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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 3 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 4 | A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease显示文摘Chronic kidney disease(CKD)poses a great burden to global public health as current therapies are generally ineffective.Early detection and effective therapy are crucial for the future prevention and progression of CKD.Nanoparticles(NPs)vary by particle size,charge,shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties,targetability,or the bioavailability of drugs.Thus,the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD.This review describes the current experimental research,clinical applications of NPs,the current challenges,and upcoming opportunities in the diagnosis and treatment of CKD. | Yanhong Ma Fanghao Cai Yangyang Li Jianghua Chen Fei Han Weiqiang Lin | 2020 | Bioactive Materials2020，5，3： | 3 |
| 5 | True random coded photon counting Lidar显示文摘A true random coded photon counting Lidar system is proposed in this paper,in which a single photon detector acts as the true random sequence signal generator instead of the traditional function generator.Compared with the traditional pseudo-random coded method,the true random coded method not only improves the anti-crosstalk capability of the system,but more importantly,it effectively overcomes the adverse effect of the detector’s dead time on the ranging performance.The experiment results show that the ranging performance of the true random coded method is obviously better than that of the pseudo-random coded method.As a result,a three-dimensional scanning imaging of a model car is completed by the true random coded method. | Bo Liu Yang Yu Zhen Chen Weiqiang Han | 2020 | Opto-Electronic Advances2020，3，2： | 3 |
| 6 | Variations of Surface Heat Fluxes over the Tibetan Plateau before and after the Onset of the South Asian Summer Monsoon during 1979–2016显示文摘As the 'Third Pole of the World,' the Tibetan Plateau (TP) is an important thermal forcing to the South Asian summer monsoon (ASM) and even the global atmospheric circulation. In this paper, surface heat fluxes from the ERA-Interim reanalysis data during March-October of 1979-2016 in the TP and its surrounding areas are examined and analyzed. The results are as follows.(1) From March to May (before the ASM onset), the main body of the TP is dominated by sensible heat flux, which increases rapidly with high (low) values in the west (east), while the change of latent heat flux is small but it increases with time.(2) From June to August (after the ASM onset), sensible heat flux over the TP decreases, while latent heat flux increases rapidly with high (low) values in the east (west).(3) From September to October (after the ASM withdrawal), sensible and latent heat fluxes are comparable to each other in strength, again with high (low) sensible heat flux in the west (east).(4) During 1979-2016, surface sensible heat flux in the whole TP shows a slightly downward trend, while latent heat flux shows an increasing trend. Specifically, in the western TP, sensible (latent) heat flux shows a weak decreasing (an increasing) trend;while in the eastern TP, sensible (latent) heat flux decreases (increases obviously). These variations are consistent with the observed warming and moistening in the TP region. The above results are useful for further analysis of the change of atmospheric heat sources and surface heat fluxes over the TP based on the data from the Third Tibetan Plateau Atmospheric Science Experiment (TIPEX-Ⅲ). | Yizhe HAN Weiqiang MA Yaoming MA Cuiyan SUN | 2019 | Journal of Meteorological Research2019，33，3： | 3 |
| 7 | Fabrication of Fe nanocomplex pillared few-layered Ti_(3)C_(2)T_(x)MXene with enhanced rate performance for lithium-ion batteries显示文摘Pillaring technologies have been considered as an effective way to improve lithium storage performance of Ti_(3)C_(2)T_(x)MXene.Nevertheless,the pillared hybrids suffer from sluggish Li^(+)diffusion kinetics and electronic transportation due to the compact multi-layered MXene structure,thus exhibiting inferior rate performance.Herein,the few-layered Ti_(3)O_(2)MXene(f-Ti_(3)C_(2)MXene)which is free from restacking can be prepared quickly based on the NH4^(+)ions method.Besides,Fe nanocomplex pillared few-layered Ti_(3)C_(2)T_(x)(FPTC)heterostructures are fabricated via the intercalation of Fe ions into the interlayer of f-Ti_(3)C_(2)MXene.The f-Ti_(3)C_(2)MXene which is immune to restacking can provide a highly conductive substrate for the rapid transport of Li+ions and electrons and possess adequate electrolyte accessible area.Moreover,f-Ti_(3)C_(2)MXene can efficiently relieve the aggregation,prevent the pulverization and buffer the large volume change of Fe nanocomplex during lithiation/delithiation process,leading to enhanced charge transfer kinetics and excellent structural stability of FPTC composites.Consequently,the FPTC hybrids exhibit a high capacity of 535 mAh·g^(-1)after 150 cycles at 0.5 A·g^(-1)and an enhanced rate performance with 310 mAh·g^(-1)after 850 cycles at 5 A·g^(-1).This strategy is facile,universal and can be extended tofabricate various few-layered MXene-derived hybrids with superior rate capability. | Pengfei Huang Shunlong Zhang Hangjun Ying Wentao Yang Jianli Wang Rongnan Guo Weiqiang Han | 2021 | Nano Research2021，14，4： | 3 |
| 8 | Shape-controlled growth of SrTiOz polyhedral submicro/ nanocrystals显示文摘 | Lingqing Dong Hui Shi Kui Cheng Qi Wang Wenjian Weng Weiqiang Han | 2014 | Nano Research2014，7，9： | 3 |
| 9 | 3UVH2 and SUVH9 Couple Two Essential Steps For Transcriptional Gene Silencing in Arabidopsis显示文摘在 Arabidopsis,一条指导 RNA 的 DNA methylation 小径(RdDM ) 为 DNA methylation 的 de novo 建立负责并且贡献 transcriptional 基因 silencing。最近, microrchidia (MORC ) 类型 ATPases 被显示在由调整高顺序的染色质建筑学的形成强制基因和 transposons 的一个子集的 transcriptional 基因 silencing 起必要作用。然而, MORC 蛋白质怎么与 RdDM 小径部件合作调整基因表示,仍然保持大部分不清楚。在这研究, SUVH9 和 MORC6 从一屏蔽 idm1 的 suppressors 被识别,它是在活跃 DNA demethylation 的一个变异的有缺陷者。没有提高 DNA methylation 层次, SUVH9 和 MORC6 为二记者基因和一些内长的基因的 silencing 被要求。SUVH9,苏(增值商) 3-9 相当或相同的事物之一在 RdDM 包含了,直接与 MORC6 和它的二个靠近的相当或相同的事物交往, MORC1 和 MORC2。类似于 MORC6, SUVH9 和它的相当或相同的事物 SUVH2 在 SDC 和 Solo-LTR loci 为 heterochromatin 冷凝作用和 3D 染色质建筑学的形成被要求。我们建议 SUVH2 和 SUVH9 绑在 methylated DNA 并且与 MORC 蛋白质联合便于改变染色质的建筑群的招募到目标 loci。 | Yuqing Jing Han Sun Wei Yuan Yue Wang Qi Li Yannan Liu Yan Li Weiqiang Qian | 2016 | Molecular Plant2016，9，8： | 2 |
| 10 | Synthesis of Gallium Nitride Nanorods through a Carbon Nanotube-Confined Reaction显示文摘 | Han Weiqiang Fan Shoushan Li Qunqing | 1997 | Science1997，277，29： | 1 |
| 11 | Polybenzimidazole functionalized electrolyte with Li-wetting and self-fluorination functionalities for practical Li metal batteries显示文摘Rough Li plating,low ionic conductivity,and low thermal stability of conventional electrolytes post-primary challenges for achieving reliable high-capacity rechargeable lithium batteries,for which lithiummetal is frequently proposed as themost promising anode material.Conventional low-polarity commercial polypropylene/polyethylene separators fail to support the application of high-energy-density Li anodes due to their rigid physicochemical properties and the high reactivity of Li metal,leading to fatal dendrite formation and vigorous exothermic reaction with electrolytes.Herein,we develop a Li-wetting,flame-retardant binary polymer electrolyte by functionalizing poly(vinylidene fluoride)(PVDF)separators with nonflammable polybenzimidazole(PBI)to build safe room-temperature solid-state electrolyte membranes.A dendrite-free LiFePO4 cell with the solid polymer electrolyte(SPE)delivers a discharge capacity of 127 mAh g^(-1) at 25℃ with a capacity retention of 87.5%after 500 cycles at 0.5℃(0.15 mA cm^(-2)).Phase-field simulations and density functional theory calculations demonstrate that the negatively charged benzimidazole chains of PBI own superior affinity to lithium bis(trifluoromethanesulfonyl)imide(LiTFSI),and shares overlapping electron density with Li anode,giving rise to accelerated Li^(+)conduction at room temperature and uniform Li electrodeposition at the electrolyte/Li metal interface.The SPE is also flame-retardant since heat-resistant polytetrafluoroethylene and a dense,heat-blocking graphitized carbon layer are formed in intense heat throughdehydrogenation/fluorination of PVDF under the catalysis of Lewis base imidazole rings and the decomposition of benzimidazole rings in PBI.No such fire-resistant mechanism is ever reported in conventional electrolytes. | Dongjiang Chen Yuanpeng Liu Chuan Xia Yupei Han Qingwei Sun Xuchang Wang Wei Chen Xian Jian Weiqiang Lv Jianyi Ma Weidong He | 2022 | InfoMat2022，4，5： | 1 |
| 12 | Coating of carbon nanotube withnickel by electroless plating method显示文摘 | Qunqing Li Shoushan Fan Weiqiang Han | 1997 | Jpn J Appl Phys1997，36，50： | 1 |
| 13 | Synthesis of gallium nitride nanorods through a carbon nanotube-confined reaction显示文摘 | HAN Weiqiang FAN Shoushan LI qunqing | 1997 | Science1997，277，29： | 1 |
| 14 | 显示文摘 | Han Weiqiang Fan Shoushan Li Qunqing | 1997 | Science1997，277，： | 1 |
| 15 | Enantioseparation of novel chiral tetrahedrane-type clusters on an amylose tris (Phenylcarbamate) chiral stationary phase显示文摘 | Han Xiaoqian Liu Yueqi Zhang Yuhua Zhang Weiqiang Li Yongmin Chen Liren | 2002 | Chromatographia (-)2002，，5： | 1 |
| 16 | Continuous synthesis and characterization of silicon carbide nanorods显示文摘 | HAN Weiqiang FAN Shoushan LI Qunqing | 1997 | Chem Phys Lett1997，265，： | 1 |
| 17 | Synthesis of Gallium Nitride Nanorods Through a Carbon Nanotube-Confined Reaction 显示文摘 | Han Weiqiang Fan Shoushan Li Qunqing | 1997 | Science1997，277，： | 1 |
| 18 | Synthesis of gallium nitride nanorods through a carbon nanotube-confined reaction 显示文摘 | Han Weiqiang Fan Shoushan Li qunqing | 1997 | Science1997，277，29： | 1 |
| 19 | Formation and oxidation state of CeO2-x nanotubes 显示文摘 | Han Weiqiang Wu Lijun Zhu Yimei | 2005 | Journal of the American Chemical Society2005，127，12： | 1 |
| 20 | 显示文摘 | Han Weiqiang Fan Shoushan Li Qunqing | 1997 | Science1997，277，： | 1 |
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