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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Suppressing unsteady motion of shock wave by high-frequency plasma synthetic jet显示文摘Three Plasma Synthetic Jet Actuators(PSJA)under the high-frequency actuation are used to control the Shock Wave Boundary Layer Interaction(SWBLI),a high-speed schlieren image processing method based on spatial Fourier transform as well as snapshot proper orthogonal decomposition were used to study the control effect of high-frequency plasma synthetic jet on lowfrequency unsteadiness of SWBLI.The analysis of the base flow shows that the separated shock wave actually has both large-and small-amplitude vibrations at low frequency.And the results revealed that the PSJA with an operating frequency of 2 k Hz has the ability to reduce the energy of low-frequency component of shock wave motion,indicating that the 2 k Hz actuation can effectively suppress low-frequency unsteadiness of the separated wave.Compared with the actuation frequency of 2 k Hz,the energy of low-frequency component of the shock wave is enhanced under the8 k Hz actuation,which aggravates the low-frequency unsteady motion of the shock wave.It is likely that the actuation frequency is too high,thus the intensity of the precursor shock wave induced by PSJA becomes weaker.Additionally,as the 4 k Hz actuation is applied,the pulsation of the separation region was enhanced,it is speculated that the actuation frequency is coupled with the oscillation frequency of the separation region. | Yanhao LUO Jun LI Hua LIANG Shanguang GUO Mengxiao TANG Hongyu WANG | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 3 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 4 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 5 | Simultaneous formation of trimetallic Pt-Ni-Cu excavated rhombic dodecahedrons with enhanced catalytic performance for the methanol oxidation reaction显示文摘有挖掘结构的 Multimetallic 基于磅的合金由于他们的组合、词法的 tunability,高特定的表面区域,和出色的电镀物品催化的活动吸引了大兴趣。此处,我们报导 trimetallic Pt-Ni-Cu 的第一灵巧的一个壶合成高度与接近 100% 的收益挖掘了菱形的十二面体(ERD ) 。更重要地,这些高度一致的 nanocrystals 有三在尺寸上的可存取的挖掘表面,在丰富的走的原子被观察的地方。得益于高度挖掘的菱形的十二面体组织,电子并且在 trimetallic 合金以内的 synergistic 效果,和丰富的走的原子,同样准备的 trimetallic Pt-Ni-Cu ERD 与商业 Pt/C 和二金属的 Pt-Cu ERD 和 Pt-Ni-Cu 稳固的菱形的十二面体相比为甲醇的电镀物品氧化展出提高的电镀物品催化的表演稳固的菱形的十二面体( SRD )。 | Min Tang Shuiping Luo Kai Wang Hongyu Du Rinrada Sriphathoorat Peikang Shen | 2018 | Nano Research2018，11，9： | 3 |
| 6 | Performance of BCC-CSM Models with Different Horizontal Resolutions in Simulating Extreme Climate Events in China显示文摘In this study,the performance of the Beijing Climate Center(BCC)Climate System Model version 1.1(BCCCSM1.1)(280-km resolution)and the BCC-CSM1.1 m(110-km resolution)in simulating extreme climate events over China in the last 40 years is compared.Both models capture the main spatial distribution features of heavy precipitation(R95T),the number of consecutive wet days(CWD),the annual count of days with precipitation≥1 mm(R1),the maximum consecutive 5-day precipitation(Rx5),and the numbers of frost days(FD)and summer days(SU).The BCC-CSM1.1 m has a better ability to simulate the detailed distribution of extreme climate events than the BCCCSM1.1,including R95T,CWD,R1,and the simple precipitation intensity index(SDII).However,the BCCCSM 1.1 m does not show an improvement in simulating the number of days with extreme precipitation(R90N),the number of consecutive dry days(CDD),the heat wave duration index(HWDI),the warm day frequency(TX90 P),and cold night frequency(TN10P).This indicates that the simulation of the R95T,CWD,R1,and SDII climate events is more sensitive to the resolution of the model.The improved BCC-CSM1.1 m is used to explore the projection of extreme climate change in China during the 21 st century under the RCP4.5(Representative Concentration Pathways)and RCP8.5 scenarios.The results show that extreme precipitation will increase dramatically over North and Southwest China in the late 21 st century.The CWD index will decrease on the Tibetan Plateau and in northeastern and central China and will increase in other parts of China;R1 will increase in northern China and decrease in southern China;Rx5 will increase dramatically in southern China;FD will decrease and SU will increase over China in the late 21 st century under both emission scenarios,with larger amplitudes in RCP8.5. | Linxiao WEI Xiaoge XIN Chan XIAO Yonghua LI Yao WU Hongyu TANG | 2019 | Journal of Meteorological Research2019，33，4： | 3 |
| 7 | Construction and characterization of a hrpG mutant rendering constitutive expression of hrp genes in Xanthomonas campestris pv.campestris显示文摘在 Xanthomonas 的 hrp 基因的表示被 hrpG, OmpR 类型 transcriptional 使活跃之物,和罐头调整被导致由人工模仿中等 XVM2,但是在富有的中等 NYG 镇压了。在这研究,在 Xanthomonas campestris pv 的 hrpG 的一个地点特定的变化。campestris (Xcc ) 被指导 PCR 的点傻瓜发育不全产生并且被它的显型和 transcriptional 表示分析描绘。结果显示 E45K 变异 hrpG 显示了在抑制媒介 NYG 组成地表示的所有 hrp 基因。植物测试证明那变异的 hrpG 提高了预定和过分敏感的反应(HR ) 的紧张在上上非招待植物辣椒,但是没在文化媒介和植物影响 Xcc 的生长。E45K 变化没引起 exopolysaccharide 绗维素酶和淀粉酶的生产的重要变化,但是在里面禁止了细胞外的朊酶的分泌物。这异种 8004 比对在学习 transcriptional 规定的 vitroand 识别 hrp 家属受动器的野类型更合适染色体宽。 | JIANG Bole XU Rongqi LI Xianzhen WEI Hongyu BAI Faan HU Xi HE Yongqiang TANG Jiliang | 2006 | Progress in Natural Science:Materials International2006，16，5： | 3 |
| 8 | Regulation of eight avr genes by hrpG and hrpX in Xanthomonas campestris pv. campestris and their role in pathogenicity显示文摘Eight putative avirulence genes in Xanthomonas campestris pv. campestris (Xcc) strain 8004 were characterized by Tn5gusA5 mutagenesis and gene expression analysis. The virulence test of mutants on Chinese radish showed that all mutants in individual avr genes except avrBs2 mutant were not significantly different from the wild type in virulence. The avrBs2 mutant showed reduced virulence and bacterial growth in planta. Gene expression analysis using β-glucuronidase as reporter indicated that avrBs1.1,avrBs1,avrXccB,avrXccC,avrXccE1 were regulated by hrpG, whereas avrXccA1, avrXccA2 and avrBs2 were not. RT-PCR analysis showed that all hrpG-regulated genes except avrBs1 were also regulated by hrpX. In addition, it was demonstrated that avrBs1 was responsible for elicitation of a type III dependent hypersensitive reaction (HR) on nonhost plant pepper ECW-10R, and wild type Xcc 8004 was unable to cause HR on pepper ECW-20R. | XU Rongqi LI Xianzhen WEI Hongyu JIANG Bole LI Kai HE Yongqiang FENG Jiaxun TANG jiliang | 2006 | Progress in Natural Science:Materials International2006，16，12： | 2 |
| 9 | The intervention effects of Lactobacillus casei LC2W on Escherichia coli O157:H7-induced mouse colitis显示文摘This study investigated the intervention effects of Lactobacillus casei LC2W in murine(SPF C57BL/c)challenge infection models induced by Escherichia coli O157:H7.Mice were fed streptomycin with water for 3 days prior to intragastric gavage by E.coli O157:H7(Control)or L.casei LC2W together with E.coli O157:H7(Intervention)to explore the role of L.casei LC2W by biochemical indicators,histological evaluation,expression of colonic pro-inflammatory and intestinal barrier factors related to enteritis.Results showed that the administration of L.casei LC2W was able to alleviate the symptoms of colitis induced by E.coli O157:H7,exhibiting lower weight loss as well as more intact colon tissue.Furthermore,L.casei LC2W could down-regulate the expression of pro-inflammatory cytokines(TNF-α,IL-6,and IL-1β)and protect the intestinal barrier function by improving the level of MUC2,ZO-1 and E-cadherin 1 compared to the control group.These results demonstrate that L.casei LC2W can reduce the severity of E.coli O157:H7 infection,and suggest L.casei LC2W may maintain the immune balance and intestinal barrier to reduce colitis.In addition,we found the effect of intervention is similar to that of prevention,which is better than that of treatment. | Guangqiang Wang Hongyu Tang Ying Zhang Xiang Xiao Yongjun Xia Lianzhong Ai | 2020 | Food Science and Human Wellness2020，9，3： | 2 |
| 10 | Auxiliary Teeth Design to Reduce Short-Circuit Current in Permanent Magnet Generators显示文摘In this paper,a new auxiliary teeth structure is proposed for fault-tolerant permanent magnet(PM)generators,which can reduce the short-circuit currents.Firstly,the short-circuit current and the phase to phase isolation of the fault-tolerant generator are analyzed briefly.Secondly,the auxiliary teeth structure is optimized to improve fault-tolerant capability.Then,the PM generators with different stator structures are compared to evaluate the proposed auxiliary teeth structure.Four critical generator parameters are investigated,i.e.back-electromotive forces,short-circuit currents,stator magneto motive force(MMF)harmonics,and torque performances.The results show that the proposed structure has better fault-tolerant capability than the conventional two-layer windings.Moreover,the stator MMF harmonics can be suppressed.Furthermore,the cogging torque and torque ripple can be suppressed by adopting the proposed structure.Finally,the simulated results are given to validate the theoretical analysis. | Yong He Wenxiang Zhao Hongyu Tang Jinghua Ji | 2020 | CES Transactions on Electrical Machines and Systems2020，4，3： | 2 |
| 11 | Amplified spontaneous emission, optical waveguide and polarized emission based on 2,5-diaminoterephthalates显示文摘A series of 2,5-diaminoterephthalates with a simple structure were synthesized through one-step reaction, and their bar-shaped single crystals with a large size and a smooth surface have been obtained via the solvent-evaporation method. These crystals exhibit bright emission with fluorescence quantum yields higher than 0.2. They display the waveguide property, and low optical loss coefficients for waveguide have been determined for the crystal of one compound. In addition, the crystal can cause linear polarization of the light emitted from it, with a high polarization contrast of 0.70. Most importantly, these crystals can realize amplified spontaneous emission(ASE), including the red ASE, with appreciable energy thresholds of 72–198 k W/cm^2 and high gain coefficients, which suggests the potential of these crystals for the application in organic solid-state lasers. | Baolei Tang Zuolun Zhang Huapeng Liu Hongyu Zhang | 2017 | Chinese Chemical Letters2017，28，11： | 1 |
| 12 | Capacitive properties of PANI/MnO 2 synthesized via simultaneous-oxidation route显示文摘 | Jie Zhang Dong Shu Tianren Zhang Hongyu Chen Haimin Zhao Yongsheng Wang Zhenjie Sun Shaoqing Tang Xueming Fang Xiufang Cao | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 13 | Nucleobase-crosslinked poly(2-oxazoline) nanoparticles as paclitaxel carriers with enhanced stability and ultra-high drug loading capacity for breast cancer therapy显示文摘Poly(2-oxazoline)(POx)has been regarded as a potential candidate for drug delivery carrier to meet the challenges of nanomedicine clinical translation,due to its excellent biocompatibility and self-assembly properties.The drug loading capacity and stability of amphiphilic POxs as drug nanocarriers,however,tend to be insufficient.Herein,we report a strategy to prepare nucleobase-crosslinked POx nanoparticles(NPs)with enhanced stability and ultra-high paclitaxel(PTX)loading capacity for breast cancer therapy.An amphiphilic amine-functionalized POx(PMBEOx-NH_(2))was firstly prepared through a click reaction between cysteamines and vinyl groups in poly(2-methyl-2-oxazoline)-block-poly(2–butyl–2-oxazoline-co-2-butenyl-2-oxazoline)(PMBEOx).Complementary nucleobase-pairs adenine(A)and uracil(U)were subsequently conjugated to PMBEOx-NH2 to give functional POxs(POxA and POxU),respectively.Due to the nucleobase interactions formed between A and U,NPs formed by POxA and POxU at a molar ratio of 1:1 displayed ultrahigh PTX loading capacity(38.2%,PTX/POxA@U),excellent stability,and reduced particle size compared to the uncross-linked PTX-loaded NPs(PTX/PMBEOx).Besides the prolonged blood circulation and enhanced tumor accumulation,the smaller PTX/POxA@U NPs also have better tumor penetration ability compared with PTX/PMBEOx,thus leading to a higher tumor suppression rate in two murine breast cancer models(E0711 and 4T1).These results proved that the therapeutic effect of chemotherapeutic drugs could be improved remarkably through a reasonable optimization of nanocarriers. | Si Dong Sheng Ma Hongyu Chen Zhaohui Tang Wantong Song Mingxiao Deng | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 1 |
| 14 | Hydrogen Reduction of Tungsten Oxides Part Ⅱ:Reduction of WO_(2.72) and WO_2,Transformation of β-W显示文摘The hydrogen reduction of tungsten oxides WO272and WO2 were studied directly using high-temperature X-raydiffraction analysis,The pure β-W was obtained from the reduction of WO272The transformation of β-W to x-W was alsostudied in both hydrogen and nitrogen.The forming condition of β-W from WO2 was discussed.Finally.a complete schematicdiagram of reduction of tungsten oxides was given in this paper. | Tang Xinhe Cao Rongjiang Chen Hongyu Sun Xu General Research Institute for Non-ferrous Metals,Beijing | 1990 | Rare Metals1990，10，1： | 1 |
| 15 | Linkages of flow regime and micro-topography:prediction for non-native mangrove invasion under sea-level rise显示文摘Flow regime is a key driver of invasive aquatic organisms,and the invasiveness of mangrove species may be simultaneously attributed to plant traits and flowing hydrological conditions at the estuary scale.We focused on hydrological and topographic conditions for a non-native mangrove species,Sonneratia apetala,in Zhangjiang Estuary of Fujian,China.A hydrological model and a micro-topographic model were used to predict its dispersal and early establishment,and field surveys and simulated experiments were integrated to estimate its future dispersal patterns.The mesohaline mudflat with a salinity of 8~10 PSU at the mangrove seaward edge was the most likely colonization area for S.apetala under current conditions.The south-western region of the estuary with native mangroves was the most likely area for its colonization according to the unstructured-grid finite-volume community ocean model(FVCOM)in September,when the largest tidal currents within a year and the maximum fruit maturity period occur.Approximately 42%of the mudflats throughout the whole estuary may be available for seedling establishment under the future sea-level rise RCP 4.5 scenarios compared with 44%for current establishment;however,the RCP 8.5 scenarios would significantly decrease seedling establishment by 2100 due to serious tidal inundation according to the micro-topographical model. | Luzhen Chen Hongyu Feng Xiaoxuan Gu Ying Dong Peng Cheng Xudong Guo Qiulian Lin Ting Tang Yihui Zhang Xudong Zhu Shengchang Yang | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 16 | Formation mechanism of high-quality reservoirs of Lower Cretaceous volcaniclastic sedimentary rocks in Songliao Basin显示文摘High abundance gas reservoirs were discovered in the volcaniclastic sedimentary rocks of Wangfu faulted depression in Songliao Basin,but the distribution pattern and formation mechanism of this type of high-quality reservoirs were not clear.In the Shahezi Formation of Well Block CS6 in Wangfu faulted depression,the void space type,reservoir property,pore throat and pore diameters were studied by means of the casting thin section,helium intrusion porosimetry,mercury intrusion porosimetry(MIP)and nuclear magnetic resonance(NMR)methods,moreover,formation mechanism and main controlling factors of the high-quality reservoirs were discussed.Results showed that lithology of high-quality reservoirs consisted of the volcaniclastic sedimentary agglomerate and the volcaniclastic sedimentary breccia,and exhibited the coarsening-upward characteristics.Furthermore,three types(seven subtypes)of void spaces were identified,among which the intragranular vesicles with primary abundant pores were uniquely developed in the high-quality reservoirs of volcaniclastic sedimentary rocks,indicating this high-quality reservoir belonged to the large-pore and small-throat reservoir;porosity and permeability of volcaniclastic sedimentary agglomerate were slightly higher than those of volcaniclastic sedimentary breccia,and both were significantly higher than those of sedimentary rock in the Shahezi Formation,the porosity was closely related with the burial depth.Formation mechanisms of reservoirs in the volcaniclastic sedimentary rocks were release of volatile matters in parent rocks,grain support,dissolution and tectonic modification,among which the former two were the main controlling factors.The high-quality reservoirs over the study area were mainly distributed in the central part of the fan of volcaniclastic sedimentary rocks,among which the grain-supported,coarse-grained volcaniclastic sedimentary rocks with high content of intragranular vesicular detritus and burial depth less than 3000 m were the most favorable area for development of the high-quality reservoirs. | Huafeng Tang Tan Kong Xiang Liu Di Yang Hongyu Huo Yulong Huang | 2017 | Petroleum Research2017，2，2： | 1 |
| 17 | Spiro-conjugated indenodiarylethenes: enabling steric-induced electronic tuning of photochromic and photoluminescent properties by spiro-conjugation显示文摘Light-operated excited-state photochemical reactions and the resulting photochromic materials have gained significant attention for their promising technological applications in molecular electronic and photonic devices.To obtain photochromic materials(e.g.,diarylethenes)with desired properties,the way to tune energy processes of the excited state is essentially important,from both fundamental and practical viewpoints.The modified diarylethenes mostly focused on structural improvements to achieve efficient photochromism.We report here two new spiro-conjugated indenodiarylethenes(named,SFI-Th and SFI-Sul)with an orthogonally arranged spiroπ-scaffold.The spiro fluorene sterically constrains the free volume of photoactive side aromatic rings,while the spiro-conjugation points toward modulation of the decaying channels of excited-state energy,thus allowing for tuning photochromic performances.These spirodiarylethenes SFI-Th and SFI-Sul are readily accessible with low cost and show distinct photochromic and photoluminescent properties.On one hand,the SFI-Th bearing bisthienyl side rings,is an excellent photochromic switch showing high thermal stability and high fatigue resistance in both solution and amorphous state,likely benefited from steric-induced excited-state energy transfer into reversible photochemical reactions,owing to higherπ-orbital spiro-conjugation between the two molecular halves.On the other hand,the SFI-Sul with bissulfonyl side rings,most notably,displays quantitative photocyclization to yield SFI-Sulc upon excitation.However,the ring-closed SFI-Sulc has an extremely slow photocycloreversion,and meanwhile immediately switches on emissive state with a strong fluorescence(Φf=0.57 in amorphous powder state).We study the modulated roles of spiroπ-scaffold in both cases computationally and experimentally,and attribute the facilitated photochemical reaction to the positively electronic effects of spiro-conjugation,and the photo-responsive radiative transition to the negatively electronic effects of spiro-conjugation,respectively.In all,this work demonstrates that the spiro-conjugation is a new and efficient strategy to deliver excitation energy transfer(EET)for featured photochromic properties,due to its advantage in steric-induced electronic modulation. | Tingting Huang Hongyu Liu Yawen Bang Yanpei Wang Yuan Liang Xinhao Wang Yang Zhang Sheng Xie Zebing Zeng Ben Zhong Tang | 2020 | Science China Chemistry2020，63，11： | 1 |
| 18 | Influence of SiO 2 coating on morphology, phase and upconversion luminescence properties of NaYF 4 :Yb 3+ ,Er 3+ submicrocubes during annealing显示文摘 | Lina Liu Chunjuan Tang Yongsheng Zhang Chunhe Zang Dongmei Zhang Hongyu Xiao Ruifei Qin Zhigang Bao | 2014 | Journal of Alloys and Compounds2014，，： | 1 |
| 19 | Hook Wire Localization of Pulmonary Pure Ground-Glass Opacities for Video-Assisted Thoracoscopic Surgery显示文摘 | Weizhao Huang Hongyu Ye Yingmeng Wu Wei Xu Xuan Tang Yi Liang Junmeng Zheng Haiming Jiang | 2013 | Thorac cardiovasc Surg2013，，： | 1 |
| 20 | Hydrogen Reduction of Tungsten Oxides Part Ⅰ:Reduction of WO_(2.90),W_(20)O_(58) and WO_3显示文摘The hydrogen reduction of tungsten oxides WO2.90,W20O58 and WO3 were directly studied using high temperature X-raydiffraction analysis.The differences between tetragonal WO2.90 and monoclinic W20O58 were discussed.Pure β-W was obtainedfrom oxide WO2.90,while there appears small amount of WO2 during the reduction of W20O58 to β-W. | Tang Xinhe Cao Rongjiang Chen Hongyu Sun Xu General Research Institute for Non-ferrous Metals,Beijing Tang Xinhe now works in Institute of Chemical Metallurgy,Academia Sinica,P.O.Box 353,Beijing,China. | 1989 | Rare Metals1989，9，4： | 1 |
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