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| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 2 | Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/ eIF2a/ATF4/CHOP Signaling Pathway显示文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke. | Yueyong Li Yingjun Zhang Huangde Fu Huadong Huang Qifeng Lu Houji Qin Yingning Wu Huatuo Huang Guizhen Mao Zhongheng Wei Pinhu Liao | 2020 | Neuroscience Bulletin2020，36，2： | 12 |
| 3 | Ecological provinces of spring phytoplankton in the Yellow Sea:species composition显示文摘Phytoplanktonic ecological provinces of the Yellow Sea(31.20°–39.23°N, 121.00°–125.16°E) is derived in terms of species composition and hydrological factors(temperature and salinity). 173 samples were collected from 40 stations from April 28 to May 18, 2014, and a total of 185 phytoplanktonic algal species belonging to 81 genera of 7phyla were identified by Uterm?hl method. Phytoplankton abundance in surface waters is concentrated in the west coast of Korean Peninsula and Korea Bay, and communities in those areas are mainly composed of diatoms and cyanobacteria with dominant species of Cylindrotheca closterium, Synechocystis pevalekii, Chroomonas acuta,Paralia sulcata, Thalassiosira pacifica and Karenia mikimotoi, etc. The first ten dominant species of the investigation area are analyzed by multidimensional scaling(MDS) and cluster analysis, then the Yellow Sea is divided into five provinces from Province I(P-I) to Province V(P-V). P-I includes the coastal areas near southern Liaodong Peninsula, with phytoplankton abundance of 35 420×10~3–36 163×10~3 cells/L and an average of 35 791×10~3 cells/L, and 99.84% of biomass is contributed by cyanobacteria. P-II is from Shandong Peninsula to Subei coastal area. Phytoplankton abundance is in a range of 2×10~3–48×10~3 cells/L with an average of 24×10~3cells/L, and 63.69% of biomass is contributed by diatoms. P-III represents the Changjiang(Yangtze River) Diluted Water. Phytoplankton abundance is 10×10~3–37×10~3 cells/L with an average of 24×10~3 cells/L, and 73.14% of biomass is contributed by diatoms. P-IV represents the area affected by the Yellow Sea Warm Current.Phytoplankton abundance ranges from 6×10~3 to 82×10~3 cells/L with an average of 28×10~3 cells/L, and 64.17% of biomass is contributed by diatoms. P-V represents the cold water mass of northern Yellow Sea. Phytoplankton abundance is in a range of 41×10~3–8 912×10~3 cells/L with an average of 1 763×10~3 cells/L, and 89.96% of biomass is contributed by diatoms. Overall, structures of phytoplankton community in spring are quite heterogeneous in different provinces. Canonical correspondence analysis(CCA) result illustrates the relationship between dominant species and environmental factors, and demonstrates that the main environmental factors that affect phytoplankton distribution are nitrate, temperature and salinity. | ZHANG Shan LENG Xiaoyun FENG Yuanyuan DING Changlin YANG Yang WANG Jing WANG Houjie SUN Jun | 2016 | Acta Oceanologica Sinica2016，35，8： | 7 |
| 4 | Grain-Size Distribution of Surface Sediments in the Bohai Sea and the Northern Yellow Sea: Sediment Supply and Hydrodynamics显示文摘The grain-size distribution of surface sediments in the Bohai Sea(BS) and the northern Yellow Sea(NYS), and its relationship with sediment supply and hydrodynamic environment were investigated based on grain-size compositions of surface sediments and modern sedimentation rates. The results showed that the surface sediments in the BS and the NYS were primarily composed of silty sand and clayey silt with a dominant size of silt. In addition, the Yellow River delivered high amount of water and sediments to the BS, and they are dominated in surface sediments(mainly silt) in the Bohai Bay, the Yellow River mouth, the center of the BS, and the north coast of Shandong Peninsula. The coarse-grained sediments were mainly deposited at the river mouth due to the estuarine filtration and physical sorting. Meanwhile, there was a significant relationship among the modern sedimentation rate, the surface sediment grain size distribution and sediment transport pattern. The areas with coarser surface sediments generally corresponded low sedimentation rates because of strong erosion;whereas the sedimentation rate was relatively high at the place that the surface sediments were fine-grained. Furthermore, the grain-size trend analysis showed that the areas with fine-grained surface sediments such as the mud area in the central BS and the upper Liaodong Bay were the convergent centers of surface sediments, except for the Bohai Bay and the subaqueous Yellow River Delta where offshore sediment transport was evident. | YUAN Ping WANG Houjie WU Xiao BI Naishuang | 2020 | Journal of Ocean University of China2020，19，3： | 6 |
| 5 | Differential AR algorithm for packet delay prediction显示文摘不同延期预言算法在多媒体通讯,因为它的低复杂性,线性预言在之中是吸引人的被使用了。AR (汽车回归) 算法是有低计算费用的传统的,当时 NLMS (使最不吝啬的平方正常化) 算法是更精确的。在这篇论文,指 ARIMA (与动人的一般水准综合的汽车回归) 模型,一个微分 AR 算法(DIAR ) 基于 AR 和 NLMS 算法的分析被建议。没有增加计算复杂性,新算法的预言精确比 AR 算法的高关于 5-10 db。与 NLMS 算法相比,它的精确稍微平均由 0.1 db 改善,但是算法复杂性减少超过 90% 。我们的模拟和测试也证明这个方法显著地改进平均端对端的延期和包损失比率的表演。 | JIAO Liangbao ZHANG De BI Houjie | 2006 | Progress in Natural Science:Materials International2006，16，4： | 5 |
| 6 | Rapid shifts of the river plume pathway off the Huanghe (Yellow) River mouth in response to water-sediment regulation scheme in 2005显示文摘Freshwater plume represents a key passage for the river to deliver sediment to the coastal ocean. A wa- ter-sediment regulation scheme was implemented for the Huanghe River in 2005; in order to examine the effect of such an activity on the river plume dynamics, three cruises were carried out off the Huanghe River mouth. The prelimi- nary results of the in-situ measurements suggested that the plume pathway shifted rapidly during the period of less than twenty days, which was confirmed by satellite remote sensing data in the same period. The rapid shifts were resulted from intensive interactions between river discharge and the vary- ing bathymetry in the river mouth area. A large amount of river sediment was delivered to the coastal region during this period and mostly deposited in the mouth bar area due to jet-flow deceleration, forming a cluster of mouth bars across the river mouth, which caused the rapid shifts of the plume pathway. | WANG Houjie YANG Zuosheng BI Naishuang LI Haidong | 2005 | Chinese Science Bulletin2005，50，24： | 5 |
| 7 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 3 |
| 8 | Geochemical and Grain-Sized Implications for Provenance Variations of the Central Yellow Sea Muddy Area Since the Middle Holocene显示文摘Based on high-resolution analysis to a 280-cm long sediment core obtained from the muddy area in the central Yellow Sea, we examined the provenance of muddy sediments and discussed the changing marine sedimentary environment since the middle Holocene. The results indicated that fine-grained sediments in the muddy area were mainly derived from the Huanghe(Yellow River) and Changjiang(Yangtze River) with considerable stepwise variations during the past 6.6 kyr. The Yellow Sea Warm Current was initiated at 6 kyr when the sea level was high together with the enhanced East Asian Winter Monsoon. These in combination established the framework of shelf circulation in the Yellow Sea that began to trap the river-derived fine-grained sediments. From 4.9 kyr to 2.8 kyr, both the Kushiro Current and East Asian Monsoon were significantly weakened, reducing the delivery of Changjiang sediments to the muddy area. As a result, the sediments were mainly originated from the Huanghe. From 2.8 kyr to 1.5 kyr the continuously weakened East Asian Winter Monsoon and enhanced Yellow Sea Warm Current entrapped more fine-grain sediments. Whereas the enhanced East Asian Winter Monsoon and the human caused increase in sediment load of the Huanghe since 1.5 kyr, and direct delivery of Huanghe sediments to the Yellow Sea during 1128–1855 AD might dominated the sedimentation in the study area. The stepwise variations of the sediment provenance and composition of the Central Yellow Sea muddy sediments are of importance to understanding the formation of muddy deposit in the central Yellow Sea and the associated variations of marine environment since the middle Holocene. | AI Lina HAN Zongzhu WU Xiao SAITO Yoshiki WANG Houjie | 2020 | Journal of Ocean University of China2020，19，3： | 3 |
| 9 | The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer显示文摘The inhibitory receptor signal regulatory protein-α(Sirpα)is a myeloid-specific immune checkpoint that engages the“don’t eat me”signal CD47,which is expressed on tumor and normal tissue cells.However,the profile and regulatory mechanism of Sirpαexpression in tumor-associated macrophages(TAMs)are still not clear.Here,we found that the expression of Sirpαin TAMs increased dynamically with colorectal cancer(CRC)progression.Mechanistically,CRC cell-derived lactate induced the nuclear translocation of the transcription factor Ap-2αfrom the cytoplasm in TAMs.Ap-2αfunctioned as a transcription factor for Elk-1 by binding to the conserved element GCCTGC located at−1396/−1391 in the mouse Elk-1 promoter.Subsequently,the Elk-1 protein bound to two conserved sites,CTTCCTACA(located at−229/−221)and CTTCCTCTC(located at−190/−182),in the mouse Sirpαpromoter and promoted Sirpαexpression in TAMs.Functionally,the macrophage-specific knockout of Ap-2αnotably promoted the phagocytic activity of TAMs and suppressed CRC progression,whereas these effects were prevented by the transgenic macrophage-specific expression of Elk-1,which regulated TAM phagocytosis and CRC development in a Sirpα-dependent manner.Furthermore,we showed that Elk-1 expression was positively correlated with Sirpαexpression in TAMs and was associated with poor survival in CRC patients.Taken together,our findings revealed a novel mechanism through which CRC evades innate immune surveillance and provided potential targets for macrophage-based immunotherapy for CRC patients. | Xiaojiao Wang Xi Luo Chuan Chen Ye Tang Lian Li Banghui Mo Houjie Liang Songtao Yu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 10 | Stepwise decreases of the Huanghe (Yellow River) sediment load (1950–2005): Impacts of climate change and human activities显示文摘 | Houjie Wang Zuosheng Yang Yoshiki Saito J. Paul Liu Xiaoxia Sun Yan Wang | 2006 | Global and Planetary Change2006，，3： | 2 |
| 11 | Numerical modeling of hyperpycnal flows in an idealized river mouth显示文摘 | Yan Wang Houjie Wang Naishuang Bi Zuosheng Yang | 2011 | Estuarine Coastal and Shelf Science2011，，3： | 1 |
| 12 | Neoadjuvant chemothcrapy lessens surgical morbidity in advanced ovarian cancer and leads to improved survival in stage IV disease显示文摘 | HouJY Kelly MG Yu H | 2007 | Gynecol Oncol2007，105，1： | 1 |
| 13 | MOTION-BASED REGION GROWING SEGMENTATION OF IMAGE SEQUENCES显示文摘This paper proposes a motion-based region growing segmentation scheme for the object-based video coding, which segments an image into homogeneous regions characterized by a coherent motion. It adopts a block matching algorithm to estimate motion vectors and uses morphological tools such as open-close by reconstruction and the region-growing version of the watershed algorithm for spatial segmentation to improve the temporal segmentation. In order to determine the reliable motion vectors, this paper also proposes a change detection algorithm and a multi-candidate pro- screening motion estimation method. Preliminary simulation results demonstrate that the proposed scheme is feasible. The main advantage of the scheme is its low computational load. | Lu Guanming Bi Houjie Jiang Ping(Department of Information Engineering, Nanjing University ofPosts & Telecommunications, Nanjing 210003) | 2000 | Journal of Electronics(China)2000，17，1： | 1 |
| 14 | Effect of human‐controlled hydrological regime on the source, transport, and flux of particulate organic carbon from the lower Huanghe (Yellow River)显示文摘 | Bangqi Hu Jun Li Naishuang Bi Houjie Wang Helong Wei Jingtao Zhao Luhua Xie Liang Zou Ruyong Cui Song Li Ming Liu Guogang Li | 2015 | Earth Surf. Process. Landforms2015，，8： | 1 |
| 15 | Impact of artificial water and sediment discharge regulation in the Huanghe (Yellow River) on the transport of particulate heavy metals to the sea显示文摘 | Naishuang Bi Zuosheng Yang Houjie Wang Congliang Xu Zhigang Guo | 2014 | Catena2014，，： | 1 |
| 16 | Effects of dams on water and sediment delivery to the sea by the Huanghe (Yellow River): The special role of Water-Sediment Modulation显示文摘 | Yu Yonggui Shi Xuefa Wang Houjie Yue Chengkun Chen Shenliang Liu Yanguang Hu Limin Qiao Shuqing | 2014 | Anthropocene2014，，： | 1 |
| 17 | Interannual and seasonal variation of the Yellow River water discharge over the past 50 years: Connections to impacts from ENSO events and dams 显示文摘 | WANG Houjie YANG Zuosheng SAITO Y | 2006 | Global and Planetary Change2006，50，34： | 1 |
| 18 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 1 |
| 19 | Silencing Fibronectin Extra Domain A Enhances Radiosensitivity in Nasopharyngeal Carcinomas Involving an FAK/Akt/JNK Pathway显示文摘 | Juanjuan Ou Feng Pan Peiliang Geng Xing Wei Ganfeng Xie Jia Deng Xueli Pang Houjie Liang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 20 | Stepwise decreases of the Huanghe (Yellow River) sediment load,(1950-2005):Impacts of climate change and human activities显示文摘 | Houjie Wang Zuosheng Yang Yoshiki Saito | | 0，，57： | 1 |
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