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	题名	作者	年代	出处	被引量
1	The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment.	Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda	2011	Cellular & Molecular Immunology2011，8，2：	47
2	Nutrient Enrichment in Tropical Wetlands:Shifts from Autotrophic to Heterotrophic Nitrogen Fixation显示文摘	HanaˇS Eliˇska R Barbora P	2010	Biogeochemistry2010，，101：	1
3	Insulin pumps in pediatricroutine care improve Long - term metabolic controc without increasing the risk of hypoglycenria显示文摘	Hanas R Adolfsson P	2006	Pediatr Diabetes2006，7，1：	1
4	BreastMRI forevaluating patientswithmetastatic axillary lymph node and initially nega- tive mammography and sonography 显示文摘	Ko E Y HanA P Shin JH	2007	Korean JRadio2007，8，5：	1
5	Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia 显示文摘	Hanas R Adolfsson P	2006	Pediatr Diabetes2006，7，1：	1
6	Lipid Remodeling of Murine Epididymosomes and spermatozoa during epididyal maturation 显示文摘	Hanae R Benoit S Gerard P	2006	Biol Reprod2006，74，6：	1
7	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver显示文摘	van de Steeg Evita Stránecky Viktor Hartmannová Hana Nosková Lenka Hrebícek Martin Wagenaar Els van Esch Anita de Waart Dirk R Elferink Ronald P J Oude Kenworthy Kathryn E Sticová Eva al-Edreesi Mohammad Knisely A S Kmoch Stanislav Jirsa Mi	2012	EN2012，，2：	1
8	Enhanced virus resistance of transgenic mice expressing the human MxA protein显示文摘	JOVAN P HEINRICH A HANA P H	1995	J Virol1995，69，7：	1
9	Insulin pumps in pediatricr outine care improve Long - term metabolic controc without increasing the risk of hypoglycenria 显示文摘	Hanas R Adolfss on P	2006	Pediatr Diabetes2006，7，1：	1
10	Defective interleukin-2 Production and inted- eukin-2 receptor expossion in Pulmonary tubeoulosis显示文摘	hana M Srivatava LM Kumar P	2003	J Commun Dia2003，35，1：	1
11	Synthesis, characterization and antibacterial activity of new fluorescent chitosan derivatives显示文摘	Hana P?ichystalová Numan Almonasy Abdel-Mohsen A M	2014	International Journal of Biological Macromolecules2014，65，4：	1
12	Customer churn analy-sis: churn determinants and mediation effects of partial defec-tion in the Korean mobile telecommunications service industry显示文摘	AHNA J H HANA S P LEE Y S	2006	Telecommunications Policy2006，30，：	1
13	Clarifying the construct of human resource systems: Relating human resource management to employee performance 显示文摘	Kaifeng Jianga David P Lepaka Kyongji Hana	2012	Human Resource Management Review2012，22，2：	1
14	Inactivation of parvovirus B19 and model viruses in factor Vm by dry heat treatment at 80 degree C 显示文摘	ROBERTS P L EI HANA C SALDANA J	2006	Tansfusion2006，46，9：	1
15	Glycogen SynthaseKinase -3beta regulates Snail and beta -catenin during gastrin -induced migration of gastric cancer cells显示文摘	Mishra P Senthivinayagam S Hana A	2010	J Mol Signal2010，5，1：	1
16	The effect of korean red ginseng extracts with escalating levels of ginsen- oside Rg3 on blood pressure in individuals with high normal blood pressure or hypertension显示文摘	STAVRO P M HANA A K VUKSAN V	2002	American Journal of Hypertension2002，15，3：	1
17	Low-temperature nitriding of 38CrMoAl steel with a nanostructured surface layer induced by surface mechanical attrition treatment 显示文摘	Tong W P Hana Z Wang L M	2008	Surface and Coatings Technology2008，202，20：	1
18	Effect of steam explosion treatment on characteristics of wheat straw 显示文摘	Hana G P Deng J Zhang S Y	2010	Industrial Crops and Products2010，，31：	1
19	Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia显示文摘	Hanas R Adolfsson P	2006	Pediatr Diabetes2006，7，：	1
20	Ornamental fish as a source of plasmid-mediated quinolone resistance genes and antibiotic resistance plamids显示文摘	Hana D Iva K Veronika P	2014	Veterinary Microbiology2014，171，34：	1

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