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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 4 | Delay-range-dependent stability for systems with time-varying delay显示文摘 | He Y Wang Q G Lin C | 2007 | Automatica2007，43，： | 1 |
| 5 | Study of the interaction between terazosin and serum albumin synchronous fluorescence determination of terazosin显示文摘 | Jiang C Q Gao M X He H X | 2002 | Analytica Chimica Acta2002，452，： | 1 |
| 6 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 7 | Multiferroic BiFeO3 thin films prepared via a simple sol-gel method显示文摘 | Wang Y Jiang Q H He H C | | 0，，14： | 1 |
| 8 | The Effect of Concentration of 'Dy3 + Ions on Luminescence Properties of Y2 02 S : Dy3 + , Mg2 + , Ti4 + Phosphors 显示文摘 | Huang P He X Q Cui C E | 2013 | Ceramics International2013，40，5： | 1 |
| 9 | A mixed microscopic meth- od for differentiating seven species of 'Bixie' -related Chinese ma- teria medica显示文摘 | Tang Y N He X C Chen Q L | 2014 | Microsc Res Tech2014，77，1： | 1 |
| 10 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 11 | The mechanism of starch granule reacted with OSA by phase transition catalyst in aqueous medium显示文摘 | WANG C HE X W HUANG Q | 2013 | Food Chemistry2013，141，4： | 1 |
| 12 | 2007b Mechanism of heterogeneous reaction of carbonyl sulfide on magnesium oxide 显示文摘 | Liu Y C He H Xu W Q | 2007 | J Phys Chem (A)2007，111，： | 1 |
| 13 | Modelling dynamic urban expansion processes incorporating a potential model with cellular automata显示文摘 | He C Y Okada N Zhang Q F | 2008 | Landscape and Urban Planning2008，86，1： | 1 |
| 14 | Diabctes increases expression of ICAM after a brief period of cerebroischemia显示文摘 | Dillg C He Q Li PA | 2005 | J Neuroimmlmol2005，161，： | 1 |
| 15 | An epoxy resin copolymer with zero shrinkage显示文摘 | He P S Zhou Z Q Pan C Y | 1989 | J Mater Sci1989，，24： | 1 |
| 16 | Crystallization behavior and foaming properties of polypropylene containing ultra-high molecular weight polyethylene under supercritical carbondiox- ide显示文摘 | XIN C L HE Y D LI Q C | 2011 | Journal of Applied Polymer Science2011，119，3： | 1 |
| 17 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice显示文摘 | Li Y B Fan C C Xing Y Z Jiang Y H Luo L J Sun L Shao D Xu C J Li X H Xiao J H He Y Q Zhang Q F | 2011 | Nature genetics2011，2，43： | 1 |
| 18 | Materials Characterization显示文摘 | Feng J C Wu H Q He J S | 2005 | 54:992005，54，： | 1 |
| 19 | Multifunctional me- soporous silica material used for detection and adsorp- tion of Cuz+ in aqueous solution and biological applica- tions in vitro and in vivo 显示文摘 | Meng Q Zhang X He C | 2010 | Adv Funct Mater2010，20，12： | 1 |
| 20 | Identification of atomic steps at AlSb/GaAs hetero-epitaxial interface using geometric phase method by high-resolution electron microscopy显示文摘 | He X Q Wen C Duan X F | | 0，，03： | 1 |
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