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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial显示文摘 | Wei Hua Run-Lin Gao Bu-Chang Zhao Jing Wang Xu-Hua Chen Chi Cai Shu Zhang | 2015 | Chinese Medical Journal2015，，19： | 35 |
| 3 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 4 | Telomerase activity in gastric cancer and its clinical implications显示文摘INTRODUCTIONThedevelopmentofcarcinomaresultsfrommultipleindependentgeneticchangesthatactivateprotooncogenesorinactivatetheac... | ZHAN Wen Hua, MA Jin Ping, PENG Jun Sheng, GAO Jing Song, CAI Shi Rong, WANG Jian Ping, ZHENG Zhang Qing and WANG Lei | 1999 | World Journal of Gastroenterology1999，5，4： | 25 |
| 5 | B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma显示文摘AIM:To investigate the expression of B7-H1 in human colorectal carcinoma (CRC) to define its regulating effects on T cells in tumor microenvironment.METHODS:One hundred and two paraffin blocks and 33 fresh samples of CRC tissues were subject to this study.Immunohistochemistry was performed for B7-H1 and CD3 staining in CRC tissues.Ficoll-Hypaque density gradient centrifugation was used to isolate peripheral blood mononuclear cells of fresh CRC tissues;flow cytometry and immunofluorescence staining were used for detection of regulatory T cells.Data was analyzed with statistical software.RESULTS:Costimulatory molecule B7-H1 was found strongly expressed in CRC tissues,localized in tumor cell membrane and cytoplasm,while weak or none expression of B7-H1 was detected in pared normal colorectal tissues.Meanwhile,CD3 positive T cells were found congregated in CRC tumor nest and stroma.Statistic analysis showed that B7-H1 expression level was negatively correlated to the total T cell density in tumor nest (P<0.0001) and tumor stroma (P=0.0200) of 102 cases of CRC tissues.Among the total T cells,a variable amount of regulatory T cells with a clear Foxp3+ (forkhead box P3) staining could be detected in CRC tissues and patients' blood.Interestingly,in the 33 samples (15 cases of B7-H1 high CRC tissues and 18 cases of B7H1 low CRC tissues) of freshly isolated mononuclear cells from CRC tissues,the percentages of CD4+ Foxp3+ and CD8+ Foxp3+ regulatory T cells were found remarkably higher in B7-H1 high CRC tissues than in B7-H1 low CRC tissues (P=0.0024,P=0.0182),indicating that B7-H1 expression was involved in proliferation of regulatory T cell.No significant difference was found in CRC peripheral blood (P=0.0863,P=0.0678).PD-1 is the specific ligand for B7-H1 pathway transferring inhibitory signal to T cell,which is expressed by activated T cell.Our further analysis of PD-1 expression on T cells in CRC tissues showed that conventional T cells (CD4+ Foxp3/CD8+ Foxp3),which was thought to contribute to the anti-tumor immune response,highly expressed PD-1;while regulatory T cells (CD4+ Foxp3+/CD8+ Foxp3) almost failed to express PD-1.The average percentage of PD-1 expression on regulatory T cells was significantly higher than the percentage of PD-1 on conventional T cells (CD4+ Foxp3 T cell,P<0.0001;CD8+ Foxp3 T cell,P<0.0001).The diverse expression of PD-1 might lead to different fate of T cell subsets in B7-H1 over-expression CRC tumor microenvironment.CONCLUSION:B7-H1 expression in tumor cells can in hibit the conventional T cell proliferation in tumor micro environment through the PD-1 expression on conventiona T cells. | Dong Hua Jing Sun Yong Mao Lu-Jun Chen Yu-Yu Wu Xue-Guang Zhang | 2012 | World Journal of Gastroenterology2012，18，9： | 25 |
| 6 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 7 | VIC distributed hydrological model to predict climate change impact in the Hanjiang Basin显示文摘The climate impact studies in hydrology often rely on climate change information at fine spatial resolution. However, the general circulation model (GCM), which is widely used to simulate future climate scenario, operates on a coarse scale and does not provide reliable data on local or regional scale for hydrological modeling. Therefore the outputs from GCM have to be downscaled to obtain the information fit for hydrologic studies. The variable infiltration capacity (VIC) distributed hydrological model with 9×9 km2 grid resolution was applied and calibrated in the Hanjiang Basin. Validation results show that SSVM can approximate observed precipitation and temperature data reasonably well, and that the VIC model can simulate runoff hydrograph with high model efficiency and low relative error. By applying the SSVM model, the trends of precipitation and temperature (including daily mean temperature, daily maximum temperature and daily minimum temperature) projected from CGCM2 under A2 and B2 scenarios will decrease in the 2020s (2011―2040), and increase in the 2080s (2071―2100). However, in the 2050s (2041―2070), the precipitation will be decreased under A2 scenario and no significant changes under B2 scenario, but the temperature will be not obviously changed under both climate change scenarios. Under both climate change scenarios, the impact analysis of runoff, made with the downscaled precipitation and temperature time series as input of the VIC distributed model, has resulted in a decreasing trend for the 2020s and 2050s, and an overall increasing trend for the 2080s. | GUO ShengLian GUO Jing ZHANG Jun CHEN Hua | 2009 | Science China(Technological Sciences)2009，52，11： | 23 |
| 8 | Hemodynamic analysis of esophageal varices in patients with liver cirrhosis using color Doppler ultrasound显示文摘AIM: To study the portal hemodynamics and their relationship with the size of esophageal varices seen at endoscopy and to evaluate whether these Doppler ultrasound parameters might predict variceal bleeding in patients with liver cirrhosis and portal hypertension.METHODS: One hundred and twenty cirrhotic patients with esophageal varices but without any previous bleeding were enrolled in the prospective study. During a 2-year observation period, 52 patients who had at least one episode of acute esophageal variceal hemorrhage constituted the bleeding group, and the remaining 68 patients without any previous hemorrhage constituted the non-bleeding group. All patients underwent endoscopy before or after color Doppler-ultrasonic examination, and images were interpreted independently by two endoscopists. The control group consisted of 30 healthy subjects, matched to the patient group in age and gender. Measurements of diameter,flow direction and flow velocity in the left gastric vein (LGV) and the portal vein (PV) were done in all patients and controls using color Doppler unit. After baseline measurements, 30 min after oral administration of 75 g glucose in 225 mL, changes of the diameter, flow velocity and direction in the PV and LGV were examined in 60 patients with esophageal varices and 15 healthy controls.RESULTS: The PV and LGV were detected successfully in 115 (96%) and 105 (88%) of 120 cirrhotic patients,respectively, and in 27 (90%) and 21 (70%) of 30 healthy controls, respectively. Among the 120 cirrhotic patients,37 had F1, 59 had F2, and 24 had F3 grade varices. Compared with the healthy controls, cirrhotic group had a significantly lower velocity in the PV, a significantly greater diameter of the PV and LGV, and a higher velocity in the LGV. In the cirrhotic group, no difference in portal flow velocity and diameter were observed between patients with or without esophageal variceal bleeding (EVB). However, the diameter and blood flow velocity of the LGV were significantly higher for EVB (+) group compared with EVB (-) group (P<0.01).Diameter of the LGV increased with enlarged size of varices.There were differences between F1 and F2, F1 and F3 varices, but no differences between F2 and F3 varices (P = 0.125). However, variceal bleeding was more frequent in patients with a diameter of LGV >6 mm. The flow velocity in the LGV of healthy controls was 8.70±1.91 cm/s (n = 21). In patients with liver cirrhosis, it was 10.3±2.1 cm/s (n = 12) when the flow was hepatopetal and 13.5±2.3 cm/s (n = 87) when it was hepatofugal. As the size of varices enlarged, hepatofugal flow velocity increased (P<0.01) and was significantly different between patients with F1 and F2 varices and between patients with F2 and F3 varices. Variceal bleeding was more frequent in patients with a hepatofugal flow velocity >15 cm/s (32 of 52 patients, 61.5%). Within the bleeding group, the mean LGV blood flow velocity was 16.6±2.62 cm/s. No correlation was observed between the portal blood flow velocity and EVB. In all healthy controls, the flow direction in the LGV was hepatopetal, toward the PV. In patients with F1 varices, flow direction was hepatopetal in 10 patients, to-and-fro state in 3 patients, and hepatofugal in the remaining 18. The flow was hepatofugal in 91% patients with F2 and all F3 varices. Changes in diameter of the PV and LGV were not significant before and after ingestion of glucose (PV: 1.41±1.5 cm before and 1.46±1.6 cm after; LGV: 0.57±1.7 cm before and 0.60±1.5 cm after).Flow direction in the LGV was hepatopetal and to-and-fro in 16 patients and hepatofugal in 44 patients before ingestion of glucose. Flow direction changed to hepatofugal in 9 of 16 patients with hepatopetal and to-and-fro blood flow after ingestion of glucose. In 44 patients with hepatofugal blood flow in the LGV, a significant increase in hepatofugal flow velocity was observed in 38 of 44 patients (86%) with esophageal vadces. There was a relationship between the percentage changes in flow velocity and the size of varices. Patients who responded excessively to food ingestion might have a high risk for bleeding. The changes of blood flow velocity in the LGV were greater than those in the PV (LGV: 28.3±26.1%, PV: 7.2±13.2%, P<0.01), whereas no significant changes in the LGV occurred before and after ingestion of glucose in the control subjects.CONCLUSION: Hemodynamics of the PV is unrelated to the degree of endoscopic abnormalities in patients with liver cirrhosis. The most important combinations are endoscopic findings followed by the LGV hemodynamics.Duplex-Doppler ultrasonography has no value in the identification of patients with cirrhosis at risk of variceal bleeding. Hemodynamics of the LGV appears to be superior to those of the PV in predicting bleeding. | Feng-Hua Li Jing Hao Jian-Guo Xia Hong-Li Li Hua Fang | 2005 | World Journal of Gastroenterology2005，11，29： | 23 |
| 9 | nsights into battles between Mycobacterium tuberculosis and macrophages显示文摘 | Guanghua Xu Jing Wang George Fu Gao Cui Hua Liu | 2014 | Protein & Cell2014，5，10： | 22 |
| 10 | Effects of Urea and Controlled Release Urea Fertilizers on Methane Emission from Paddy Fields: A Multi-Year Field Study显示文摘A four-year(2008–2011) field study was implemented in a major rice-growing region of China to better understand the effect of urea and controlled release fertilier(CRF, thermoplastic resin-coated urea in this study) on CH4 emission from paddy fields. Over the four years, the average CH4 emission during the rice growing seasons was 76.9, 65.8 and 64.9 kg CH4ha-1in treatments CK(zero N), U(urea) and C(CRF), respectively. Urea and CRF significantly reduced CH4 emission by 14.4% and 15.6%, and increased average rice grain yield by 25.8% and 19.7%(P < 0.05), respectively, compared with treatment CK. Flooding duration would affect CRF's effect on CH4 emission from paddy fields. Under normal aeration conditions, CH4 emission tended to be 3.9%–15.2% lower in treatment C than in treatment U from 2009 to 2011, while it tended to be 4.2% higher under delayed aeration conditions in 2008. The findings suggest that mid-season aeration(MSA) starting on D30(30 days after rice transplanting), just like the local practice, would optimize the CRF's effect on CH4 emission from rice fields in China. Over the four years, average rice yield did not differ between treatments U and C, and tended to be 5% lower in treatment C than in treatment U. | JI Yang LIU Gang MA Jing ZHANG Guang-Bin XU Hua | 2014 | Pedosphere2014，24，5： | 21 |
| 11 | Human adipose-derived mesenchymal stem cells: a better cell source for nervous system regeneration显示文摘 | Han Chao Zhang Liang Song Lin Liu Yang Zou Wei Piao Hua Liu Jing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 12 | Population pharmacokinetics modeling of oxcarbazepine to characterize drug interactions in Chinese children with epilepsy显示文摘 | Yang WANG Hua-nian ZHANG Chang-he NIU Ping GAO Yu-jun CHEN Jing PENG Mao-chang LIU Hua XU | 2014 | Acta Pharmacologica Sinica2014，35，10： | 20 |
| 13 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 14 | Effect of lipid on proliferation and activation of rat hepatic stellate cells(Ⅰ)显示文摘INTRODUCTIONDespitetheearlycontroversyovertheprimarycelularsourceofextracelularmatrixproteinsinliverfibrosis,compelinginvitro... | LU Lun Gen, ZENG Min De, LI Ji Qiang, HUA Jing, FAN Jian Gao, FAN Zhu Ping and QIU De Kai | 1998 | World Journal of Gastroenterology1998，4，6： | 18 |
| 15 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 16 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 17 | Efficacy and safety of neoadjuvant chemotherapy with modified FOLFOX7 regimen on the treatment of advanced gastric cancer显示文摘 | ZHANG Jun CHEN Ren-xiong ZHANG Jing CAI Jun MENG Hua WU Guo-cong ZHANG Zhong-tao WANG Yu WANG Kang-li | 2012 | Chinese Medical Journal2012，，12： | 16 |
| 18 | Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery显示文摘丰满的酸可以获利地影响愈合的背景多元不堡和 omega-3 处理,这研究的耐心的 outcomes.The 目的是学习鱼油的临床的功效在在 colorectal 癌症 surgery.Methods 以后的老病人的充实的全部的非肠道的营养有 colorectal 癌症的 57 个老病人在这被注册未来,使随机化,双窗帘,控制临床的 trial.All 病人收到了 isocaloric 和 isonitrogenous 总数由连续 i 的非肠道的营养这些结果到达了统计 significance.In 治疗组,有全身的煽动性的反应症候群(先生)的更少传染复杂并发症和发生,并且医院停留的更短的长度是医疗保健的 observed.The 总数费用为二 groups.No 是可比较的严肃的不利事件发生在任何一个 group.Conclusions 鱼每在 colorectal 外科是安全的并且可以弄短以后,管理到老病人的天给 0.2 g/kg 上油长度医院呆在并且改善 | Zhu Ming-wei Tang Da-nian Hou Jing Wei Jun-min Hua Bin Sun Jian-hua Cui Hong-yuan | 2012 | Chinese Medical Journal2012，，2： | 16 |
| 19 | Structural characterization and identification of major constituents in Radix Scrophulariae by HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry显示文摘AIM: To analyze the major constituents in Radix Scrophulariae(Scrophularia ningpoensis). METHOD: Radix Scrophulariae was analyzed by HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(ESI-Q-TOF MS/MS). Compounds were separated by HPLC using a C18 column and gradient elution of acetonitrile and 0.1 %(V/V) acetic acid-water. Negative ion mode was employed. RESULTS: A total of thirty-six compounds, including fourteen iridoid glycosides, nineteen phenylpropanoid glycosides, and three organic acids, were identified from Radix Scrophulariae based on the accurate mass measurement of precursor and product ions. Twenty-one of the constituents were identified by comparing their retention times(tR) and ESI-MS/MS data with those of reference standards and/or previous publications, while another fifteen compounds were tentatively identified or deduced according to their Q-TOF MS/MS data which afforded sufficient structural information. CONCLUSION: It is believed that this study is useful for the identification of constituents in Radix Scrophulariae, as well as related plants and complex prescriptions. | CHEN You-Hua QI Jin HUA Jing YU Bo-Yang | 2014 | Chinese Journal of Natural Medicines2014，12，1： | 16 |
| 20 | Association between inflammatory mediators and angiographic morphologic features indicating thrombus formation in patients with acute myocardial infarction显示文摘背景煽动性的机制在尖锐心肌的梗塞的出现和预后起了一个重要作用,煽动性的调停人与测试的尖锐心肌的 infarction.This 学习的不利结果被联系假设在有圣片断举起的心肌的梗塞的尖锐阶段,嗜中性的计数和高敏感的C反应的蛋白质 angiographic 是预兆的在梗塞相关的 artery.Methods | LI Dong-bao HUA Qi LIU Zhi LI Jing XU Li-qing WANG Shan JIN Wei-ying | 2009 | Chinese Medical Journal2009，，15： | 15 |
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