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| 1 | Diagnosis of IgG4-related sclerosing cholangitis显示文摘IgG4-related sclerosing cholangitis(IgG4-SC)is often associated with autoimmune pancreatitis.However,the diffuse cholangiographic abnormalities observed in IgG4-SC may resemble those observed in primary sclerosing cholangitis(PSC),and the presence of segmental stenosis suggests cholangiocarcinoma(CC).IgG4-SC responds well to steroid therapy,whereas PSC is only effectively treated with liver transplantation and CC requires surgical intervention.Since IgG4-SC was first described,it has become a third distinct clinical entity of sclerosing cholangitis.The aim of this review was to introduce the diagnostic methods for IgG4-SC.IgG4-SC should be carefully diagnosed based on a combination of characteristic clinical,serological,morphological,and histopathological features after cholangiographic classification and targeting of a disease for differential diagnosis.When intrapancreatic stenosis is detected,pancreatic cancer or CC should be ruled out.If multiple intrahepatic stenoses are evident,PSC should be distinguished on the basis of cholangiographic findings and liver biopsy with IgG4 immunostaining.Associated inflammatory bowel disease is suggestive of PSC.If stenosis is demonstrated in the hepatic hilar region,CC should be discriminated by ultrasonography,intraductal ultrasonography,bile duct biopsy,and a higher cutoff serum IgG4 level of 182 mg/dL. | Takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Katsuyuki Miyabe Shuya Simizu Takashi Joh | 2013 | World Journal of Gastroenterology2013,19,43: | 20 |
| 2 | Inflammatory bowel disease of primary sclerosing cholangitis:A distinct entity?显示文摘This is a review of the characteristic findings of inflammatory bowel disease(IBD)associated with primary sclerosing cholangitis(PSC)and their usefulness in the diagnosis of sclerosing cholangitis.PSC is a chronic inflammatory disease characterized by idiopathic fibrous obstruction and is frequently associated with IBD.IBDassociated with PSC(PSC-IBD)shows an increased incidence of pancolitis,mild symptoms,and colorectal malignancy.Although an increased incidence of pancolitis is a characteristic finding,some cases are endoscopically diagnosed as right-sided ulcerative colitis.Pathological studies have revealed that inflammation occurs more frequently in the right colon than the left colon.The frequency of rectal sparing and backwash ileitis should be investigated in a future study based on the same definition.The cholangiographic findings of immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)are similar to those of PSC.The rare association between IBD and IgG4-SC and the unique characteristics of PSC-IBD are useful findings for distinguishing PSC from IgG4-SC. | Takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Hitoshi Sano Katsuyuki Miyabe Shuya Shimizu Takashi Joh | 2014 | World Journal of Gastroenterology2014,20,12: | 6 |
| 3 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019,25,15: | 5 |
| 4 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016,8,20: | 4 |
| 5 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016,8,25: | 3 |
| 6 | Diagnostic criteria for IgG4-related sclerosing cholangitis based on cholangiographic classification显示文摘 | Takahiro Nakazawa Itaru Naitoh Kazuki Hayashi Fumihiro Okumura Katsuyuki Miyabe Michihiro Yoshida Hiroaki Yamashita Hirotaka Ohara Takashi Joh | 2012 | Journal of Gastroenterology2012,,1: | 2 |
| 7 | Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report显示文摘A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests. | Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada | 2018 | World Journal of Gastroenterology2018,24,2: | 2 |
| 8 | Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report显示文摘A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens. | Hiromi Tamura Hirotsugu Saiki Takahiro Amano Masashi Yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu Nishida Katsumi Yamamoto Shiro Adachi | 2017 | World Journal of Gastroenterology2017,23,21: | 2 |
| 9 | Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle显示文摘 | Shinichiro Hayashi Hisashi Aso Kouichi Watanabe Hidetoshi Nara Michael T. Rose Shyuichi Ohwada Takahiro Yamaguchi | 2000 | Histochemistry and Cell Biology2000,,5: | 1 |
| 10 | Highly efficient visible-light driven AgBr/Ag3PO4 hybrid photocatalysts with enhanced photocatalytic activity 显示文摘 | Katsumata Hideyuki Hayashi Takahiro Taniguchi Masanao | 2014 | Mater Sci Semicond Pro- cess2014,25,: | 1 |
| 11 | Defect imaging with guided waves in pipe显示文摘 | Morimasa Murase | 2005 | Acoustical Society of America2005,117,4: | 1 |
| 12 | Aberrant Crypt Foci: Detection, Gene Abnormalities, and Clinical Usefulness显示文摘 | Tetsuji Takayama Koji Miyanishi Tsuyoshi Hayashi Takehiro Kukitsu Kunihiro Takanashi Hirotoshi Ishiwatari Takahiro Kogawa Tomoyuki Abe Yoshiro Niitsu | 2005 | Clinical Gastroenterology and Hepatology2005,,7: | 1 |
| 13 | Selective oxidation of alcohol over supported gold catalysts: methyl glycolate formation from ethylene glycol and methanol显示文摘 | Toshio Hayashi Takahiro Inagaki Naohiko Itayama Hideyuki Baba | 2006 | Catalysis Today2006,,1: | 1 |
| 14 | Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer显示文摘 | Tomiyasu Arisawa Tomomitsu Tahara Hisakazu Shiroeda Yasuhito Matsue Takahiro Minato Tomoe Nomura Hideto Yamada Ranji Hayashi Takashi Saito Kazuhiro Matsunaga Tomoki Fukuyama Nobuhiko Hayashi Toshimi Otsuka Atsushi Fukumura Masakatsu Nakamura Tomoyuki Shib | 2012 | Human Immunology2012,,7: | 1 |
| 15 | Analysis of flexural mode focusing by a semianalytical finite element method显示文摘 | HAYASHI Takahiro KAWASHIMA Koichiro | 2003 | Journal of the Acoustical Society of America2003,113,3: | 1 |
| 16 | Analysis of flexural mode focusing by a semianalytical finite element method显示文摘 | Hayashi Takahiro Kawashima Koichiro Sun Zongqi | 2003 | J Acoust Soc Am2003,113,3: | 1 |
| 17 | Transplantation of Osteogenically Differentiated Mouse iPS Cells for Bone Repair 显示文摘 | Takahiro Hayashi Haruo Misawa Hiroyuki Nakahara et al | 2012 | Cell Transplantation2012,21,23: | 1 |
| 18 | The long‐term outcomes after curative resection for mass‐forming intrahepatic cholangiocarcinoma associated with hepatitis C viral infection: A multicenter analysis by Osaka Hepatic Surgery Study Group显示文摘 | Takahiro Uenishi Hiroaki Nagano Shigeru Marubashi Michihiro Hayashi Fumitoshi Hirokawa Masaki Kaibori Kousuke Matsui Shoji Kubo | 2014 | J Surg Oncol2014,,2: | 1 |
| 19 | Usefulness of the neutrophil/lymphocyte ratio measured preoperatively as a predictor of peritoneal metastasis in patients with advanced gastric cancer显示文摘 | Yusuke Nakayama Naoto Gotohda Hidehito Shibasaki Shogo Nomura Takahiro Kinoshita Ryuichi Hayashi | 2014 | Surgery Today2014,,11: | 1 |
| 20 | The long‐term outcomes after curative resection for mass‐forming intrahepatic cholangiocarcinoma associated with hepatitis C viral infection: A multicenter analysis by Osaka Hepatic Surgery Study Group显示文摘 | Takahiro Uenishi Hiroaki Nagano Shigeru Marubashi Michihiro Hayashi Fumitoshi Hirokawa Masaki Kaibori Kousuke Matsui Shoji Kubo | 2014 | J. Surg. Oncol2014,,2: | 1 |