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| 1 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 2 | Intelligent classification model of surrounding rock of tunnel using drilling and blasting method显示文摘Classification of surrounding rock is the cornerstone of tunnel design and construction.The traditional methods are mainly qualitative and manual and require extensive professional knowledge and engineering experience.To minimize the effect of the empirical judgment on the accuracy of surrounding rock classification,it is necessary to reduce human participation.An intelligent classification technique based on information technology and artificial intelligence could overcome these issues.In this regard,using 299 groups of drilling parameters collected automatically using intelligent drill jumbos in tunnels for the Zhengzhou-Wanzhou high-speed railway in China,an intelligent-classification surrounding-rock database is constructed in this study.Based on a machine learning algorithm,an intelligent classification model is then developed,which has an overall accuracy of 91.9%.Finally,using the core of the model,the intelligent classification system for the surrounding rock of drilled and blasted tunnels is integrated,and the system is carried by intelligent jumbos to perform automatic recording and transmission of drilling parameters and intelligent classification of the surrounding rock.This approach provides a foundation for the dynamic design and construction(both conventional and intelligent)of tunnels. | Mingnian Wang Siguang Zhao Jianjun Tong Zhilong Wang Meng Yao Jiawang Li Wenhao Yi | 2021 | Underground Space2021，6，5： | 5 |
| 3 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 4 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 5 | An infrastructure with user-centered presentation data model for integrated management of materials data and services显示文摘With scientific research in materials science becoming more data intensive and collaborative after the announcement of the Materials Genome Initiative,the need for modern data infrastructures that facilitate the sharing of materials data and analysis tools is compelling in the materials community.In this paper,we describe the challenges of developing such infrastructure and introduce an emerging architecture with high usability.We call this architecture the Materials Genome Engineering Databases(MGED).MGED provides cloud-hosted services with features to simplify the process of collecting datasets from diverse data providers,unify data representation forms with user-centered presentation data model,and accelerate data discovery with advanced search capabilities.MGED also provides a standard service management framework to enable finding and sharing of tools for analyzing and processing data.We describe MGED’s design,current status,and how MGED supports integrated management of shared data and services. | Shilong Liu Yanjing Su Haiqing Yin Dawei Zhang Jie He Haiyou Huang Xue Jiang Xuan Wang Haiyan Gong Zhuang Li Hao Xiu Jiawang Wan Xiaotong Zhang | 2021 | npj Computational Materials2021，，1： | 4 |
| 6 | Publisher's note to“Texture engineering of mono-crystalline silicon via alcohol-free alkali solution for efficient PERC solar cells”[J.Energy Chem.71(2022)104-107显示文摘The publisher regrets that the page range of this paper was incorrect due to production error,and we added al-a5 after page 107 to the pdf version to correct this mistake. | Danni Zhang Jiawang Chen Rui Jia Zhibo Gao Ke Tao Longjie Wang Huayun Ge Xinpu Li Xing Li | 2022 | Journal of Energy Chemistry2022，31，8： | 3 |
| 7 | Influence of temperature on the transformation and self-control of energy during sandstone damage:Experimental and theoretical research显示文摘The surrounding rock in tunnelling engineering and coal mining will sometimes be exposed to high temperature. Rock failure is the result of energy dissipation, and the study of the evolution and transformation behavior of energy is of great significance for the in-depth understanding of the deformation and failure of rock after high temperature. This study analyzed the intrinsic connection between mechanical properties and acoustic emission(AE) energy under temperature effect. Based on the energy dissipation and release theory, the distribution and transformation of energy was analyzed, and the energy selfincentive and self-inhibition(EII) model was further established. The main findings are that temperature effect affects the confidence interval trend and the value of AE energy rate, which is related to the change in mechanical properties. The ability of sandstone to store elastic strain energy after exposure to high temperature is independent of the mechanical properties. In this study, the ratio of dissipated energy to elastic energy is used to characterize the stable state of the sandstone system, which can be used as the energy indicator of rock failure precursor. During the absorption, storage, and release of energy before the peak stress, there exists self-incentive and self-inhibition of energy(control behavior). | Lan Qiao Jiawang Hao Zhiyi Liu Qingwen Li Naifu Deng | 2022 | International Journal of Mining Science and Technology2022，32，4： | 3 |
| 8 | A TiO_(2)nanotubes film with excellent antireflective and near-perfect self-cleaning performances显示文摘SiO_(2)/TiO_(2)composite films have been frequently used to realize the functions of self-cleaning and antireflection.Increasing the TiO_(2)volume ratio in SiO_(2)/TiO_(2)composite film is beneficial to enhance the self-cleaning effect,while high TiO_(2)content leads to a strong Rayleigh scattering and depresses the antireflective performance,resulting in a bottleneck problem for the dual-functional application.Here,we have achieved a high-quality TiO_(2)nanotubes film with excellent antireflective and near-perfect selfcleaning performances.Ultrasound assisted pickling method has been developed to effectively prepare the well-dispersed protonated titanate nanotubes colloid.After spin-coating and annealing treatment,glass substrate coated with double-side TiO_(2)nanotubes film has a peak transmittance of 99.2%and average transmittance of 97.4%at 400-800 nm.Ultra-high porosity of TiO_(2)nanotubes film(80%)and ultra-fine size of TiO_(2)nanotubes(8.6 nm in outer diameter)lead to excellent antireflective performance.With high UV absorptivity(80%at 254 nm)and formal quantum efficiency of stearic acid(10.9×10^(-3)),TiO_(2)nanotubes film shows near-perfect self-cleaning performance.A persistent anti-fogging ability is also presented.This study demonstrates the feasibility to fabricate pure TiO_(2)antireflective coating for glass substrate,extends application field of the classic TiO_(2)nanotubes,and sheds lights on the practical applications of high-powered TiO_(2)nanotube-based multi-functional films. | Kaibin Li Ming Li Chang Xu Zengyan Du Jiawang Chen Fengxia Zou Chongwen Zou Sichao Xu Guanghai Li | 2021 | Journal of Materials Science & Technology2021，，29： | 3 |
| 9 | Deformation Analysis and Fixture Design of Thin-walled Cylinder in Drilling Process Based on TRIZ Theory显示文摘Thin-walled cylindrical workpiece is easy to deform during machining and clamping processes due to the insufficient rigidi.Moreover,it’s also difficult to ensure the perpendicularity of flange holes during drilling process.In this paper,the element birth and death technique is used to obtain the axial deformation of the hole through finite element simulation.The measured value of the perpendicularity of the hole was compared with the simulated value to verify then the rationality of the simulation model.To reduce the perpendicularity error of the hole in the drilling process,the theory of inventive principle solution(TRIZ)was used to analyze the drilling process of thin-walled cylinder,and the corresponding fixture was developed to adjust the supporting surface height adaptively.Three different fixture supporting layout schemes were used for numerical simulation of drilling process,and the maximum,average and standard deviation of the axial deformation of the flange holes and their maximum hole perpendicularity errors were comparatively analyzed,and the optimal arrangement was optimized.The results show that the proposed deformation control strategy can effectively improve the drilling deformation of thin-walled cylindrical workpiece,thereby significantly improving the machining quality of the parts. | Fulin WANG Bo SHENG Yongwen WU Jiawang LI Zhou XU Zhaoxia ZHU | 2021 | Mechanical Engineering Science2021，3，1： | 1 |
| 10 | Electrospinning direct preparation of SnO 2 /Fe 2 O 3 heterojunction nanotubes as an efficient visible-light photocatalyst显示文摘 | Chengquan Zhu Yuren Li Qing Su Bingan Lu Jiaqi Pan Jiawang Zhang Erqing Xie Wei Lan | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 11 | Phonon anharmonicity:a pertinent review of recent progress and perspective显示文摘Anharmonic lattice vibrations play pivotal roles in the thermal dynamics in condense matters and affect how the atoms interact and conduct heat.An in-depth understanding of the microscopic mechanism of phonon anharmonicity in condensed systems is critical for developing better functional and energy materials.In recent years,various novel behaviors in condense matters driven by phonon anharmonic effects were discovered,such as soft mode phase transition,negative thermal expansion(NTE),multiferroicity,ultralow thermal conductivity(κ),high thermal resistance,and high-temperature superconductivity.These properties have endowed anharmonicity with many promising applications and provided remarkable opportunities for developing“Anharmonicity Engineering”-regulating heat transport towards excellent performance in materials.In this work,we review the recent development of studies on phonon anharmonic effect and summarize its origin,mechanism,research methods,and applications.Besides,the remaining challenges,future trends,and prospects of phonon anharmonicity are also discussed. | Bin Wei Qiyang Sun Chen Li Jiawang Hong | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，11： | 1 |
| 12 | Influence of White Spot Syndrome Virus Infection on Hepatopancreas Gene Expression of ‘Huanghai No.2' Shrimp(Fenneropenaeus chinensis)显示文摘To elucidate the molecular response of shrimp hepatopancreas to white spot syndrome virus(WSSV) infection, microarray was applied to investigate the differentially expressed genes in the hepatopancreas of ‘Huanghai No. 2'(Fenneropenaeus chinensis). A total of 59137 unigenes were designed onto a custom-made 60 K Agilent chip. After infection, the gene expression profiles in the hepatopancreas of the shrimp with a lower viral load at early(48–96 h), peak(168–192 h) and late(264–288 h) infection phases were analyzed. Of 18704 differentially expressed genes, 6412 were annotated. In total, 5453 differentially expressed genes(1916 annotated) expressed at all three phases, and most of the annotated were either up-or down-regulated continuously. These genes function diversely in, for example, immune response, cytoskeletal system, signal transduction, stress resistance, protein synthesis and processing, metabolism among others. Some of the immune-related genes, including antilipopolysaccharide factor, Kazal-type proteinase inhibitor, C-type lectin and serine protease encoding genes, were up-regulated after WSSV infection. These genes have been reported to be involved in the anti-WSSV responses. The expression of genes related to the cytoskeletal system, including β-actin and myosin but without tubulin genes, were down-regulated after WSSV infection. Astakine was found for the first time in the WSSV-infected F. chinensis. To further confirm the expression of differentially expressed genes, quantitative real-time PCR was performed to test the expression of eight randomly selected genes and verified the reliability and accuracy of the microarray expression analysis. The data will provide valuable information to understanding the immune mechanism of shrimp's response to WSSV. | MENG Xianhong SHI Xiaoli KONG Jie LUAN Sheng LUO Kun CAO Baoxiang LIU Ning LU Xia LI Xupeng DENG Kangyu CAO Jiawang ZHANG Yingxue ZHANG Hengheng | 2017 | Journal of Ocean University of China2017，16，5： | 1 |
| 13 | Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane显示文摘It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed yet.Herein, we decouple and elaborate two distinctive pathways regarding film degradation based on FACsPbI3perovskites.Moreover, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability. | Xiao Zhang Changsu Cao Yang Bai Cheng Zhu Huachao Zai Sai Ma Yihua Chen Zhenhua Cui Congbo Shi Chenyue Wang Chenxiao Zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao Wang Huanping Zhou Hai Xiao Jun Li Qi Chen | 2022 | Science China Chemistry2022，65，11： | 0 |
| 14 | Breaking the symmetry of colloidal 2D nanoplatelets:Twist induced quantum coupling显示文摘Twist provides a new degree of freedom for nanomaterial modifications,which can provide novel physical properties.Here,colloidal two-dimensional(2D)twisted CdSe nanoplatelets(NPLs)are successfully fabricated and their morphology can change from totally flat to edge-twisted,and then to middle-twisted with prolonged reaction time.By combining experiments and corresponding theoretical analyses,we have established the length-dependent relationships between the surface energy and twist,with a critical lateral dimension of 30 nm.We found that the defects formed during the synthesis process play a vital role in generating intense stress that develops a strong torsion tensor around the edges,resulting in edge-twisted and final middletwisted NPLs.Furthermore,due to the geometric asymmetry of twisted NPLs,the dissymmetry factor of single particle NPLs can reach up to 0.334.Specifically,quantum coupling occurs in middle-twisted NPLs by twisting one parent NPL into two daughter NPLs,which are structurally and electronically coupled.This work not only further deepens our understanding of the twist mechanism of 2D NPLs during colloidal synthesis,but also opens a pathway for applications using twistronics and quantum technology. | Zahid Nazir Yingzhuo Lun Jialu Li Gaoling Yang Mingrui Liu Shuqi Li Gang Tang Guofeng Zhang Jiawang Hong Liantuan Xiao Haizheng Zhong | 2023 | Nano Research2023，16，7： | 0 |
| 15 | Chemical characteristics of long-term acid rain and its impact on lake water chemistry:A case study in Southwest China显示文摘The chemical composition of acid rain and its impact on lake water chemistry in Chongqing,China,from 2000 to 2020 were studied in this study.The regional acid rain intensity is affected jointly by the acid gas emissions and the neutralization of alkaline substances.The pH of precipitation experienced three stages of fluctuating decline,continuous improvement,and a slight correction.Precipitation pH showed inflection points in 2010,mainly due to the total control actions of SO_(2)and NO_(x)implemented in 2011.The total ion concentrations in rural areas and urban areas were 489.08μeq/L and 618.57μeq/L,respectively.The top four ions were SO_(4)^(2-),Ca^(2+),NH_(4)^(+)and NO_(3)^(-),which accounted for more than 90%of the total ion concentration,indicating the anthropogenic effects.Before 2010,SO_(4)^(2-)fluctuated greatly while NO_(3)^(-)continued to rise;however,after 2010,both SO_(4)^(2-)and NO_(3)^(-)began to decline rapidly,with the rates of-12.03μeq/(L·year)and-4.11μeq/(L·year).Because the decline rate of SO_(4)^(2-)was 2.91 times that of NO_(3)^(-),the regional acid rain has changed from sulfuric acid rain to mixed sulfuric and nitric acid rain.The lake water is weakly acidic,with an average pH of 5.86,and the acidification frequency is 30.00%.Acidification of lake water is jointly affected by acid deposition and acid neutralization capacity of lake water.Acid deposition has a profound impact on water acidification,and nitrogen(N)deposition,especially reduced N deposition,should be the focus of future research. | Liuyi Zhang JiaWang Shuxiao Wang Chunbo Wang Fumo Yang Tingzhen Li | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 16 | Heterogeneity identification method for surrounding rock of large-section rock tunnel faces based on support vector machine显示文摘Purpose–The purpose of the study is to quickly identify significant heterogeneity of surrounding rock of tunnel face that generally occurs during the construction of large-section rock tunnels of high-speed railways.Design/methodology/approach–Relying on the support vector machine(SVM)-based classification model,the nominal classification of blastholes and nominal zoning and classification terms were used to demonstrate the heterogeneity identification method for the surrounding rock of tunnel face,and the identification calculation was carried out for the five test tunnels.Then,the suggestions for local optimization of the support structures of large-section rock tunnels were put forward.Findings–The results show that compared with the two classification models based on neural networks,the SVM-based classification model has a higher classification accuracy when the sample size is small,and the average accuracy can reach 87.9%.After the samples are replaced,the SVM-based classification model can still reach the same accuracy,whose generalization ability is stronger.Originality/value–By applying the identification method described in this paper,the significant heterogeneity characteristics of the surrounding rock in the process of two times of blasting were identified,and the identification results are basically consistent with the actual situation of the tunnel face at the end of blasting,and can provide a basis for local optimization of support parameters. | Wenhao Yi Mingnian Wang Jianjun Tong Siguang Zhao Jiawang Li Dengbin Gui Xiao Zhang | 2023 | Railway Sciences2023，2，1： | 0 |
| 17 | Stress compensation based on interfacial nanostructures for stable perovskite solar cells显示文摘The long-term stability issue of halide perovskite solar cells hinders their commercialization.The residual stress-strain affects device stability,which is derived from the mismatched thermophysical and mechanical properties between adjacent layers.In this work,we introduced the Rb_(2)CO_(3)layer at the interface of SnO_(2)/perovskite with the hierarchy morphology of snowflake-like microislands and dendritic nanostructures.With a suitable thermal expansion coefficient,the Rb_(2)CO_(3)layer benefits the interfacial stress relaxation and results in a compressive stress-strain in the perovskite layer.Moreover,reduced nonradiative recombination losses and optimized band alignment were achieved.An enhancement of open-circuit voltage from 1.087 to 1.153 V in the resultant device was witnessed,which led to power conversion efficiency(PCE)of 22.7%(active area of 0.08313 cm^(2))and 20.6%(1 cm2).Moreover,these devices retained 95%of its initial PCE under the maximum power point tracking(MPPT)after 2700 h.It suggests inorganic materials with high thermal expansion coefficients and specific nanostructures are promising candidates to optimize interfacial mechanics,which improves the operational stability of perovskite cells. | Cheng Zhu Xi Wang Hangxuan Li Chenyue Wang Ziyan Gao Pengxiang Zhang Xiuxiu Niu Nengxu Li Zipeng Xu Zhenhuang Su Yihua Chen Huachao Zai Haipeng Xie Yizhou Zhao Ning Yang Guilin Liu Xueyun Wang Huanping Zhou Jiawang Hong Xingyu Gao Yang Bai Qi Chen | 2023 | Interdisciplinary Materials2023，2，2： | 0 |
| 18 | N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA显示文摘Mitochondria undergo fission and fusion that are critical for cell survival and cancer development,while the regulatory factors for mitochondrial dynamics remain elusive.Herein we found that RNA m^(6)A accelerated mitochondria fusion of colorectal cancer(CRC)cells.Metabolomics analysis and function studies indicated that m^(6)A triggered the generation of glutathione(GSH)via the upregulation of RRM2B-a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential.This in turn resulted in the mitochondria fusion of CRC cells.Mechanistically,m^(6)A methylation of A1240 at 3'UTR of RRM2B increased its mRNA stability via binding with IGF2BP2.Similarly,m^(6)A methylation of A2212 at the coding sequence(CDS)of OPA1-an essential GTPase protein for mitochondrial inner membrane fusion-also increased mRNA stability and triggered mitochondria fusion.Targeting m^(6)A through the methyltransferase inhibitor STM2457 or the dm^(6)ACRISPR system significantly suppressed mitochondria fusion.In vivo and clinical data confirmed the positive roles of the m^(6)A/mitochondrial dynamics in tumor growth and CRC progression.Collectively,m^(6)A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression,which facilitated cancer cell growth and CRC development. | Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang | 2024 | National Science Review2024，11，3： | 0 |
| 19 | Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFC显示文摘Transition metal-nitrogen-carbon(M-N-C)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-HC)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination reaction.The as-synthesized S-Fe-N-HC features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-C with soft or graphitic carbon structures.These unique characteristics endow S-Fe-N-HC with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 cycles.Meanwhile,its practical PEMFC performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical operation.Additionally,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)C.These results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-C catalysts,providing a new guidance for developing advanced M-N-C catalysts for ORR. | Bin Liu Jiawang Li Bowen Yan Qi Wei Xingyu Wen Huarui Xie Huan He Pei Kang Shen Zhi Qun Tian | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 20 | Network pharmacology and experimental validation of Maxing Shigan decoction in the treatment of influenza virus-inducedferroptosis显示文摘Influenza is an acute viral respiratory infection that has caused high morbidity and mortality worldwide.Influenza A virus(IAV)has been found to activate multiple programmed cell death pathways,including ferroptosis.Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation,leading to cell death.However,little is known about how influenza viruses induce ferroptosis in the host cells.In this study,based on network pharmacology,we predicted the mechanism of action of Maxing Shigan decoction(MXSGD)in IAV-induced ferroptosis,and found that this process was related to biological processes,cellular components,molecular function and multiple signaling pathways,where the hypoxia inducible factor-1(HIF-1)signaling pathway plays a significant role.Subsequently,we constructed the mouse lung epithelial(MLE-12)cell model by IAV-infected in vitro cell experiments,and revealed that IAV infection induced cellular ferroptosis that was characterized by mitochondrial damage,increased reactive oxygen species(ROS)release,increased total iron and iron ion contents,decreased expression of ferroptosis marker gene recombinant glutathione peroxidase 4(GPX4),increased expression of acyl-CoA synthetase long chain family member 4(ACSL4),and enhanced activation of hypoxia inducible factor-1α(HIF-1α),induced nitric oxide synthase(iNOS)and vascular endothelial growth factor(VEGF)in the HIF-1 signaling pathway.Treatment with MXSGD effectively reduced intracellular viral load,while reducing ROS,total iron and ferrous ion contents,repairing mitochondrial results and inhibiting the expression of cellular ferroptosis and the HIF-1 signaling pathway.Finally,based on animal experiments,it was found that MXSGD effectively alleviated pulmonary congestion,edema and inflammation in IAV-infected mice,and inhibited the expression of ferroptosis-related protein and the HIF-1 signaling pathway in lung tissues. | HUANG Jiawang MA Xinyue LIAO Zexuan LIU Zhuolin WANG Kangyu FENG Zhiying NING Yi LU Fangguo LI Ling | 2023 | Chinese Journal of Natural Medicines2023，21，10： | 0 |
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