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| 1 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 2 | Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs显示文摘Background: Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most of the world. In China, pigs were raised with alfalfa-containing diets to seek for good quality pork.However, the influence of dietary alfalfa involving high level of insoluble dietary fiber(IDF) on pig intestinal luminal microbiota composition remains unclear. The objective of this study was to investigate the effects of alfalfa on luminal microbiota and short chain fatty acids(SCFA) production, and gene expressions involved in SCFA sensing, transporting and absorbing in pig caecal mucosa.Results: Twenty-four growing pigs were randomly allotted to four diets containing 0%, 5%, 10% and 15% alfalfa meal for a 28-d experiment. Ingestion of alfalfa meal-contained diets significantly increased the ratio of body weight gain to feed consumption. Illumina MiS eq sequencing of the V3 region of the 16 S r RNA genes showed that alfalfa-containing diet significantly decreased the relative abundance of genera Turicibacter, Acidiphilium, Paracoccus, Propionibacterium,Corynebacterium, Pseudomonas, Acinetobacter, and Staphylococcus, and increased the relative abundance of genera Lachnospira, Marvinbryantia, and Desulfovibrio in the caecal digesta. Butyrate concentration was significantly increased in the hindgut by the supplementation of alfalfa meal in diets. The m RNA gene expressions of FFAR3, SMCT1, MCT1,PYY, and GCG were significantly increased in the caecal mucosa of pigs fed alfalfa meal.Conclusions: Our results suggested that alfalfa-containing diet has exerted significant impacts on caecal microbiota composition, butyrate concentration and significantly upregulated m RNA expression of host caecal mucosal genes involved in SCFA sensing and absorption as well as regulation of satiety. | Jiawei Wang Chunfu Qin Ting He Kai Qiu Wenjuan Sun Xin Zhang Ning Jiao Weiyun Zhu Jingdong Yin | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 12 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | Defect and Doping Co‑Engineered Non‑Metal Nanocarbon ORR Electrocatalyst显示文摘Exploring low-cost and earth-abundant oxygen reduction reaction(ORR)electrocatalyst is essential for fuel cells and metal–air batteries.Among them,non-metal nanocarbon with multiple advantages of low cost,abundance,high conductivity,good durability,and competitive activity has attracted intense interest in recent years.The enhanced ORR activities of the nanocarbons are normally thought to originate from heteroatom(e.g.,N,B,P,or S)doping or various induced defects.However,in practice,carbon-based materials usually contain both dopants and defects.In this regard,in terms of the co-engineering of heteroatom doping and defect inducing,we present an overview of recent advances in developing non-metal carbon-based electrocatalysts for the ORR.The characteristics,ORR performance,and the related mechanism of these functionalized nanocarbons by heteroatom doping,defect inducing,and in particular their synergistic promotion effect are emphatically analyzed and discussed.Finally,the current issues and perspectives in developing carbon-based electrocatalysts from both of heteroatom doping and defect engineering are proposed.This review will be beneficial for the rational design and manufacturing of highly efficient carbon-based materials for electrocatalysis. | Jian Zhang Jingjing Zhang Feng He Yijun Chen Jiawei Zhu Deli Wang Shichun Mu Hui Ying Yang | 2021 | Nano-Micro Letters2021，13，4： | 8 |
| 5 | Overexpression of micro RNA_(40)8 enhances photosynthesis, growth, and seed yield in diverse plants显示文摘The ability of a plant to produce grain, fruit, or forage depends ultimately on photosynthesis. There have been few attempts, however, to study micro RNAs, which are a class of endogenous small RNAs post-transcriptionally programming gene expression, in relation to photosynthetic traits. We focused on miR_(40)8, one of the most conserved plant miRNAs, and overexpressed it in parallel in Arabidopsis, tobacco, and rice. The transgenic plants all exhibited increased copper content in the chloroplast, elevated abundance of plastocyanin,and an induction of photosynthetic genes. By means of gas exchange and optical spectroscopy analyses, we showed that higher expression of miR_(40)8 leads to enhanced photosynthesis through improving efficiency of irradiation utilization and the capacity for carbon dioxide fixation. Consequently, miR_(40)8 hyper-accumulating plants exhibited higher rate of vegetative growth. An enlargement of seed size was also observed in all three species overproducing miR_(40)8. Moreover, we conducted a 2-year-two-location field trial and observed miR_(40)8 overexpression in rice significantly increased yield, which was primarily attributed to an elevation in grain weight. Taken together, these results demonstrate that miR_(40)8 is a positive regulator of photosynthesis and that its genetic engineering is a promising route for enhancing photosynthetic performance and yield in diverse plants. | Jiawei Pan Dahui Huang Zhonglong Guo Zheng Kuang He Zhang Xinyu Xie Zengfeng Ma Shaopei Gao Manuel T.Lerdau Chengcai Chu Lei Li | 2018 | Journal of Integrative Plant Biology2018，60，4： | 8 |
| 6 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 7 | THE CONSTRUCTION OF WAVELET-BASED TRUNCATED CONICAL SHELL ELEMENT USING B-SPLINE WAVELET ON THE INTERVAL显示文摘在间隔(BSWI ) 上基于 B 花键小浪,截断的圆锥形的壳元素的二个班被构造解决 axisymmetric 问题,即 BSWI 薄截断的圆锥形的壳元素和 BSWI 有独立斜坡变丑插值的中等厚的截断的圆锥形的壳元素。在基于小浪的元素的构造,而不是传统的多项式插值, BSWI 的可伸缩的功能被采用经由变化原则通过构造元素的转变矩阵,然后构造 BSWI 元素形成形状功能。不同于把小浪 Galerkin 方法加在一起的直接小浪的进程,小浪扩大的系数代表的元素的排水量域经由构造转变矩阵被转变成边和内部模式。BSWI 元素为结构的分析联合 B 花键功能近似和各种各样的基于小浪的元素的精确性。圆锥形的壳的一些静态、动态的数字例子被学习比传统的元素与更高的效率和精确表明现在的元素。 | Xiang Jiawei He Zhengjia Chen Xuefeng | 2006 | Acta Mechanica Solida Sinica2006，19，4： | 7 |
| 8 | Discovery of tip induced unconventional superconductivity on Weyl semimetal显示文摘Weyl fermion is a massless Dirac fermion with definite chirality,which has been long pursued since 1929.Though it has not been observed as a fundamental particle in nature,Weyl fermion can be realized as low-energy excitation around Weyl point in Weyl semimetal,which possesses Weyl fermion cones in the bulk and nontrivial Fermi arc states on the surface. As a firstly discovered Weyl semimetal,Ta As crystal possesses 12 pairs of Weyl points in the momentum space,which are topologically protected against small perturbations. Here,we report for the first time the tip induced superconductivity on Ta As crystal by point contact spectroscopy. The zero bias conductance peak as well as a conductance plateau with double conductance peaks and sharp double dips are observed in the point contact spectra simultaneously,indicating unconventional superconductivity. Our further theoretical study suggests that the induced superconductivity may have nontrivial topology. The present work opens a new route in investigating the novel superconducting states based on Weyl materials. | He Wang Huichao Wang Yuqin Chen Jiawei Luo Zhujun Yuan Jun Liu Yong Wang Shuang Jia Xiong-Jun Liu jian Wei Jian Wang | 2017 | Science Bulletin2017，62，6： | 7 |
| 9 | Preparation and Characterization of Natural Bamboo Fiber显示文摘In this study,natural bamboo fiber was prepared combining chemical pretreatment with mechanical disc refining,opening,and carding.An orthogonal experiment was designed based on four factors and three levels;thereafter,the manufacturing process was optimized.The length,diameter,tensile strength,and elastic modulus of the bamboo fiber were determined,and the crystallinity and morphology of the fiber were analyzed using X-ray diffraction(XRD)and scanning electron microscopy(SEM).The results showed that the optimum parameters for the chemical pretreatment were a cooking temperature of 130℃,heating time of 2 h,NaOH dosage of 2%,and Na2SO3 dosage of 10%.The cooking yield of bamboo chips was 89.5%,and the carding yield of natural bamboo fiber was 43.0% under the optimum conditions.The length,diameter,tensile strength,and elastic modulus of the obtained fiber were 36.71 mm,0.285 mm,407 MPa,and 27.7 GPa,respectively.XRD analysis and SEM observations showed that the technology used in this study can produce bright and compact natural bamboo fibers with high crystallinity. | Kaixuan Li Qingxian Miao He Zhao Jiawei Yang Haitao Cheng Lihui Chen | 2020 | Paper And Biomaterials2020，5，2： | 6 |
| 10 | Triply periodic minimal surface(TPMS)porous structures:from multi-scale design,precise additive manufacturing to multidisciplinary applications显示文摘Inspired by natural porous architectures,numerous attempts have been made to generate porous structures.Owing to the smooth surfaces,highly interconnected porous architectures,and mathematical controllable geometry features,triply periodic minimal surface(TPMS)is emerging as an outstanding solution to constructing porous structures in recent years.However,many advantages of TPMS are not fully utilized in current research.Critical problems of the process from design,manufacturing to applications need further systematic and integrated discussions.In this work,a comprehensive overview of TPMS porous structures is provided.In order to generate the digital models of TPMS,the geometry design algorithms and performance control strategies are introduced according to diverse requirements.Based on that,precise additive manufacturing methods are summarized for fabricating physical TPMS products.Furthermore,actual multidisciplinary applications are presented to clarify the advantages and further potential of TPMS porous structures.Eventually,the existing problems and further research outlooks are discussed. | Jiawei Feng Jianzhong Fu Xinhua Yao Yong He | 2022 | International Journal of Extreme Manufacturing2022，4，2： | 6 |
| 11 | Tianwen-1 MINPA observations in the solar wind显示文摘The Mars Ion and Neutral Particle Analyzer(MINPA)is one of the three scientific instruments onboard the Tianwen-1 orbiter to investigate the Martian space environment.During Tianwen-1’s transfer orbit to Mars,the MINPA was switched on to measure the solar wind ions.Here,we present the first results of the MINPA observations in the solar wind.During cruise,nearly half of the MINPA ion field-of-view(FOV)was blocked by the lander capsule;thus only the solar-wind ions with azimuthal speeds pointing towards the unblocked FOV sectors could be detected.We perform a detailed comparison of the MINPA’s solar wind observations with data from Earth-based missions when MINPA reached its count-rate peak,finding a general consistency of the ion moments between them.The blocking effect due to the lander is evaluated quantitatively under varying solar-wind velocity conditions.Despite the blocking effect,the MINPA’s solar wind measurements during the transfer orbit suggest a good performance. | AiBing Zhang LingGao Kong WenYa Li Lei Li BinBin Tang ZhaoJin Rong Yong Wei JiJie Ma YiTeng Zhang LiangHai Xie YuXian Wang JianSen He Bin Liu WenJing Wang Bin Su JiaWei Li Xu Tan Fang Wang TaiFeng Jin FuHao Qiao Peter Wurz Yan Zhu YunFei Bai YiRen Li XinBo Zhu YueQiang Sun YongLiao Zou Chi Wang | 2022 | Earth and Planetary Physics2022，6，1： | 5 |
| 12 | Detecting Global Vegetation Changes Using Mann-Kendal(MK) Trend Test for 1982–2015 Time Period显示文摘Vegetation is the main component of the terrestrial ecosystem and plays a key role in global climate change. Remotely sensed vegetation indices are widely used to detect vegetation trends at large scales. To understand the trends of vegetation cover, this research examined the spatial-temporal trends of global vegetation by employing the normalized difference vegetation index(NDVI) from the Advanced Very High Resolution Radiometer(AVHRR) Global Inventory Modeling and Mapping Studies(GIMMS) time series(1982–2015). Ten samples were selected to test the temporal trend of NDVI, and the results show that in arid and semi-arid regions, NDVI showed a deceasing trend, while it showed a growing trend in other regions. Mann-Kendal(MK) trend test results indicate that 83.37% of NDVI pixels exhibited positive trends and that only 16.63% showed negative trends(P < 0.05) during the period from 1982 to 2015. The increasing NDVI trends primarily occurred in tree-covered regions because of forest growth and re-growth and also because of vegetation succession after a forest disturbance. The increasing trend of the NDVI in cropland regions was primarily because of the increasing cropland area and the improvement in planting techniques. This research describes the spatial vegetation trends at a global scale over the past 30+ years, especially for different land cover types. | GUO Meng LI Jing HE Hongshi XU Jiawei JIN Yinghua | 2018 | Chinese Geographical Science2018，28，6： | 5 |
| 13 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 14 | Soil Microbial Community and Enzyme Activity Responses to Herbaceous Plant Expansion in the Changbai Mountains Tundra, China显示文摘As one of the most sensitive regions to global climate change, alpine tundra in many places around the world has been undergoing dramatic changes in vegetation communities over the past few decades.Herbaceous plant species in the Changbai Mountains area have significantly expanded into tundra shrub communities over the past 30 yr.Soil microbial communities, enzyme activities, and soil nutrients are intertwined with this expansion process.In order to understand the responses of the soil microbial communities to such an expansion, we analyzed soil microbial community structures and enzyme activities in shrub tundra as well as areas with three different levels of herbaceous plant expansion.Our investigation was based on phospholipid fatty acid(PLFA) analysis and 96-well microtiter plates.The results showed that herbs have expanded greatly in the tundra, and they have become the dominant species in herbaceous plant expansion areas.There were differences for community composition and appearance among the shrub tundra and the mild expansion, moderate expansion, and severe expansion areas.Except for soil organic matter, soil nutrients were increased in herbaceous plant expansion areas, and the total nitrogen(TN), total phosphorus(TP), available nitrogen(AN), and available phosphorus(AP) were greatest in moderate expansion areas(MOE), while soil organic matter levels were highest in the non-expanded areas(CK).The total soil PLFAs in the three levels of herbaceous plant expansion areas were significantly higher than those in the non-expanded areas, and total soil PLFAs were highest in the moderately expanded area and lowest in the severely expanded area(SEE).Bacteria increased significantly more than fungi and actinomycetes with herbaceous plant expansion.Soil hydrolase activities(β-1,4-glucosidase(βG) activity, β-1, 4-N-acetylglucosaminidase(NAG) activity, and acid phosphatase(aP) activity) were highest in MOE and lowest in the CK treatment.Soil oxidase activities(polyphenol oxidase(PPO) activities and peroxidase(PER) activities) were also highest in MOE, but they were lowest in the SEE treatment.The variations in total soil PLFAs with herbaceous plant expansion were mostly correlated with soil organic matter and available phosphorus concentrations, while soil enzyme activities were mostly correlated with the total soil nitrogen concentration.Our results suggest that herbaceous plant expansion increase the total soil PLFAs and soil enzyme activities and improved soil nutrients.However, soil microorganisms, enzyme activity, and nutrients responded differently to levels of herbaceous plant expansion.The soil conditions in mild and moderate expansion areas are more favorable than those in severe expansion areas. | JIN Yinghua ZHANG Yingjie XU Zhiwei GU Xiaonan XU Jiawei TAO Yan HE Hongshi WANG Ailin LIU Yuxia NIU Liping | 2019 | Chinese Geographical Science2019，29，6： | 4 |
| 15 | A Joint Learning Framework for the CCKS-2020 Financial Event Extraction Task显示文摘This paper presents a winning solution for the CCKS-2020 financial event extraction task, where the goal is to identify event types, triggers and arguments in sentences across multiple event types. In this task, we focus on resolving two challenging problems(i.e., low resources and element overlapping) by proposing a joint learning framework, named SaltyFishes. We first formulate the event extraction task as a joint probability model. By sharing parameters in the model across different types, we can learn to adapt to low-resource events based on high-resource events. We further address the element overlapping problems by a mechanism of Conditional Layer Normalization, achieving even better extraction accuracy. The overall approach achieves an F1-score of 87.8% which ranks the first place in the competition. | Jiawei Sheng Qian Li Yiming Hei Shu Guo Bowen Yu Lihong Wang Min He Tingwen Liu Hongbo Xu | 2021 | Data Intelligence2021，3，3： | 4 |
| 16 | Research on DC Protection Strategy in Multi-Terminal Hybrid HVDC System显示文摘Multi-terminal hybrid high-voltage direct current(HVDC)systems have been developed quickly in recent years in power transmission area.However,for voltage-source converter(VSC)stations in hybrid HVDC systems,no direct current(DC)filters are required.In addition,the DC reactor is also not installed at the line end because the DC fault can be limited by the converter itself.This means that the boundary element at the line end is absent,and the single-ended protections used in line commutated converter(LCC)based HVDC(LCC-HVDC)systems or VSC-HVDC systems cannot distinguish the fault line in multi-terminal hybrid HVDC systems.This paper proposes a novel singleended DC protection strategy suitable for the multi-terminal hybrid HVDC system,which mainly applies the transient information and active injection concept to detect and distinguish the fault line.Compared with the single-ended protections used in LCC-HVDC and VSC-HVDC systems,the proposed protection strategy is not dependent on the line boundary element and is thus suitable for the multiterminal hybrid HVDC system.The corresponding simulation cases based on power systems computer aided design(PSCAD)/electromagnetic transients including DC(EMTDC)are carried out to verify the superiority of the proposed protection. | Yuping Zheng Jiawei He Bin Li Tonghua Wua Wei Dai Ye Li | 2021 | Engineering2021，7，8： | 4 |
| 17 | Comparative Assessment of Tundra Vegetation Changes Between North and Southwest Slopes of Changbai Mountains, China, in Response to Global Warming显示文摘Vegetation in high altitude areas normally exhibits the strongest response to global warming. We investigated the tundra vegetation on the Changbai Mountains and revealed the similarities and differences between the north and the southwest slopes of the Changbai Mountains in response to global warming. Our results were as follows: 1) The average temperatures in the growing season have increased from 1981 to 2015, the climate tendency rate was 0.38℃/10 yr, and there was no obvious change in precipitation observed. 2) The tundra vegetation of the Changbai Mountains has changed significantly over the last 30 years. Specifically, herbaceous plants have invaded into the tundra zone, and the proportion of herbaceous plants was larger than that of shrubs. Shrub tundra was transforming into shrub-grass tundra. 3) The tundra vegetation in the north and southwest slopes of the Changbai Mountains responded differently to global warming. The southwest slope showed a significantly higher degree of invasion from herbaceous plants and exhibited greater vegetation change than the north slope. 4) The species diversity of plant communities on the tundra zone of the north slope changed unimodally with altitude, while that on the tundra zone of the southwest slope decreased monotonously with altitude. Differences in the degree of invasion from herbaceous plants resulted in differences in species diversity patterns between the north and southwest slopes. Differences in local microclimate, plant community successional stage and soil fertility resulted in differential responses of tundra vegetation to global warming. | JIN Yinghua ZHANG Yingjie XU Jiawei TAO Yan HE Hongshi GUO Meng WANG Ailin LIU Yuxia NIU Liping | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 18 | Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis显示文摘The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed.'TRAIL sensitize'and'Chinese medicine'were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. | Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 3 |
| 19 | Mesoscale oceanic eddies in the South China Sea from 1992 to 2012:evolution processes and statistical analysis显示文摘Automated identification and tracking of mesoscale ocean eddies has recently become one research hotspot in physical oceanography. Several methods have been developed and applied to survey the general kinetic and geometric characteristics of the ocean eddies in the South China Sea(SCS). However, very few studies attempt to examine eddies' internal evolution processes. In this study, we reported a hybrid method to trace eddies' propagation in the SCS based on their internal structures, which are characterized by eddy centers, footprint borders, and composite borders. Eddy identification and tracking results were represented by a GIS-based spatiotemporal model. Information on instant states, dynamic evolution processes, and events of disappearance, reappearance, split, and mergence is stored in a GIS database. Results were validated by comparing against the ten Dongsha Cyclonic Eddies(DCEs) and the three long-lived anticyclonic eddies(ACEs) in the northern SCS, which were reported in previous literature. Our study confirmed the development of these eddies. Furthermore, we found more DCE-like and ACE-like eddies in these areas from 2005 to 2012 in our database. Spatial distribution analysis of disappearing, reappearing, splitting, and merging activities shows that eddies in the SCS tend to cluster to the northwest of Luzon Island, southwest of Luzon Strait, and around the marginal sea of Vietnam. Kuroshio intrusions and the complex sea floor topography in these areas are the possible factors that lead to these spatial clusters. | DU Yunyan YI Jiawei WU Di HE Zhigang WANG Dongxiao LIANG Fuyuan | 2014 | Acta Oceanologica Sinica2014，33，11： | 3 |
| 20 | SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice显示文摘Establishment of the primordial follicle(PF)pool is pivotal for the female reproductive lifespan;however,the mechanism of primordial folliculogenesis is poorly understood.Here,the transcription factor SP1 was shown to be essential for PF formation in mice.Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary.Knockdown of Sp1 expression,especially in pregranulosa cells,significantly suppressed nest breakdown,oocyte apoptosis,and PF formation,suggesting that SP1 expressed by somatic cells functions in the process of primordial folliculogenesis.We further demonstrated that SP1 governs the recruitment and maintenance of Forkhead box L2-positive(FOXL2^+)pregranulosa cells using an Lgr5-EGFP-IRES-CreER^T2(Lgr5-KI)reporter mouse model and a FOXL2^+ cell-specific knockdown model.At the molecular level,SP1 functioned mainly through manipulation of NOTCH2 expression by binding directly to the promoter of the Notch2 gene.Finally,consistent with the critical role of granulosa cells in follicle survival in vitro,massive loss of oocytes in SP1 knockdown ovaries was evidenced before puberty after the ovaries were tranSP1anted under the renal capsules.Conclusively,our results reveal that SP1 controls the establishment of the ovarian reserve by regulating pregranulosa cell development in the mammalian ovary. | Han Cai Bingying Liu Huarong Wang Guanghong Sun Lizhao Feng Ziqi Chen Jiaqi Zhou Jiawei Zhang Tuo Zhang Meina He Tingting Yang Qirui Guo Zhen Teng Qiliang Xin Bo Zhou Hua Zhang Guoliang Xia Chao Wang | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
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