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| 1 | Responses of rice growth to copper stress under free-air CO_2 enrichment (FACE)显示文摘The responses of rice to the second degree contamination of copper were studied by pot experiments under free-air CO2 enrichment (FACE) with 570 μmol·mol-1 of CO2. The results showed that the content of copper in rice leaves was reduced with the CO2 concentration reaching 570 μmol·mol-1 and this happened more significantly under the second degree contamination of copper. Under FACE, activities of superoxide dismutase (SOD) enzyme in rice leaves treated by copper contamination were induced, whereas the contents of glutathione (GSH) and glutathione disulfide (GSSG) had no significant difference from the control. In the presence of ambient CO2, activities of SOD enzyme treated by copper pollution were suppressed during the whole rice growth, however, the contents of GSH and GSSG were induced at tillering and jointing stages, and then restored to the control levels in later growth under the second degree contamination of copper. With the rice growing, the content of malondialdehyde (MDA) rises continuously, but there had been no significant difference between the treatments at the same growth stage. Further studies are needed on the response mechanism of rice to Cu stress under elevated CO2. | JIA HaiXia GUO HongYan YIN Ying WANG Qiang SUN Qin WANG XiaoRong ZHU JianGuo | 2007 | Chinese Science Bulletin2007，52，19： | 10 |
| 2 | Characteristics of distribution of Mycobacterium tuberculosis lineages in China显示文摘The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905(2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases(975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages(Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation(farmer), and degree of education(non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment. | Haixia Chen Li He Chao Cai Jingyi Liu Junnan Jia Liang Ma Hairong Huang Lixia Wang Xumin Ni Jimin Gao Weimin Li | 2018 | Science China(Life Sciences)2018，61，6： | 7 |
| 3 | Influence of the environmental behavior and ecological effect of cropland heavy metal contaminants by CO_2 enrichment in atmosphere显示文摘 | Hongyan GUO Haixia JIA Jianguo ZHU Xiaorong WANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 4 |
| 4 | Analysis of enlargement of the omnidirectional total reflection band in a special kind of photonic crystal based on the incident angle domain显示文摘 | Qiang Haixia Jiang Liyong Jia Wei | 2011 | Optik2011，122，4： | 1 |
| 5 | Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice显示文摘 | Shuqin Li Haixia Chen Jia Wang Xiuming Wang Bo Hu Funing Lv | 2015 | International Journal of Biological Macromolecule2015，，： | 1 |
| 6 | Enzymolysis-ultrasonic assisted extraction, chemical characteristics and bioactivities of polysaccharides from corn silk显示文摘 | Shuhan Chen Haixia Chen Jingge Tian Jia Wang Yanwei Wang Lisha Xing | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 7 | Chemical modification, antioxidant and α-amylase inhibitory activities of corn silk polysaccharides显示文摘 | Shuhan Chen Haixia Chen Jingge Tian Yanwei Wang Lisha Xing Jia Wang | 2013 | Carbohydrate Polymers2013，，1： | 1 |
| 8 | Correlation of effective hepatic blood flow with liver pathology in patients with hepatitis B virus显示文摘Background and aims:Effective hepatic blood flow(EHBF)decreases with liver disease progression,and identifying liver pathology is critical for patients with liver disease.This study was designed to elucidate the correlation between EHBF and liver pathology and explore the potential of EHBF for predicting the degree of liver pathology.Methods:In this study,207 patients with hepatitis B virus(HBV)who underwent liver biopsy and indocyanine green(ICG)clearance tests were enrolled.EHBF was measured using the ICG clearance test,and liver tissue was histologically analyzed to determine the pathological stage according to the Scheuer scoring system.Demographic data,biochemical indexes,and FibroScan data were collected for statistical analysis.Results:EHBF levels decreased as the liver histological stages of inflammation and fibrosis increased(P<0.01).EHBF was significantly negatively associated with the levels of alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpeptidase,alkaline phosphatase,aspartate aminotransferase-to-platelet ratio index,fibrosis index based on the four factors,and liver stiffness measurement(P<0.05).The EHBF levels of patients without liver inflammation(G0)were significantly higher than those of patients with liver inflammation(G1e4)(P<0.001).The area under the receiver operating characteristic curve(AUROC)value for discriminating patients without liver inflammation was 0.827,and the optimal cutoff value was 0.936 L/min.The EHBF levels of patients with severe liver inflammation(G4)were significantly lower than those of patients with G0e3 liver inflammation(P<0.001).The AUROC value for discriminating patients with severe liver inflammation was 0.792,and the optimal cutoff value was 0.552 L/min.The EHBF levels of patients without liver fibrosis(S0)were significantly higher than those of patients with liver fibrosis(S1e4)(P<0.001).The AUROC value for discriminating patients without liver fibrosis was 0.633,and the optimal cutoff value was 1.173 L/min.The EHBF levels of patients with liver cirrhosis(S4)were significantly lower than those of patients with S0e3 liver fibrosis(P<0.001).The AUROC value for discriminating patients with liver cirrhosis(S4)was 0.630,and the optimal cutoff value was 0.562 L/min.Conclusions:EHBF levels and liver pathology are significantly correlated.EHBF could effectively reflect liver inflammation and fibrosis in patients infected with HBV,especially for patients without liver inflammation or liver fibrosis. | Xin Shu Haixia Sun Xiaoan Yang Yifan Jia Peiyan Xu Hong Cao Ka Zhang | 2021 | Liver Research2021，5，4： | 1 |
| 9 | Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression显示文摘 | Haixia Dang Ying Chen Xinmin Liu Qiong Wang Liwei Wang William Jia Yuqing Wang | 2009 | Progress in Neuropsychopharmacology & Biological Psychiatry2009，，8： | 1 |
| 10 | Understanding Family Support for People Living with HIV/AIDS in Yunnan, China显示文摘 | Li Li Sheng Wu Zunyou Wu Stephanie Sun Haixia Cui Manhong Jia | 2006 | AIDS and Behavior2006，，5： | 1 |
| 11 | Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing显示文摘Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implicated in carcinogenesis,aging,and other pathological processes.Although many CFSs were identified decades ago,a consensus is still lacking for why they are particularly unstable and sensitive to replication perturbations.This is in part due to the lack of high-resolution mapping data for the vast majority of the CFSs,which has hindered mechanistic interrogations.Here,we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis(MiDASeq)that are specific for CFSs.We generated a nucleotide-resolution atlas of MiDAS sites(MDSs)that covered most of the known CFSs,and comprehensively analyzed their sequence characteristics and genomic features.Our data on MDSs tallied well with long-standing hypotheses to explain CFS fragility while highlighting the contributions of late replication timing and large transcription units.Notably,the MDSs also encompassed most of the recurrent double-strand break clusters previously identified in mouse neural stem/progenitor cells,thus bridging evolutionarily conserved break points across species.Moreover,MiDAseq provides an important resource that can stimulate future research on CFSs to further unravel the mechanisms and biological relevance underlying these labile genomic regions. | Fang Ji Hongwei Liao Sheng Pan Liujian Ouyang Fang Jia Zaiyang Fu Fengjiao Zhang Xinwei Geng Xinming Wang Tingting Li Shuangying Liu Madiha Zahra Syeda Haixia Chen Wen Li Zhihua Chen Huahao Shen Songmin Ying | 2020 | Cell Research2020，30，11： | 1 |
| 12 | Regulation and functional role of eEF1A2 in pancreatic carcinoma显示文摘 | Haixia Cao Qi Zhu Jia Huang Baiwen Li Su Zhang Weiyan Yao Yongping Zhang | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 1 |
| 13 | Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^(pro) inhibitors as potential candidate for COVID-19 treatment显示文摘In our recent review of the article[1],the author noticed that the dots(red squares)in Fig 1m were accidentally removed from its original location during figure formatting,and the related data analysis is correct.Furthermore,we checked this paper again and this situation only occurred in Fig 1m.In addition,in Fig 1c,a legend for SARS-CoV-1 is missing and we have supplemented it.For the text section,no modifications are required.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected.We regret any inconvenience this has caused. | Zhidong Jiang Bo Feng Yumin Zhang Tianqing Nie Hong Liu Jia Li Haixia Su Leike Zhang Yi Zang Yu Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 14 | Discovery of novel non-peptidic and non-covalent small-molecule 3CL^(pro)inhibitors as potential candidate for COVID-19 treatment显示文摘Dear Editor,The global coronavirus disease 2019(COVID-19)pandemic,which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has brought a profound impact on humanity.SARS-CoV-2 enters host cells through the interaction of its spike glycoprotein with angiotensin-converting enzyme 2(ACE2)of the host and releases its viral RNA genome.^(1) | Zhidong Jiang Bo Feng Yumin Zhang Tianqing Nie Hong Liu Jia Li Haixia Su Leike Zhang Yi Zang Yu Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 15 | High-throughput single-сell sequencing in cancer research显示文摘With advances in sequencing and instrument technology,bioinformatics analysis is being applied to batches of massive cells at single-cell resolution.High-throughput single-cell sequencing can be utilized for multi-omics characterization of tumor cells,stromal cells or infiltrated immune cells to evaluate tumor progression,responses to environmental perturbations,heterogeneous composition of the tumor microenvironment,and complex intercellular interactions between these factors.Particularly,single-cell sequencing of T cell receptors,alone or in combination with single-cell RNA sequencing,is useful in the fields of tumor immunology and immunotherapy.Clinical insights obtained from single-cell analysis are critically important for exploring the biomarkers of disease progression or antitumor treatment,as well as for guiding precise clinical decision-making for patients with malignant tumors.In this review,we summarize the clinical applications of single-cell sequencing in the fields of tumor cell evolution,tumor immunology,and tumor immunotherapy.Additionally,we analyze the tumor cell response to antitumor treatment,heterogeneity of the tumor microenvironment,and response or resistance to immune checkpoint immunotherapy.The limitations of single-cell analysis in cancer research are also discussed. | Qingzhu Jia Han Chu Zheng Jin Haixia Long Bo Zhu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
| 16 | Enhancing the Performance of the Organic Light-emitting Device (OLED) by Thermal Treatment显示文摘 | ZHANG Chunlin ZHANG Yong LI Haixia WANG Fangcong ZHANG Guobing CHEN Da JIA Xiaoyun LIU Su | 2011 | Chinese Journal of Electronics2011，20，1： | 0 |
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