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您的检索式：作者名="He Xuejiang"
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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Experimental studies on the utilization of steel slag in the steam-cured concrete显示文摘The possibility of applying steel slag as mineraladmixture in steam-cured concrete was investigated. Thecompressive strength, chloride permeability, carbonationdepth and drying shrinkage of concrete and the microstructurecharacteristics of hardened paste were studied. Results showthat the steam-cured concrete containing steel slag at a highwater-to-binder ratio has low compressive strength, coarsepore structure, moderate permeability, large carbonation depthand great drying shrinkage. The negative effects of steel slagon the mechanical and durability performance of steam-curedconcrete become smaller at a low water-to-binder ratio or byadding ultrafine ground granulated blast furnace slag(UGGBS). The later-age hydration of cement is significantlypromoted by adding steel slag. The pozzolanic reaction andmicro-filler effect of UGGBS result in dense structure, whichmakes great contribution to the strength development anddurability performance of steam-cured concrete. These effectsof steel slag and UGGBS are significant at a low water tobinder ratio. The steam-cured concrete containing steel slag-UGGBS blended mineral admixture at a low water-to-binderratio has the best performance with high compressive strength,fine pore structure and good durability. | Han Fanghui Liu Juanhong He Xuejiang Song Shaomin | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 1 |
| 3 | The testis-specifically expressed gene Trim69 is not essential for fertility in mice显示文摘Protein ubiquitination is essential for diverse cellular functions including spermatogenesis.The tripartite motif(TRIM)family proteins,most of which have E3 ubiquitin ligase activity,are highly conserved in mammals.They are involved in important cellular processes such as embryonic development,immunity,and fertility.Our previous studies indicated that Trim69,a testis-specific expressed TRIM family gene,potentially participates in the spermatogenesis by mediating testicular cells apoptosis.In this study,we investigated the biological functions of Trim69 in male mice by established Trim69 knockout mice with CRISPR/Cas9 genomic editing technology.Here,we reported that the male Trim69 knockout mice had normal fertility.The adult knockout mice have shown that the appearance of testes,testis/body weight ratios,testicular histomorphology,and the number and quality of sperm were consistent with wild-type mice.These results indicated that the E3 ubiquitin ligase protein Trim69 was not essential for male mouse fertility,and it might be compensated by other TRIM family members such as Trim58 in Trim69-deficiency testis.This study would help to elucidate the functions of tripartite motif protein family and the regulation of spermatogenesis. | Xi He Wenxiu Xie Huiling Li Yiqiang Cui Ya Wang Xuejiang Guo Jiahao Sha | 2021 | The Journal of Biomedical Research2021，35，1： | 0 |
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