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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro显示文摘AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) cells.METHODS: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 B cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TGF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine stimulation.RESULTS: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TGF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TGF-β, positively influence CA9 expression under both normoxic and hypoxic conditions.CONCLUSION: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and on the role of the CA9 gene as a positive disease regulator in human cancer. | Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten Hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said | 2012 | World Journal of Clinical Oncology2012，3，6： | 2 |
| 3 | Computational analysis offouling by low energy surfaces 显示文摘 | Hatice 0 0 Virendra M P | 2010 | Journal of Food Engineering2010，99，3： | 1 |
| 4 | 3-T MRI of the biliary tract variations显示文摘 | Hakan ?nder Muhammed S?dd?k ?zdemir Güven Tekba? Faysal Ekici Hatice Gümü? Aslan Bilici | 2013 | Surgical and Radiologic Anatomy2013，，2： | 1 |
| 5 | Modulation of transcription factor Nrf2 inaninvitromodel of traumatic brain injury显示文摘 | Hatic H Kane M J Saykally J N | 2012 | Neurotrauma2012，29，6： | 1 |
| 6 | The effects of propofol infu- sion on hepatic and pancreatic function and acid base status in children undergoing craniotomy and receiving phenytoin显示文摘 | Hatice T Arzu M Ozge K | 2009 | Anesth Analg2009，109，36： | 1 |
| 7 | Performance status of patients is the major prognostic factor at all stages of pancreatic cancer显示文摘 | Faruk Tas Fatma Sen Hatice Odabas Leyla K?l?c Serkan Kesk?n Ibrah?m Y?ld?z | 2013 | International Journal of Clinical Oncology2013，，5： | 1 |
| 8 | Modeling the pathobiology of repetitive traumatic brain injury in immortalized neuronal cell lines显示文摘 | Kane M J Hatic H Delic V | 2011 | Brain Res2011，，1425： | 1 |
| 9 | Unusual Noncommunicating Isolated Enteric Duplication Cyst in Adults显示文摘 | Metehan Gümü? Murat Kapan Hatice Gümü? Akin ?nder Sadullah Girgin A. Andoh | 2011 | Gastroenterology Research and Practice2011，，： | 1 |
| 10 | Glutathione S-transferase gene polymorphism as a susceptibility factor in smoking-related coronary artery disease显示文摘 | Lülüfer Tamer PhD Bahad?r Ercan Msc Ahmet Camsar? M. D. Hatice Y?ld?r?m Msc Dilek ?i?ek M. D. Nehir Sucu M. D. Nurcan Aras Ate? PhD U?ur Atik PhD | 2004 | Basic Research in Cardiology2004，，3： | 1 |
| 11 | A study on development of a scale to assess nursing students'performance in clinical settings显示文摘 | zgul K Hatice M Ayse B | 2008 | Journal of clinical nursing2008，18，： | 1 |
| 12 | Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients显示文摘 | Murat D Hatice A Fatma M | 2006 | Nephrol Dial Transplant2006，21，： | 1 |
| 13 | Migraine prevalence, alexithymia, and post- traumatic stress disorder among medical students in Turkey 显示文摘 | BALABAN Hatice SEMIZ M SENTURK IA | 2012 | J Headache Pain2012，13，6： | 1 |
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