate of the Ca(OH)_(2) droplet increased at first, and then decreased during the falling process, and remained constant at last. The average evaporation rate of the Ca(OH)_(2) droplets increased significantly with the temperature increasing. | Yilin Song Yize Zhang Hao Zhou | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 7 | Revealing the intrinsic nonlinear optical response of a single MoS_(2) nanosheet in a suspension based on spatial self-phase modulation显示文摘The reorientation of 2D materials caused by nonlocal electron coherence is the formation mechanism of 2D material spatial self-phase modulation under laser irradiation,which is widely known as the“wind-chime”model.Here,we present a method that provides strong evidence for the reorientation of 2D-material-induced spatial self-phase modulation.The traditional“wind-chime”model was modified by taking into account the attenuation,i.e.,damping of the incident light beam in the direction of the optical path.Accordingly,we can extract the nonlinear refractive index of a single MoS2 nanosheet,instead of simply obtaining the index from an equivalent MoS2 film that was constructed by all nanosheets.Our approach introduces a universal and accurate method to extract intrinsic nonlinear optical parameters from 2D material systems. | Si Xiao Ying Ma Yilin He Yiduo Wang Hao Xin Qi Fan Jingdi Zhang Xiaohong Li Yu Zhang Jun He Yingwei Wang | 2020 | Photonics Research2020，8，11： | 0 |
| 8 | Human endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling显示文摘Acute liver failure(ALF)is a life-threatening disease that occurs secondary to drug toxicity,infection or a devastating immune response.Orthotopic liver transplantation is an effective treatment but limited by the shortage of donor organs,the requirement for life-long immune suppression and surgical challenges.Stem cell transplantation is a promising alternative therapy for fulminant liver failure owing to the immunomodulatory abilities of stem cells.Here,we report that when transplanted into the liver,human endoderm stem cells(hEnSCs)that are germ layer-specific and nontumorigenic cells derived from pluripotent stem cells are able to effectively ameliorate hepatic injury in multiple rodent and swine drug-induced ALF models.We demonstrate that hEnSCs tune the local immune microenvironment by skewing macrophages/Kupffer cells towards an anti-inflammatory state and by reducing the infiltrating monocytes/macrophages and inflammatory T helper cells.Single-cell transcriptomic analyses of infiltrating and resident monocytes/macrophages isolated from animal livers revealed dramatic changes,including changes in gene expression that correlated with the change of activation states,and dynamic population heterogeneity among these cells after hEnSC transplantation.We further demonstrate that hEnSCs modulate the activation state of macrophages/Kupffer cells via cystatin SN(CST1)-mediated inhibition of interferon signaling and therefore highlight CST1 as a candidate therapeutic agent for diseases that involve over-activation of interferons.We propose that hEnSC transplantation represents a novel and powerful cell therapeutic treatment for ALF. | Yilin Xu Jinglin Wang Haozhen Ren Hao Dai Ying Zhou Xiongzhao Ren Yang Wang Sisi Feng Xiaogang Deng Jiaying Wu Tianlong Fu Tengfei Nie Haifeng He Tongkun Wei Bing Zhu Lijian Hui Bin Li Jing Wang Hongyan Wang Luonan Chen Xiaolei Shi Xin Cheng | 2023 | Cell Research2023，33，2： | 0 |
| 9 | Classification Method for Mechanical Defects in GIS Equipment Based on Mode Function Analysis and Improved Relevance Vector Machines显示文摘Mechanical defects,in gas-insulated switchgear(GIS)equipment,have weak response characteristics,leading to significant difficulties in the classification of defects.Therefore,this paper proposes a novel mechanical defect feature extraction and classification method that combines independent intrinsic mode function(IIMF)analysis and an improved multikernel mapping fast multi-classification relevance vector machine(MKF-mRVM).Enlightened by the differences in the GIS operating vibration mode,the IIMF series were first obtained based on regenerated phase-shifted sinusoid-assisted empirical mode decomposition(RPSEMD)and modal judgments.Then singular value decomposition and time-frequency conversions were performed to construct combined feature matrices.Finally,multikernel mapping and domain sampling were introduced to improve the calculation speed and recognition accuracy of the mRVM,which was more suitable for on-line monitoring.Results show that the proposed RPSEMD-MKF-mRVM model achieves a faster training speed(14.23 s)and higher accuracy(98.21%)than other algorithms,and it can adapt to variable loads. | Yao Zhong Jian Hao Xupeng Wang Ruijin Liao Ruilei Gong Yilin Ding | 2023 | CSEE Journal of Power and Energy Systems2023，9，2： | 0 |
| 10 | Bisphosphonium salt: an effective photocatalyst for the intramolecular hydroalkoxylation of olefins显示文摘A photocatalytic, intramolecular hydroalkoxylation of alkenes has been achieved by utilizing simple and readily available biphosphonium salts as an effective organic photocatalyst. The unique photocatalytic properties of biphosphonium salt enables facile oxidations of substituted alkenes to facilitate the streamline and regioselective synthesis of a series of saturated cyclic ethers from simple alkenes under mild conditions. | Hao Cheng Xin Wang Liang Chang Yilin Chen Lingling Chua Zhiwei Zuo | 2019 | Science Bulletin2019，64，24： | 0 |
| 11 | Preparation of highly stable diclofenac potassium pellet with microcrystalline cellulose by extrusionespheronization显示文摘The main purpose of this study is to prepare highly stable diclofenac potassium(DP)pellet with microcrystalline cellulose(MCC)by extrusionespheronization.Using MCC,DP pellets were prepared and the stability was investigated.Related compounds of DP pellets were analyzed by High Pressure Liquid Chromatography(HPLC).After stability test of 60℃/75%RH for 10 d,the values of two main related compounds were 0.94%and 2.17%,respectively.Compatibility tests show that instability of DP was mainly caused by MCC.To improve the stability of DP in presence of MCC,different kinds of stabilizers were investigated.Upon addition of 1.5%(w/w)sodium hydroxide,the primary related compound of pellets was reduced to be 0.159%after stability test of 60℃/75%RH for 50 d.This study demonstrated that MCC induced decomposition of DP upon exposure to moisture could be prohibited by addition of sodium hydroxide.The mechanisms were discussed and residual hydroxyl free radicals in excipients were responsible for decomposition of DP.Finally,this formulation of DP is highly stable with sustained-release behavior. | Yueqi Wang Hao Huang Chungang Zhang Yilin Tang Jinzhuo Li Xing Tang Cuifang Cai | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，6： | 0 |
| 12 | Improved transport properties and mechanism in recessed-gate InAlN/GaN HEMTs using a self-limited surface restoration method显示文摘The etching process of high-performance recessed-gate In Al N/Ga N high-electron mobility transistors(HEMTs)has been actively researched.This paper proposes a post-etching self-limited surface restoration method that effectively suppresses the etching damage,enhancing the transport properties of recessed-gate In Al N/Ga N HEMTs.We fabricated planar-gate devices,inductively coupled plasma(ICP)-etched devices,and post-etching-treated(PET)devices.The damage caused by the ICP etching process severely deteriorated the transport properties of the devices.However,the post-etching process effectively inhibited the etching damage and improved the device transport properties.Through temperature-dependent tests and a simulation,the change in the peak transconductance was compared among different devices.The temperature-dependent optical phonon scattering and impurity-dependent remote charge scattering mechanisms were analyzed.The results confirmed that the etching damage significantly affected the channel electron scattering mechanism.The field-effect mobility showed a linear relationship with temperature,and the optical phonon scattering model illustrated that the field-effect mobility decreased with increasing temperature.The etching damage caused a decrease in the field-effect mobility from 1075.5 to 699.1 cm^(2)/V·s,which increased the fitting error between this empirical line and the optical phonon scattering fitting curve from 0.086 to 0.948,similar to the remote charge scattering fitting curve.The combined error range is from 0.896 to 0.054. | Siyu LIU Xiaohua MA Jiejie ZHU Minhan MI Jingshu GUO Jielong LIU Yilin CHEN Qing ZHU Ling YANG Yue HAO | 2022 | Science China(Information Sciences)2022，65，10： | 0 |
| 13 | Luminescent nanoparticle-arrays synthesized via polymer pen lithography显示文摘We report a high-throughput approach to generating lanthanide-doped upconversion nanoparticle(UCNP)arrays through polymer pen lithography(PPL),where instead of the expensive block co-polymer,two types of polymers are employed with one working as ink carrier,e.g.,polyethylene glycol-400(PEG-400)to facilitate smooth transfer from the tip to the substrate and the other,e.g.,polyvinyl pyrrolidone(PVP),as chelator to ensure successful patterning of metal ions.The strong coordination of PVP with rare earth ions(RE^(3+))is the key for weakening the interaction between RE3+ions and the carrier PEG-400 so that the good mobility of ink can be retained.Further experimental results have shown that besides PVP,small molecules with functional groups that can coordinate with RE^(3+)ions,such as oleic acid,can also serve the same role as PVP,which greatly enriches the ink library for PPL.Over 1 cm^(2)area arrays comprising individual UCNP can be reliably generated with characteristic upconversion luminescence.This strategy not only allows reliable production of individual UCNP arrays,it also paves new avenue to the precise synthesis of multifunctional NPs for lasing,imaging,encryption,and anticounterfeiting. | Ping Wang Shuyi Bao Shuqian Qiao Ce Li Zhang Jiang Hao Song Yilin Wang Qiuqiang Zhan Ling Huang | 2023 | Nano Research2023，16，2： | 0 |
| 14 | Analytical and experimental study of a valveless piezoelectric micropump with high flowrate and pressure load显示文摘Miniaturized gas pumps based on electromagnetic effect have been intensively studied and widely applied in industries.However,the electromagnetic effect-based gas pumps normally have large sizes,high levels of noises and high power consumption,thus they are not suitable for wearable/portable applications.Herein,we propose a high-flowrate and high-pressure load valveless piezoelectric micropump with dimensions of 16 mm*16 mm*5 mm.The working frequency,vibration mode and displacement of the piezoelectric actuator,the velocity of gas flow,and the volume flowrate of the micropump are analyzed using the finite element analysis method.The maximum vibration amplitude of the piezoelectric actuator reaches~29.4μm.The output gas flowrate of the pump is approximately 135 mL/min,and the maximum output pressure exceeds 40 kPa.Then,a prototype of the piezoelectric micropump is fabricated.Results show that performance of the micropump is highly consistent with the numerical analysis with a high flowrate and pressure load,demonstrated its great potential for wearable/portable applications,especially for blood pressure monitoring. | Jiafeng Ni Weipeng Xuan Yilin Li Jinkai Chen Wenjun Li Zhen Cao Shurong Dong Hao Jin Lingling Sun Jikui Luo | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
| 15 | Degradation induced by holes in Si_(3)N_(4)/AlGaN/GaN MIS HEMTs under off-state stress with UV light显示文摘In this study, the negative shift of the threshold voltage(VTH) and degradation of the leakage current triggered by the ultraviolet(UV) light(375 nm) have been investigated when a large reverse gateto-drain voltage was applied to a Si_(3)N_(4)/AlGaN/GaN metal-insulator-semiconductor high electron mobility transistor. However, an increase in leakage was not observed under the blue light or in the dark. The holes generated in the channel by UV illumination were attracted by the gate electrode owing to the reverse voltage.During the movement, holes were captured by border traps at very deep levels in the Si_(3)N_(4) near AlGaN,leading to a negative shift of VTH that was difficult to recover. According to the simulation based on Silvaco Atlas TCAD, the trapped holes significantly increased the electric field strength in Si_(3)N_(4). Therefore, as the injection barrier for electrons from the gate became thinner, it was easier for electrons to tunnel through the Si_(3)N_(4). Finally, for the degraded devices under the UV light stress, Fowler-Nordheim tunneling was the dominant leakage conduction mechanism, as exhibited by the current density versus electric field strength curve fitting. In addition, the holes with high energies collided with Si_(3)N_(4) and generated new defects at the edge of the gate near the drain side. | Yilin CHEN Qing ZHU Jiejie ZHU Minhan MI Meng ZHANG Yuwei ZHOU Ziyue ZHAO Xiaohua MA Yue HAO | 2023 | Science China(Information Sciences)2023，66，2： | 0 |
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