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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | The Cenozoic activities of Yangjiang-Yitongdong Fault: insights from analysis of the tectonic characteristics and evolution processes in western Zhujiang(Pearl) River Mouth Basin显示文摘The Yangjiang-Yitongdong Fault (YJF) is an important NW-trending regional fault, which divides the Zhujiang (Pearl) River Mouth Basin (ZRMB) into western and eastern segments. In Cenozoic, the northern continental margin of the South China Sea (SCS) underwent continental rifting, breakup, seafloor spreading and thermal subsidence processes, and the Cenozoic activities of YJF is one part of this series of complex processes. Two long NW-trending multichannel seismic profiles located on both sides of the YJF extending from the continental shelf to Continent-Ocean Boundary (COB) were used to study the tectonic and sedimentary characteristics of western ZRMB. Using the 2D-Move software and back-stripping method, we constructed the balance cross-section model and calculated the fault activity rate. Through the comprehensive consideration of tectonic position, tectonic evolution history, featured structure, and stress analysis, we deduced the activity history of the YJF in Cenozoic. The results showed that the YJF can be divided into two segments by the central uplift belt. From 65 Ma to 32 Ma, the YJF was in sinistral motion as a whole, inherited the preexisting sinistral motion of Mesozoic YJF, in which, the southern part of YJF was mainly in extension activity, controlling the formation and evolution of Yunkai Low Uplift, coupled with slight sinistral motion. From 32 Ma to 23.8 Ma, the sinistral motion in northern part of YJF continued, while the sinistral motion in southern part began to stop or shifted to a slightly dextral motion. After 23.8 Ma, the dextral motion in southern part of YJF continued, while the sinistral motion in northern part of YJF gradually stopped, or shifted to the slightly dextral motion. The shift of the YJF strike-slip direction may be related to the magmatic underplating in continent-ocean transition, southeastern ZRMB. According to the analysis of tectonic activity intensity and rift sedimentary structure, the activities of YJF in Cenozoic played a regulating role in the rift extension process of ZRMB. | Yuhan Li Rongwei Zhu Hailing Liu Xuelin Qiu Haibo Huang | 2019 | Acta Oceanologica Sinica2019，38，9： | 10 |
| 3 | GNSS Spoofing Detection Based on Consistency Check of Velocities显示文摘Spoofing attacks for Global navigation satellite system(GNSS) would cause the abnormal changes of receiver measurements. Monitoring the abnormal changes is the main pattern of anti-spoofing techniques.Anomalies of Doppler shifts are important for GNSS spoofing detection. Most researchers focus on the consistency of Doppler such as the consistency of carrier Doppler and code rate. But the method is powerless in some cases.Doppler shift measurement is proportional to change rate of pseudorange, and the relationship would be broken in the case of spoofing attack. As both Doppler measurements and pseudoranges are related to velocity of receiver,two approaches of computing velocity can be used to check the consistency of Doppler shifts and pseudoranges measurements. An efficient spoofing detection method based on the consistency check of velocities is proposed in the paper. Principle of the method is given in detail and its performance evaluations are provided as well. Simulation results demonstrate the effectiveness of the solution. | TAO Huiqi WU Hailing LI Hong LU Mingquan | 2019 | Chinese Journal of Electronics2019，28，2： | 10 |
| 4 | Study on the Behavior of Solar Array Deployment with Root Hinge Drive Assembly显示文摘In this paper, a method of using a root hinge drive assembly (RHDA) to control the solar array deployment is provided and a multi-DOF mechanism dynamic model of the system is established. In this way, the root hinge torque can be calculated iteratively. Then taking the predicted torque as a reference, a RHDA is designed for a large multiple-stage packaging and deployable solar array system. The control effect of the drive assembly is validated by ground tests. The test results indicate that the solar arrays can be deployed smoothly, and the deployment velocities are restricted by the drive assembly as expected. During the tests, the RHDA output speed and output torque are obtained. In order to examine the impact force when the yoke is lock-up with a hard stop, dynamics simulations are performed according to the actual behavior. The simulation result indicates that the designed RHDA reduces the impact force significantly and improves the lock-up reliability effectively. | DING Xilun LI Xin XU Kun YANG Qiaolong PU Hailing | 2012 | Chinese Journal of Aeronautics2012，25，2： | 6 |
| 5 | Transcriptome-wide reprogramming of N^6-methyladenosine modification by the mouse microbiome显示文摘Dear Editor, Microbiome affects many aspects of human health and disease and elicits a wide range of host responses including remarkable epigenetic changes such as DNA methylation,histone modification and non-coding RNA expression.A still poorly explored area of microbiome-host interaction is the response of host RNA modification.N^6-methyladenosine (m^6A)is the most abundant mRNA modification in mammalian cells,occurring at -3 modified adenosine residues per transcript. | Xiaoyun Wang Yan Li Wenjun Chen Hailing Shi A.Murat Eren Aleksey Morozov Chuan He Guan-Zheng Luo Tao Pan | 2019 | Cell Research2019，29，2： | 4 |
| 6 | Enhancement of transfection efficiency for HeLa cells via incorporating arginine moiety into chitosan显示文摘Arginine-rich peptides have attracted considerable attention due to their distinct internalization mechanism. It was reported that arginine and guanidino moieties were able to translocate through cell membranes and played a critical role in the process of membrane permeation. In this work, arginine was conjugated to the backbone of chitosan to form a novel chitosan derivative, arginine modified chitosan (Arg-CS). Arg-CS/DNA complexes were prepared according to the method of coacervation process. The physicochemical properties of Arg-CS and Arg-CS/DNA complexes were characterized and the transfection activity and efficiency mediated by Arg-CS/DNA complexes were investigated taking HeLa cells as target cells. Arg-CS was characterized by FTIR and 13C NMR. Arg-CS/DNA polye- lectrolyte complexes were investigated by agarose gel retardation, dynamic light scattering (DLS) and atomic force microscopy (AFM). The results revealed that the Arg-CS/DNA complexes started to form at N/P ratio of 2:1, and the size of particles varied from 100 to 180 nm. The cytotoxicity of Arg-CS and their complexes with plasmid DNA were determined by MTT assay for HeLa cells, and the results suggested that Arg-CS/DNA complexes were slightly less toxic than Arg-CS. Moreover, the derivative alone and their complexes showed significantly lower toxicity than PEI and PEI/DNA complexes, respectively. Taking HeLa cells as target cells and using pGL3-control as reporter gene, the luciferase expression mediated by Arg-CS was greatly enhanced to about 100 folds compared with the luciferase expression mediated by chitosan at different pH media. These results suggest that Arg-CS is a promising candi- date as a safe and efficient vector for gene delivery and transfection. | ZHU DunWan ZHANG HaiLing BAI JinGen LIU WenGuang LENG XiGang SONG CunXian YANG Jian LI XiaoWei JIN Xu SONG LiPing LIU LanXia LI XiuLan ZHANG Yang YAO KangDe | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 7 | Cenozoic Volcanism in South China Sea and Its Vicinity and South China Sea Spreading显示文摘The rock series, rock types and Sr Nd isotopic dating of the Cenozoic volcanic rocks in the South China Sea are similar to those in its vicinity. On the basis of the spreading age of the South China Sea, the Cenozoic volcanic rocks are divided into three stages: the pre spreading stage, the spreading stage and the post spreading stage. The deep process characteristics of the asthenosphere and lithosphere may be inferred from the study on primary basaltic magma. The top layers of the asthenosphere both in the spreading stage and in the pre spreading stage are closer to the earth surface than that in the post spreading stage. From the pre spreading stage to the spreading stage, the top layer of the asthenosphere decreased in depth, while the amount of interstitial partial melts increased. The evolution of the primary basaltic magma shows a progressive evolution sequence of the rifting volcanism and a faster lithospheric spreading velocity. From the spreading stage to the post spreading stage, the top layer of the asthenosphere gradually increased in depth, but the amount of interstitial partial melts decreased. The evolution of primary basaltic magma shows a retrogressive evolution sequence of the rifting volcanism and a gradual decrease in the lithospheric spreading velocity. The depth recognized by the study on the Cenozoic volcanism demonstrates the deep environment for the formation and evolution of the South China Sea. | Zhao Hailing Deng Jinfu Li Kaiming Di Yongjun Yu Junji Zhao Jianhua Li Yonghua Faculty of Earth Sciences and Mineral Resources, China University of Geosciences, Beijing 100083 | 2002 | Journal of China University of Geosciences2002，13，3： | 4 |
| 8 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 9 | Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population显示文摘KCNQ1 has been identified as a susceptibility gene of type 2 diabetes mellitus(T2DM) in Asian populations through genome-wide association studies. However, studies on the association between gene polymorphism of KCNQ1 and T2 DM complications remain unclear. To further analyze the association between different alleles at the single nucleotide polymorphism(SNP) rs2237892 within KCNQ1 and TD2 M and its complications, we conducted a case-control study in a Chinese Han population. The C allele of rs2237892 variant contributed to susceptibility to T2DM(odds ratio [OR], 1.45; 95% confidence interval [CI], 1.20–1.75). Genotypes CT(OR, 1.97; 95% CI,1.24–3.15) and CC(OR, 2.49; 95% CI, 1.57–3.95) were associated with an increased risk of T2 DM. Multivariate regression analysis was performed with adjustment of age, gender, and body mass index. We found that systolic blood pressure(P = 0.015), prevalence of hypertension(P = 0.037), and risk of macrovascular disease(OR, 2.10; CI, 1.00–4.45) were significantly higher in subjects with the CC genotype than in the combined population with genotype either CT | Wanlin Zhang Hailing Wang Xiaomin Guan Qing Niu Wei Li | 2015 | Genomics, Proteomics & Bioinformatics2015，13，6： | 4 |
| 10 | Synthesis,Characterization and Photocatalytic Activity of TiO_2 Film/Bi_2O_3 Microgrid Heterojunction显示文摘TiO2 film modified by Bi2O3 microgrid array was successfully fabricated by using a microsphere lithography method.The structure and morphology of TiO2 film,Bi2O3 film and TiO2 film/Bi2O3 microgrid heterojunction were characterized through X-ray diffraction,atomic force microscopy and scanning electron microscopy.The optical transmittance spectra and the photocatalytic degradation capacity of these samples to rhodamine B were determined via ultraviolet-visible spectroscopy.The results indicated that the coupled system showed higher photocatalytic activity than pure TiO2 and Bi2O3 films under xenon lamp irradiation.The enhancement of the photocatalytic activity was ascribed to the special structure,which could improve the separation of photo-generated electrons and holes,enlarge the surface area and extend the response range of TiO2 film from ultraviolet to visible region. | Liugang Wang Junying Zhang Chunzhi Li Hailing Zhu Wenwen Wang Tianmin Wang | 2011 | Journal of Materials Science & Technology2011，27，1： | 3 |
| 11 | Meta-analysis of new genome-wide association studies of colorectal cancer risk显示文摘 | Ulrike Peters Carolyn M. Hutter Li Hsu Fredrick R. Schumacher David V. Conti Christopher S. Carlson Christopher K. Edlund Robert W. Haile Steven Gallinger Brent W. Zanke Mathieu Lemire Jagadish Rangrej Raakhee Vijayaraghavan Andrew T. Chan Aditi Hazra Dav | 2012 | Human Genetics2012，，2： | 2 |
| 12 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 13 | Mycorrhizas Affect Polyphyllin Accumulation of Paris polyphylla var.yunnanensis through Promoting PpSE Expression显示文摘Paris polyphylla var.yunnanensis is a traditional Chinese medicinal plant,in which polyphyllin as the main medicinal component is an important secondary metabolite with bioactivity.Arbuscular mycorrhizal fungi(AMF)have multiple positive effects on plants,while it is not clear whether AMF increase the content of medicinal components in medicinal plants.In this study,a total of nine AMF treatments were laid to analyze the mycorrhizal effect on polyphyllin accumulation and PpHMGR and PpSE expression of P.polyphylla var.yunnanensis.AMF increased the content of polyphyllin in the cultivated variety with low relation to the increase of inoculation intensity.Polyphyllin I,II,and VII were identified and partly improved by AMF inoculation,dependent on AMF treatments and culture environments.Similarly,the PpHMGR and PpSE expression was induced by mycorrhization,dependent on AMF species,whilst the induction was more obvious in PpSE than in PpHMGR after mycorrhization.It concluded that the symbiotic relationship between P.polyphylla var.yunnanensis and AMF increased polyphyllin content level in the plant,which was associated with the up-regulation of PpSE transcripts. | Hailing Li Lingfeng Xu Zhuowei Li Shunxin Zhao Dongqin Guo Lu Rui Nong Zhou | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 14 | In Situ Synthesis of Core-Shell Li4Ti5O(12) @ Polyaniline Composites with Enhanced Rate Performance for Lithium-ion Battery Anodes显示文摘The core-shell Li_4Ti_5O_(12) @ polyaniline composites(LP) have been synthesized via an in situ synthesis with different mole ratios(25:1, 50:1 and 100:1, aniline:LTO). As an anode material of lithium-ion batteries,the LP-2 electrodes(50:1) exhibit a high initial reversible capacity of 205 mAh g^(-1)with an initial coulombic efficiency of 97.6% at 0.1 C. Even at a high current density of 10 C, the reversible capacity of the LP-2 electrodes still remains at 102 mAh g^(-1). Moreover, the LP-2 electrodes retain an impressive high capacity of 161 mAh g^(-1)after 100 cycles at 1 C, with 0.11% capacity fading per cycle. The promising electrochemical performance may be attributed to the significantly decreasing charge-transfer impedance of the LP composite and reductive polarity difference between the cathode and the electrolyte. | Yani Hui Liyun Cao Zhanwei Xu Jianfeng Huang Haibo Ouyang Jiayin Li Hailing Hu | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 15 | Construction of ZnIn_(2)S_(4)-CdIn_(2)S_(4) Microspheres for Efficient Photo-catalytic Reduction of CO_(2) with Visible Light显示文摘ZnIn_(2)S_(4) has emerged in water splitting and degradation of dyes due to its good stability and light absorption properties.However,there are still few reports of CO_(2) photoreduction.Herein,we successfully synthesized ZnIn_(2)S_(4) and obtained a series of ZnIn_(2)S_(4)-CdIn_(2)S_(4) heterostructured microspheres through the ion exchange method,and first used them in photocatalytic CO_(2) reduction in noble-metal-free systems.The activity results showed that these ZnIn_(2)S_(4)-CdIn_(2)S_(4) photocatalysts exhibit excellent catalytic activity under visible light,and the best CO yield is as high as 33.57μmol・h^(-1) with a selectivity of 91%.Furthermore,the stability and reusability of ZnIn_(2)S_(4)-CdIn_(2)S_(4) was firmly confirmed by diverse characterizations,including X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),energy-dispersive X-ray spectroscopy(EDX)and N2 adsorption measurements. | Shitong Han Bifang Li Lijuan Huang Hailing Xi Zhengxin Ding Jinlin Long | 2022 | Chinese Journal of Structural Chemistry2022，41，1： | 2 |
| 16 | Controllable defects implantation in MoS2 grown by chemical vapor deposition for photoluminescence enhancement显示文摘 | Ke Wu Zhe Li Jibo Tang Xianglong Lv Hailing Wang Ruichun Luo Pan Liu Lihua Qian Shunping Zhang Songliu Yuan | 2018 | Nano Research2018，11，8： | 2 |
| 17 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 18 | Cu2O thin films deposited by reactive direct current magnetron sputtering显示文摘 | ZHU HAILING ZHANG JUNYING LI CHUNZHI | 2009 | Thin Solid Films2009，517，19： | 1 |
| 19 | Quality changes of whole and fresh-cut Zizania latifolia during refrigerated (1 ~C) storage显示文摘 | LUO Hail~o~ JiANG Li zHANG i i 6t al | 2012 | Food Bioorocess Technology2012，5，： | 1 |
| 20 | The dynamics of a Beddington-type system with impulsive control strategy 显示文摘 | LI Zhenqing WANG Weiming WANG Hailing | 2006 | Chaos Solitons Fremtals2006，29，5： | 1 |
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