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| 1 | First-principles Study of NiAl Alloyed with Rare Earth Element Ce显示文摘The structural, elastic, and electronic properties of NiAl alloyed with rare earth element (REE) Ce have been investigated by using density functional theory (DFT). It is found that Ce has a strong Al site preference and causes lattice distortion of NiAl. The calculation of elastic constants shows that Ce increased both the hardness and the ductility of NiAl, which could be explained by the formation of new ionic bonds between Al (and Ni) and Ce and the enhancement of covalent bonds in Ni8Al7Ce. Our results are in good agreement with the available experimental data and other theoretical results. | You Wang Junqi He Mufu Yan Chonggui Li Liang Wang YeZhou | 2011 | Journal of Materials Science & Technology2011，27，8： | 5 |
| 2 | Doppler radar by using single multicarrier pulse based on optical fibre delay lines显示文摘The proposed Doppler measurement technique shows that the Doppler measurements can be accomplished by a single pulse with multiple frequency components through optical fibre delay lines.Range and velocity ambiguity can be removed,and the velocity resolution can be improved dramatically by using long optical fibre delay lines.Furthermore,the velocity resolution can be modified by adjusting the length of optical fibre delay lines.In addition,the proposed radar can achieve high range resolution by using a single wideband pulse.As a result,the new approach can improve radar performance significantly. | Junqi Duan Zishu He | 2010 | Journal of Systems Engineering and Electronics2010，21，3： | 2 |
| 3 | Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway显示文摘Although cisplatin is one of the chemotherapeutics most frequently used in oral squamous cell carcinoma(OSCC)treatment,it exerts multiple side effects and poor chemosensitivity.Nitrate reportedly demonstrates several beneficial biological functions,and synthesized nitrates enhance the therapeutic efficacy of chemotherapy.However,the role of inorganic nitrate in cisplatin chemotherapy remains unclear.We therefore investigated the effect of inorganic nitrate exerted on cisplatin sensitivity in OSCC.We found that nitrate did not affect OSCC cell growth and apoptosis in OSCC cells and OSCC xenograft tumor animal studies.Cisplatin induced REDD1 expression and AKT activation in OSCC.However,nitrate could increase cisplatin chemosensitivity,reduce its REDD1 expression,and attenuate AKT signaling activation in OSCC cells.Dysregulation of high levels of REDD1,which could enhance AKT activation,was positively associated with poor prognosis in OSCC patients.Thus,reduced REDD1 expression and retarded AKT activation induced by inorganic nitrate might be a new potential approach to the sensitization of oral cancer to cisplatin treatment in the future. | Yuanyong Feng Xuedi Cao Bin Zhao Chunyan Song Baoxing Pang Liang Hu Chunmei Zhang Jinsong Wang Junqi He Songlin Wang | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 4 | EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity显示文摘 | Jun-Fang Zheng Li-Cui Sun Hua Liu Yan Huang Yang Li Junqi He | 2010 | Amino Acids2010，，4： | 1 |
| 5 | Defective TiO_(2)-graphene heterostructures enabling in-situ electrocatalyst evolution for lithium-sulfur batteries显示文摘Lithium-sulfur (Li-S) batteries are considered as one of the promising next-generation energy storage systems because of their high energy density. While the low utilization of sulfur and sluggish reaction kinetics would lead to degradation of electrochemical performance and thus hinder the practical application of Li-S batteries. Herein, a double-shelled TiO_(2)-graphene heterostructure (H-TiO_(2)/rGO) with abundant oxygen vacancies (OVs) and highly exposed active plane as advanced host material in Li-S batteries is designed. This rational structure not only provides sufficient active sites and lower bandgap for lithium polysulfides (LiPSs), but also builds smooth adsorption-diffusion-conversion of LiPSs on catalyst, which greatly reduces interfacial energy barrier and promotes the utilization of sulfur through suppressing the devastating shuttling effect. Combining the synergetic merits of strong anchoring ability and catalyzing the of LiPSs, the electrode (S-TiO_(2)/rGO-1) exhibits superior rate performance and long lifespan (1000 cycles at 1C, 0.023% capacity loss per cycle) with high columbic efficiency. This work paves an alternative way to establish smooth adsorption-diffusion-conversion of polysulfides on catalyst in Li-S batteries and provides a new sight to understand catalyst design in energy storage devices. | Yanqi Feng Hui Liu Yi Liu Fuwei Zhao Junqi Li Xuanmeng He | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 6 | Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination显示文摘Poly(ADP-ribosyl)ation(PARylation)is a posttranslational modification reversibly catalyzed by poly(ADP-ribose)polymerases(PARPs)and poly(ADP-ribose)glycohydrolases(PARGs)and plays a key role in multi-ple cellular processes.The molecular mechanisms by which PARylation regulates innate immunity remain largely unknown in eukaryotes.Here we show that Arabidopsis UBC13A and UBC13B,the major drivers of lysine 63(K63)-linked polyubiquitination,directly interact with PARPs/PARGs.Activation of pathogen-associated molecular pattern(PAMP)-triggered immunity promotes these interactions and enhances PARylation of UBC13.Both parp1 parp2 and ubc13a ubc13b mutants are compromised in immune responses with increased accumulation of total pathogenesis-related(PR)proteins but decreased accu-mulation of secreted PR proteins.Protein disulfide-isomerases(PDIs),essential components of endo-plasmic reticulum quality control(ERQC)that ensure proper folding and maturation of proteins destined for secretion,complex with PARPs/PARGs and are PARylated upon PAMP perception.Significantly,PARylation of UBC13 regulates K63-linked ubiquitination of PDIs,which may further promote their disulfide isomerase activities for correct protein folding and subsequent secretion.Taken together,these results indicate that plant immunity is coordinately regulated by PARylation and K63-linked ubiquitination. | Dongsheng Yao Marcus A.Arguez Ping He Andrew F.Bent Junqi Song | 2021 | Molecular Plant2021，14，12： | 1 |
| 7 | Laser remelting of plasma-sprayed conventional and nanostructured Al 2 O 3 –13<ce:hsp sp='0.25'/>wt.%TiO 2 coatings on titanium alloy显示文摘 | Chonggui Li You Wang Lixin Guo Junqi He Zhaoyi Pan Liang Wang | 2010 | Journal of Alloys and Compounds2010，，1： | 1 |
| 8 | The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function显示文摘 | Xinglu Huang Xu Teng Dong Chen Fangqiong Tang Junqi He | 2009 | Biomaterials2009，，3： | 1 |
| 9 | The combination stretching function technique with simulated annealing algorithm for global optimization显示文摘 | He Junqi Dai Huiya Song Xueli | 2014 | Optimization Methods and Software2014，29，3： | 1 |
| 10 | Size effect of (Al 2 O 3 –Y 2 O 3 )/YSZ micro-laminated coating on high-temperature oxidation resistance显示文摘 | Junqi Yao Lili Lv Yedong He Deren Wang | 2013 | Applied Surface Science2013，，： | 1 |
| 11 | Thermal barrier coatings with (Al 2 O 3 –Y 2 O 3 )/(Pt or Pt–Au) composite bond coat and 8YSZ top coat on Ni-based superalloy显示文摘 | Junqi Yao Yedong He Deren Wang Hui Peng Hongbo Guo Shengkai Gong | 2013 | Applied Surface Science2013，，： | 1 |
| 12 | Autumn NDVI contributes more and more to vegetation improvement in the growing season across the Tibetan Platea显示文摘Detecting changes in vegetation,distinguishing the persistence of changes,and seeking their causes during multiple periods are important to gaining a deeper understanding of vegetation dynamics.Using the Global Inventory Modeling and Mapping Studies Normalized Difference Vegetation Index(NDVI)version NDVI_(3g) dataset in the Tibetan Plateau,the trends in the seasonal components of NDVI and their linkage with climatic factors were analyzed over 14 asymptotic periods of 18–31 years since 1982.Dynamic trends in vegetation experienced an obvious increase at regional scale,but the increases of vegetation activity mostly tended to stall or slow down as the studied time period was extended.At pixel scale,areas with significant browning significantly expanded over 14 periods for all seasons,but for significant greening significantly increased only in autumn.The changes of vegetation activity in spring were the most drastic among three seasons.Increased increments of NDVI in summer,spring,and autumn took turns being the main reason for the enhanced vegetation activity in the growing season in the nested 14 periods.Vegetation activity was mainly regulated by a thermal factor,and the dominant climatic drivers of vegetation growth varied across different seasons and regions.We speculate that the increase of NDVI will continue but the increments will decline in all seasons except autumn. | Jiaqiang Du Ping He Shifeng Fang Weiling Liu Xinjie Yuan Junqi Yin | 2017 | International Journal of Digital Earth2017，10，11： | 0 |
| 13 | Enhanced Water Resistance Performance of Castor Oil—Based Waterborne Polyurethane Modified by Methoxysilane Coupling Agents via Thiol-Ene Photo Click Reaction显示文摘Nowadays,waterborne polyurethanes(WPUs)prepared from renewable resources has attracted more and more attention.However,due to its structure,the prepared films easily swells in water and greatly affects the application range of WPUs.Therefore,solving the problem of water resistance is a way to improve the application range of WPUs.In this study,a series of WPU dispersions were prepared using castor oil as the bio-based polyol.Besides,the thiol-ene photo click reaction was carried out on the WPU films for silane modification.The effect of the silane modification on the chemical structures of the WPU dispersions and the properties of the WPU films was investigated and discussed.The results revealed that the WPU dispersions had a smaller particle size and potential,showing excellent stability.In addition,the modified WPU films showed highly water resistance which 72 h water absorption could be reduced to 1.94%and the contact angle was up to 99.34?.Moreover,the modified WPU films also exhibited excellent solvent resistance(in acid and salt solution)and thermal stability.This study can provide a new way to improve the water-resistance,hydrophobicity,and thermal stability of bio-based waterborne polyurethane for potential application in painting,adhesives and inks. | Zhipeng He Junqi Xue Yanzi Ke Ying Luo Qiming Lu Yuehua Xu Chaoqun Zhang | 2022 | Journal of Renewable Materials2022，10，3： | 0 |
| 14 | Selection of HBV preSl-binding penta-peptides by phage display显示文摘 | Yonggang He Xiaoli Ye Pierre Tiollais Jiming Zhang Junqi Zhang Jing Liu Youhua Xie | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 0 |
| 15 | Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody显示文摘Induction of broadly neutralizing monoclonal antibodies(bNAbs)that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus(HCV)vaccine research.The study of bNAbs arising in natural infection is essential in this endeavor.We generated a human antibody,8D6,recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient.This antibody shows broadly neutralizing activity,which covers a pan-genotypic panel of cell culture-derived HCV virions(HCVcc).Functional and epitope analyses demonstrated that 8D6 can block the interaction between E2 and CD81 by targeting a highly conserved epitope on E2.We describe how the 8D6 lineage evolved via somatic hypermutation to achieve broad neutralization.We found that the V(D)J recombination-generated junctional and somatic hypermutation-induced disulfide bridge(C-C)motif in the CDRH3 is critical for the broad neutralization and binding activity of 8D6.This motif is conserved among a series of broadly neutralizing HCV antibodies,indicating a common binding model.Next,the 8D6 inferred germline(iGL)was reconstructed and tested for its binding affinity and neutralization activity.Interestingly,8D6 iGL-mediated relatively strong inhibition of the 1b genotype PR79L9 strain,suggesting that PR79L9 may serve as a potential natural viral strain that provides E2 sequences that induce bNAbs.Overall,our detailed epitope mapping and genetic studies of the HCV E2-specific mAb 8D6 have allowed for further refinement of antigenic sites on E2 and reveal a new mechanism to generate a functional CDRH3,while its iGL can serve as a probe to identify potential HCV vaccine strains. | Chunyan Yi Jing Xia Lan He Zhiyang Ling Xuesong Wang Yu Yan Jiangjun Wang Xinhao Zhao Weiguo Fan Xiaoyu Sun Ronghua Zhang Sheng Ye Rongguang Zhang Yongfen Xu Liyan Ma Yaguang Zhang Honglin Zhou Zhong Huang Junqi Niu Gang Long Junxia Lu Jin Zhong Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 16 | Expert consensus on irrigation and intracanal medication in root canal therapy显示文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. | Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 17 | Study of Uranium Plating Prepared by Electro-deposition Method显示文摘Uranium plating prepared by electro-deposition method can be used in high temperature fission ionization chamber,so it’s an important work to determine the optimum preparation conditions and detect the quality and thickness of the uranium plating coating.In this paper,the optimum process conditions for the preparation of uranium plating are determined by discussing the effects of different concentrations of uranium solution,temperature,pH and current density on the electro-deposition efficiency and coating quality. | SHAO Junqi ZHAO Jiangbin HE Gaokui ZHANG Xiangyang LIU Yang GUO Li | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 18 | 诱导多能性干细胞过程中染色质可及性动态变化规律显示文摘文章简介关于体细胞重编程中染色质结构重排的机制一直没有被清晰地研究过。本研究通过采用可在全基因组范围内研究开放染色质的ATAC(Assay for Transposase-Accessible Chromatin)技术。 | 李东伟 刘晶 杨雪洁 Chunhua Zhou Jing Guo Chuman Wu Yue Qin Lin Guo Jiangping He Shenyong Yu He Liu Xiaoshan Wang Fang Wu Junqi Kuang Andrew P.Hutchins 陈捷凯 裴端卿 | 2018 | 科学新闻2018，0，4： | 0 |
| 19 | Adaptive fault-tolerant control of high-speed maglev train suspension system with partial actuator failure: design and experiments显示文摘High-speed maglev trains will play an important role in the high-speed transportation system in the near future.However,under the conditions of strong magnetic fields and continuous operation,the actuators of the high-speed maglev train suspension system are prone to lose partial effectiveness,which makes the suspension control problem challenging.In addition,most existing fault-tolerant control(FTC)methods for suspension systems require linearization around the equilibrium points during the controller design or stability analysis.Therefore,from a practical perspective,this study presents a novel nonlinear FTC strategy with adaptive compensation for high-speed maglev train suspension systems.First,a nonlinear dynamic model of the suspension system based on join-structure is established and the actuator failures are described.Then,a nonlinear fault-tolerant suspension control law with an adaptive update law is designed to achieve stable suspension against partial actuator failure.The Lyapunov theory and extended Barbalat lemma are utilized to rigorously prove the closed-loop asymptotic stability even if there is partial actuator failure,without any approximation to the original nonlinear dynamics.Finally,hardware experimental results are included to demonstrate the effectiveness of the proposed approach. | Yougang SUN Fengxing LI Guobin LIN Junqi XU Zhenyu HE | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，3： | 0 |
| 20 | EBP50影响HeLa细胞微丝骨架的分布和定位(英文)显示文摘Objective:To explore the influence of EBP50(ezrin-radixin-moesin-binding phospho-protein-50) on microfilament cytoskeleton content and distribution in cultured Hela cells, and to investigate the relationship between the changes in microfilament cytoskeleton localization and EBP50 after PDGF(platelet-derived growth factor) stimulation, and to further clarify the molecular mechanism by which EBP50 suppresses tumor cell proliferation and migration.Methods:pBK-CMV-HAEBP50 wild type recombinant plasmid and pBK-CMV-HA empty vector were transfected into Hela cells.G418 at 350 mg/L was used to screen for cell clones stably expressing EBP50.Western blot was carried out to detect EBP50 expression.Similarities and differences in microfilament cytoskeleton content and distribution in Hela cells transfected with pBK-CMV-HA-EBP50 wild type recombinant plasmid and pBK-CMV-HA empty vector were also treated with PDGF(10 ng/mL and 20 ng/mL, 37 ℃, 15 min) and stained by rhodamine-labeled phalloidin to observe the distribution of microfilament cytoskeleton in the two groups.EBP50 protein distribution in PDGF-stimulated Hela cells was detected by immunofluorescence.Results:Western blot results confirmed that the EBP50 cDNA fragment could express EBP50 in cultured Hela cell lines and that cell lines stably expressing EBP50 were successfully obtained.Western blot and fluorescence results showed that in the cell line transfected with empty vector, the microfilament cytoskeleton was thick, loose, multidirectional and displayed crossing arrangements.The content of microfilament cytoskeleton in the cell line transfected with pBK-CMV-HA-EBP50 was different from that found in the cell line transfected with empty vector.EBP50 expression enhanced microfilament cytoskeleton polymerization into compact thin filaments.Under the stimulation of PDGF, EBP50 migrated to the cell membrane from the cytosol together with microfilament cytoskeleton and co-localized there.Conclusion:EBP50 can change the distribution of microfilament cytoskeleton in cultured Hela cells and can also bind the microfilament cytoskeleton to the cell membrane under the stimulation of PDGF.EBP50 may play a role in the proliferation and migration of tumor cells by influencing the distribution and localization of microfilament cytoskeleton. | Kun Liu Junfang Zheng Ying Wang Peng Chen Junqi He | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，5： | 0 |
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