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| 1 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 2 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 3 | Effects of age on survival and morbidity in gastric cancer patients undergoing gastrectomy显示文摘AIM To evaluate clinicopathological features and surgical outcomes of gastric cancer in elderly and non-elderly patients after inverse probability of treatment weighting(IPTW) method using propensity score.METHODS We enrolled a total of 448 patients with histologically confirmed primary gastric carcinoma who received gastrectomies. Of these, 115 patients were aged > 80 years old(Group A), and 333 patients were aged < 79 years old(Group B). We compared the surgical outcomes and survival of the two groups after IPTW.RESULTS Postoperative complications, especially respiratory complications and hospital deaths, were significantly more common in Group A than in Group B(P < 0.05). Overall survival(OS) was significantly lower in Group A patients than in Group B patients. Among the subset of patients who had pathological Stage Ⅰ?disease, OS was significantly lower in Group A(P < 0.05) than Group B, whereas cause-specific survival was almost equal in the two groups. In multivariate analysis, pathological stage, histology, and extent of lymph node dissection wereindependent prognostic values for OS.CONCLUSION When the gastrectomy was performed in gastric cancer patients, we should recognized high mortality and comorbidities in that of elderly. More extensive lymph node dissection might improve prognoses of elderly gastric cancer patients. | Yoshinori Fujiwara Shuichi Fukuda Masanori Tsujie Hajime Ishikawa Kotaro Kitani Keisuke Inoue Masao Yukawa Masatoshi Inoue | 2017 | World Journal of Gastrointestinal Oncology2017，9，6： | 4 |
| 4 | Adult case of an omphalomesenteric cyst resected by laparoscopic-assisted surgery显示文摘这份报告由帮助 laparoscopic 的外科描述脐肠系膜包囊 resected 的一个极其稀罕的成年案例。A 29-years-old 日语人被提交并且因为一个腹的团和提高的浆液 CEA (carcinoembryonic 抗原) ,承认了到九州大学医院在 2001 年 8 月的水平(21.3 ng/mL ) 。腹的 CT 和美国与中隔和石灰化表明了一个膀胱的团。腹腔镜检查显示了一个大团被纳入他的腹壁,测量 110 公里 x 70 公里 x 50 公里并且充满了粘液。团是由帮助 laparoscopic 的外科的 resected。它的墙的组织检查所见显示出纤维肌性织物,脂肪组织,石灰化,和肠的结构。是脐肠系膜包囊最后被诊断。 | Fumi Sawada Rie Yoshimura Kenichi Ito Kazuhiko Nakamura Hajime Nawata Kazuhiro Mizumoto Shuji Shimizu Takahiro Inoue Takashi Yao Masazumi Tsuneyoshi Atushi Kondo Naohiko Harada | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 5 | Aluminium-Oxygen Equilibrium Between CaO-AlzOa Melts and Liquid Iron显示文摘 | Suito Hideaki Inoue Hajime Inoue Ryo | 1991 | ISIJ International1991，31，12： | 1 |
| 6 | Application for regenerative medicine of epithelial cell culture-vistas of cultured epithelium 显示文摘 | Hajime Inoue Hideo Oshima Kyo-Ichi Matsuzaki | 2006 | Congenital Anomalies2006，46，： | 1 |
| 7 | Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease显示文摘 | Hiromasa Takaishi Takahiro Matsuki Atsushi Nakazawa Toshihiko Takada Shoichi Kado Takashi Asahara Nobuhiko Kamada Atsushi Sakuraba Tomoharu Yajima Hajime Higuchi Nagamu Inoue Haruhiko Ogata Yasushi Iwao Koji Nomoto Ryuichiro Tanaka Toshifumi Hibi | 2007 | International Journal of Medical Microbiology2007，，： | 1 |
| 8 | Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease显示文摘 | Hiromasa Takaishi Takahiro Matsuki Atsushi Nakazawa Toshihiko Takada Shoichi Kado Takashi Asahara Nobuhiko Kamada Atsushi Sakuraba Tomoharu Yajima Hajime Higuchi Nagamu Inoue Haruhiko Ogata Yasushi Iwao Koji Nomoto Ryuichiro Tanaka Toshifumi Hibi | 2007 | International Journal of Medical Microbiology2007，，5： | 1 |
| 9 | Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma显示文摘 | Masayoshi Inoue Mitsunori Ohta Keiji Iuchi Akihide Matsumura Kan Ideguchi Tsutomu Yasumitsu Katsuhiro Nakagawa Kenjiro Fukuhara Hajime Maeda Shin-ichi Takeda Masato Minami Yuko Ohno Hikaru Matsuda | 2004 | The Annals of Thoracic Surgery2004，，1： | 1 |
| 10 | Interweaving MicroRNAs and Proinflammatory Cytokines in Gastric Mucosa with Reference to H. pylori Infection显示文摘 | Hajime Isomoto Kayoko Matsushima Naoki Inoue Tomayoshi Hayashi Toshiyuki Nakayama Masaki Kunizaki Shigekazu Hidaka Masaaki Nakayama Junzo Hisatsune Masahiro Nakashima Takeshi Nagayasu Kazuhiko Nakao Toshiya Hirayama | 2012 | Journal of Clinical Immunology2012，，： | 1 |
| 11 | Image restoration using the RBF network with variable regularization parameters 显示文摘 | Kaoru Inoue Youji Iiguni Hajime Maeda | 2003 | Neurocomputing2003，50，： | 1 |
| 12 | Peroral endoscopic myotomy for esophageal achalasia: C linical impact of 28 cases显示文摘 | Hitomi Minami Hajime Isomoto Naoyuki Yamaguchi Kayoko Matsushima Yuko Akazawa Ken Ohnita Fuminao Takeshima Haruhiro Inoue Kazuhiko Nakao | 2014 | Digestive Endoscopy2014，，1： | 1 |
| 13 | New roots to formation of nanostructures on glass surface through anodie oxidation of sputtered aluminum 显示文摘 | Satoru Inoue Song-Zhu Chu Hajime Haneda | 2003 | Sci Technol Adv Mater2003，4，： | 1 |
| 14 | YS 500N/mm2 high strength steel for offshore structures with good CTOD properties at welded joints显示文摘 | Nagai Yoshihide Fukami Hidenori Inoue Hajime | | 0，，： | 1 |
| 15 | Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome显示文摘 | Yoshiyuki Matsuo Masashi Tanaka Hajime Yamakage Yousuke Sasaki Kazuya Muranaka Hiroaki Hata Iwao Ikai Akira Shimatsu Mayumi Inoue Tae-Hwa Chun Noriko Satoh-Asahara | 2015 | Metabolism2015，，11： | 1 |
| 16 | Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin显示文摘 | Keiichi Kontani Osamu Taguchi Yoshitomo Ozaki Jun Hanaoka Satoru Sawai Shuhei Inoue Hajime Abe Kazuyoshi Hanasawa Shozo Fujino | 2003 | International Journal of Molecular Medicine2003，，4： | 1 |
| 17 | A new cell line separated from the contractile muscle cell line of Chinese oak silkworm, Antheraea pernyi显示文摘 | Hajime Inoue Shoji Hayasaka | 1995 | J Seric Sci Jpn1995，64，1： | 1 |
| 18 | The effectiveness of high-flow regional cerebral perfusion in Norwood stage I palliation显示文摘 | Kagami Miyaji Takashi Miyamoto Satoshi Kohira Takeshi Yoshii Kei-ichi Itatani Hajime Sato Nobuyuki Inoue | 2011 | European Journal of Cardio-Thoracic Surgery2011，，5： | 1 |
| 19 | Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis显示文摘 | Hajime Isomoto Aiping Wang Yohei Mizuta Yuko Akazawa Kazuo Ohba Katsuhisa Omagari Masanobu Miyazaki Kunihiko Murase Tomayoshi Hayashi Kenichiro Inoue Ikuo Murata Shigeru Kohno | 2003 | The American Journal of Gastroenterology2003，，3： | 1 |
| 20 | world's largest capacity 65 MW bulb generating unit for Tadami project 显示文摘 | Hajime Nishizawa Hisao Inoue Isao Yanagida Hisashi Toshima | 1988 | Hitachi Review1988，37，2： | 1 |
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