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| 1 | The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia显示文摘The programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)pathway is critical for normal pregnancy by promoting regulatory T(Treg)cell development and inhibiting the Th17 response.However,the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia(PE)is an enigma.In this study,decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE.The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation,differentiation and transdifferentiation.First,decreased PD-1 expression might contribute to a higher Th17 cell frequency by promoting proliferation in PE.Second,the percentages of Treg but not Th17 cells differentiated from peripheral naive CD4+T cells were increased by PD-L1 Fc administration.This effect was accompanied by decreased PI3K/AKT/m-TOR and increased PTEN mRNA expression and was completely reversed by PD-1 blockade.Finally,the percentage of IL-17-producing Treg cells increased and was positively associated with the Th17 cell frequency in PE.Increased RORγt and IL-17 but not Foxp3 and IL-10 mRNA expression by Treg cells was observed with PD-1 blockade.Similar findings occurred when Treg cells were exposed to IL-6/IL-23/IL-1βand were reversed by PD-L1 Fc.Taken together,our findings indicate that the PD-1/PD-L1 pathway contributes to the Treg/Th17 imbalance via‘one-two punch’approaches:(i)promoting Th17 cell proliferation,(ii)inhibiting Treg cell differentiation and(iii)enhancing Treg cell plasticity into Th17 cells in PE.The therapeutic value of PD-L1 Fc for PE treatment will be explored in the future. | Yonghong Zhang Zhaozhao Liu Mei Tian Xiaohui Hu Liling Wang Jinlu Ji Aihua Liao | 2018 | Cellular & Molecular Immunology2018，15，7： | 21 |
| 2 | Safety Research in Traditional Chinese Medicine: Methods, Applications, and Outlook显示文摘Traditional Chinese medicine (TCM) is a medical system that has collected and summarized abundant clinical experience over its long history of more than 2000 years. However, the frequent occurrence of TCM-induced adverse reactions has hindered the modernization and internationalization of TCM, while attracting increasing attention from around the world. Unlike chemical drugs and biological agents, the difficulties involved in research on the toxicity and safety of TCM mainly include the complexity of its components and the unpredictability of drug–body interactions. Much of TCM, which has overall therapeutic effects, has the typical mechanisms of multiple components, multiple pathways, and multiple targets. While considering the gradualness and unpredictability of TCM toxicity, the ambiguity of toxicants and safe dosage, and individual differences during long-term TCM administration, we have systematically established key techniques for the toxicity assessment of TCM. These techniques mainly include TCM toxicity discovery in an early phase, based on a combination of drug toxicology genomics and metabolomics;methods to identify dose–toxicity relationships in TCM;and integrated techniques for the exploration of TCM interactions, such as fast-screening tests based on drug-metabolizing enzymes and receptor pathways. In particular, we have developed a new technical system for TCM safety evaluation using molecular toxicology, which has been validated well in research on TCM compatibility contraindication, quality control, and allergen discovery. The application of this key technical platform is introduced here in detail. This application includes model organisms, toxicant biomarkers, a magnetic suspension technique, and the application of network toxicology and computational toxicology in research on the toxicity of Fructus toosendan, Semen cassiae, Polygonum multiflorum, and Fructus psoraleae. | Yue Gao Aihua Liang Xiaohui Fan Limin Hu Feiran Hao Yubo Li | 2019 | Engineering2019，5，1： | 19 |
| 3 | Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice显示文摘Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular functions.This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics strategy.The effects of APS were determined in eight-week high-fat diet(HFD)-fed obese mice.Then,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was performed.The potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic disorders.Our results first confirmed the metabolic benefits of APS in obese mice.Then,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by APS.Further study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)accumula-tion.It was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 cells.Moreover,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed mice.In conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in vivo.Our results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides. | Bingbing Li Ying Hong Yu Gu Shengjie Ye Kaili Hu Jian Yao Kan Ding Aihua Zhao Wei Jia Houkai Li | 2022 | Engineering2022，8，2： | 6 |
| 4 | Effect of transverse static magnetic field on radial microstructure of hypereutectic aluminum alloy during directional solidification显示文摘The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field. | Shaodong Hu Long Hou Kang Wang Zhongmiao Liao Wen Zhu Aihua Yi Wenfang Li Yves Fautrelle Xi Li | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
| 5 | Preparation of PE/MMT nanocomposite by monomer intercalation and in situ copolymerization显示文摘The catalyst {[(2-ArN=C(Me))2C5H3N]FeCl3} (Ar = 2-C6H4(i-Pr)) with methylaluminoxane (MAO) as co-catalyst was intercalated between layers of montmorillonite (MMT) for ethylene oligomerization. Metallocene catalyst Me2Si(Ind)2ZrCl2 and MAO was then added to form a dual functional catalytic system. A PE/MMT nanocomposite was prepared by copolymerization of ethylene with α-olefins produced in situ from ethylene over the dual functional catalytic system. The catalytic system was of high polymeric activity. The resultant PE/MMT nanocomposites were stable and got increases in tensile strength and temperature of maximum weight loss (Tonset). | GUO Cunyue MA Zhi ZHANG Mingge HE Aihua KE Yucai HU Youliang | 2002 | Chinese Science Bulletin2002，47，15： | 4 |
| 6 | Catalytic ozonation performance and surface property of supported Fe304 catalysts dispersions显示文摘 | Zhendong YANG Aihua LV Yulun NIE Chun HU | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 3 |
| 7 | Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin显示文摘We applied a combination of inorganic mesoporous silica material,frequently used as drug carriers,and a natural organic polymer alginate(ALG),to establish a sustained drug delivery system for the poorly water-soluble drug Indomethacin(IND).Mesoporous silica nanospheres(MSNs)were synthesized using an organic template method and then functionalized with aminopropyl groups through postsynthesis.After drug loading into the pores of aninopropyl functionalized MSNs(AP-MSNs),IND loaded AP-MSNs(IND-AP-MSNs)were encapsulated by ALG through the ionic interaction.The effects of surface chemical groups and ALG layer on IND release were systematically studied using scanning electron microscopy(SEM),transmission electron microscopy(TEM),nitrogen adsorption,zetapotential analysis and TGA analysis.The surface structure and surface charge changes of the ALG encapsulated AP-MSNs(ALG-AP-MSNs)were also investigated.The results showed that sustained release of IND from the designed drug delivery system was mainly due to the blockage effect from the coated ALG.We believe that this combination will help designing oral sustained drug delivery systems for poorly water-soluble drugs. | Liang Hu Changshan Sun Aihua Song Di Chang Xin Zheng Yikun Gao Tongying Jiang Siling Wang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，4： | 2 |
| 8 | Generalized Consensus of Discrete-Time Multi-Agent Systems with Directed Topology and Communication Delay显示文摘Compared with traditional consensus,this paper studies the generalized consensus problem for discrete-time multi-agent systems with directed topology and communication delay.Novel distributed consensus protocols with and without communication delay are designed.Based on the analysis of error dynamical system and graph theory,the generalized consensus is globally asymptotically achieved under suitable conditions without changing the zero row-sums property of Laplacian matrix in networks.Moreover,the sufficient conditions for generalized consensus of communication delay are obtained under directed connections.Finally,some simulations have been provided to verify the theoretical results. | LIU Huwei CHEN Xin GUO Liuxiao HU Aihua | 2020 | Journal of Systems Science & Complexity2020，33，6： | 2 |
| 9 | Event-triggered bipartite consensus over cooperation-competition networks under DoS attacks显示文摘This paper addresses the bipartite consensus over cooperation-competition networks affected by denial-of-service(DoS) attacks.Consider that a network consists of multiple interactive agents, and the relationship between neighboring agents is cooperative or competitive. Meanwhile, information transmission among the agents is unavailable during the intervals of attacks. In order to save communication resources and exclude the Zeno behavior, an event-triggered scheme depending on the sampled-data information from neighboring agents is proposed, and efficient defense strategies in response to the attacks are put forward.Suppose that the frequency and duration of DoS attacks meet certain requirements, then according to the signed graph theory,the La Salle’s invariance principle, and the convergence of monotone sequences, the results of bipartite consensus via the eventtriggered protocol are provided, which are mainly related to the communication topology of the network, the sampling period,and the threshold parameters in the event-triggered scheme. It is shown that the bipartite consensus is realized even though the DoS attacks take place frequently. Furthermore, this paper discusses the bipartite consensus in the presence of DoS attacks with a random unsuccessful rate. Finally, numerical simulations illustrate the theoretical results. | HU AiHua PARK J H CAO JinDe HU ManFeng LUO YiPing | 2021 | Science China(Technological Sciences)2021，64，1： | 2 |
| 10 | Cluster syn-chronization in directed networks of non-identical systemswith noises via random pinning control 显示文摘 | Hu Aihua Cao Jinde Hu Manfeng | 2014 | Physica A :Statistical Mechanics and its Applications2014，395，4： | 1 |
| 11 | Superhigh selective capture of volatile organic compounds exploiting cigarette butts-derived engineering carbonaceous adsorbent显示文摘Herein,we develop cost-efficient superhigh-performance of engineering carbonaceous adsorbent from cigarette butts using combined wet-impregnated and re-dispersed method of KOH,which optimizes the implant approach of activator,breaking the restriction of selective capture of toluene using traditional activated carbon.The Brunauer-Emmett-Teller(BET)surface area and pore volume of targeted adsorbent can attain 3088 m^(2)·g^(-1) and 1.61 cm^(3)·g^(-1),respectively,by optimizing the temperaturedependent synthetic factor effect of the adsorbent.The adsorption capacity of resultant adsorbent for presenting volatile benzene and toluene shows a positive correlation with increasing carbonization temperature of carbon precursor.Besides,we demonstrated the unsmoked and smoked butts derived adsorbents afford feeble difference in saturated adsorbed capacity of volatile organic compounds(VOCs).The highest adsorption capacity of sample CF-800 for benzene and toluene in CF group is as high as 1268.1 and 1181.6 mg·g^(-1) respectively,slightly higher than that of sample UF-800,but far outperforming reported other adsorbents.The predicted adsorption selectivity of CF-800 and UF-800 for C_(7)H_(8)/H_(2)O(g)using the DIH(difference of isosteric heats)equation reach up to ca.3800 and 7500 respectively,indicating the weak adsorbability of water vapor on the developed adsorbent and greater superiority of the smoked butts derived adsorbents in selective capture of VOCs at low relative humidity in the competitive adsorption process for practical mixed VOCs. | Wenjian Zhu Xuhua Shen Rui Ou Manoj Murugesan Aihua Yuan Jianfeng Liu Xiaocai Hu Zhen Yang Ming Shen Fu Yang | 2022 | Chinese Journal of Chemical Engineering2022，35，6： | 1 |
| 12 | The effect ofcalcium on the treatment of fresh leachate in an expanded granularsludge bed bioreactor 显示文摘 | Liu Jianyong Hu Jun Zhong Jiangping Luo Jinghuan Zhao Aihua Liu Feng Hong Ruijing Qian Guangren Xu Zhiping | 2011 | Bioresource Technology2011，102，： | 1 |
| 13 | The Existence of Generalized Synchronization of Chaotic Systems in Complex Networks 显示文摘 | AIHUA HU ZHENYUAN XU LIUXIAO GUO | 2010 | Chaos2010，20，1： | 1 |
| 14 | Assessment of respiratory support decision and the outcome of invasive mechanical ventilation in severe COVID-19 with ARDS显示文摘Background:The coronavirus disease 2019(COVID-19)is an ongoing pandemic.Invasive mechanical ventilation(IMV)is essential for the management of COVID-19 with acute respiratory distress syndrome(ARDS).We aimed to assess the impact of compliance with a respiratory decision support system on the outcomes of patients with COVID-19-associated ARDS who required IMV.Methods:In this retrospective,single-center,case series study,patients with COVID-19-associated ARDS who required IMV at Zhongnan Hospital of Wuhan University,China,from January 8th,2020,to March 24th,2020,with the final follow-up date of April 20th,2020,were included.Demographic,clinical,laboratory,imaging,and management information were collected and analyzed.Compliance with the respiratory support decision system was documented,and its relationship with 28-day mortality was evaluated.Results:The study included 46 COVID-19-associated ARDS patients who required IMV.The median age of the 46 patients was 68.5 years,and 31 were men.The partial pressure of arterial oxygen(PaO_(2))/fraction of inspired oxygen(FiO_(2))ratio at intensive care unit(ICU)admission was 104 mmHg.The median total length of IMV was 12.0(interquartile range[IQR]:6.0–27.3)days,and the median respiratory support decision score was 11.0(IQR:7.8–16.0).To 28 days after ICU admission,18(39.1%)patients died.Survivors had a significantly higher respiratory support decision score than non-survivors(15.0[10.3–17.0]vs.8.5(6.0–10.3),P=0.001).Using receiver operating characteristic(ROC)curve to assess the discrimination of respiratory support decision score to 28-day mortality,the area under the curve(AUC)was 0.796(95%confidence interval[CI]:0.657–0.934,P=0.001)and the cut-offwas 11.5(sensitivity=0.679,specificity=0.889).Patients with a higher score(>11.5)were more likely to survive at 28 days after ICU admission(log-rank test,P<0.001).Conclusions:For severe COVID-19-associated ARDS with IMV,following the respiratory support decision and assessing completion would improve the progress of ventilation.With a decision score of>11.5,the mortality at 28 days after ICU admission showed an obvious decrease. | Shuhan Cai Fangfang Zhu Hongtao Hu Hui Xiang Dawei Wang Jing Wang Lu Li Xiao Yang Aihua Qin Xin Rao Yun Luo Jianguo Li Kianoush B.Kashani Bo Hu Zhiyong Peng | 2022 | Journal of Intensive Medicine2022，2，2： | 1 |
| 15 | Catalytic ozonation of toxic pollutants over magnetic cobalt and manganese co-doped γ-Fe 2 O 3显示文摘 | Aihua Lv Chun Hu Yulun Nie Jiuhui Qu | 2010 | Applied Catalysis B Environmental2010，，1： | 1 |
| 16 | Adaptive backstepping trajectory tracking control of robotmanipulator显示文摘 | Hu Qinglei Xu Liang Zhang Aihua | 2012 | Journal of the Franklin Institute2012，349，3： | 1 |
| 17 | Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-κB signal pathways显示文摘 | Li Yonghai Chu Niansheng Hu Aihua | 2008 | Exp Mol Pathol2008，84，1： | 1 |
| 18 | Adaptive full state hybrid projective synchronization of chaotic systems with the same and different order显示文摘 | Manfeng Hu Zhenyuan Xu Rong Zhang Aihua Hu | 2007 | Physics Letters A2007，，4： | 1 |
| 19 | Parameters identification and adaptive full state hybrid projective synchronization of chaotic (hyper-chaotic) systems显示文摘 | HU MANFENG XU ZHENYUAN ZHANG RONG HU AIHUA | 2007 | Physics Letters A2007，361，： | 1 |
| 20 | Multi-stable chaotic attractors in generalized synchronization显示文摘 | Hu Aihua Xu Zhenyuan | | 0，，8： | 1 |
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