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| 1 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 2 | The AGL6-like gene OsMADS6 regulates floral organ and meristem identities in rice显示文摘Although AGAMOUS-LIKE6 (AGL6) MADS-box genes are ancient with wide distributions in gymnosperms and angiosperms, their functions remain poorly understood. Here, we show the biological role of the AGL6-1ike gene, OsMADS6, in specifying floral organ and meristem identities in rice (Oryza sativa L.). OsMADS6 was strongly ex- pressed in the floral meristem at early stages. Subsequently, OsMADS6 transcripts were mainly detectable in paleas, lodicules, carpels and the integument of ovule, as well as in the receptacle. Compared to wild type plants, osmads6 mutants displayed altered palea identity, extra glume-like or mosaic organs, abnormal carpel development and loss of floral meristem determinacy. Strikingly, mutation of a SEPALLATA (SEP)-like gene, OsMADS1 (LHS1), enhanced the defect of osmads6 flowers, and no inner floral organs or glume-like structures were observed in whorls 2 and 3 of osmadsl-z osmads6-1 flowers. Furthermore, the osmadsl-z osmads6-1 double mutants developed severely indetermi- nate floral meristems. Our finding, therefore, suggests that the ancient OsMADS6 gene is able to specify 'floral state' by determining floral organ and meristem identities in monocot crop rice together with OsMADS1. | Haifeng Li Wanqi Liang Ruidong Jia Changsong Yin Jie Zong Hongzhi Kong Dabing Zhang | 2010 | Cell Research2010，20，3： | 33 |
| 3 | Effectiveness and safety of noninvasive positive-pressure ventilation for severe hypercapnic encephalopathy due to acute exacerbation of chronic obstructive pulmonary disease:a prospective case-control study显示文摘背景尽管严重 encephalopathy 作为可能的禁止徵候被建议了到 noninvasive 的使用积极压力的通风( NPPV ),增加的临床的报告证明它在有损害知觉甚至对尖锐呼吸失败第二等的昏迷的病人是有效的,特别 hypercapnic 尖锐呼吸失败( HARF ) .To 进一步为严重 hypercapnic encephalopathy 评估 NPPV 的有效性和安全。 | ZHU Guang-fa ZHANG Wei ZONG Hua XU Qiu-fen LIANG Ying | 2007 | Chinese Medical Journal2007，，24： | 30 |
| 4 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 5 | Idealized Numerical Simulations of Tropical Cyclone Formation Associated with Monsoon Gyres显示文摘Monsoon gyres have been identified as one of the important large-scale circulation patterns associated with tropical cyclone(TC)formation in the western North Pacific.A recent observational analysis indicated that most TCs form near the center of monsoon gyres or at the northeast end of the enhanced low-level southwesterly flows on the southeast–east periphery of monsoon gyres.In the present reported study,idealized numerical experiments were conducted to examine the tropical cyclogenesis associated with Rossby wave energy dispersion with an initial idealized monsoon gyre.The numerical simulations showed that the development of the low-level enhanced southwesterly flows on the southeast–east periphery of monsoon gyres can be induced by Rossby wave energy dispersion.Mesoscale convective systems emerged from the northeast end of the enhanced southwesterly flows with mid-level maximum relative vorticity.The simulated TC formed in the northeast of the monsoon gyre and moved westward towards the center of the monsoon gyre.The numerical experiment with a relatively smaller sized initial monsoon gyre showed the TC forming near the center of the initial monsoon gyre.The results of the present study suggest that Rossby wave energy dispersion can play an important role in TC formation in the presence of monsoon gyres. | LIANG Jia WU Liguang ZONG Huijun | 2014 | Advances in Atmospheric Sciences2014，31，2： | 13 |
| 6 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 7 | Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review显示文摘Social and environmental factors render premature ovarian failure(POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF.Due to the unique ovarian physiological environment and follicular developmental processes, the apoptosis of ovarian granulosa cells and oocytes together cause follicular atresia, which involves the apoptosis-related internal and external pathways.Furthermore, during POF, apoptosis and oxidative stress forms a 'vicious circle', which involves a variety of changes between the molecules. The existing pharmaceutical preparations such as gonadal hormones are the basic methods for the treatment of POF, and the curative effect was affirmative;however, it was ineffective after withdrawn, while the long-term application led to adverse reactions. Traditional Chinese Medicine(TCM) has a history of treating gynecological diseases and infertility and has gained increasing attention. Studies have shown that compounds isolated from herbal medicine exerted a positive effect on follicular atresia caused by cell apoptosis that also improved the POF. The present study reviewed the mechanisms underlying the apoptosis in POF and elaborated the internal mechanism of TCM in the treatment of the condition. | CAI Liang ZONG Daokuan TONG Guoqing LI Li | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 10 |
| 8 | A Pyramid Breeding of Eight Grain-yield Related Quantitative Trait Loci Based on Marker-assistant and Phenotype Selection in Rice(Oryza sativa L.)显示文摘1000 谷物重量和小穗状花小穗数字每圆锥花序是为米饭谷物产量的二个重要部件。在我们的以前的学习,每圆锥花序和 1000 谷物重量授与小穗状花小穗数字的八量的特点 loci (QTL ) 通过 150 米饭 recombinant 的基于顺序的 genotyping 被印射生来的线(RIL ) 。在这研究,我们用染色体片断替换线(CSSL ) 从 Nipponbare 验证了四 QTL 的效果,并且节节上升八谷物收益联系了 QTL。与积极效果包含八 QTL 的新线作为与父母变化 93-11 相比显示出增加的圆锥花序和小穗状花小穗尺寸。我们进一步建议了基于标记助手和显型选择(地图) 引起计划的一座新奇金字塔。没有巨大的生气工作,这个计划允许在单个杂交象 24 QTL 一样同样多节节上升。这研究提供了卓见进 high-yielding 米饭繁殖的直接财富的米饭谷物产量的分子的基础。 | Guo Zong Ahong Wang Lu Wang Guohua Liang Minghong Gu Tao Sang Bin Han | 2012 | Journal of Genetics and Genomics2012，39，7： | 9 |
| 9 | Strong ozone production at a rural site in the North China Plain: Mixed effects of urban plumes and biogenic emissions显示文摘Regional ozone(O_3) pollution has drawn increasing attention in China over the recent decade, but the contributions from urban pollution and biogenic emissions have not been clearly elucidated. To better understand the formation of the regional O_3 problem in the North China Plain(NCP), intensive field measurements of O_3 and related parameters were conducted at a rural site downwind of Ji'nan, the capital city of Shandong province, in the summer of 2013. Markedly severe O_3 pollution was recorded, with the O_3 mixing ratios exceeding the Chinese national ambient air quality standard on 28 days(a frequency of 78%) and with a maximum hourly value of 198 ppbv. Extensive regional transport of wellprocessed urban plumes to the site was identified. An observation-constrained chemical box model was deployed to evaluate in situ photochemical O_3 production on two episodes.The results show that the in situ formation accounted for approximately 46% of the observed O_3 accumulation, while the remainder(~54%) was contributed by regional transport of the O_3-laden urban plumes. The in situ ozone production was in a mixed controlled regime that reducing either NOx or VOCs would lead to a reduction of ozone formation. Biogenic VOCs played an important role in the local ozone formation. This study demonstrates the significant mixed effects of both anthropogenic pollution from urban zones and biogenic emission in rural areas on the regional O_3 pollution in the NCP region,and may have general applicability in facilitating the understanding of the formation of secondary pollution over China. | Ruihan Zong Xue Yang Liang Wen Caihong Xu Yanhong Zhu Tianshu Chen Lan Yao Liwei Wang Junmei Zhang Lingxiao Yang Xinfeng Wang Min Shao Tong Zhu Likun Xue Wenxing Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 8 |
| 10 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 11 | Development of the detonation-driven expansion tube for orbital speed experiments显示文摘The hypersonic flow at orbital speeds is a fundamental issue for the ground tests of aerospace crafts.The detonation-driven high-enthalpy expansion tube(JF16 expansion tube)was developed to investigate re-entry physics.A forward detonation cavity(FDC)driver was applied in the JF16 expansion tube to create stable driving flows.The sound speed ratio of the detonated to test gas was examined to minimize the magnitude of test flow perturbations.The acceleration section length,incident shock decay and diaphragms thickness were investigated in detail to obtain optimal operation parameters.Flow visualization was also carried out with schlieren system to demonstrate the test flow stability and the effective test duration.Experimental data showed that the test flow with a velocity of 8.3 km/s and a total enthalpy up to 40 MJ/kg can be generated successfully and the test duration lasts for more than 50μs. | JIANG Zong Lin WU Bo GAO Yun Liang ZHAO Wei HU Zong Min | 2015 | Science China(Technological Sciences)2015，58，4： | 8 |
| 12 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000，6，6： | 7 |
| 13 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 7 |
| 14 | Molecular and functional characterization of sulfiredoxin homologs from higher plants显示文摘由在氧化 peroxiredoxin 减少 cysteine-sulfinic 酸, sulfiredoxin (Srx ) 在酵母和人的房间在氧化压力抵抗起一个重要作用。这里,我们从更高的植物报导 Srx 相当或相同的事物的第一分子、功能的描述。生物信息的分析揭示了把序列编码为两张单音的简易窄床和 dicot 植物种类的潜在的 Srx 的存在。通常认为的植物 Srx 蛋白质从酵母和人展出了重要身份到他们的 orthologs,并且为催化作用包含了保存签名顺序和残余必需品。然而,植物 Srxs 不同于酵母和人的 orthologs,都被预言在他们的主要结构拥有叶绿体运输肽。从 Arabidopsis 和米饭的 Srx 蛋白质(指定了为 AtSrx 和 OsSrx,分别地) 在 SRX1 删除酵母房间的 Srx 的补充功能的缺乏。AtSrx 的 GFP 熔化蛋白质在 Arabidopsis 叶肉原物被指向到叶绿体。AtSrx 抄写在植物、繁殖的机关发生了,并且最高的抄本水平在叶子被检测。在氧化应力下面, AtSrx 抄本水平实质地被增加,哪个有在维持被发现必要的 2-Cys peroxiredoxins 的提高的抄写的 paralleled 叶绿体氧化还原作用平衡。除了氧化应力, osmotic/water 赤字或冷处理也提起了 AtSrx 抄本水平。与上面的调查结果一致, AtSrx 的猛烈异种是显著地,产生氧化的更多比野类型 Arabidopsis 强调植物。总起来说,这个工作的结果在是必要的让工厂应付氧化应力的更高的工厂显示功能的 Srx 相当或相同的事物的存在。 | Xian Peng Liu Xue Ying Liu Juan Zhang Zong Liang Xia Xin Liu Huan Ju Qin Dao Wen Wang | 2006 | Cell Research2006，16，3： | 7 |
| 15 | Identification of AtENT3 as the main transporter for uridine uptake in Arabidopsis roots显示文摘当在酵母细胞生产了,差别在 Arabidopsis 器官被表示时,以前的研究证明了 Arabidopsis equilibrative nucleoside 运输 ers (AtENTs ) 拥有运输活动。此处,我们在 nucleoside 运输活动和 AtENT 成员的 transcriptional 模式报导进一步的分析。AtENTs 3 的 recombinant 蛋白质, 6,和 7,然而并非那些 AtENTs 1, 2, 4,和 8,被发现与高亲密关系搬运 thymidine。与以前的建议相反,那 AtENT1 不能搬运 uridine,这个工作证明 recombinant AtENT1 是 uridine 的 pH 依赖、高亲密关系的 transporter。当在 MS 盘子上成长时, AtENT3 猛烈植物比野类型的植物和 AtENT1 或 AtENT6 的猛烈植物对细胞毒素的 uridine 类似物 5-fluorouridine 更容忍。与这观察一致, AtENT3 猛烈的线展出了一个显著地减少的能力收起[(3 ) H ] 经由根的 uridine 什么时候与有变异的 AtENT1 或 AtENT6 的野类型的植物和植物相比。这显示那 AtENT3,然而并非 AtENTs 1 并且 6,是为在 Arabidopsis 根的 uridine 举起的主要 transporter。AtENTs 1 的抄写, 3, 4, 6, 7,和 8 在叶开发和老朽期间以一种复杂方式被调整。相反,六个 AtENT 成员并列地在种子萌芽期间被劝诱。这个工作为未来研究在 recombinant AtENT 蛋白质和新线索的运输性质上提供新信息在里面 vivo 运输活动和在 Arabidopsis 工厂的不同 ENT 蛋白质的生理的功能。 | Kun Ling Chen Min Xin Xu Guang Yong Li Hui Liang Zong Liang Xia Xin Liu Ji Shu Zhang Ai Min Zhang Dao Wen Wang | 2006 | Cell Research2006，16，4： | 7 |
| 16 | cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in Murine Peritoneal Macrophages显示文摘cAMP mediated signaling may play a suppressive role in immune response. We previously found that the cAMP-elevators (CTx and 8-Br-cAMP) inhibited IL-12, IL-la, IL-6 gene expression, but increased the transcriptional levels of IL-10 and IL-1Ra in LPS-treated murine peritoneal macrophages. The present study examined a possible molecular mechanism involved in cAMP elevators-induced inhibition of IL-12 p40 expression in response to LPS. Our data demonstrated that cAMP elevators downregulated IL-12 p40 mRNA expression and IL-12 pT0 production in murine peritoneal macrophages. Subsequent studies revealed that cAMP-elevators blocked phosphorylation of p38 MAPK, but did not affect the activity of NF-κB binding to IL-12 promoter (-136/-112). This is the first report that cAMP elevators inhibit LPS-induced IL-12 production by a mechanism that is associated, at least in part, with p38-dependent inhibition by cAMP signaling pathways. | WEI Guo FENG, YI BING WANG, JIN SONG ZHANG, XING Yu WANG, CHANG LIN LI, ZONG LIANG CHANGLaboratory of Immune Signaling Transduction, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China | 2002 | Cell Research2002，12，5： | 6 |
| 17 | The fluidity and molding ability of glass-forming Zr-based alloy melt显示文摘The fluidity and filling ability of glass-forming Zr-based alloy melt in copper mould were investigated both theoretically and experimentally. The major factors which affected the flowing behavior of the metallic melt in the mold were determined,which provides the foundation for overcoming the contradiction between the filling and formation of amorphous alloy during the rapid cooling process of the metallic melts. The casting factors to prepare a metallic ring were discussed and selected. As a result,a Zr-based bulk metallic glass ring was prepared successfully. | MA MingZhen ZONG HaiTao WANG HaiYan QI YanPeng LIANG SunXing SONG AiJun ZHANG WeiGuo WANG Qiang ZHANG XinYu JING Qin LI Gong LIU RiPing | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 6 |
| 18 | Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors:A meta-analysis显示文摘AIM:To perform a meta-analysis to derive a more precise estimation of imatinib treatment for different genotypes of gastrointestinal stromal tumors(GIST).METHODS:Studies were identified by searching PubMed and Embase.Inclusive criteria were patients with exon 9-mutant,exon 11-mutant or wide type(WT) GIST,receiving chemotherapy of imatinib for clinical trial,and efficacy evaluation was cumulative response (CR)including complete response and partial response.The odds ratios(OR)for CR in stem cell factor receptor (KIT)mutation patients vs WT genotype patients,KIT exon 11-mutant genotype patients vs KIT exon 9-mutant genotype patients and KIT exon 9-mutant genotype patients vs WT genotype patients were calculated with 95%confidence interval(CI)for each study as an estimation of the efficacy of imatinib.RESULTS:Five studies including 927 patients were involved in this meta-analysis.The overall OR(KIT group vs WT group)was 3.34(95%CI:2.30-4.86,P <0.00001,P heterogeneity=0.04).The overall OR in KIT exon 11 group vs KIT exon 9 group was 3.29(95%CI: 2.17-5.00,P<0.00001,P heterogeneity=0.33).The overall OR in KIT exon 9 group vs WT group was 1.23(95% CI:0.73-2.10,P=0.44,P heterogeneity=0.42).CONCLUSION:Most patients with different genotypes of GIST and KIT exon 11-mutant will benefit from the individualized treatment of imatinib. | Ping Chen Liang Zong Wei Zhao Lei Shi | 2010 | World Journal of Gastroenterology2010，16，33： | 5 |
| 19 | Selective transmission and channel estimation in massive MIMO systems显示文摘Massive MIMO systems have got extraordinary spectral efficiency using a large number of base station antennas,but it is in the challenge of pilot contamination using the aligned pilots.To address this issue,a selective transmission is proposed using time-shifted pilots with cell grouping,where the strong interfering users in downlink transmission cells are temporally stopped during the pilots transmission in uplink cells.Based on the spatial characteristics of physical channel models,the strong interfering users are selected to minimize the inter-cell interference and the cell grouping is designed to have less temporally stopped users within a smaller area.Furthermore,a Kalman estimator is proposed to reduce the unexpected effect of residual interferences in channel estimation,which exploits both the spatial-time correlation of channels and the share of the interference information.The numerical results show that our scheme significantly improves the channel estimation accuracy and the data rates. | 杨睿哲 Zong Liang Si Pengbo Ma Dawei Zhang Yanhua | 2016 | High Technology Letters2016，22，1： | 5 |
| 20 | Effects of continuous tracheal gas insufflation during pressure limited ventilation on pulmonary surfactant in rabbits with acute lung injury显示文摘背景肺的表面活化剂机能障碍可以贡献通风机的发展导致的肺损害(VILI ) 。气管的煤气的 insufflation (TGI ) 是新鲜气体在被介绍进气管并且由减少死了的空格 ofventilatory 系统扩充通风的一种技术,当维持经常的部分动脉的 CO_2 压力(PaCO_2 ) 时,减少 ventilatory 压力和潮汐的体积(V_T ) 。我们 hypothesised 那座 TGI 有限山峰吸入的压力(果仁) 和 V_T 并且将最小化导致的常规机械通风(CMV ) 肺的表面活化剂机能障碍并且从而与尖锐的肺损害(ALI ) 在兔子稀释 VILI。MethodsALI 被脂肪的多糖的 intratracheal 管理在随机在 0.5 L/min (TGI 组) 或 CMV 组(n=8for 各个组) 分到连续 TGI 的使麻木的、通气健康成年兔子导致,并且随后与有限果仁和 V_T 通气了在 35to 以内维持 PaCO_2 为 4 个小时的 45 mmHg。到 V_T 比率(V_D/V_T ) 的生理的死了的空间,动态呼吸依从(Cdyn ) 和部分动脉的 O_2 压力(PaO_2 ) 被监视。在通风以后,肺为全部的 phospholipids (TPL ) 被分析,全部的蛋白质(TP ) ,对在 bronchoalveolar 洗室年龄液体(BALF ) 并且为牙槽的体积密度(V_V ) 的决心的大总数比率(SA/LA ) 小的肺的表面活化剂, myeloperoxidase 和 interleukin (IL )-8。结果 TGI 结果不足道( P <
0.05 或 P <
0.01 )在果仁的减少[( 22.4+1.8 ) cmH_2O 对( 29.5 ±1 .1 ) cmH_2O ], V_T [( 6.9 ±1 .3 ) ml/kg 对( 9.8 ±1 .11 ) ml/kg ], V_D/V_T [( 32 ±5 )%对( 46 ±2 )%], TP [( 109 ±2 2 ) mg/kg 对( 187 ±2 5 ) mg/kg ], SA/LA ( 2.5 ±0 .4 对 5.4 ±0 .7 ), myeloperoxidase [( 6.2 ±0 .5 ) U/g 织物对( 12.3 ±0 .8 ) U/g 织物]并且 IL-8 [( 987 ±1 06 ) ng/g 织物对( 24 ±3 ) mN/m ] BALF ,并且重要( P <
0.05 )在 Cdyn 增加[( 0.47 ±0 .02 ) ml ?cmH_2O^(-1)?kg^(-1)对( 0.31 ±0 .02 ) ml ?cmH_2O^(-1)?kg^(-1)], PaO_2 [( 175 ±2 4 ) mmHg 对( 135 ±2 6 ) mmHg ], TPL/TP ( 52 ±8 vs33 ±1 1 )并且 V_V ( 0.65 ±0 .05 对 0.44 ±0 .07 )同样与 CMV 相比。在这个动物的结论为 ofALI 建模, TGI 减少了 ventilatory 要求(果仁, V_T 和 V_D/V_T ) ,比在有压力的联合的 CMV.TGI 限制通风导致了更赞成的牙槽的肺的表面活化剂作文和功能和肺损害的更少的严厉可以是一个肺为 ALI 的保护的策略。 | ZHU Guang-fa ZHANG Wei ZONG Hua LIANG Ying | 2006 | Chinese Medical Journal2006，，17： | 5 |
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