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| 1 | Geophysical survey and geodynamic study of crust and upper mantle in the Qinghai-Tibet Plateau显示文摘 | Rui Gao Zhanwu Lu Qiusheng Li Ye Guan Jisheng Zhang Rizheng He Liyan Huang | 2005 | Episodes2005，28，4： | 26 |
| 2 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 3 | Research and development of new neodymium laser glasses显示文摘This work presents a brief introduction on three kinds of newly developed Nd^(3+)-doped laser glasses in Shanghai Institute of Optics and Fine Mechanics(SIOM), China. Two Nd^(3+)-doped phosphate glasses with lower thermal expansion coefficient and thermal shock resistance 4 times higher than that of N31 glass are developed for laser processing.Nd:Silicate and Nd:Aluminate glasses with peak emission wavelength at 1061 and 1065 nm, effective emission bandwidth of 34 and 50 nm, respectively, are developed for Exawatt-class laser system application. Fluorophosphate glasses with low nonlinear refractive index(n_2=0.6–0.86) and long fluorescence lifetime(430–510 μs) are investigated for the purpose of decreasing B integral in high-power laser system. The properties of all these glasses are presented and compared with those of commercial neodymium laser glasses. | Dongbing He Shuai Kang Liyan Zhang Lin Chen Yajun Ding Qianwen Yin Lili Hu | 2017 | High Power Laser Science and Engineering2017，5，1： | 6 |
| 4 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 5 | Nano-and microphytoplankton community characteristics in brown tide bloom-prone waters of the Qinhuangdao coast,Bohai Sea, China显示文摘Since 2009, the newly recorded species Aureococcus anophagefferens has successively induced brown tides in the Qinhuangdao coastal waters of the Bohai Sea. Here, we focus on the phytoplankton community structure in this region and try to point out the biological background characteristics of the outbreaks of successive brown tides. We analyzed species composition,cell abundance, diversity indices and size-fractionated chlorophyll a(Chl-a) concentration monthly from March 2013 to January2014. The phytoplankton community, as observed by microscopy, underwent succession from nano-celled chained diatoms to dinoflagellates in the spring and summer, and then to micro-celled diatoms and nano-celled chained diatoms as the most prominent groups in the subsequent autumn and winter. Canonical correspondence analysis revealed that changes in the abundance of diatoms were related to nutrient availability, especially of nitrogen, while water temperature was the crucial factor influencing the abundance of dinoflagellates and A. anophagefferens. Considering the contribution of nano-celled chained species to the micro-sized Chl-a,small phytoplankton(<20 μm) composed the majority of total Chl-a and were generally abundant during our study. Abundant and diverse small phytoplankton seemed to serve as a background or seedbank for the formation of blooms of A. anophagefferens and other small-celled algae. | XU Xin YU ZhiMing HE LiYan CHENG FangJin CAO XiHua SONG XiuXian | 2017 | Science China Earth Sciences2017，60，6： | 3 |
| 6 | Role of helicity of a-helical antimicrobia peptides to improve specificity显示文摘 | Yibing Huang Liyan He Guirong Li Naicui Zhai Hongyu Jiang Yuxin Chen | 2014 | Protein & Cell2014，5，8： | 3 |
| 7 | Influence of the replacement of alkoxyl with alkylthienyl on photovoltaic properties of two small molecule donors for organic solar cells显示文摘Two benzo[1,2-b:4,5-b￠]dithiophene(BDT)-based small molecule(SM) donor materials with identical conjugated backbones but different substitution groups, named as DRTB-O and DRTB-T, were well explored to demonstrate the influence of the replacement of alkoxy with alkylthienyl on their photovoltaic properties in fullerene-based and fullerene-free organic solar cells(OSCs). The study shows that the two SM donors possess similar absorption spectra and energy levels but different crystalline structures in solid films. The carrier transport property and phase separation morphologies of the blend films have also been fully investigated.By employing PC71 BM as the acceptor, the power conversion efficiency(PCE) of DRTB-O:PC71BM and DRTB-T:PC71BM based devices were 4.91% and 7.08%, respectively. However, by blending with IDIC, the two SM donors exhibited distinctly different photovoltaic properties in fullerene-free OSCs, and the PCE of DRTB-O:IDIC and DRTB-T:IDIC based devices were 0.15% and9.06%, respectively. These results indicate that the replacement of alkoxyl with alkylthienyl in designing SM donor materials plays an important role in the application of fullerene-free OSCs. | Shaoqing Zhang Liyan Yang Delong Liu Chang He Jianqi Zhang Yun Zhang Jianhui Hou | 2017 | Science China Chemistry2017，60，10： | 2 |
| 8 | A novel purification technique for noble gas isotope analyses of authigenic minerals显示文摘高贵、活跃的气体为高贵煤气的同位素分析在煤气的抽取期间被免除地质的样品。活跃气体应该为分析在 inletting 前被移开到集体分光计。准备系统能在很地质的样品上面清洗的正常高贵气体。然而,从油 / 气体地里的沉积岩石的 authigenic 矿物质包含有机物,它不能被正常准备系统清理并且因此影响高贵煤气的分析。我们介绍一个新奇煤气的纯化系统(中华人民共和国专利没有。ZL201320117751.2 ) ,它与不同吸收并且排除包括几可逆纯化泵温度。它能很好清理水蒸气,二氧化碳和器官的气体。云母矿物质经常为 40Ar/39 标明日期的 Ar。不能被正常准备系统与二 SAES NP10 ? getters 清理的一件白云母样品(2082MS ) ,在这研究为一个比较实验成为测试样品。实验与接着关上 / 打开的器官的煤气的移动系统(OGRS ) 被分配进 4 节。当 OGRS 为纯化仅仅与二 NP10 getters 被关上时, 40 因为杂质, Ar 紧张与入口时间在曲线增加, 40Ar/39 关于瑥潲潬楧慣?洠湩牥污杯捩污愠摮朠潥档浥捩污攠楶敤据 e 的 Ar | HE LiYan QIU HuaNing SHI HeSheng ZHU JunZhang BAI XiuJuan YUN JianBing | 2016 | Science China Earth Sciences2016，59，1： | 2 |
| 9 | Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagus显示文摘 | Jacques J.G.H.M. Bergman Yue-Ming Zhang Shun He Bas Weusten Liyan Xue David E. Fleischer Ning Lu Sanford M. Dawsey Gui-Qi Wang | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 10 | 3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering显示文摘Acellular tissue matrix scaffolds are much closer to tissue’s complex natural structure and biological characteristics,thus assess great advantages in cartilage engineering.We used rabbit costal cartilage to prepare acellular microfilaments and further 3D porous acellular cartilage scaffold via crosslinking.Poly(_L-lysine)/hyaluronic acid(PLL/HA)multilayer film was then built up onto the surface of the resulting porous scaffold.Furthermore,TGF-β3 was loaded into the PLL/HA multilayer film coated scaffold to obtain a 3D porous acellular cartilage scaffold with sustained releasing of TGF-β3 up to 60 days.The success of this project will provide a new way for the treatment of articular cartilage defects.Meanwhile,the anchoring and on-site sustained releasing of growth factors mediated by polyelectrolyte multilayered film can also provide a new method for improving the biocompatibility and the biofunctionality for other implanted biomaterials. | Yixing Huang Xingfang Yu Linjie He Xin Liao Shuo Wang Zhiyong Qian Liyan Shen | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 11 | Segmentation of scattered point data through a new curvature analysis algorithm 显示文摘 | He Meifang Zhou Laishui Zhang Liyan | 2004 | Journal of Southeast University2004，20，1： | 1 |
| 12 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 13 | Enhanced 2<ce:hsp sp='0.25'/>μm emission of Yb–Ho doped fluorophosphates glass显示文摘 | Meng Wang Chunlei Yu Dongbing He Suya Feng Shunguang Li Liyan Zhang Junjie Zhang Lili Hu | 2010 | Journal of Non-Crystalline Solids2010，，11： | 1 |
| 14 | Programmed cell death induced by modified clay in controlling Prorocentrum donghaiense bloom显示文摘Modified clay(MC),an effective material used for the emergency elimination of algal blooms,can rapidly reduce the biomass of harmful algal blooms(HABs)via flocculation.After that,MC can still control bloom population through indirect effects such as oxidative stress,whichwas initially proposed to be related to programmedcell death(PCD)at molecular level.To further study theMC induced cell death in residual bloom organisms,especially identifying PCD process,we studied the physiological state of the residual Prorocentrum donghaiense.The experimental results showed that flocculation changed the physiological state of the residual cells,as evidenced by growth inhibition and increased reactive oxygen species production.Moreover,this research provides biochemical and ultrastructural evidence showing that MC induces PCD in P.donghaiense.Nuclear changes were observed,and increased caspase-like activity,externalization of phosphatidylserine and DNA fragmentation were detected in MC-treated groups and quantified.And the mitochondrial apoptosis pathway was activated in both MC-treated groups.Besides,the features of MC-induced PCD in a unicellular organism were summarized and its concentration dependent manner was proved.All our preliminary results elucidate the mechanism through which MC can further control HABs by inducing PCD and suggest a promising application of PCD in bloom control. | Hena Ji Zhiming Yu Liyan He Jianan Zhu Xihua Cao Xiuxian Song | 2021 | Journal of Environmental Sciences2021，33，11： | 1 |
| 15 | Variation in Sunshine Duration and Related Aerosol Influences at Shangdianzi GAW Station, China: 1958–2021显示文摘Sunshine duration(SD) is adopted widely to study global dimming/brightening. However, long-term simultaneous measurements of SD and closely related impact factors require further analysis to elucidate how and why SD has varied during the past decades. In this study, a long-term(1958–2021) SD data series obtained from the Shangdianzi Global Atmosphere Watch(GAW) station in China was analyzed to detect linear trends, climatic jumps, and climatic periods in SD using linear fitting, the Mann–Kendall trend test, and the continuous wavelet transform method. Annual SD exhibited steady dimming(-67.3 h decade-1) before 2010, followed by a period of brightening(189.9 h decade-1)during 2011–2020. An abrupt jump in annual SD occurred in 1995, and the annual SD anomaly exhibited significant oscillation with ~3-yr periodicity during 1960–1978. Partial least squares analysis revealed that annual SD anomaly was associated with variations in relative humidity, gale days, cloud cover, and black carbon(BC). Further analysis of the clear-sky daily sunshine percentage(DSP) and simultaneous measurements of aerosol properties, including aerosol optical depth, aerosol extinction coefficient, single scattering albedo(SSA), BC, and total suspended particulates, suggested that variation in DSP was affected primarily by aerosol scattering and absorption. Furthermore, the hourly clear-sky SD at high aerosol loading was approximately 60% and 56% of that at middle and low aerosol loadings, respectively. The pattern of diurnal variation in clear-sky hourly SD, as well as the actual values, can be affected by the fine particulate concentration, aerosol extinction coefficient, and SSA. | Weijun QUAN Zhiqiang MA Ziming LI Xiaolan LI Yingruo LI Xiangao XIA Huaigang ZHOU Hujia ZHAO Zhenfa WANG Weiwei PU Fan DONG Di HE Liyan ZHOU Qingfeng SHI Wenyan WANG Fang JIA | 2023 | Journal of Meteorological Research2023，37，4： | 0 |
| 16 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 17 | Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice显示文摘Hearing impairment constitutes a global public health problem with severe social,political,and economic consequences,and the World Health Organization estimates that about 466 million individuals globally have some degree of hearing loss.Genetic factors account for about half of all deafness cases.Currently,more than 100 genes are known to be involved in hearing loss,but the underlying molecular mechanisms behind these deafness genes have not been fully characterized.The main clinical treatment for deafness is hearing aids and cochlear implants,but their efficacy depends heavily on the quantity and quality of residual hair cells(HCs)and spiral ganglion neurons and has only limited auditory effects. | Cheng Cheng Jieyu Qi Liyan Zhang He Li Jie Lu Siyu Li Zhong Zhang Yue Qiu Chen Zhang Lulu Jiang Chaorong Yu Xia Gao Phillip I.Bird Renjie Chai | 2023 | Journal of Genetics and Genomics2023，50，2： | 0 |
| 18 | Corrigendum to“Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice”[Journal of Genetics and Genomics(2023)50,122-125]显示文摘This corrigendum clarifies information in the article'Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice'by Cheng et al.(2023).In the author list,the author'Cheng Cheng'should be corrected into'Cheng Cheng'. | Cheng Cheng Jieyu Qi Liyan Zhang He Li Jie Lu Siyu Li Zhong Zhang Yue Qiu Chen Zhang Lulu Jiang Chaorong Yu Xia Gao Philip I.Bird Renjie Chai | 2023 | Journal of Genetics and Genomics2023，50，6： | 0 |
| 19 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 20 | Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines显示文摘The ongoing global pandemic of coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),has caused devastating impacts on the public health and the global economy.Rapid viral antigenic evolution has led to the continual generation of new variants.Of special note is the recently expanding Omicron subvariants that are capable of immune evasion from most of the existing neutralizing antibodies(nAbs).This has posed new challenges for the prevention and treatment of COVID-19.Therefore,exploring broad-spectrum antiviral agents to combat the emerging variants is imperative.In sharp contrast to the massive accumulation of mutations within the SARS-CoV-2 receptor-binding domain(RBD),the S2 fusion subunit has remained highly conserved among variants.Hence,S2-based therapeutics may provide effective cross-protection against new SARS-CoV-2 variants.Here,we summarize the most recently developed broad-spectrum fusion inhibitors(e.g.,nAbs,peptides,proteins,and small-molecule compounds)and candidate vaccines targeting the conserved elements in SARS-CoV-2 S2 subunit.The main focus includes all the targetable S2 elements,namely,the fusion peptide,stem helix,and heptad repeats 1 and 2(HR1-HR2)bundle.Moreover,we provide a detailed summary of the characteristics and action-mechanisms for each class of cross-reactive fusion inhibitors,which should guide and promote future design of S2-based inhibitors and vaccines against new coronaviruses. | Liyan Guo Sheng Lin Zimin Chen Yu Cao Bin He Guangwen Lu | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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