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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | FAM19A4 is a novel cytokine ligand of formyl peptide receptor I (FPR 1) and is able to promote the migration and phagocytosis of macrophages显示文摘FAM19A4 是为有顺序类似 19 的家庭的缩写(chemokine (C-C 主题)-like) 成员 A4,它能分泌的蛋白质在正常纸巾在底层被表示。坚定的 FAM19A4 遗体的生物功能,和它的潜在的受体是 unclarified。在这研究,我们证明 FAM19A4 是古典能分泌的蛋白质,我们第一次证实它的成熟蛋白质由 95 氨基酸组成。我们发现这新奇 cytokine 的表示是 upregulated 在里面 lipopolysaccharide (LPS ) 刺激了单核白血球和巨噬细胞并且典型地在极化的 M1。FAM19A4 在巨噬细胞上显示出趋化性的活动并且随蛋白质 kinase B (Akt ) 的 phosphorylation 的显著增加在 vitro 并且在 vivo 提高 zymosan 的巨噬细胞吞噬作用。FAM19A4 能也在 zymosan 刺激之上增加反应的氧种类(ROS ) 的版本。基于受体成为主观,收音机 ligand 绑定试金和受体阻塞,而且,我们第一次证明 FAM19A4 是甲酰肽受体 1 的新奇 ligand (FPR1 ) 。上述数据显示在煽动性的刺激之上, monocyte/macrophage-derived FAM19A4 可以在病原的感染期间在巨噬细胞的移植和激活起一个关键作用。 | Wenyan Wang Ting Li Xiaolin Wang Wanxiong Yuan Yingying Cheng Heyu Zhang Enquan Xu Yingmei Zhang Shuang Shi Dalong Ma Wenling Han | 2015 | Cellular & Molecular Immunology2015，12，5： | 8 |
| 3 | CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2,and STAT3 pathway in colorectal cancer显示文摘CMTM4(CKLF-like MARVEL transmembrane domain containing 4),a potential tumor suppressor gene,is involved in several types of malignancies.It has been reported to be downregulated and exhibit anti-tumorigenic activities by regulating cell growth and cell cycle in clear cell renal cell carcinoma.It has also been identified as a tumor suppressor in hepatocellular carcinoma(HCC),and its negative expression is a risk factor for poor prognosis of HCC patients.In the present study,an integrated bioinformatics analysis based on The Cancer Genome Atlas(TCGA)database showed that CMTM4 was frequently reduced in colorectal cancer(CRC)and high expression of CMTM4 was associated with increased overall survival rates.Based on these findings,we adopted gain-of-function and lost-of-function strategies using SW480 and HT29 CRC cell lines which have relatively low and high endogenous CMTM4 levels,respectively.We observed impeded cell proliferation and migration upon overexpression of CMTM4 in SW480 cells,and the opposite effects were observed upon knockdown of CMTM4 in HT-29 cells.Cell signaling pathways essential for CRC progression were then examined,and the phosphorylation levels of AKT,ERK1/2,and STAT3 were found to be decreased by CMTM4 overexpression in SW480 cells and elevated by CMTM4 silencing in HT29 cells.Their inhibitors were used to validate that the three signaling pathways contributed to the inhibitory effects of CMTM4 on CRC cells.Taken together,our results suggest that CMTM4 plays a tumor suppressive role in CRC. | Hui Xue Ting Li Pingzhang Wang Xiaoning Mo Hejun Zhang Shigang Ding Dalong Ma Wenping Lv Jing Zhang Wenling Han | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 5 |
| 4 | First Human Infection Case of Monkey B Virus Identified in China,2021显示文摘Monkey B virus(BV),initially isolated in 1932,is currently designated as Macacine alphaherpesvirus 1 by the International Committee on Taxonomy of Viruses(1).BV is an alphaherpesvirus enzootic in macaques of the genus Macaca,normally transmitted horizontally via direct contact and exchange of bodily secretions,just like herpes simplex virus(HSV)in humans. | Wenling Wang Wenjie Qi Jingyuan Liu Haijun Du Li Zhao Yang Zheng Guoxing Wang Yang Pan Baoying Huang Zhaomin Feng Daitao Zhang Peng Yang Jun Han Quanyi Wang Wenjie Tan | 2021 | China CDC weekly2021，3，29： | 4 |
| 5 | Efficient production of CYTL1 protein using mouse IgGK signal peptide in the CHO cell expression system显示文摘 | Xiaolin Wang Huihui Liu Wanqiong Yuan Yingying Cheng Wenling Han | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 3 |
| 6 | Research progress in cytokines with chemokine-like function显示文摘Cytokines are small proteins secreted by a variety of cells,which regulate not only cell growth and differentiation but also immune function by binding to their corresponding receptors.1 Cytokines mainly include interleukin,colonystimulating factor(CSF),interferon,tumor necrosis factor,growth factor(GF)and chemokine.Chemokines are a class of cytokines with chemotactic activity and function by binding to G proteincoupled receptors.2 Chemokines and their receptors have important roles in inflammation and tumors by regulating chemotaxis,immunoregulation and the behavior of various cells. | Kai Zhang Shuang Shi Wenling Han | 2018 | Cellular & Molecular Immunology2018，15，7： | 2 |
| 7 | Identification of eight genes encoding chemokine-like factor super family members 1-8 (CKLFSF 1 -8) by in silico cloning and experimental validation 显示文摘 | Han Wenling Ding Peiguo Xu Mingxu | 2003 | Genomics2003，81，： | 1 |
| 8 | Molecular cloning and characterization of chemokinc-like factor 1 ( CKLF1 ), a novel human eytnkine with unique structure and potential ehenaotaetie activity显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochem J2001，357，： | 1 |
| 9 | The first strain of monkeypox isolated in the Chinese Mainland and preserved at the National Pathogen Resource Center of China显示文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future. | Qiang Wei Baoying Huang Wei Huang Jingdong Song Li Mei Li Zhao Jing Yin Juan Zhang Wenling Wang Fei Ye Caiyun Li Liling Bai Yanhai Wang Yao Deng Bo Liu Mengnan Jiang Guizhen Wu Jun Han Hua Zhao Hua Ling Wenjie Tan Jianjun Liu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 10 | Research of cervical cytology screening in diagnosis of 370,000 cases with cervical lesion in Guangdong显示文摘由使用颈的基于液体的细胞学屏蔽的 3700 万个盒子的结果的客观分析,讨论在广东的颈的癌症和癌前期损害的状况省。从 2002 ~ 2006 的方法,在广东在 371,929 个女人以内屏蔽颈的损害的使用的基于液体的薄层的细胞学(TCT ) 方法。Cytological 诊断 adopt TBS (Bethesda 系统) 标准(TBS 改进了诊断标准的 2001 版本) ,到年龄和区域的统计的积极的率分别地。结果妇科学的 371,929 个盒子在广东的颈的样品, 331,251 个盒子是否定的,占了 91.23% ;细胞学积极盒子:32,548 个盒子是有鳞的 intraepithelial 损害(8.96%) , 486 个盒子是腺的上皮的损害(0.13%) ;根据年龄组织了:30 是 9.13% 到 50 岁的积极的率, 40 是 9.60% 到 50 岁的积极的率,后者有更高的细胞学积极的率;根据区域组织了:在 PRD 区域的全部的样品是 304.951 个盒子,占了81.99%,在哪个 24301 个盒子是积极的(8.14%)在 NON-PRD 区域的 66978 种情况(18.01%)中, 7645 个盒子是积极的(11.87%),有 1858 个盒子从 2004~2005 的有的活体检视/后续结果,并且率是2.88%。结论 cytological 颈的癌症和它的癌前期损害的积极的率在广东是9.09%(哪个 cytological 诊断的率作为癌前期损害是3.40%), 30~50 年龄组有颈的癌症和它的先锋损害的高发生,并且也,main 为颈的癌症预防上演。细胞学积极的率在经济发展不足非珍珠河三角洲区域是 11.87% ,比珍珠河三角洲区域高得多。 | Baowen Zheng Congde Chen Anxiang Wei Han Ran Dong Liu Wenling Yue Huirong Zhou Qingyi Zhu Juming Su | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 1 |
| 11 | Characteristics of Climate Change and its Response in the Qinghai-Tibet Plateau during 1971-2010显示文摘Climate data during 1971-2010 showed that mo st areas of Qinghai-Tibet Plateau showed warm wet climate change type dominated by temperature and humidity increase.Temperature increase magnitude was the smallest in spring and the largest in winter,and the precipitation increased at the low-altitude area and decreased at high altitude.The warm wet climate change caused Qinghai-Tibet Plateau alpine grassland degradation,reduction of glacier and frozen soil,wetland reduction and other environmental problems. | ZHANG Zhichun HAN Wenling WANG Jun CAI Yongxiang LI Gang CAI Zhongzhou ZHANG Chengjia SHENG Haiyan ZHAO Chaojun | 2016 | Journal of Landscape Research2016，8，6： | 1 |
| 12 | Molecular cloning and characterization of chemokine-like factor 1(CKLF1), a novel human cytokine with unique structure and potential chemotatic activity显示文摘 | Wenling HAN Yaxin LOU Junmin TANG | 2001 | Biochem J2001，357，1： | 1 |
| 13 | Molecular cloning and characterization of chemokine-like factor 1 ( CKLF1 ), a novel human cytokine with unique structure and potential chemotactic activity 显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochemistry2001，57，1： | 1 |
| 14 | Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Wenling Han Yaxin Lou Junmin Tang | 2001 | Biochem J2001，357，： | 1 |
| 15 | The Stimulating effect of chemokine-like factors (CKLFs) on skeletal muscle cells 显示文摘 | Han Wenling Xia Donglan Lou Yaxin | 2001 | Cell Biol Int2001，25，10： | 1 |
| 16 | Molecular clonging and characterization of chemokine-like factor 1 (CKLF-1), a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Wenling Han Yanxin Lou Junmin Tang | 2001 | Biochem J2001，357，： | 1 |
| 17 | Molecular cloning and characterization of chemokine-like factorl ( CKLF ), a novel human cytekine with unique structure and potential chemotactic activity显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochem J2001，357，4： | 1 |
| 18 | The Stimulating effect of chemokine like factors (CKLFs) on skeletal muscle cells 显示文摘 | Han Wenling Xia Donglan Lou Yaxin | 2001 | Cell Biol Inte2001，25，10： | 1 |
| 19 | Selecti- vity of Br/Li exchange and deprotonanon of 4,4'-di- bromo-3,3 '-bithiophene for synthesis of symmetrical and unsymmetrical dithienoheteroaromatic rings显示文摘 | Han Hui Zhao Wenling Song Jinsheng | 2013 | J Org Chem2013，78，6： | 1 |
| 20 | Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation显示文摘 | Han Wenling Ding Peiguo Xu Mingxu | 2003 | Genomics2003，81，： | 1 |
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