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| 1 | Genome-wide Association Analyses Reveal the Genetic Basis of Stigma Exsertion in Rice显示文摘耻辱 exsertion,交配系统的米饭的一个关键决定因素,极大地在米饭贡献杂种优势的申请。尽管与耻辱 exsertion 联系的一些量的特点 loci 是印射或克隆的罚款,内在的基因建筑学仍然保持不清楚。我们用在 Oryza sativa 的 533 多样的就职描绘的 650 万 SNP 在耻辱 exsertion 和相关花的特点上执行了染色体宽的协会研究。我们识别了显著地与耻辱 exsertion 和相关特点,其三与三主要谷物尺寸基因 GS3, GW5,和 GW2 co 局部性被联系的 23 genomic loci。进一步的分析显示这三基因由控制小穗状花小穗和耻辱的尺寸和形状影响了耻辱 exsertion。GS3 和 GW5 的联合大部分定义耻辱 exsertion 和相关特点的层次。这二基因的选择在 O 的 subpopulations 之中导致了花的特点的特定的分布。sativa。低耻辱 exsertion 联合 gw5GS3 在栽培米饭变化的一半存在;因此,介绍 GW5gs3 联合进男无菌的线具有为改进混合米饭的种子生产的高潜力。 | Hao Zhou Pingbo Li WeiboXie Saddam Hussain Yibo Li Duo Xia Hu Zhao Shengyuan Sun Junxiao Chen Hong Ye Jun Hou Da Zhao Guanjun Gao Qinglu Zhang Gongwei Wang Xingming Lian Jinghua Xiao Sibin Yu Xianghua Li Yuqing He | 2017 | Molecular Plant2017，10，4： | 15 |
| 2 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 3 | Microstructure and mechanical property of a high-strength Mg-10Gd-6Y-1.5Zn-0.5Zr alloy prepared by multi-pass equal channel angular pressing显示文摘In this work,a high-strength Mg–10Gd–6Y–1.5Zn–0.5Zr(wt.%)alloy was fabricated by successive multi-pass equal channel angular pressing(ECAP).The microstructure and mechanical property of as-cast and ECAP alloys were systematically researched by X-ray diffractometer,scanning electron microscopy,transmission electron microscopy and compression test.The results show that the microstructure of as-cast alloy consists ofα-Mg grains,Mg24Y5 networks,18R blocks,fine 14H lamellas,and fewY-rich particles.After 8 passes ECAP,dynamic recrystallization ofα-Mg is developed and their average grain size decreases to about 1μm.The network Mg_(24)Y_(5) phase at grain boundaries is broken into small particles with average diameter lower than 0.5μm.Moreover,18R blocks are kinked and delaminated,or broken into small particles and blended with Mg24Y5 particles.14H lamellas grow gradually or are dynamically precipitated within certainα-Mg grains.Compression tests indicate that 8p ECAP alloy exhibits excellent mechanical property with compressive strength of 537 MPa and fracture strain of 17.0%.The significant improvement for both strength and ductility of deformed alloy could be ascribed to DRX grains,refined Mg24Y5 particles,18R kinking and dynamical precipitation of 14H. | Huan Liu He Huang Xiaowei Yang Cheng Li Jingli Yan Jinghua Jiang Aibin Ma | 2017 | Journal of Magnesium and Alloys2017，5，2： | 10 |
| 4 | Potential of multi-pass ECAP on improving the mechanical properties of a high-calcium-content Mg-Al-Ca-Mn alloy显示文摘In this study,the multi-pass equal channel angular pressing(ECAP)was employed on a high-calcium-content Mg-Al-Ca-Mn alloy to tailor its microstructure and mechanical properties.The obtained results showed that the network-shaped Mg2Ca and(Mg,Al)2Ca eutectic compounds in as-cast alloy were gradually crushed into ultra-fine particles after ECAP,which exhibited a bimodal particle size distribution and most aggregated at original grain boundaries.Dynamic recrystallization(DRX)of α-Mg occurred during hot deformation via a particle stimulated mechanism,and the almost complete DRX with an average grain size around 1.5μm was obtained after 12p-ECAP.Moreover,abundant nano-sized acicular and spherical precipitates were dynamically precipitated withinα-Mg grains during ECAP.Tensile test results indicated that the maximum strength and ductility were acquired for 12p-ECAP alloy with ultimate tensile strength of 372 MPa and fracture elongation of 8%.The enhanced strength of the alloy could be ascribed to fine DRX grains,ultra-fine Ca-containing particles and dynamically precipitated nano-precipitates,while the improved ductility was mainly due to the refined and homogeneous microstructure,and weak texture with high average Schmid factors. | He Huang Huan Liu Ce Wang Jiapeng Sun Jing Bai Feng Xue Jinghua Jiang Aibin Ma | 2019 | Journal of Magnesium and Alloys2019，7，4： | 10 |
| 5 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 6 | Synergetic effects of aqueous extracts of Fuzi(Radix Aconiti Lateralis Preparata) and Tubeimu(Rhizoma Bolbostemmatis) on MDA-MB-231 and SKBR3 cells显示文摘OBJECTIVE: To test the synergistic effects of the aqueous extract of Tubeimu(Rhizoma Bolbostemmatis) and Fuzi(Radix Aconiti Lateralis Preparata) on MDA-MB-231 and SKBR3 breast cancer cells.METHODS: A combined index was created for the effects of Tubeimu(Rhizoma Bolbostemmatis) and Fuzi(Radix Aconiti Lateralis Preparata) extracts. Cell proliferation was performed by trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS) assays. Flow cytometry was used to assess cell cycle distribution and apoptosis. Cell migration was determined by wound-healing and transwell assays. Confocal microscopy was used to detect E-cadherin and actin filaments.RESULTS: The aqueous extract from Tubeimu(Rhizoma Bolbostemmatis) and Fuzi(Radix Aconiti Lateralis Preparata) exerted synergetic effects on the growth of MDA-MB-231 cells and G1 phase arrest.When exposed to extracts at concentrations of 62.5∶62.5 and 62.5∶31.3 μg/m L, the combination index was 0.83 and 0.74, respectively. Interestingly, 62.5∶31.3 μg/m L of combined drugs enhanced the inhibitory effect of Tubeimu(Rhizoma Bolbostemmatis)on the migration of SKBR3 cells and reduced the stimulative effect of Fuzi(Radix Aconiti Lateralis Preparata)(P < 0.01), in which cells showed an increased expression of E-cadherin and reorganization of actin filaments(P < 0.001). 62.5∶62.5 μg/m L extract also synergistically induced apoptosis of MDA-MB-231 cells(P < 0.05 and P < 0.001). Acting as the main active ingredients in the extract, tubeimoside I and acetylbenzoylaconine at 10∶10 μg/m L and 5∶2.5 μg/m L also produced inhibitory effects on the proliferation and migration of cells(P <0.01).CONCLUSION: Tubeimu(Rhizoma Bolbostemmatis)and Fuzi(Radix Aconiti Lateralis Preparata) extracts had synergic effects on MDA-MB-231 and SKBR3 cells. | Chen Dan Cao Rui He Jinghua Guo Yuan Wang Liping Ji Wei Wu Xiongzhi | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 8 |
| 7 | The origin of Wx^(la) provides new insights into the improvement of grain quality in rice显示文摘Appearance and taste are important factors in rice(Oryza sativa) grain quality. Here, we investigated the taste scores and related eating-quality traits of533 diverse cultivars to assess the relationships between—and genetic basis of—rice taste and eating-quality. A genome-wide association study highlighted the Wx gene as the major factor underlying variation in taste and eating quality. Notably, a novel waxy(Wx) allele, Wx^(la), which combined two mutations from Wx^(b) and Wx^(in), exhibited a unique phenotype. Reduced GBSSI activity conferred Wx^(la) rice with both a transparent appearance and good eating quality. Haplotype analysis revealed that Wx^(la) was derived from intragenic recombination. In fact,the recombination rate at the Wx locus was estimated to be 3.34 kb/c M, which was about 75-fold higher than the genome-wide mean, indicating that intragenic recombination is a major force driving diversity at the Wx locus. Based on our results, we propose a new network for Wx evolution, noting that new Wx alleles could easily be generated by crossing genotypes with different Wx alleles. This study thus provides insights into the evolution of the Wx locus and facilitates molecular breeding for quality in rice. | Hao Zhou Duo Xia Da Zhao Yanhua Li Pingbo Li Bian Wu Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Journal of Integrative Plant Biology2021，63，5： | 8 |
| 8 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 9 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 10 | An injectable and self-healing hydrogel with controlled release of curcumin to repair spinal cord injury显示文摘The harsh local micro-environment following spinal cord injury(SCI)remains a great challenge for neural regeneration.Local reconstitution of a favorable micro-environment by biocompatible scaffolds with desirable functions has thus been an area of concern.Herein,a hybrid hydrogel was developed using Fmoc-grafted chitosan(FC)and Fmoc peptide(FI).Dynamic reversibleπ-πstacking interactions of the fluorenyl rings enabled the FC/FI hybrid hydrogel to exhibit excellent injectable and self-healing properties,as characterized by visual appearances and rheological tests.Furthermore,the FC/FI hybrid hydrogel showed a slow and persistent release of curcumin(Cur),which was named as FC/FI-Cur hydrogel.In vitro studies confirmed that with the support of FC/FI-Cur hydrogel,neurite outgrowth was promoted,and Schwann cell(SC)migration away from dorsal root ganglia(DRG)spheres with enhanced myelination was substantiated.The FC/FI-Cur hydrogel well reassembled extracellular matrix at the lesion site of rat spinal cord and exerted outstanding effects in modulating local inflammatory reaction by regulating the phenotypes of infiltrated inflammatory cells.In addition,endogenous SCs were recruited in the FC/FI-Cur graft and participated in the remyelination process of the regenerated nerves.These outcomes favored functional recovery,as evidenced by improved hind limbs movement and enhanced electrophysiological properties.Thus,our study not only advanced the development of multifunctional hydrogels but also provided insights into comprehensive approaches for SCI repair. | Jinghua Luo Xueshuang Shi Liming Li Zan Tan Feng Feng Jun Li Mao Pang Xiaoying Wang Liumin He | 2021 | Bioactive Materials2021，6，12： | 4 |
| 11 | Genetic architecture and key genes controlling the diversity of oil composition in rice grains显示文摘Rice grain oil is a valuable nutrient source.However,the genetic basis of oil biosynthesis in rice grains remains unclear.In this study,we performed a genome-wide association study on oil composition and oil concentration in a diverse panel of 533 cultivated rice accessions.High variation for 11 oil-related traits was observed,and the oil composition of rice grains showed differentiation among the subpopulations.We identified 46 loci that are significantly associated with grain oil concentration or composition,16 of which were detected in three recombinant inbred line populations.Twenty-six candidate genes encoding enzymes involved in oil metabolism were identified from these 46 loci,four of which(PAL6,LIN6,MYR2,and ARA6)were found to contribute to natural variation in oil composition and to show differentiation among the subpopulations.Interestingly,population genetic analyses revealed that specific haplotypes of PAL6 and LIN6 have been selected in japonica rice.Based on these results,we propose a possible oil biosynthetic pathway in rice grains.Collectively,our results provide new insights into the genetic basis of oil biosynthesis in rice grains and can facilitate marker-based breeding of rice varieties with enhanced oil and grain quality. | Hao Zhou Duo Xia Pingbo Li Yiting Ao Xiaodong Xu Shanshan Wan Yanhua Li Bian Wu Huan Shi Kaiyue Wang Guanjun Gao Qinglu Zhang Gongwei Wang Jinghua Xiao Xianghua Li Sibin Yu Xingming Lian Yuqing He | 2021 | Molecular Plant2021，14，3： | 4 |
| 12 | The effect of erythropoietin to the proliferation of cancer cell lines显示文摘对客观调查了红细胞生成素(EPO ) 是否将支持人的癌症房间线 MCF-7, Panc-1 和 HepG2 的增长以便决定 EPO 是否将结果更坏的预后到有恶性病的病人。我们由 MTT 试金检验了禁止的生长或 EPO 的宣传效果到 MCF-7, Panc-1 和 HepG2 的方法。然后,我们检验了与 EPO 并且没有由 FCM 的 EPO 有教养的那些癌症房间线的房间周期。结果在那里显示出的结果不是禁止的重要生长或到 MCF-7, Panc-1 和 HepG2 的 EPO 的宣传效果。与 EPO 有教养的那些癌症房间线的房间周期也有不重要对没有 EPO 有教养的那些癌症房间线的不同。EPO 没有提升,这被结束的结论完成到癌症房间线的增长,并且也许不结果更坏的预后到有恶性病的病人。 | Wenshan He Tao Huang Jinghua Ren Jinghui Zhang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 3 |
| 13 | Study on the effect of electrostatic interaction on core-shell nanoparticles preparation with microemulsion technique显示文摘The routine method for preparation of silica core-shell nanoparticles (NPs) is to carry out nucleation and shell coating through the hydrolysis of silane in water in oil (W/O) microemulsion to form three-dimensional netted silica shell. We found that electrostatic interaction of the core ma- terials with shell materials would determine whether the stable core-shell silica NPs formed or not. The traditional important factors such as molecular weight of core materials or the thickness of the shell have no obvious relationship with it. And the stability of the core-shell silica NPs can be im- proved after changing the electric charge polarity by regu- lating the experiment condition of relevant materials if some core materials cannot be doped inside to form the stable core-shell silica NPs based on the traditional method, which provided experimental and theoretic foundation for prepara- tion and application of the core-shell silica NPs. | HE Xiaoxiao WANG Kemin TAN Weihong CHEN Jiyun DUAN Jinghua YUAN Yin LIN Xia | 2005 | Chinese Science Bulletin2005，50，24： | 2 |
| 14 | Projection of droughts and their socioeconomic exposures based on terrestrial water storage anomaly over China显示文摘Global warming has altered the thermodynamic and dynamic environments of the climate system, thus affecting the energy budget and water cycle process of the land-atmosphere system. Under changes in key hydrological elements such as precipitation, runoff, and terrestrial water storage, future drought variation remains a complex question. Existing studies have utilized terrestrial water storage anomaly(TWSA) in drought monitoring and assessment, but they usually focused on either drought duration or intensity, overlooking the multi-faced attributes of droughts as well as their socioeconomic impacts under a non-stationary condition. In this study, we first identify dry/wet conditions over China using GRACE/GRACE-FO satellite observations, and then evaluate the feedback effects of humidity and energy factors(e.g., sensible heat flux, latent heat flux,atmospheric relative humidity, and convective available potential energy) to drought events. Future changes in TWSA and dry/wet conditions are projected by eight Coupled Model Inter-comparison Project Phase 6(CMIP6) global climate models(GCMs)under three shared socioeconomic pathways(SSPs), with their biases corrected by a trend-preserving quantile mapping method.The time-varying Copula function of drought duration and intensity is constructed by a moving windows method, and future bivariate drought risks are quantified with the most likely realization method. The population and GDP affected by increasing drought risks are finally quantified based on the SSPs data. It is found that the land-atmosphere coupling effects closely interact with drought evolution, and the uneven distribution of water resources is projected to be further aggravated, with most areas of China will be threatened by continuous drying tendency. By the end of the century, the duration of moderate, severe and exceptional droughts in some regions of China will double, and the drought intensity will increase by over 80%. For the 50-year bivariate droughts during the historical period, their occurrence may increase by 5–10 times in several regions, and might affect about 35–55% of China’s population and GDP at the end of 21st century. | Jiabo YIN Shenglian GUO Yan YANG Jie CHEN Lei GU Jun WANG Shaokun HE Boyang WU Jinghua XIONG | 2022 | Science China Earth Sciences2022，65，9： | 2 |
| 15 | Auxiliary Teeth Design to Reduce Short-Circuit Current in Permanent Magnet Generators显示文摘In this paper,a new auxiliary teeth structure is proposed for fault-tolerant permanent magnet(PM)generators,which can reduce the short-circuit currents.Firstly,the short-circuit current and the phase to phase isolation of the fault-tolerant generator are analyzed briefly.Secondly,the auxiliary teeth structure is optimized to improve fault-tolerant capability.Then,the PM generators with different stator structures are compared to evaluate the proposed auxiliary teeth structure.Four critical generator parameters are investigated,i.e.back-electromotive forces,short-circuit currents,stator magneto motive force(MMF)harmonics,and torque performances.The results show that the proposed structure has better fault-tolerant capability than the conventional two-layer windings.Moreover,the stator MMF harmonics can be suppressed.Furthermore,the cogging torque and torque ripple can be suppressed by adopting the proposed structure.Finally,the simulated results are given to validate the theoretical analysis. | Yong He Wenxiang Zhao Hongyu Tang Jinghua Ji | 2020 | CES Transactions on Electrical Machines and Systems2020，4，3： | 2 |
| 16 | Using unmanned aerial vehicles with thermal-image acquisition cameras for animal surveys:a case study on the Sichuan snub-nosed monkey in the Qinling Mountains显示文摘Following significant developments in technology,alternative devices have been applied in fieldwork for animal and plant surveys.Thermal-image acquisition cameras installed on unmanned aerial vehicles(UAVs)have been used in animal surveys in the wilderness.This article demonstrates an example of how UAVs can be used in high mountainous regions,presenting a case study on the Sichuan snub-nosed monkey with a detection rate of 65.19%for positive individual identification.It also presents a model that can prospectively predict population size for a given animal species,which is based on combined initial work using UAVs and traditional surveys on the ground.A great potential advantage of UAVs is significantly shortening survey procedures,particularly for areas with high mountains and plateaus,such as the Himalayas,the Qinghai-Tibet Plateau,Hengduan Mountains,the Yunnan-Gui Plateau and Qinling Mountains in China,where carrying out a traditional survey is extremely difficult,so that species and population surveys,particularly for critically endangered animals,are largely absent.This lack of data has impacted the management of endangered animals as well as the formulation and amendment of conservation strategies. | Gang HE Haitao YANG Ruliang PAN Yewen SUN Pengbin ZHENG Jinghua WANG Xuelin JIN Jingjie ZHANG Baoguo LI Songtao GUO | 2020 | Integrative Zoology2020，15，1： | 2 |
| 17 | Improved elec- trochemical redox performance of 2,5-dimercapto-1,3,4- thiadiazole by poly ( 3-methoxythiophene ) 显示文摘 | Shu Dong Zhang Jinghua He Chun | 2006 | Applied Electrochemistry2006，36，： | 1 |
| 18 | In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan induced pancreaticislets damage显示文摘 | ZHANG Huina HE Jinghua LAN Yuan | 2003 | Life Sciences2003，73，18： | 1 |
| 19 | Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy显示文摘The combination of photodynamic therapy(PDT)and photothermal therapy(PTT)has attracted much interest in recent years,but non-specific distribution of photosensitizers and intrinsic tumor hypoxic microenvironment have continued to limit its therapeutic efficiency.We herein report a nano-theranostic system,denoted as Ce6-CuS/MSN@PDA@MnO2-FA NPs,which combines PDT,PTT,magnetic resonance(MR)imaging with hypoxia-relieving and tumor-targeting functionalities.Central to this design is the use of mussel-inspired polydopamine(PDA)coating to encapsulate the chlorin e6(Ce6)and copper sulfide nanoparticles(CuS NPs)loaded mesoporous silica nanoparticle(MSN)core.The PDA coating not only acts as pH sensitive gatekeeper to prevent the premature release of Ce6 under non-acidic tumor microenvironment(TME),but also facilitates post-functionalization so that hypoxia-relieving MnO2 nano-sheets and tumor-targeting ligand folic acid-PEG-thiol(FA-PEG-SH)can be decorated on the outer part of the drug system.In vitro and in vivo measurements clearly demonstrated that all these functionalities worked synergistically as expected.The system,having a low dark cytotoxicity,can be effectively internalized by 4T1 cells and decrease the cell viability to 2%upon 660 nm/808 nm laser irradiation.Tumors in 4T1 tumor-bearing mice can almost be completely destroyed in 2 weeks via combined PDT/PTT.Together with the TME-sensitive MR imaging performance demonstrated,Ce6-CuS/MSN@PDA@MnO2-FA NPs represent a multifunctional prototype which holds great potential to be developed into clinical theranostics. | Li Zhang Zhe Yang Jinghua Ren Li Ba Wenshan He Chun-Yuen Wong | 2020 | Nano Research2020，13，5： | 1 |
| 20 | In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on aUoxan- induced pancreatic islets damage显示文摘 | ZHANG Huina HE Jinghua YUAN Lan | 2003 | Life Sciences2003，73，18： | 1 |
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